Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Oncology Letters
      • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Biomedical Reports
      • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • Information for Authors
    • Information for Reviewers
    • Information for Librarians
    • Information for Advertisers
    • Conferences
  • Language Editing
Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • For Authors
    • For Reviewers
    • For Librarians
    • For Advertisers
    • Conferences
  • Language Editing
Login Register Submit
  • This site uses cookies
  • You can change your cookie settings at any time by following the instructions in our Cookie Policy. To find out more, you may read our Privacy Policy.

    I agree
Search articles by DOI, keyword, author or affiliation
Search
Advanced Search
presentation
Oncology Letters
Join Editorial Board Propose a Special Issue
Print ISSN: 1792-1074 Online ISSN: 1792-1082
Journal Cover
April-2021 Volume 21 Issue 4

Full Size Image

Sign up for eToc alerts
Recommend to Library

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
April-2021 Volume 21 Issue 4

Full Size Image

Sign up for eToc alerts
Recommend to Library

  • Article
  • Citations
    • Cite This Article
    • Download Citation
    • Create Citation Alert
    • Remove Citation Alert
    • Cited By
  • Similar Articles
    • Related Articles (in Spandidos Publications)
    • Similar Articles (Google Scholar)
    • Similar Articles (PubMed)
  • Download PDF
  • Download XML
  • View XML
Review

Role of MALAT1 in gynecological cancers: Pathologic and therapeutic aspects (Review)

  • Authors:
    • Feng-Hua Qiao
    • Min Tu
    • Hong-Yan Liu
  • View Affiliations / Copyright

    Affiliations: Department of Gynecology, Second People's Hospital of Jingmen, Jingmen, Hubei 448000, P.R. China, Department of Orthopedics, Second People's Hospital of Jingmen, Jingmen, Hubei 448000, P.R. China, Department of Gynecology, Maternal and Child Health Hospital of Jingmen, Jingmen, Hubei 448000, P.R. China
  • Article Number: 333
    |
    Published online on: February 25, 2021
       https://doi.org/10.3892/ol.2021.12594
  • Expand metrics +
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
Cited By (CrossRef): 0 citations Loading Articles...

This article is mentioned in:



Abstract

Gynecological cancers, including breast, ovarian, uterine, vaginal, cervical and vulvar cancers are among the major threats to modern life, particularly to female health. Long non‑coding RNAs (lncRNAs) play critical roles in normal development of organisms, as well as the tumorigenesis process, and metastasis‑associated lung adenocarcinoma transcript 1 (MALAT1) is a large infrequently spliced lncRNA, which have been implicated in different gynecological cancers. MALAT1 is overexpressed in breast, ovarian, cervical and endometrial cancers, which initiates cancer progression by inducing changes in the expression of several anti‑apoptotic and epithelial‑to‑mesenchymal transition‑related genes. Targeting MALAT1 is an important strategy to combat gynecological cancers, and application of RNA‑interference technology and chemotherapeutic process are crucial to target and minimize MALAT1 activity. The present review discusses the role of MALAT1 in gynecological cancers, and potential strategies to target this lncRNA to develop cancer therapeutics. However, further clinical studies are required to determine the prognostic potential of MALAT1 in gynecological cancers.
View Figures

Figure 1

View References

1 

Jeong HM, Kwon MJ and Shin YK: Overexpression of cancer-associated genes via epigenetic derepression mechanisms in gynecologic cancer. Front Oncol. 4:122014. View Article : Google Scholar : PubMed/NCBI

2 

Zhou XM, Zhang H and Han X: Role of epithelial to mesenchymal transition proteins in gynecological cancers: Pathological and therapeutic perspectives. Tumour Biol. 35:9523–9530. 2014. View Article : Google Scholar : PubMed/NCBI

3 

Liu DT: EMMPRIN in gynecologic cancers: Pathologic and therapeutic aspects. Tumour Biol. 36:4883–4888. 2015. View Article : Google Scholar : PubMed/NCBI

