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Psoriasin expression is associated with survival in patients with human papillomavirus-positive base of tongue squamous cell carcinoma

  • Authors:
    • Mark Zupancic
    • Linnea Haeggblom
    • David Landin
    • Linda Marklund
    • Tina Dalianis
    • Anders Näsman
  • View Affiliations / Copyright

    Affiliations: Department of Oncology-Pathology, Karolinska Institutet, 171 64 Stockholm, Sweden, Division of Ear, Nose and Throat Diseases, Department of Clinical Science, Intervention and Technology - CLINTEC, Karolinska Institutet, 171 64 Stockholm, Sweden
    Copyright: © Zupancic et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 277
    |
    Published online on: February 10, 2021
       https://doi.org/10.3892/ol.2021.12538
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Abstract

Patients with human papillomavirus-positive (HPV+) base of tongue squamous cell carcinomas (BOTSCC) have an improved survival compared with patients with HPV-negative BOTSCC and it has been suggested that treatment should be tailored. Before individualized treatment can be introduced, additional prognostic markers are required. A prognostic role of psoriasin has previously been demonstrated outside BOTSCC. Therefore, the present study aimed to examine psoriasin in BOTSCC, with focus on HPV+ BOTSCC, in relation to prognosis. A total of 72 BOTSCC samples were stained for psoriasin by immunohistochemistry, and the association between expression and clinical outcomes was analyzed. Patients with low psoriasin expression exhibited significantly improved overall survival (OS; P=0.001) and disease-free survival (DFS; P=0.007), which also was observed in patients with HPV+ BOTSCC (OS, P<0.001; DFS, P=0.02). Furthermore, psoriasin was a significant prognostic factor in univariable and multivariable analyses. In conclusion, psoriasin could be used as a prognostic marker in HPV+ BOTSCC.
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Copy and paste a formatted citation
Spandidos Publications style
Zupancic M, Haeggblom L, Landin D, Marklund L, Dalianis T and Näsman A: Psoriasin expression is associated with survival in patients with human papillomavirus-positive base of tongue squamous cell carcinoma. Oncol Lett 21: 277, 2021.
APA
Zupancic, M., Haeggblom, L., Landin, D., Marklund, L., Dalianis, T., & Näsman, A. (2021). Psoriasin expression is associated with survival in patients with human papillomavirus-positive base of tongue squamous cell carcinoma. Oncology Letters, 21, 277. https://doi.org/10.3892/ol.2021.12538
MLA
Zupancic, M., Haeggblom, L., Landin, D., Marklund, L., Dalianis, T., Näsman, A."Psoriasin expression is associated with survival in patients with human papillomavirus-positive base of tongue squamous cell carcinoma". Oncology Letters 21.4 (2021): 277.
Chicago
Zupancic, M., Haeggblom, L., Landin, D., Marklund, L., Dalianis, T., Näsman, A."Psoriasin expression is associated with survival in patients with human papillomavirus-positive base of tongue squamous cell carcinoma". Oncology Letters 21, no. 4 (2021): 277. https://doi.org/10.3892/ol.2021.12538
Copy and paste a formatted citation
x
Spandidos Publications style
Zupancic M, Haeggblom L, Landin D, Marklund L, Dalianis T and Näsman A: Psoriasin expression is associated with survival in patients with human papillomavirus-positive base of tongue squamous cell carcinoma. Oncol Lett 21: 277, 2021.
APA
Zupancic, M., Haeggblom, L., Landin, D., Marklund, L., Dalianis, T., & Näsman, A. (2021). Psoriasin expression is associated with survival in patients with human papillomavirus-positive base of tongue squamous cell carcinoma. Oncology Letters, 21, 277. https://doi.org/10.3892/ol.2021.12538
MLA
Zupancic, M., Haeggblom, L., Landin, D., Marklund, L., Dalianis, T., Näsman, A."Psoriasin expression is associated with survival in patients with human papillomavirus-positive base of tongue squamous cell carcinoma". Oncology Letters 21.4 (2021): 277.
Chicago
Zupancic, M., Haeggblom, L., Landin, D., Marklund, L., Dalianis, T., Näsman, A."Psoriasin expression is associated with survival in patients with human papillomavirus-positive base of tongue squamous cell carcinoma". Oncology Letters 21, no. 4 (2021): 277. https://doi.org/10.3892/ol.2021.12538
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