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Nuclear factor‑κB inhibitor Bay11‑7082 inhibits gastric cancer cell proliferation by inhibiting Gli1 expression

  • Authors:
    • Yan Yan
    • Heya Qian
    • Ying Cao
    • Tao Zhu
  • View Affiliations / Copyright

    Affiliations: Department of Pharmacology, The Affiliated Zhangjiagang Hospital of Soochow University, Zhangjiagang, Jiangsu 215600, P.R. China, Department of Oncology, The Affiliated Zhangjiagang Hospital of Soochow University, Zhangjiagang, Jiangsu 215600, P.R. China, Department of Laboratory, The Affiliated Zhangjiagang Hospital of Soochow University, Zhangjiagang, Jiangsu 215600, P.R. China
    Copyright: © Yan et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 301
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    Published online on: February 17, 2021
       https://doi.org/10.3892/ol.2021.12562
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Abstract

Dysregulated nuclear factor (NF)‑κB signaling pathway is involved in gastric carcinogenesis. The present study aimed to investigate the antitumor effects of the NF‑κB inhibitor, Bay11‑7082, on gastric cancer (GC) and elucidate its underlying molecular mechanisms. The MTT assay was performed to assess the effects of Bay11‑7082 on the proliferation of HGC27 and MKN45 gastric cancer cells. In addition, the Transwell and wound healing assays were performed to determine cell migration and invasion, respectively. Reverse transcription‑quantitative PCR and western blot analyses were performed to detect the mRNA and protein expression levels of the target genes. The results demonstrated that the half‑maximal inhibitory concentration (IC50) of Bay11‑7082 in HGC27 cells was 24.88, 6.72 and 4.23 nM at 24, 48 and 72 h, respectively. Furthermore, the IC50 of Bay11‑7082 in MKN45 cells was 29.11, 11.22 and 5.88 nM at 24, 48 and 72 h, respectively. Treatment with Bay11‑7082 significantly suppressed the cell migratory and invasive abilities compared with the control group. Notably, Bay11‑7082 suppressed GLI Family Zinc Finger 1 (Gli1) mRNA and protein expression levels. Taken together, the results of the present study demonstrated that Bay11‑7082 inhibited GC cell proliferation, at least in part through inhibition of Gli1.
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View References

1 

Rawla P and Barsouk A: Epidemiology of gastric cancer: Global trends, risk factors and prevention. Prz Gastroenterol. 14:26–38. 2019.PubMed/NCBI

2 

Machlowska J, Baj J, Sitarz M, Maciejewski R and Sitarz R: Gastric Cancer: Epidemiology, risk factors, classification, genomic characteristics and treatment strategies. Int J Mol Sci. 21:40122020. View Article : Google Scholar

3 

Balar AV, Galsky MD, Rosenberg JE, Powles T, Petrylak DP, Bellmunt J, Loriot Y, Necchi A, Hoffman-Censits J, Perez-Gracia JL, et al IMvigor210 Study Group, : Atezolizumab as first-line treatment in cisplatin-ineligible patients with locally advanced and metastatic urothelial carcinoma: A single-arm, multicentre, phase 2 trial. Lancet. 389:67–76. 2017. View Article : Google Scholar : PubMed/NCBI

4 

Winawer SJ: Gastric cancer: Worldwide burden and prevention opportunities. Chin J Dig Dis. 6:107–109. 2005. View Article : Google Scholar : PubMed/NCBI

5 

Ilson DH: Advances in the treatment of gastric cancer. Curr Opin Gastroenterol. 33:473–476. 2017. View Article : Google Scholar : PubMed/NCBI

6 

Hess LM, Michael D, Mytelka DS, Beyrer J, Liepa AM and Nicol S: Chemotherapy treatment patterns, costs, and outcomes of patients with gastric cancer in the United States: A retrospective analysis of electronic medical record (EMR) and administrative claims data. Gastric Cancer. 19:607–615. 2016. View Article : Google Scholar : PubMed/NCBI

7 

Lordick F and Siewert JR: Recent advances in multimodal treatment for gastric cancer: A review. Gastric Cancer. 8:78–85. 2005. View Article : Google Scholar : PubMed/NCBI

8 

Zali H, Rezaei-Tavirani M and Azodi M: Gastric cancer: Prevention, risk factors and treatment. Gastroenterol Hepatol Bed Bench. 4:175–185. 2011.PubMed/NCBI

9 

Liccardi G and Pentimalli F: Cancer, immunity and inflammation. Report from the CDD Cambridge Conferences 2018 and 2019. Cell Death Dis. 10:7982019. View Article : Google Scholar : PubMed/NCBI

10 

Grivennikov SI, Greten FR and Karin M: Immunity, inflammation, and cancer. Cell. 140:883–899. 2010. View Article : Google Scholar : PubMed/NCBI

