Role of MALAT1 in gynecological cancers: Pathologic and therapeutic aspects (Review)

  • Authors:
    • Feng-Hua Qiao
    • Min Tu
    • Hong-Yan Liu
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  • Published online on: February 25, 2021     https://doi.org/10.3892/ol.2021.12594
  • Article Number: 333
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Abstract

Gynecological cancers, including breast, ovarian, uterine, vaginal, cervical and vulvar cancers are among the major threats to modern life, particularly to female health. Long non‑coding RNAs (lncRNAs) play critical roles in normal development of organisms, as well as the tumorigenesis process, and metastasis‑associated lung adenocarcinoma transcript 1 (MALAT1) is a large infrequently spliced lncRNA, which have been implicated in different gynecological cancers. MALAT1 is overexpressed in breast, ovarian, cervical and endometrial cancers, which initiates cancer progression by inducing changes in the expression of several anti‑apoptotic and epithelial‑to‑mesenchymal transition‑related genes. Targeting MALAT1 is an important strategy to combat gynecological cancers, and application of RNA‑interference technology and chemotherapeutic process are crucial to target and minimize MALAT1 activity. The present review discusses the role of MALAT1 in gynecological cancers, and potential strategies to target this lncRNA to develop cancer therapeutics. However, further clinical studies are required to determine the prognostic potential of MALAT1 in gynecological cancers.
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April-2021
Volume 21 Issue 4

Print ISSN: 1792-1074
Online ISSN:1792-1082

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Spandidos Publications style
Qiao F, Tu M and Liu H: Role of MALAT1 in gynecological cancers: Pathologic and therapeutic aspects (Review). Oncol Lett 21: 333, 2021
APA
Qiao, F., Tu, M., & Liu, H. (2021). Role of MALAT1 in gynecological cancers: Pathologic and therapeutic aspects (Review). Oncology Letters, 21, 333. https://doi.org/10.3892/ol.2021.12594
MLA
Qiao, F., Tu, M., Liu, H."Role of MALAT1 in gynecological cancers: Pathologic and therapeutic aspects (Review)". Oncology Letters 21.4 (2021): 333.
Chicago
Qiao, F., Tu, M., Liu, H."Role of MALAT1 in gynecological cancers: Pathologic and therapeutic aspects (Review)". Oncology Letters 21, no. 4 (2021): 333. https://doi.org/10.3892/ol.2021.12594