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Hippo/TEAD4 signaling pathway as a potential target for the treatment of breast cancer (Review)

  • Authors:
    • Yujian Wu
    • Mengjie Li
    • Jiayi Lin
    • Chenxia Hu
  • View Affiliations / Copyright

    Affiliations: School of Pharmaceutical Science, Guangzhou University of Chinese Medicine, Guangzhou, Guangdong 510006, P.R. China
    Copyright: © Wu et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 313
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    Published online on: February 23, 2021
       https://doi.org/10.3892/ol.2021.12574
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Abstract

Breast cancer is the most common type of cancer among women worldwide. The Hippo signaling pathway is strongly associated with cell proliferation, migration, invasion, metastasis and resistance to breast cancer treatment. The upstream factors involved in the Hippo signaling pathway, including mammalian Ste20 kinases 1/2, large tumor suppressor kinases 1/2 and transcription coactivator Yes‑associated protein (YAP)/transcriptional coactivator with PDZ‑binding motif (TAZ), have been extensively studied as they are considered therapeutic targets for breast cancer. Recently, it has been suggested that the transcriptional enhancer factor domain (TEAD) family of transcription factors, particularly TEAD4, plays an important role in breast cancer. TEADs interact with YAP/TAZ to act as transcription factors. Notably, recent studies have demonstrated that TEAD4 may also function in a YAP/TAZ‑independent manner and serve as a prognostic marker for breast cancer. The present review summarizes the current research on the effect of the aberrant activation of the Hippo signaling pathway on breast cancer progression. Furthermore, the latest advances on the role of the TEAD family in breast cancer are highlighted, and the role of TEAD4 as a potential target for therapeutic intervention in breast cancer is discussed.
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1 

Sung H, Ferlay J, Siegel RL, Laversanne M, Soerjomataram I, Jemal A and Bray F: Global cancer statistics 2020: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA Cancer J Clin. 2021.(Epub ahead of print). View Article : Google Scholar : PubMed/NCBI

2 

Gadag S, Sinha S, Nayak Y, Garg S and Nayak UY: Combination therapy and nanoparticulate systems: Smart approaches for the effective treatment of breast cancer. Pharmaceutics. 12:5242020. View Article : Google Scholar

3 

Zanconato F, Cordenonsi M and Piccolo S: YAP/TAZ at the roots of cancer. Cancer Cell. 29:783–803. 2016. View Article : Google Scholar : PubMed/NCBI

4 

Yin F, Yu J, Zheng Y, Chen Q, Zhang N and Pan D: Spatial organization of Hippo signaling at the plasma membrane mediated by the tumor suppressor Merlin/NF2. Cell. 154:1342–1355. 2013. View Article : Google Scholar : PubMed/NCBI

5 

Maugeri-Sacca M and De Maria R: The Hippo pathway in normal development and cancer. PharmacolTher. 186:60–72. 2018.

6 

Moroishi T, Hansen CG and Guan KL: The emerging roles of YAP and TAZ in cancer. Nat Rev Cancer. 15:73–79. 2015. View Article : Google Scholar : PubMed/NCBI

7 

Maugeri-Sacca M, Barba M, Pizzuti L, Vici P, Di Lauro L, Dattilo R, Vitale I, Bartucci M, Mottolese M and De Maria R: The Hippo transducers TAZ and YAP in breast cancer: Oncogenic activities and clinical implications. Expert Rev Mol Med. 17:e142015. View Article : Google Scholar : PubMed/NCBI

8 

Lamar JM, Stern P, Liu H, Schindler JW, Jiang ZG and Hynes RO: The Hippo pathway target, YAP, promotes metastasis through its TEAD-interaction domain. Proc Natl Acad Sci USA. 109:E2441–E2450. 2012. View Article : Google Scholar : PubMed/NCBI

9 

Wang Y, Li J, Gao Y, Luo Y, Luo H, Wang L, Yi Y, Yuan Z and Jim Xiao ZX: Hippo kinases regulate cell junctions to inhibit tumor metastasis in response to oxidative stress. Redox Biol. 26:1012332019. View Article : Google Scholar : PubMed/NCBI