11 

Diakos CI, Charles KA, McMillan DC and Clarke SJ: Cancer-related inflammation and treatment effectiveness. Lancet Oncol. 15:e493–e503. 2014. View Article : Google Scholar : PubMed/NCBI

12 

Kawanishi S, Ohnishi S, Ma N, Hiraku Y and Murata M: Crosstalk between DNA Damage and Inflammation in the Multiple Steps of Carcinogenesis. Int J Mol Sci. 18:18082017. View Article : Google Scholar

13 

Zamarron BF and Chen W: Dual roles of immune cells and their factors in cancer development and progression. Int J Biol Sci. 7:651–658. 2011. View Article : Google Scholar : PubMed/NCBI

14 

Del Prete A, Allavena P, Santoro G, Fumarulo R, Corsi MM and Mantovani A: Molecular pathways in cancer-related inflammation. Biochem Med (Zagreb). 21:264–275. 2011. View Article : Google Scholar : PubMed/NCBI

15 

Dolcet X, Llobet D, Pallares J and Matias-Guiu X: NF-kB in development and progression of human cancer. Virchows Arch. 446:475–482. 2005. View Article : Google Scholar : PubMed/NCBI

16 

Zhao J, Zhang H, Huang Y, Wang H, Wang S, Zhao C, Liang Y and Yang N: Bay11-7082 attenuates murine lupus nephritis via inhibiting NLRP3 inflammasome and NF-κB activation. Int Immunopharmacol. 17:116–122. 2013. View Article : Google Scholar : PubMed/NCBI

17 

Zhang Q, Mao Z and Sun J: NF-κB inhibitor, BAY11-7082, suppresses M2 tumor-associated macrophage induced EMT potential via miR-30a/NF-κB/Snail signaling in bladder cancer cells. Gene. 710:91–97. 2019. View Article : Google Scholar : PubMed/NCBI

18 

Zhang L, Xie J, Gan R, Wu Z, Luo H, Chen X, Lu Y, Wu L and Zheng D: Synergistic inhibition of lung cancer cells by EGCG and NF-κB inhibitor BAY11-7082. J Cancer. 10:6543–6556. 2019. View Article : Google Scholar : PubMed/NCBI

19 

Viola K, Kopf S, Huttary N, Vonach C, Kretschy N, Teichmann M, Giessrigl B, Raab I, Stary S, Krieger S, et al: Bay11-7082 inhibits the disintegration of the lymphendothelial barrier triggered by MCF-7 breast cancer spheroids; the role of ICAM-1 and adhesion. Br J Cancer. 108:564–569. 2013. View Article : Google Scholar : PubMed/NCBI

20 

Tang CT, Liang Q, Yang L, Lin XL, Wu S, Chen Y, Zhang XT, Gao YJ and Ge ZZ: RAB31 Targeted by miR-30c-2-3p regulates the GLI1 signaling pathway, affecting gastric cancer cell proliferation and apoptosis. Front Oncol. 8:5542018. View Article : Google Scholar : PubMed/NCBI

21 

Livak KJ and Schmittgen TD: Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) Method. Methods. 25:402–408. 2001. View Article : Google Scholar : PubMed/NCBI

22 

Yu M, Ren L, Liang F, Zhang Y, Jiang L, Ma W, Li C, Li X and Ye X: Effect of epiberberine from Coptis chinensis Franch on inhibition of tumor growth in MKN-45 ×enograft mice. Phytomedicine. 76:1532162020. View Article : Google Scholar : PubMed/NCBI

23 

Yang H, Wang J, Fan JH, Zhang YQ, Zhao JX, Dai XJ, Liu Q, Shen YJ, Liu C, Sun WD, et al: Ilexgenin A exerts anti-inflammation and anti-angiogenesis effects through inhibition of STAT3 and PI3K pathways and exhibits synergistic effects with Sorafenib on hepatoma growth. Toxicol Appl Pharmacol. 315:90–101. 2017. View Article : Google Scholar : PubMed/NCBI

24 

García MG, Alaniz L, Lopes EC, Blanco G, Hajos SE and Alvarez E: Inhibition of NF-kappaB activity by BAY 11-7082 increases apoptosis in multidrug resistant leukemic T-cell lines. Leuk Res. 29:1425–1434. 2005. View Article : Google Scholar : PubMed/NCBI

25 

Zheng X, Chang RL, Cui XX, Avila G, Huang MT, Liu Y, Kong AN, Rabson AB and Conney AH: Inhibition of NF-kappaB by (E)3-[(4-methylphenyl)-sulfonyl]-2-propenenitrile (BAY11-7082; BAY) is associated with enhanced 12-O-tetradecanoylphorbol-13-acetate-induced growth suppression and apoptosis in human prostate cancer PC-3 cells. Int J Oncol. 32:257–264. 2008.PubMed/NCBI