4 

Gusberg SB: The gynecologist and breast cancer. Isr J Med Sci. 17:843–846. 1981.PubMed/NCBI

5 

Imani S, Hosseinifard H, Cheng J, Wei C and Fu J: Prognostic value of EMT-inducing transcription factors (EMT-TFs) in metastatic breast cancer: A systematic review and meta-analysis. Sci Rep. 6:285872016. View Article : Google Scholar : PubMed/NCBI

6 

Liu S, Wang H, Zhang L, Tang C, Jones L, Ye H, Ban L, Wang A, Liu Z, Lou F, et al: Rapid detection of genetic mutations in individual breast cancer patients by next-generation DNA sequencing. Hum Genomics. 9:22015. View Article : Google Scholar : PubMed/NCBI

7 

Brody JG, Rudel RA, Michels KB, Moysich KB, Bernstein L, Attfield KR and Gray S: Environmental pollutants, diet, physical activity, body size, and breast cancer: Where do we stand in research to identify opportunities for prevention? Cancer. 109 (12 Suppl):S2627–S2634. 2007. View Article : Google Scholar

8 

Rezaeian M, Sharifirad G, Mostafavi F, Moodi M and Abbasi MH: The effects of breast cancer educational intervention on knowledge and health beliefs of women 40 years and older, Isfahan, Iran. J Educ Health Promot. 3:432014.PubMed/NCBI

9 

Tania M, Khan MA and Song Y: Association of lipid metabolism with ovarian cancer. Curr Oncol. 17:6–11. 2010. View Article : Google Scholar : PubMed/NCBI

10 

Goff BA: Ovarian cancer: Screening and early detection. Obstet Gynecol Clin North Am. 39:183–194. 2012. View Article : Google Scholar : PubMed/NCBI

11 

Piek JM, van Diest PJ and Verheijen RH: Ovarian carcinogenesis: An alternative hypothesis. Adv Exp Med Biol. 622:79–87. 2008. View Article : Google Scholar : PubMed/NCBI

12 

Vargas-Hernández VM, Moreno-Eutimio MA, Acosta-Altamirano G and Vargas-Aguilar VM: Management of recurrent epithelial ovarian cancer. Gland Surg. 3:198–202. 2014.PubMed/NCBI

13 

Canavan TP and Doshi NR: Cervical cancer. Am Fam Physician. 61:1369–1376. 2000.PubMed/NCBI

14 

Jemal A, Bray F, Center MM, Ferlay J, Ward E and Forman D: Global cancer statistics. CA Cancer J Clin. 61:69–90. 2011. View Article : Google Scholar : PubMed/NCBI

15 

Muñoz N, Castellsagué X, de González AB and Gissmann L: Chapter 1: HPV in the etiology of human cancer. Vaccine. 24 (Suppl 3):S3/1–10. 2006. View Article : Google Scholar

16 

Pessoa JN, Freitas AC, Guimaraes RA, Lima J, Dos Reis HL and Filho AC: Endometrial assessment: When is it necessary? J Clin Med Res. 6:21–25. 2014.PubMed/NCBI

17 

Colombo N, Preti E, Landoni F, Carinelli S, Colombo A, Marini C and Sessa C; ESMO Guidelines Working Group, : Endometrial cancer: ESMO clinical practice guidelines for diagnosis, treatment and follow-up. Ann Oncol. 24 (Suppl 6):vi33–vi38. 2013. View Article : Google Scholar : PubMed/NCBI

18 

Lozano R, Naghavi M, Foreman K, Lim S, Shibuya K, Aboyans V, Abraham J, Adair T, Aggarwal R, Ahn SY, et al: Global and regional mortality from 235 causes of death for 20 age groups in 1990 and 2010: A systematic analysis for the global burden of disease study 2010. Lancet. 380:2095–2128. 2012. View Article : Google Scholar : PubMed/NCBI