10 

Lin XY, Cai FF, Wang MH, Pan X, Wang F, Cai L, Cui RR, Chen S and Biskup E: Mammalian sterile 20-like kinase 1 expression and its prognostic significance in patients with breast cancer. Oncol Lett. 14:5457–5463. 2017.PubMed/NCBI

11 

Heidary Arash E, Shiban A, Song S and Attisano L: MARK4 inhibits Hippo signaling to promote proliferation and migration of breast cancer cells. EMBO Rep. 18:420–436. 2017. View Article : Google Scholar : PubMed/NCBI

12 

Ercolani C, Di Benedetto A, Terrenato I, Pizzuti L, Di Lauro L, Sergi D, Sperati F, Buglioni S, Ramieri MT, Mentuccia L, et al: Expression of phosphorylated Hippo pathway kinases (MST1/2 and LATS1/2) in HER2-positive and triple-negative breast cancer patients treated with neoadjuvant therapy. Cancer Biol Ther. 18:339–346. 2017. View Article : Google Scholar : PubMed/NCBI

13 

Furth N and Aylon Y: The LATS1 and LATS2 tumor suppressors: Beyond the Hippo pathway. Cell Death Differ. 24:1488–1501. 2017. View Article : Google Scholar : PubMed/NCBI

14 

Lehn S, Tobin NP, Sims AH, Stal O, Jirstrom K, Axelson H and Landberg G: Decreased expression of Yes-associated protein is associated with outcome in the luminal a breast cancer subgroup and with an impaired tamoxifen response. BMC Cancer. 14:1192014. View Article : Google Scholar : PubMed/NCBI

15 

Maugeri-Sacca M and De Maria R: Hippo pathway and breast cancer stem cells. Crit Rev Oncol Hematol. 99:115–122. 2016. View Article : Google Scholar : PubMed/NCBI

16 

Cordenonsi M, Zanconato F, Azzolin L, Forcato M, Rosato A, Frasson C, Inui M, Montagner M, Parenti AR, Poletti A, et al: The Hippo transducer TAZ confers cancer stem cell-related traits on breast cancer cells. Cell. 147:759–772. 2011. View Article : Google Scholar : PubMed/NCBI

17 

Bartucci M, Dattilo R, Moriconi C, Pagliuca A, Mottolese M, Federici G, Benedetto AD, Todaro M, Stassi G, Sperati F, et al: TAZ is required for metastatic activity and chemoresistance of breast cancer stem cells. Oncogene. 34:681–690. 2015. View Article : Google Scholar : PubMed/NCBI

18 

Diaz-Martin J, Lopez-Garcia MA, Romero-Perez L, Atienza-Amores MR, Pecero ML, Castilla MA, Biscuola M, Santon A and Palacios J: Nuclear TAZ expression associates with the triple-negative phenotype in breast cancer. EndocrRelat Cancer. 22:443–454. 2015. View Article : Google Scholar

19 

Huang YT, Lan Q, Lorusso G, Duffey N and Ruegg C: The matricellular protein CYR61 promotes breast cancer lung metastasis by facilitating tumor cell extravasation and suppressing anoikis. Oncotarget. 8:9200–9215. 2017. View Article : Google Scholar : PubMed/NCBI

20 

Di Benedetto A, Mottolese M, Sperati F, Ercolani C, Di Lauro L, Pizzuti L, Vici P, Terrenato I, Sperduti I, Shaaban AM, et al: The Hippo transducers TAZ/YAP and their target CTGF in male breast cancer. Oncotarget. 7:43188–43198. 2016. View Article : Google Scholar : PubMed/NCBI

21 

Elster D, Jaenicke LA, Eilers M and von Eyss B: TEAD activity is restrained by MYC and stratifies human breast cancer subtypes. Cell Cycle. 15:2551–2556. 2016. View Article : Google Scholar : PubMed/NCBI

22 

Xiang G, Liu F, Liu J, Meng Q, Li N and Niu Y: Prognostic role of Amphiregulin and the correlation with androgen receptor in invasive breast cancer. Pathol Res Pract. 215:1524142019. View Article : Google Scholar : PubMed/NCBI