26 

Li B, Li YY, Tsao SW and Cheung AL: Targeting NF-kappaB signaling pathway suppresses tumor growth, angiogenesis, and metastasis of human esophageal cancer. Mol Cancer Ther. 8:2635–2644. 2009. View Article : Google Scholar : PubMed/NCBI

27 

Xue W, Meylan E, Oliver TG, Feldser DM, Winslow MM, Bronson R and Jacks T: Response and resistance to NF-κB inhibitors in mouse models of lung adenocarcinoma. Cancer Discov. 1:236–247. 2011. View Article : Google Scholar : PubMed/NCBI

28 

Scaife CL, Kuang J, Wills JC, Trowbridge DB, Gray P, Manning BM, Eichwald EJ, Daynes RA and Kuwada SK: Nuclear factor kappaB inhibitors induce adhesion-dependent colon cancer apoptosis: Implications for metastasis. Cancer Res. 62:6870–6878. 2002.PubMed/NCBI

29 

Keller SA, Hernandez-Hopkins D, Vider J, Ponomarev V, Hyjek E, Schattner EJ and Cesarman E: NF-kappaB is essential for the progression of KSHV- and EBV-infected lymphomas in vivo. Blood. 107:3295–3302. 2006. View Article : Google Scholar : PubMed/NCBI

30 

Dewan MZ, Terashima K, Taruishi M, Hasegawa H, Ito M, Tanaka Y, Mori N, Sata T, Koyanagi Y, Maeda M, et al: Rapid tumor formation of human T-cell leukemia virus type 1-infected cell lines in novel NOD-SCID/gammac(null) mice: Suppression by an inhibitor against NF-kappaB. J Virol. 77:5286–5294. 2003. View Article : Google Scholar : PubMed/NCBI

31 

Miyamoto R, Ito T, Nomura S, Amakawa R, Amuro H, Katashiba Y, Ogata M, Murakami N, Shimamoto K, Yamazaki C, et al: Inhibitor of IkappaB kinase activity, BAY 11-7082, interferes with interferon regulatory factor 7 nuclear translocation and type I interferon production by plasmacytoid dendritic cells. Arthritis Res Ther. 12:R872010. View Article : Google Scholar : PubMed/NCBI

32 

Jia YT, Ma B, Wei W, Xu Y, Wang Y, Tang HT and Xia ZF: Sustained activation of nuclear factor-kappaB by reactive oxygen species is involved in the pathogenesis of stress-induced gastric damage in rats. Crit Care Med. 35:1582–1591. 2007. View Article : Google Scholar : PubMed/NCBI

33 

Kumar A, Negi G and Sharma SS: Suppression of NF-κB and NF-κB regulated oxidative stress and neuroinflammation by BAY 11-7082 (IκB phosphorylation inhibitor) in experimental diabetic neuropathy. Biochimie. 94:1158–1165. 2012. View Article : Google Scholar : PubMed/NCBI

34 

Piechota A and Goraca A: Influence of nuclear factor-κB inhibition on endothelin-1 induced lung edema and oxidative stress in rats. J Physiol Pharmacol. 62:183–188. 2011.PubMed/NCBI

35 

Terzioğlu G, Türksoy Ö and Bayrak ÖF: Identification of An mtDNA Setpoint Associated with Highest Levels of CD44 Positivity and Chemoresistance in HGC-27 and MKN-45 Gastric Cancer Cell Lines. Cell J. 20:312–317. 2018.PubMed/NCBI

36 

Peng Y, Liu YM, Li LC, Wang LL and Wu XL: MicroRNA-503 inhibits gastric cancer cell growth and epithelial-to-mesenchymal transition. Oncol Lett. 7:1233–1238. 2014. View Article : Google Scholar : PubMed/NCBI

37 

Akagi T and Kimoto T: Human cell line (HGC-27) derived from the metastatic lymph node of gastric cancer. Acta Med Okayama. 30:215–219. 1976.PubMed/NCBI

38 

Busuttil RA, Liu DS, Di Costanzo N, Schröder J, Mitchell C and Boussioutas A: An orthotopic mouse model of gastric cancer invasion and metastasis. Sci Rep. 8:8252018. View Article : Google Scholar : PubMed/NCBI

39 

Kasperczyk H, Baumann B, Debatin KM and Fulda S: Characterization of sonic hedgehog as a novel NF-kappaB target gene that promotes NF-kappaB-mediated apoptosis resistance and tumor growth in vivo. FASEB J. 23:21–33. 2009. View Article : Google Scholar : PubMed/NCBI

40 

Cai K, Na W, Guo M, Xu R, Wang X, Qin Y, Wu Y, Jiang J and Huang H: Targeting the cross-talk between the hedgehog and NF-κB signaling pathways in multiple myeloma. Leuk Lymphoma. 60:772–781. 2019. View Article : Google Scholar : PubMed/NCBI