19 

Dittmer C, Katalinic A, Mundhenke C, Thill M and Fischer D: Epidemiology of vulvar and vaginal cancer in Germany. Arch Gynecol Obstet. 284:169–174. 2011. View Article : Google Scholar : PubMed/NCBI

20 

Kopp F and Mendell JT: Functional classification and experimental dissection of long noncoding RNAs. Cell. 172:393–407. 2018. View Article : Google Scholar : PubMed/NCBI

21 

Bassett AR, Akhtar A, Barlow DP, Bird AP, Brockdorff N, Duboule D, Ephrussi A, Ferguson-Smith AC, Gingeras TR, Haerty W, et al: Considerations when investigating lncRNA function in vivo. Elife. 3:e030582014. View Article : Google Scholar : PubMed/NCBI

22 

Soudyab M, Iranpour M and Ghafouri-Fard S: The role of long non-coding RNAs in breast cancer. Arch Iran Med. 19:508–517. 2016.PubMed/NCBI

23 

Geisler S and Coller J: RNA in unexpected places: Long non-coding RNA functions in diverse cellular contexts. Nat Rev Mol Cell Biol. 14:699–712. 2013. View Article : Google Scholar : PubMed/NCBI

24 

Grote P and Herrmann BG: Long noncoding RNAs in organogenesis: Making the difference. Trends Genet. 31:329–335. 2015. View Article : Google Scholar : PubMed/NCBI

25 

Nagano T and Fraser P: No-nonsense functions for long noncoding RNAs. Cell. 145:178–181. 2011. View Article : Google Scholar : PubMed/NCBI

26 

Zhu Y, Luo M, Brooks M, Clouthier SG and Wicha MS: Biological and clinical significance of cancer stem cell plasticity. Clin Transl Med. 3:322014. View Article : Google Scholar : PubMed/NCBI

27 

Ørom UA and Shiekhattar R: Long noncoding RNAs usher in a new era in the biology of enhancers. Cell. 154:1190–1193. 2013. View Article : Google Scholar : PubMed/NCBI

28 

Wahlestedt C: Targeting long non-coding RNA to therapeutically upregulate gene expression. Nat Rev Drug Discov. 12:433–446. 2013. View Article : Google Scholar : PubMed/NCBI

29 

Zhang X, Hamblin MH and Yin KJ: The long noncoding RNA Malat1: Its physiological and pathophysiological functions. RNA Biol. 14:1705–1714. 2017. View Article : Google Scholar : PubMed/NCBI

30 

Hutchinson JN, Ensminger AW, Clemson CM, Lynch CR, Lawrence JB and Chess A: A screen for nuclear transcripts identifies two linked noncoding RNAs associated with SC35 splicing domains. BMC Genomics. 8:392007. View Article : Google Scholar : PubMed/NCBI

31 

Zhang B, Arun G, Mao YS, Lazar Z, Hung G, Bhattacharjee G, Xiao X, Booth CJ, Wu J, Zhang C and Spector DL: The lncRNA Malat1 is dispensable for mouse development but its transcription plays a cis-regulatory role in the adult. Cell Rep. 2:111–123. 2012. View Article : Google Scholar : PubMed/NCBI

32 

Bernard D, Prasanth KV, Tripathi V, Colasse S, Nakamura T, Xuan Z, Zhang MQ, Sedel F, Jourdren L, Coulpier F, et al: A long nuclear-retained non-coding RNA regulates synaptogenesis by modulating gene expression. EMBO J. 29:3082–3093. 2010. View Article : Google Scholar : PubMed/NCBI

33 

Wilusz JE, Freier SM and Spector DL: 3′ end processing of a long nuclear-retained noncoding RNA yields a tRNA-like cytoplasmic RNA. Cell. 135:919–932. 2008. View Article : Google Scholar : PubMed/NCBI

34 

Tano K, Mizuno R, Okada T, Rakwal R, Shibato J, Masuo Y, Ijiri K and Akimitsu N: MALAT-1 enhances cell motility of lung adenocarcinoma cells by influencing the expression of motility-related genes. FEBS Lett. 584:4575–4580. 2010. View Article : Google Scholar : PubMed/NCBI