23 

Niu J, Ma J, Guan X, Zhao X, Li P and Zhang M: Correlation between doppler ultrasound blood flow parameters and angiogenesis and proliferation activity in breast cancer. Med Sci Monit. 25:7035–7041. 2019. View Article : Google Scholar : PubMed/NCBI

24 

He Z, Zhao TT, Jin F, Li JG, Xu YY, Dong HT, Liu Q, Xing P, Zhu GL, Xu H and Miao ZF: Downregulation of RASSF6 promotes breast cancer growth and chemoresistance through regulation of Hippo signaling. BiochemBiophys Res Commun. 503:2340–2347. 2018. View Article : Google Scholar

25 

Liu J, Li J, Li P, Wang Y, Liang Z, Jiang Y, Li J, Feng C, Wang R, Chen H, et al: Loss of DLG5 promotes breast cancer malignancy by inhibiting the Hippo signaling pathway. Sci Rep. 7:421252017. View Article : Google Scholar : PubMed/NCBI

26 

Song GQ and Zhao Y: MAC30 knockdown involved in the activation of the Hippo signaling pathway in breast cancer cells. Biol Chem. 399:1305–1311. 2018. View Article : Google Scholar : PubMed/NCBI

27 

Han H, Qi R, Zhou JJ, Ta AP, Yang B, Nakaoka HJ, Seo G, Guan KL, Luo R and Wang W: Regulation of the Hippo pathway by phosphatidic Acid-Mediated Lipid-Protein Interaction. Mol Cell. 72:328–340.e8. 2018. View Article : Google Scholar : PubMed/NCBI

28 

Elaimy AL, Guru S, Chang C, Ou J, Amante JJ, Zhu LJ, Goel HL and Mercurio AM: VEGF-neuropilin-2 signaling promotes stem-like traits in breast cancer cells by TAZ-mediated repression of the Rac GAP β2-chimaerin. Sci Signal. 11:eaao68972018. View Article : Google Scholar : PubMed/NCBI

29 

Kim YN, Choe SR, Cho KH, Cho DY, Kang J, Park CG and Lee HY: Resveratrol suppresses breast cancer cell invasion by inactivating a RhoA/YAP signaling axis. Exp Mol Med. 49:e2962017. View Article : Google Scholar : PubMed/NCBI

30 

Verma S, Yeddula N, Soda Y, Zhu Q, Pao G, Moresco J, Diedrich JK, Hong A, Plouffe S, Moroishi T, et al: BRCA1/BARD1-dependent ubiquitination of NF2 regulates Hippo-YAP1 signaling. Proc Natl Acad Sci USA. 116:7363–7370. 2019. View Article : Google Scholar : PubMed/NCBI

31 

Li W, Cooper J, Zhou L, Yang C, Erdjument-Bromage H, Zagzag D, Snuderl M, Ladanyi M, Hanemann CO, Zhou P, et al: Merlin/NF2 loss-driven tumorigenesis linked to CRL4(DCAF1)-mediated inhibition of the hippo pathway kinases Lats1 and 2 in the nucleus. Cancer Cell. 26:48–60. 2014. View Article : Google Scholar : PubMed/NCBI

32 

Ho KC, Zhou Z, She YM, Chun A, Cyr TD and Yang X: Itch E3 ubiquitin ligase regulates large tumor suppressor 1 stability [corrected]. Proc Natl Acad Sci USA. 108:4870–4875. 2011. View Article : Google Scholar : PubMed/NCBI

33 

Ma B, Chen Y, Chen L, Cheng H, Mu C, Li J, Gao R, Zhou C, Cao L, Liu J, et al: Hypoxia regulates Hippo signalling through the SIAH2 ubiquitin E3 ligase. Nat Cell Biol. 17:95–103. 2015. View Article : Google Scholar : PubMed/NCBI

34 

Toloczko A, Guo F, Yuen HF, Wen Q, Wood SA, Ong YS, Chan PY, Shaik AA, Gunaratne J, Dunne MJ, et al: Deubiquitinating enzyme USP9X suppresses tumor growth via LATS kinase and core components of the Hippo pathway. Cancer Res. 77:4921–4933. 2017. View Article : Google Scholar : PubMed/NCBI

