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lncRNA UASR1 is overexpressed in oral squamous cell carcinoma and regulates cancer cell proliferation by regulating miR‑375/JAK2 axis

  • Authors:
    • Yugang Sun
    • Liang Chen
    • Lina Pan
  • View Affiliations / Copyright

    Affiliations: Department of Oral and Maxillofacial Surgery, Shungeng Branch, Jinan Stomatological Hospital, Jinan, Shandong 250001, P.R. China, Department of Endodontics, Shungeng Branch, Jinan Stomatological Hospital, Jinan, Shandong 250001, P.R. China
    Copyright: © Sun et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 288
    |
    Published online on: February 12, 2021
       https://doi.org/10.3892/ol.2021.12549
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Abstract

Long non‑coding RNAs (lncRNAs) have been confirmed to participate in cancer regulation, including oral squamous cell carcinoma (OSCC). The aim of the present study was to investigate the role of UASR1 in OSCC. The expression levels of UASR1, miR‑375 and JAK2 were detected in OSCC tissues by reverse transcriptase quantitative PCR. The targets of UASR1 were predicted by IntaRNA. Colony formation and CCK‑8 assays were conducted to estimate cell proliferation. Western blotting was used to detect the protein expression of JAK2. The results demonstrated that UASR1 was upregulated in OSCC tissues compared with non‑tumor tissues, and the high level of UASR1 expression was associated with poor overall survival. UASR1 is predicted to interact with miR‑375 and the interaction was confirmed by dual-luciferase activity assay. However, overexpression of UASR1 and miR‑375 did not affect the expression of each other. Instead, upregulation of JAK2, a target of miR‑375, was observed after the overexpression of UASR1 in OSCC cells. Moreover, overexpression of UASR1 attenuated the inhibitory effects of miR‑375 on the expression of JAK2 and cell proliferation. Therefore, UASR1 is overexpressed in OSCC and regulates cancer cell proliferation by regulating the miR‑375/JAK2 axis.
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1 

Lydiatt WM, Patel SG, O'Sullivan B, Brandwein MS, Ridge JA, Migliacci JC, Loomis AM and Shah JP: Head and neck cancers-major changes in the American joint committee on cancer eighth edition cancer staging manual. CA Cancer J Clin. 67:122–137. 2017. View Article : Google Scholar : PubMed/NCBI

2 

Bray F, Ferlay J, Soerjomataram I, Siegel RL, Torre LA and Jemal A: Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA Cancer J Clin. 68:394–424. 2018. View Article : Google Scholar : PubMed/NCBI

3 

Kumar M, Nanavati R, Modi TG and Dobariya C: Oral cancer: Etiology and risk factors: A review. J Cancer Res Ther. 12:458–463. 2016. View Article : Google Scholar : PubMed/NCBI

4 

Ghantous Y and Abu Elnaaj I: Global incidence and risk factors of oral cancer. Harefuah. 156:645–649. 2017.(In Hebrew). PubMed/NCBI

5 

Rivera C: Essentials of oral cancer. Int J Clin Exp Pathol. 8:11884–11894. 2015.PubMed/NCBI

6 

Ram H, Sarkar J, Kumar H, Konwar R, Bhatt ML and Mohammad S: Oral cancer: Risk factors and molecular pathogenesis. J Maxillofac Oral Surg. 10:132–137. 2011. View Article : Google Scholar : PubMed/NCBI

7 

Brocklehurst P, Kujan O, O'Malley LA, Ogden G, Shepherd S and Glenny AM: Screening programmes for the early detection and prevention of oral cancer. Cochrane Database Syst Rev. CD0041502013.PubMed/NCBI

8 

Mishra R: Glycogen synthase kinase 3 beta: Can it be a target for oral cancer. Mol Cancer. 9:1442010. View Article : Google Scholar : PubMed/NCBI

9 

Molinolo AA, Marsh C, El Dinali M, Gangane N, Jennison K, Hewitt S, Patel V, Seiwert TY and Gutkind JS: mTOR as a molecular target in HPV-associated oral and cervical squamous carcinomas. Clin Cancer Res. 18:2558–2568. 2012. View Article : Google Scholar : PubMed/NCBI

10 

Ohnishi Y, Yasui H, Nozaki M and Nakajima M: Molecularly-targeted therapy for the oral cancer stem cells. Jpn Dent Sci Rev. 54:88–103. 2018. View Article : Google Scholar : PubMed/NCBI