35 

Yang L, Lin C, Liu W, Zhang J, Ohgi KA, Grinstein JD, Dorrestein PC and Rosenfeld MG: ncRNA- and Pc2 methylation-dependent gene relocation between nuclear structures mediates gene activation programs. Cell. 147:773–788. 2011. View Article : Google Scholar : PubMed/NCBI

36 

Ji P, Diederichs S, Wang W, Böing S, Metzger R, Schneider PM, Tidow N, Brandt B, Buerger H, Bulk E, et al: MALAT-1, a novel noncoding RNA, and thymosin beta4 predict metastasis and survival in early-stage non-small cell lung cancer. Oncogene. 22:8031–8041. 2003. View Article : Google Scholar : PubMed/NCBI

37 

Gutschner T, Hämmerle M, Eissmann M, Hsu J, Kim Y, Hung G, Revenko A, Arun G, Stentrup M, Gross M, et al: The noncoding RNA MALAT1 is a critical regulator of the metastasis phenotype of lung cancer cells. Cancer Res. 73:1180–1189. 2013. View Article : Google Scholar : PubMed/NCBI

38 

Shi X, Sun M, Wu Y, Yao Y, Liu H, Wu G, Yuan D and Song Y: Post-transcriptional regulation of long noncoding RNAs in cancer. Tumour Biol. 36:503–513. 2015. View Article : Google Scholar : PubMed/NCBI

39 

Li Z, Xu L, Liu Y, Fu S, Tu J, Hu Y and Xiong Q: LncRNA MALAT1 promotes relapse of breast cancer patients with postoperative fever. Am J Transl Res. 10:3186–3197. 2018.PubMed/NCBI

40 

Zhao M, Wang S, Li Q, Ji Q, Guo P and Liu X: MALAT1: A long non-coding RNA highly associated with human cancers. Oncol Lett. 16:19–26. 2018.PubMed/NCBI

41 

Tee AE, Ling D, Nelson C, Atmadibrata B, Dinger ME, Xu N, Mizukami T, Liu PY, Liu B, Cheung B, et al: The histone demethylase JMJD1A induces cell migration and invasion by up-regulating the expression of the long noncoding RNA MALAT1. Oncotarget. 5:1793–1804. 2014. View Article : Google Scholar : PubMed/NCBI

42 

Peng R, Luo C, Guo Q, Cao J, Yang Q, Dong K, Wang S, Wang K and Song C: Association analyses of genetic variants in long non-coding RNA MALAT1 with breast cancer susceptibility and mRNA expression of MALAT1 in Chinese Han population. Gene. 642:241–248. 2018. View Article : Google Scholar : PubMed/NCBI

43 

Chen Q, Zhu C and Jin Y: The oncogenic and tumor suppressive functions of the long noncoding RNA MALAT1: An emerging controversy. Front Genet. 11:932020. View Article : Google Scholar : PubMed/NCBI

44 

Ni W, Wang X, Sun Y and Gao X: Meta-analysis of the association between MALAT1 rs619586 A>G polymorphism and cancer risk. J Int Med Res. 48:3000605209419692020. View Article : Google Scholar : PubMed/NCBI

45 

Zhang P, Zhou H, Lu K, Lu Y, Wang Y and Feng T: Exosome-mediated delivery of MALAT1 induces cell proliferation in breast cancer. Onco Targets Ther. 11:291–299. 2018. View Article : Google Scholar : PubMed/NCBI

46 

Wang Y, Zhang Y, Hu K, Qiu J, Hu Y, Zhou M and Zhang S: Elevated long noncoding RNA MALAT-1 expression is predictive of poor prognosis in patients with breast cancer: A meta-analysis. Biosci Rep. 40:BSR202002152020. View Article : Google Scholar : PubMed/NCBI