41 

Wei L, Yan N, Sun L, Bao C and Li D: Interplay between the NF κB and hedgehog signaling pathways predicts prognosis in esophageal squamous cell carcinoma following neoadjuvant chemoradiotherapy. Int J Mol Med. 41:2961–2967. 2018.PubMed/NCBI

42 

Chen M, Carkner R and Buttyan R: The hedgehog/Gli signaling paradigm in prostate cancer. Expert Rev Endocrinol Metab. 6:453–467. 2011. View Article : Google Scholar : PubMed/NCBI

43 

Xie H, Paradise BD, Ma WW and Fernandez-Zapico ME: Recent Advances in the Clinical Targeting of Hedgehog/GLI Signaling in Cancer. Cells. 8:3942019. View Article : Google Scholar

44 

Wessler S, Krisch LM, Elmer DP and Aberger F: From inflammation to gastric cancer - the importance of Hedgehog/GLI signaling in Helicobacter pylori-induced chronic inflammatory and neoplastic diseases. Cell Commun Signal. 15:152017. View Article : Google Scholar : PubMed/NCBI

45 

Wu WK, Cho CH, Lee CW, Fan D, Wu K, Yu J and Sung JJ: Dysregulation of cellular signaling in gastric cancer. Cancer Lett. 295:144–153. 2010. View Article : Google Scholar : PubMed/NCBI

46 

Kasper M, Regl G, Frischauf AM and Aberger F: GLI transcription factors: Mediators of oncogenic Hedgehog signalling. Eur J Cancer. 42:437–445. 2006. View Article : Google Scholar : PubMed/NCBI

47 

Sasaki H, Nishizaki Y, Hui C, Nakafuku M and Kondoh H: Regulation of Gli2 and Gli3 activities by an amino-terminal repression domain: Implication of Gli2 and Gli3 as primary mediators of Shh signaling. Development. 126:3915–3924. 1999.PubMed/NCBI

48 

Lauth M and Toftgård R: Non-canonical activation of GLI transcription factors: Implications for targeted anti-cancer therapy. Cell Cycle. 6:2458–2463. 2007. View Article : Google Scholar : PubMed/NCBI

49 

Damhofer H, Veenstra VL, Tol JA, van Laarhoven HW, Medema JP and Bijlsma MF: Blocking Hedgehog release from pancreatic cancer cells increases paracrine signaling potency. J Cell Sci. 128:129–139. 2015. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Yan Y, Qian H, Cao Y and Zhu T: Nuclear factor‑κB inhibitor Bay11‑7082 inhibits gastric cancer cell proliferation by inhibiting Gli1 expression. Oncol Lett 21: 301, 2021.
APA
Yan, Y., Qian, H., Cao, Y., & Zhu, T. (2021). Nuclear factor‑κB inhibitor Bay11‑7082 inhibits gastric cancer cell proliferation by inhibiting Gli1 expression. Oncology Letters, 21, 301. https://doi.org/10.3892/ol.2021.12562
MLA
Yan, Y., Qian, H., Cao, Y., Zhu, T."Nuclear factor‑κB inhibitor Bay11‑7082 inhibits gastric cancer cell proliferation by inhibiting Gli1 expression". Oncology Letters 21.4 (2021): 301.
Chicago
Yan, Y., Qian, H., Cao, Y., Zhu, T."Nuclear factor‑κB inhibitor Bay11‑7082 inhibits gastric cancer cell proliferation by inhibiting Gli1 expression". Oncology Letters 21, no. 4 (2021): 301. https://doi.org/10.3892/ol.2021.12562
Copy and paste a formatted citation
x
Spandidos Publications style
Yan Y, Qian H, Cao Y and Zhu T: Nuclear factor‑κB inhibitor Bay11‑7082 inhibits gastric cancer cell proliferation by inhibiting Gli1 expression. Oncol Lett 21: 301, 2021.
APA
Yan, Y., Qian, H., Cao, Y., & Zhu, T. (2021). Nuclear factor‑κB inhibitor Bay11‑7082 inhibits gastric cancer cell proliferation by inhibiting Gli1 expression. Oncology Letters, 21, 301. https://doi.org/10.3892/ol.2021.12562
MLA
Yan, Y., Qian, H., Cao, Y., Zhu, T."Nuclear factor‑κB inhibitor Bay11‑7082 inhibits gastric cancer cell proliferation by inhibiting Gli1 expression". Oncology Letters 21.4 (2021): 301.
Chicago
Yan, Y., Qian, H., Cao, Y., Zhu, T."Nuclear factor‑κB inhibitor Bay11‑7082 inhibits gastric cancer cell proliferation by inhibiting Gli1 expression". Oncology Letters 21, no. 4 (2021): 301. https://doi.org/10.3892/ol.2021.12562
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