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Human cytomegalovirus infection: A considerable issue following allogeneic hematopoietic stem cell transplantation (Review)

  • Authors:
    • Xinyi Zhou
    • Nan Jin
    • Baoan Chen
  • View Affiliations / Copyright

    Affiliations: Department of Hematology and Oncology, Zhongda Hospital, Medical School, Southeast University, Nanjing, Jiangsu 210009, P.R. China
    Copyright: © Zhou et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 318
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    Published online on: February 23, 2021
       https://doi.org/10.3892/ol.2021.12579
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Abstract

Cytomegalovirus (CMV) is an opportunistic virus, whereby recipients are most susceptible following allogeneic hematopoietic stem cell transplantation (allo‑HSCT). With the development of novel immunosuppressive agents and antiviral drugs, accompanied with the widespread application of prophylaxis and preemptive treatment, significant developments have been made in transplant recipients with human (H)CMV infection. However, HCMV remains an important cause of short‑ and long‑term morbidity and mortality in transplant recipients. The present review summarizes the molecular mechanism and risk factors of HCMV reactivation following allo‑HSCT, the diagnosis of CMV infection following allo‑HSCT, prophylaxis and treatment of HCMV infection, and future perspectives. All relevant literature were retrieved from PubMed and have been reviewed.
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Spandidos Publications style
Zhou X, Jin N and Chen B: Human cytomegalovirus infection: A considerable issue following allogeneic hematopoietic stem cell transplantation (Review). Oncol Lett 21: 318, 2021.
APA
Zhou, X., Jin, N., & Chen, B. (2021). Human cytomegalovirus infection: A considerable issue following allogeneic hematopoietic stem cell transplantation (Review). Oncology Letters, 21, 318. https://doi.org/10.3892/ol.2021.12579
MLA
Zhou, X., Jin, N., Chen, B."Human cytomegalovirus infection: A considerable issue following allogeneic hematopoietic stem cell transplantation (Review)". Oncology Letters 21.4 (2021): 318.
Chicago
Zhou, X., Jin, N., Chen, B."Human cytomegalovirus infection: A considerable issue following allogeneic hematopoietic stem cell transplantation (Review)". Oncology Letters 21, no. 4 (2021): 318. https://doi.org/10.3892/ol.2021.12579
Copy and paste a formatted citation
x
Spandidos Publications style
Zhou X, Jin N and Chen B: Human cytomegalovirus infection: A considerable issue following allogeneic hematopoietic stem cell transplantation (Review). Oncol Lett 21: 318, 2021.
APA
Zhou, X., Jin, N., & Chen, B. (2021). Human cytomegalovirus infection: A considerable issue following allogeneic hematopoietic stem cell transplantation (Review). Oncology Letters, 21, 318. https://doi.org/10.3892/ol.2021.12579
MLA
Zhou, X., Jin, N., Chen, B."Human cytomegalovirus infection: A considerable issue following allogeneic hematopoietic stem cell transplantation (Review)". Oncology Letters 21.4 (2021): 318.
Chicago
Zhou, X., Jin, N., Chen, B."Human cytomegalovirus infection: A considerable issue following allogeneic hematopoietic stem cell transplantation (Review)". Oncology Letters 21, no. 4 (2021): 318. https://doi.org/10.3892/ol.2021.12579
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