47 

Stone JK, Kim JH, Vukadin L, Richard A, Giannini HK, Lim SS, Tan M and Ahn EE: Hypoxia induces cancer cell-specific chromatin interactions and increases MALAT1 expression in breast cancer cells. J Biol Chem. 294:11213–11224. 2019. View Article : Google Scholar : PubMed/NCBI

48 

Zheng L, Zhang Y, Fu Y, Gong H, Guo J, Wu K, Jia Q and Ding X: Long non-coding RNA MALAT1 regulates BLCAP mRNA expression through binding to miR-339-5p and promotes poor prognosis in breast cancer. Biosci Rep. 39:BSR201812842019. View Article : Google Scholar : PubMed/NCBI

49 

Fattahi Dolatabadi N, Dehghani A, Shahand E, Yazdanshenas M, Tabatabaeian H, Zamani A, Azadeh M and Ghaedi K: The interaction between MALAT1 target, miR-143-3p, and RALGAPA2 is affected by functional SNP rs3827693 in breast cancer. Hum Cell. 33:1229–1239. 2020. View Article : Google Scholar : PubMed/NCBI

50 

Gomes CP, Nóbrega-Pereira S, Domingues-Silva B, Rebelo K, Alves-Vale C, Marinho SP, Carvalho T, Dias S and Bernardes de Jesus B: An antisense transcript mediates MALAT1 response in human breast cancer. BMC Cancer. 19:7712019. View Article : Google Scholar : PubMed/NCBI

51 

Wu Y, Sarkissyan M, Ogah O, Kim J and Vadgama JV: Expression of MALAT1 promotes trastuzumab resistance in HER2 overexpressing breast cancers. Cancers (Basel). 12:19182020. View Article : Google Scholar

52 

Huang XJ, Xia Y, He GF, Zheng LL, Cai YP, Yin Y and Wu Q: MALAT1 promotes angiogenesis of breast cancer. Oncol Rep. 40:2683–2689. 2018.PubMed/NCBI

53 

Kim J, Piao HL, Kim BJ, Yao F, Han Z, Wang Y, Xiao Z, Siverly AN, Lawhon SE, Ton BN, et al: Long noncoding RNA MALAT1 suppresses breast cancer metastasis. Nat Genet. 50:1705–1715. 2018. View Article : Google Scholar : PubMed/NCBI

54 

Kwok ZH, Roche V, Chew XH, Fadieieva A and Tay Y: A non-canonical tumor suppressive role for the long non-coding RNA MALAT1 in colon and breast cancers. Int J Cancer. 143:668–678. 2018. View Article : Google Scholar : PubMed/NCBI

55 

Eastlack SC, Dong S, Mo YY and Alahari SK: Expression of long noncoding RNA MALAT1 correlates with increased levels of Nischarin and inhibits oncogenic cell functions in breast cancer. PLoS One. 13:e01989452018. View Article : Google Scholar : PubMed/NCBI

56 

Arun G and Spector DL: MALAT1 long non-coding RNA and breast cancer. RNA Biol. 16:860–863. 2019. View Article : Google Scholar : PubMed/NCBI

57 

Liu SP, Yang JX, Cao DY and Shen K: Identification of differentially expressed long non-coding RNAs in human ovarian cancer cells with different metastatic potentials. Cancer Biol Med. 10:138–141. 2013.PubMed/NCBI

58 

Hosseini ES, Meryet-Figuiere M, Sabzalipoor H, Kashani HH, Nikzad H and Asemi Z: Dysregulated expression of long noncoding RNAs in gynecologic cancers. Mol Cancer. 16:1072017. View Article : Google Scholar : PubMed/NCBI

59 

Sun Q, Li Q and Xie F: LncRNA-MALAT1 regulates proliferation and apoptosis of ovarian cancer cells by targeting miR-503-5p. Onco Targets Ther. 12:6297–6307. 2019. View Article : Google Scholar : PubMed/NCBI