11 

Sanchez Calle A, Kawamura Y, Yamamoto Y, Takeshita F and Ochiya T: Emerging roles of long non-coding RNA in cancer. Cancer Sci. 109:2093–2100. 2018. View Article : Google Scholar : PubMed/NCBI

12 

Gutschner T and Diederichs S: The hallmarks of cancer: A long non-coding RNA point of view. RNA Biol. 9:703–719. 2012. View Article : Google Scholar : PubMed/NCBI

13 

Cao Z, Wu P, Su M, Ling H, Khoshaba R, Huang C, Gao H, Zhao Y, Chen J, Liao Q, et al: Long non-coding RNA UASR1 promotes proliferation and migration of breast cancer cells through the AKT/mTOR pathway. J Cancer. 10:2025–2034. 2019. View Article : Google Scholar : PubMed/NCBI

14 

Ding L, Xu Y, Zhang W, Deng Y, Si M, Du Y, Yao H, Liu X, Ke Y, Si J and Zhou T: MiR-375 frequently downregulated in gastric cancer inhibits cell proliferation by targeting JAK2. Cell Res. 20:784–793. 2010. View Article : Google Scholar : PubMed/NCBI

15 

Livak KJ and Schmittgen TD: Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) method. Methods. 25:402–408. 2001. View Article : Google Scholar : PubMed/NCBI

16 

Tirelli G, Gatto A, Boscolo Nata F, Bussani R, Piccinato A, Marcuzzo AV and Tofanelli M: Prognosis of oral cancer: A comparison of the staging systems given in the 7th and 8th editions of the American Joint Committee on Cancer Staging Manual. Br J Oral Maxillofac Surg. 56:8–13. 2018. View Article : Google Scholar : PubMed/NCBI

17 

Jairajpuri ZS, Rana S, Hajela A and Jetley S: Toward early diagnosis of oral cancer: Diagnostic utility of cytomorphological features, a pilot study. Natl J Maxillofac Surg. 10:20–26. 2019. View Article : Google Scholar : PubMed/NCBI

18 

Wu Y, Sun X, Song B, Qiu X and Zhao J: MiR-375/SLC7A11 axis regulates oral squamous cell carcinoma proliferation and invasion. Cancer Med. 6:1686–1697. 2017. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Sun Y, Chen L and Pan L: lncRNA UASR1 is overexpressed in oral squamous cell carcinoma and regulates cancer cell proliferation by regulating miR‑375/JAK2 axis. Oncol Lett 21: 288, 2021.
APA
Sun, Y., Chen, L., & Pan, L. (2021). lncRNA UASR1 is overexpressed in oral squamous cell carcinoma and regulates cancer cell proliferation by regulating miR‑375/JAK2 axis. Oncology Letters, 21, 288. https://doi.org/10.3892/ol.2021.12549
MLA
Sun, Y., Chen, L., Pan, L."lncRNA UASR1 is overexpressed in oral squamous cell carcinoma and regulates cancer cell proliferation by regulating miR‑375/JAK2 axis". Oncology Letters 21.4 (2021): 288.
Chicago
Sun, Y., Chen, L., Pan, L."lncRNA UASR1 is overexpressed in oral squamous cell carcinoma and regulates cancer cell proliferation by regulating miR‑375/JAK2 axis". Oncology Letters 21, no. 4 (2021): 288. https://doi.org/10.3892/ol.2021.12549
Copy and paste a formatted citation
x
Spandidos Publications style
Sun Y, Chen L and Pan L: lncRNA UASR1 is overexpressed in oral squamous cell carcinoma and regulates cancer cell proliferation by regulating miR‑375/JAK2 axis. Oncol Lett 21: 288, 2021.
APA
Sun, Y., Chen, L., & Pan, L. (2021). lncRNA UASR1 is overexpressed in oral squamous cell carcinoma and regulates cancer cell proliferation by regulating miR‑375/JAK2 axis. Oncology Letters, 21, 288. https://doi.org/10.3892/ol.2021.12549
MLA
Sun, Y., Chen, L., Pan, L."lncRNA UASR1 is overexpressed in oral squamous cell carcinoma and regulates cancer cell proliferation by regulating miR‑375/JAK2 axis". Oncology Letters 21.4 (2021): 288.
Chicago
Sun, Y., Chen, L., Pan, L."lncRNA UASR1 is overexpressed in oral squamous cell carcinoma and regulates cancer cell proliferation by regulating miR‑375/JAK2 axis". Oncology Letters 21, no. 4 (2021): 288. https://doi.org/10.3892/ol.2021.12549
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