Open Access

Clinical significance of hypertension in patients with different types of cancer treated with antiangiogenic drugs (Review)

  • Authors:
    • Mei Dong
    • Rujian Wang
    • Ping Sun
    • Dongxia Zhang
    • Zhenzhen  Zhang
    • Jing Zhang
    • Gary Tse
    • Lin Zhong
  • View Affiliations

  • Published online on: February 23, 2021     https://doi.org/10.3892/ol.2021.12576
  • Article Number: 315
  • Copyright: © Dong et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Hypertension is a common comorbidity in patients receiving antiangiogenic therapy. Prior studies have reported worsening or new‑onset hypertension as an adverse event of antiangiogenetic therapy, which can be managed by dose reduction or discontinuation of the culprit medication. By contrast, other studies have found that the occurrence of hypertension is a potential biomarker associated with greater efficacy of antiangiogenic therapy and predicts improved survival. At present, there is no consensus on the effects of hypertension in patients treated with antiangiogenic drugs. The present study reviewed the relationship between antiangiogenic drugs and hypertension in different types of cancer. It was demonstrated that the use of antiangiogenic drugs was associated with an increased risk of hypertension in most types of solid cancers. There was no significant difference in the incidence of hypertension between monoclonal antibody and small‑molecule tyrosine kinase inhibitor treatments. Hypertension was more likely to occur in patients younger than 75 years old, female, and those with no history of bevacizumab use. Discontinuation or death caused by hypertension was rare, although previous studies have reported that hypertension was a risk factor for acute and chronic cardiovascular diseases and ischemic stroke. Of note, the early development of hypertension may serve as a potential biomarker associated with greater efficacy of antiangiogenic therapy.
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April-2021
Volume 21 Issue 4

Print ISSN: 1792-1074
Online ISSN:1792-1082

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Spandidos Publications style
Dong M, Wang R, Sun P, Zhang D, Zhang Z, Zhang J, Tse G and Zhong L: Clinical significance of hypertension in patients with different types of cancer treated with antiangiogenic drugs (Review). Oncol Lett 21: 315, 2021
APA
Dong, M., Wang, R., Sun, P., Zhang, D., Zhang, Z., Zhang, J. ... Zhong, L. (2021). Clinical significance of hypertension in patients with different types of cancer treated with antiangiogenic drugs (Review). Oncology Letters, 21, 315. https://doi.org/10.3892/ol.2021.12576
MLA
Dong, M., Wang, R., Sun, P., Zhang, D., Zhang, Z., Zhang, J., Tse, G., Zhong, L."Clinical significance of hypertension in patients with different types of cancer treated with antiangiogenic drugs (Review)". Oncology Letters 21.4 (2021): 315.
Chicago
Dong, M., Wang, R., Sun, P., Zhang, D., Zhang, Z., Zhang, J., Tse, G., Zhong, L."Clinical significance of hypertension in patients with different types of cancer treated with antiangiogenic drugs (Review)". Oncology Letters 21, no. 4 (2021): 315. https://doi.org/10.3892/ol.2021.12576