60 

Khan MA, Chen HC, Zhang D and Fu J: Twist: A molecular target in cancer therapeutics. Tumour Biol. 34:2497–2506. 2013. View Article : Google Scholar : PubMed/NCBI

61 

Tania M, Khan MA and Fu J: Epithelial to mesenchymal transition inducing transcription factors and metastatic cancer. Tumour Biol. 35:7335–7342. 2014. View Article : Google Scholar : PubMed/NCBI

62 

Jin Y, Feng SJ, Qiu S, Shao N and Zheng JH: LncRNA MALAT1 promotes proliferation and metastasis in epithelial ovarian cancer via the PI3K-AKT pathway. Eur Rev Med Pharmacol Sci. 21:3176–3184. 2017.PubMed/NCBI

63 

Guo C and Wang X, Chen LP, Li M, Li M, Hu YH, Ding WH and Wang X: Long non-coding RNA MALAT1 regulates ovarian cancer cell proliferation, migration and apoptosis through Wnt/β-catenin signaling pathway. Eur Rev Med Pharmacol Sci. 22:3703–3712. 2018.PubMed/NCBI

64 

Wang ZM, Wan XH, Sang GY, Zhao JD, Zhu QY and Wang DM: miR-15a-5p suppresses endometrial cancer cell growth via Wnt/β-catenin signaling pathway by inhibiting WNT3A. Eur Rev Med Pharmacol Sci. 21:4810–4818. 2017.PubMed/NCBI

65 

Qiu JJ, Lin XJ, Tang XY, Zheng TT, Lin YY and Hua KQ: Exosomal metastasis-associated lung adenocarcinoma transcript 1 promotes angiogenesis and predicts poor prognosis in epithelial ovarian cancer. Int J Biol Sci. 14:1960–1973. 2018. View Article : Google Scholar : PubMed/NCBI

66 

Zhou Y, Xu X, Lv H, Wen Q, Li J, Tan L, Li J and Sheng X: The long noncoding RNA MALAT-1 is highly expressed in ovarian cancer and induces cell growth and migration. PLoS One. 11:e01552502016. View Article : Google Scholar : PubMed/NCBI

67 

Yang L, Bai HS, Deng Y and Fan L: High MALAT1 expression predicts a poor prognosis of cervical cancer and promotes cancer cell growth and invasion. Eur Rev Med Pharmacol Sci. 19:3187–3193. 2015.PubMed/NCBI

68 

Jiang Y, Li Y, Fang S, Jiang B, Qin C, Xie P, Zhou G and Li G: The role of MALAT1 correlates with HPV in cervical cancer. Oncol Lett. 7:2135–2141. 2014. View Article : Google Scholar : PubMed/NCBI

69 

Lu H, He Y, Lin L, Qi Z, Ma L, Li L and Su Y: Long non-coding RNA MALAT1 modulates radiosensitivity of HR-HPV+ cervical cancer via sponging miR-145. Tumour Biol. 37:1683–1691. 2016. View Article : Google Scholar : PubMed/NCBI

70 

Han X, Wang Q, Wang Y, Hu B, Dong X, Zhang H and Wang W: Long non-coding RNA metastasis-associated lung adenocarcinoma transcript 1/microRNA-202-3p/periostin axis modulates invasion and epithelial-mesenchymal transition in human cervical cancer. J Cell Physiol. 234:14170–14180. 2019. View Article : Google Scholar : PubMed/NCBI

71 

Wang N, Hou MS, Zhan Y, Shen XB and Xue HY: MALAT1 promotes cisplatin resistance in cervical cancer by activating the PI3K/AKT pathway. Eur Rev Med Pharmacol Sci. 22:7653–7659. 2018.PubMed/NCBI

72 

Zhao Y, Yang Y, Trovik J, Sun K, Zhou L, Jiang P, Lau TS, Hoivik EA, Salvesen HB, Sun H and Wang H: A novel wnt regulatory axis in endometrioid endometrial cancer. Cancer Res. 74:5103–5117. 2014. View Article : Google Scholar : PubMed/NCBI