35 

Chen D, Sun Y, Wei Y, Zhang P, Rezaeian AH, Teruya-Feldstein J, Gupta S, Liang H, Lin HK, Hung MC and Ma L: LIFR is a breast cancer metastasis suppressor upstream of the Hippo-YAP pathway and a prognostic marker. Nat Med. 18:1511–1517. 2012. View Article : Google Scholar : PubMed/NCBI

36 

Li Z, Razavi P, Li Q, Toy W, Liu B, Ping C, Hsieh W, Sanchez-Vega F, Brown DN, Da Cruz Paula AF, et al: Loss of the FAT1 tumor suppressor promotes resistance to CDK4/6 inhibitors via the hippo pathway. Cancer Cell. 34:893–905.e8. 2018. View Article : Google Scholar : PubMed/NCBI

37 

Dang DK, Makena MR, Llongueras JP, Prasad H, Ko M, Bandral M and Rao R: A Ca2+-ATPase regulates E-cadherin biogenesis and epithelial-mesenchymal transition in breast cancer cells. Mol Cancer Res. 17:1735–1747. 2019. View Article : Google Scholar : PubMed/NCBI

38 

Yu S, Zhang M, Huang L, Ma Z, Gong X, Liu W, Zhang J, Chen L, Yu Z, Zhao W, et al: ERK1 indicates good prognosis and inhibits breast cancer progression by suppressing YAP1 signaling. Aging (Albany NY). 11:12295–12314. 2019. View Article : Google Scholar : PubMed/NCBI

39 

Dethlefsen C, Hansen LS, Lillelund C, Andersen C, Gehl J, Christensen JF, Pedersen BK and Hojman P: Exercise-induced catecholamines activate the Hippo tumor suppressor pathway to reduce risks of breast cancer development. Cancer Res. 77:4894–4904. 2017. View Article : Google Scholar : PubMed/NCBI

40 

Wang Z, Kong Q, Su P, Duan M, Xue M, Li X, Tang J, Gao Z, Wang B, Li Z, et al: Regulation of Hippo signaling and triple negative breast cancer progression by an ubiquitin ligase RNF187. Oncogenesis. 9:362020. View Article : Google Scholar : PubMed/NCBI

41 

Zhang Z, Du J, Wang S, Shao L, Jin K, Li F, Wei B, Ding W, Fu P, van Dam H, et al: OTUB2 promotes cancer metastasis via Hippo-independent activation of YAP and TAZ. Mol Cell. 73:7–21.e7. 2019. View Article : Google Scholar : PubMed/NCBI

42 

Hou L, Xie S, Li G, Xiong B, Gao Y, Zhao X, Hu J, Deng S and Jiang J: IL-6 triggers the migration and invasion of oestrogen receptor-negative breast cancer cells via regulation of Hippo pathways. Basic Clin PharmacolToxicol. 123:549–557. 2018. View Article : Google Scholar

43 

Lv M, Lv M, Chen L, Qin T, Zhang X, Liu P and Yang J: Angiomotin promotes breast cancer cell proliferation and invasion. Oncol Rep. 33:1938–1946. 2015. View Article : Google Scholar : PubMed/NCBI

44 

Zanconato F, Forcato M, Battilana G, Azzolin L, Quaranta E, Bodega B, Rosato A, Bicciato S, Cordenonsi M and Piccolo S: Genome-wide association between YAP/TAZ/TEAD and AP-1 at enhancers drives oncogenic growth. Nat Cell Biol. 17:1218–1227. 2015. View Article : Google Scholar : PubMed/NCBI

45 

Janse van Rensburg HJ, Azad T, Ling M, Hao Y, Snetsinger B, Khanal P, Minassian LM, Graham CH, Rauh MJ and Yang X: The Hippo pathway component TAZ promotes immune evasion in human cancer through PD-L1. Cancer Res. 78:1457–1470. 2018. View Article : Google Scholar : PubMed/NCBI

46 

Rashidian J, Le Scolan E, Ji X, Zhu Q, Mulvihill MM, Nomura D and Luo K: Ski regulates Hippo and TAZ signaling to suppress breast cancer progression. Sci Signal. 8:ra142015. View Article : Google Scholar : PubMed/NCBI

