Research update on the anticancer effects of buparlisib (Review)

  • Authors:
    • Jinshan Xing
    • Jun Yang
    • Yingjiang Gu
    • Jingyan Yi
  • View Affiliations

  • Published online on: February 9, 2021     https://doi.org/10.3892/ol.2021.12527
  • Article Number: 266
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Abstract

Buparlisib is a highly efficient and selective PI3K inhibitor and a member of the 2,6‑dimorpholinopyrimidine‑derived family of compounds. It selectively inhibits four isomers of PI3K, PI3Kα, PI3Kβ, PI3Kγ and PI3Kδ, by competitively binding the lipid kinase domain on adenosine 5'‑triphosphate (ATP), and serves an important role in inhibiting proliferation, promoting apoptosis and blocking angiogenesis, predominantly by antagonizing the PI3K/AKT pathway. Buparlisib has been confirmed to have a clinical effect in patients with solid tumors and hematological malignancies. A global, phase II clinical trial with buparlisib and paclitaxel in head and neck squamous cell carcinoma has now been completed, with a manageable safety profile. Buparlisib currently has fast‑track status with the United States Food and Drug Administration. The present review examined the biochemical structure, pharmacokinetic characteristics, preclinical data and ongoing clinical studies of buparlisib. The various mechanisms of influence of buparlisib in tumors, particularly in preclinical research, were summarized, providing a theoretical basis and direction for basic research on and clinical treatment with buparlisib.
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April-2021
Volume 21 Issue 4

Print ISSN: 1792-1074
Online ISSN:1792-1082

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Copy and paste a formatted citation
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Spandidos Publications style
Xing J, Yang J, Gu Y and Yi J: Research update on the anticancer effects of buparlisib (Review). Oncol Lett 21: 266, 2021
APA
Xing, J., Yang, J., Gu, Y., & Yi, J. (2021). Research update on the anticancer effects of buparlisib (Review). Oncology Letters, 21, 266. https://doi.org/10.3892/ol.2021.12527
MLA
Xing, J., Yang, J., Gu, Y., Yi, J."Research update on the anticancer effects of buparlisib (Review)". Oncology Letters 21.4 (2021): 266.
Chicago
Xing, J., Yang, J., Gu, Y., Yi, J."Research update on the anticancer effects of buparlisib (Review)". Oncology Letters 21, no. 4 (2021): 266. https://doi.org/10.3892/ol.2021.12527