73 

Chen G, Zhang M, Liang Z, Chen S, Chen F, Zhu J, Zhao M, He J, Hua W and Duan P: Association of polymorphisms in MALAT1 with the risk of endometrial cancer in Southern Chinese women. J Clin Lab Anal. 34:e231462020.PubMed/NCBI

74 

Cao X, Zhao R, Chen Q, Zhao Y, Zhang B, Zhang Y, Yu J, Han G, Cao W, Li J and Chen X: MALAT1 might be a predictive marker of poor prognosis in patients who underwent radical resection of middle thoracic esophageal squamous cell carcinoma. Cancer Biomark. 15:717–723. 2015. View Article : Google Scholar : PubMed/NCBI

75 

Liu R, Li J, Lai Y, Liao Y, Liu R and Qiu W: Hsa-miR-1 suppresses breast cancer development by down-regulating K-ras and long non-coding RNA MALAT1. Int J Biol Macromol. 81:491–497. 2015. View Article : Google Scholar : PubMed/NCBI

76 

Arun G, Diermeier S, Akerman M, Chang KC, Wilkinson JE, Hearn S, Kim Y, MacLeod AR, Krainer AR, Norton L, et al: Differentiation of mammary tumors and reduction in metastasis upon Malat1 lncRNA loss. Genes Dev. 30:34–51. 2016. View Article : Google Scholar : PubMed/NCBI

77 

Gordon MA, Babbs B, Cochrane DR, Bitler BG and Richer JK: The long non-coding RNA MALAT1 promotes ovarian cancer progression by regulating RBFOX2-mediated alternative splicing. Mol Carcinog. 58:196–205. 2019. View Article : Google Scholar : PubMed/NCBI

78 

Bai L, Wang A, Zhang Y, Xu X and Zhang X: Knockdown of MALAT1 enhances chemosensitivity of ovarian cancer cells to cisplatin through inhibiting the Notch1 signaling pathway. Exp Cell Res. 366:161–171. 2018. View Article : Google Scholar : PubMed/NCBI

79 

Worku T, Bhattarai D, Ayers D, Wang K, Wang C, Rehman ZU, Talpur HS and Yang L: Long non-coding RNAs: The new horizon of gene regulation in ovarian cancer. Cell Physiol Biochem. 44:948–966. 2017. View Article : Google Scholar : PubMed/NCBI

80 

Pa M, Naizaer G, Seyiti A and Kuerbang G: Long noncoding RNA MALAT1 functions as a sponge of MiR-200c in ovarian cancer. Oncol Res. Sep 11–2017.(Epub ahead of print). View Article : Google Scholar : PubMed/NCBI

81 

Lei R, Xue M, Zhang L and Lin Z: Long noncoding RNA MALAT1-regulated microRNA 506 modulates ovarian cancer growth by targeting iASPP. Onco Targets Ther. 10:35–46. 2016. View Article : Google Scholar : PubMed/NCBI

82 

Zhu P, Wang FQ and Li QR: Correlation study between long non-coding RNA MALAT1 and radiotherapy efficiency on cervical carcinoma and generation of radiotherapy resistant model of cancer. Eur Rev Med Pharmacol Sci. 22:5140–5148. 2018.PubMed/NCBI

83 

Sun R, Qin C, Jiang B, Fang S, Pan X, Peng L, Liu Z, Li W, Li Y and Li G: Down-regulation of MALAT1 inhibits cervical cancer cell invasion and metastasis by inhibition of epithelial-mesenchymal transition. Mol Biosyst. 12:952–962. 2016. View Article : Google Scholar : PubMed/NCBI

84 

Xia C, Liang S, He Z, Zhu X, Chen R and Chen J: Metformin, a first-line drug for type 2 diabetes mellitus, disrupts the MALAT1/miR-142-3p sponge to decrease invasion and migration in cervical cancer cells. Eur J Pharmacol. 830:59–67. 2018. View Article : Google Scholar : PubMed/NCBI

