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April-2021 Volume 21 Issue 4

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Review

The changing treatment of metastatic her2‑positive breast cancer (Review)

  • Authors:
    • Maria Mitsogianni
    • Ioannis P. Trontzas
    • Georgia Gomatou
    • Stephanie Ioannou
    • Nikolaos K. Syrigos
    • Elias A. Kotteas
  • View Affiliations / Copyright

    Affiliations: Oncology Unit, ‘Sotiria’ General Hospital, Athens School of Medicine, Athens 11527, Greece
  • Article Number: 287
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    Published online on: February 12, 2021
       https://doi.org/10.3892/ol.2021.12548
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Abstract

Human epidermal growth factor receptor 2 (HER2)‑overexpressing breast cancer has been historically associated with an aggressive disease course with common distant metastasis and poor prognosis. HER2‑targeting therapies have significantly changed treatment and drastically improved outcomes for this group of patients. However, primary or acquired resistance to anti‑HER2 regimens leads almost universally to disease progression, often with difficult to treat central nervous system (CNS) metastases. The current review summarized the existing therapeutic options for HER2‑positive metastatic disease in the first, second and further line setting. Furthermore, novel agents currently under development were presented, which have demonstrated encouraging results in heavily pretreated patients or specific subgroups, such as HR‑positive/HER2‑positive tumors and CNS disease.
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Copy and paste a formatted citation
Spandidos Publications style
Mitsogianni M, Trontzas IP, Gomatou G, Ioannou S, Syrigos NK and Kotteas EA: The changing treatment of metastatic her2‑positive breast cancer (Review). Oncol Lett 21: 287, 2021.
APA
Mitsogianni, M., Trontzas, I.P., Gomatou, G., Ioannou, S., Syrigos, N.K., & Kotteas, E.A. (2021). The changing treatment of metastatic her2‑positive breast cancer (Review). Oncology Letters, 21, 287. https://doi.org/10.3892/ol.2021.12548
MLA
Mitsogianni, M., Trontzas, I. P., Gomatou, G., Ioannou, S., Syrigos, N. K., Kotteas, E. A."The changing treatment of metastatic her2‑positive breast cancer (Review)". Oncology Letters 21.4 (2021): 287.
Chicago
Mitsogianni, M., Trontzas, I. P., Gomatou, G., Ioannou, S., Syrigos, N. K., Kotteas, E. A."The changing treatment of metastatic her2‑positive breast cancer (Review)". Oncology Letters 21, no. 4 (2021): 287. https://doi.org/10.3892/ol.2021.12548
Copy and paste a formatted citation
x
Spandidos Publications style
Mitsogianni M, Trontzas IP, Gomatou G, Ioannou S, Syrigos NK and Kotteas EA: The changing treatment of metastatic her2‑positive breast cancer (Review). Oncol Lett 21: 287, 2021.
APA
Mitsogianni, M., Trontzas, I.P., Gomatou, G., Ioannou, S., Syrigos, N.K., & Kotteas, E.A. (2021). The changing treatment of metastatic her2‑positive breast cancer (Review). Oncology Letters, 21, 287. https://doi.org/10.3892/ol.2021.12548
MLA
Mitsogianni, M., Trontzas, I. P., Gomatou, G., Ioannou, S., Syrigos, N. K., Kotteas, E. A."The changing treatment of metastatic her2‑positive breast cancer (Review)". Oncology Letters 21.4 (2021): 287.
Chicago
Mitsogianni, M., Trontzas, I. P., Gomatou, G., Ioannou, S., Syrigos, N. K., Kotteas, E. A."The changing treatment of metastatic her2‑positive breast cancer (Review)". Oncology Letters 21, no. 4 (2021): 287. https://doi.org/10.3892/ol.2021.12548
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