47 

Holden JK and Cunningham CN: Targeting the Hippo pathway and cancer through the TEAD family of transcription factors. Cancers (Basel). 10:812018. View Article : Google Scholar

48 

Qi Y, Yu J, Han W, Fan X, Qian H, Wei H, Tsai YH, Zhao J, Zhang W, Liu Q, et al: A splicing isoform of TEAD4 attenuates the Hippo-YAP signalling to inhibit tumour proliferation. Nat Commun. 7:ncommss118402016. View Article : Google Scholar

49 

Gibault F, Sturbaut M, Bailly F, Melnyk P and Cotelle P: Targeting transcriptional enhanced associate domains (TEADs). J Med Chem. 61:5057–5072. 2018. View Article : Google Scholar : PubMed/NCBI

50 

Zhou Y, Huang T, Cheng AS, Yu J, Kang W and To KF: The TEAD family and its oncogenic role in promoting tumorigenesis. Int J Mol Sci. 17:1382016. View Article : Google Scholar

51 

Zhu C, Li L, Zhang Z, Bi M, Wang H, Su W, Hernandez K, Liu P, Chen J, Chen M, et al: A non-canonical role of YAP/TEAD is required for activation of estrogen-regulated enhancers in breast cancer. Mol Cell. 75:791–806.e8. 2019. View Article : Google Scholar : PubMed/NCBI

52 

Liu Y, Wang G, Yang Y, Mei Z, Liang Z, Cui A, Wu T, Liu CY and Cui L: Increased TEAD4 expression and nuclear localization in colorectal cancer promote epithelial-mesenchymal transition and metastasis in a YAP-independent manner. Oncogene. 35:2789–2800. 2016. View Article : Google Scholar : PubMed/NCBI

53 

Yu MH and Zhang W: TEAD1 enhances proliferation via activating SP1 in colorectal cancer. Biomed Pharmacother. 83:496–501. 2016. View Article : Google Scholar : PubMed/NCBI

54 

He L, Yuan L, Sun Y, Wang P, Zhang H, Feng X, Wang Z, Zhang W, Yang C, Zeng YA, et al: Glucocorticoid receptor signaling activates TEAD4 to promote breast cancer progression. Cancer Res. 79:4399–4411. 2019. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Wu Y, Li M, Lin J and Hu C: Hippo/TEAD4 signaling pathway as a potential target for the treatment of breast cancer (Review). Oncol Lett 21: 313, 2021.
APA
Wu, Y., Li, M., Lin, J., & Hu, C. (2021). Hippo/TEAD4 signaling pathway as a potential target for the treatment of breast cancer (Review). Oncology Letters, 21, 313. https://doi.org/10.3892/ol.2021.12574
MLA
Wu, Y., Li, M., Lin, J., Hu, C."Hippo/TEAD4 signaling pathway as a potential target for the treatment of breast cancer (Review)". Oncology Letters 21.4 (2021): 313.
Chicago
Wu, Y., Li, M., Lin, J., Hu, C."Hippo/TEAD4 signaling pathway as a potential target for the treatment of breast cancer (Review)". Oncology Letters 21, no. 4 (2021): 313. https://doi.org/10.3892/ol.2021.12574
Copy and paste a formatted citation
x
Spandidos Publications style
Wu Y, Li M, Lin J and Hu C: Hippo/TEAD4 signaling pathway as a potential target for the treatment of breast cancer (Review). Oncol Lett 21: 313, 2021.
APA
Wu, Y., Li, M., Lin, J., & Hu, C. (2021). Hippo/TEAD4 signaling pathway as a potential target for the treatment of breast cancer (Review). Oncology Letters, 21, 313. https://doi.org/10.3892/ol.2021.12574
MLA
Wu, Y., Li, M., Lin, J., Hu, C."Hippo/TEAD4 signaling pathway as a potential target for the treatment of breast cancer (Review)". Oncology Letters 21.4 (2021): 313.
Chicago
Wu, Y., Li, M., Lin, J., Hu, C."Hippo/TEAD4 signaling pathway as a potential target for the treatment of breast cancer (Review)". Oncology Letters 21, no. 4 (2021): 313. https://doi.org/10.3892/ol.2021.12574
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