85 

Li Q, Zhang C, Chen R, Xiong H, Qiu F, Liu S, Zhang M, Wang F, Wang Y, Zhou X, et al: Disrupting MALAT1/miR-200c sponge decreases invasion and migration in endometrioid endometrial carcinoma. Cancer Lett. 383:28–40. 2016. View Article : Google Scholar : PubMed/NCBI

86 

Tian X and Xu G: Clinical value of lncRNA MALAT1 as a prognostic marker in human cancer: Systematic review and meta-analysis. BMJ Open. 5:e0086532015. View Article : Google Scholar : PubMed/NCBI

87 

Du Z, Fei T, Verhaak RG, Su Z, Zhang Y, Brown M, Chen Y and Liu XS: Integrative genomic analyses reveal clinically relevant long noncoding RNAs in human cancer. Nat Struct Mol Biol. 20:908–913. 2013. View Article : Google Scholar : PubMed/NCBI

88 

Liao H, Chen Q and Xiao J: Reflections on the role of Malat1 in gynecological cancer. Cancer Manag Res. 12:13489–13500. 2020. View Article : Google Scholar : PubMed/NCBI

89 

Sun Y and Ma L: New insights into long non-coding RNA MALAT1 in cancer and metastasis. Cancers (Basel). 11:2162019. View Article : Google Scholar

90 

Amodio N, Raimondi L, Juli G, Stamato MA, Caracciolo D, Tagliaferri P and Tassone P: MALAT1: A druggable long non-coding RNA for targeted anti-cancer approaches. J Hematol Oncol. 11:632018. View Article : Google Scholar : PubMed/NCBI

Related Articles

  • Abstract
  • View
  • Download
  • Twitter
Copy and paste a formatted citation
Spandidos Publications style
Qiao F, Tu M and Liu H: Role of MALAT1 in gynecological cancers: Pathologic and therapeutic aspects (Review). Oncol Lett 21: 333, 2021.
APA
Qiao, F., Tu, M., & Liu, H. (2021). Role of MALAT1 in gynecological cancers: Pathologic and therapeutic aspects (Review). Oncology Letters, 21, 333. https://doi.org/10.3892/ol.2021.12594
MLA
Qiao, F., Tu, M., Liu, H."Role of MALAT1 in gynecological cancers: Pathologic and therapeutic aspects (Review)". Oncology Letters 21.4 (2021): 333.
Chicago
Qiao, F., Tu, M., Liu, H."Role of MALAT1 in gynecological cancers: Pathologic and therapeutic aspects (Review)". Oncology Letters 21, no. 4 (2021): 333. https://doi.org/10.3892/ol.2021.12594
Copy and paste a formatted citation
x
Spandidos Publications style
Qiao F, Tu M and Liu H: Role of MALAT1 in gynecological cancers: Pathologic and therapeutic aspects (Review). Oncol Lett 21: 333, 2021.
APA
Qiao, F., Tu, M., & Liu, H. (2021). Role of MALAT1 in gynecological cancers: Pathologic and therapeutic aspects (Review). Oncology Letters, 21, 333. https://doi.org/10.3892/ol.2021.12594
MLA
Qiao, F., Tu, M., Liu, H."Role of MALAT1 in gynecological cancers: Pathologic and therapeutic aspects (Review)". Oncology Letters 21.4 (2021): 333.
Chicago
Qiao, F., Tu, M., Liu, H."Role of MALAT1 in gynecological cancers: Pathologic and therapeutic aspects (Review)". Oncology Letters 21, no. 4 (2021): 333. https://doi.org/10.3892/ol.2021.12594
Follow us
  • Twitter
  • LinkedIn
  • Facebook
About
  • Spandidos Publications
  • Careers
  • Cookie Policy
  • Privacy Policy
How can we help?
  • Help
  • Live Chat
  • Contact
  • Email to our Support Team