Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Oncology Letters
      • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Biomedical Reports
      • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • Information for Authors
    • Information for Reviewers
    • Information for Librarians
    • Information for Advertisers
    • Conferences
  • Language Editing
Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • For Authors
    • For Reviewers
    • For Librarians
    • For Advertisers
    • Conferences
  • Language Editing
Login Register Submit
  • This site uses cookies
  • You can change your cookie settings at any time by following the instructions in our Cookie Policy. To find out more, you may read our Privacy Policy.

    I agree
Search articles by DOI, keyword, author or affiliation
Search
Advanced Search
presentation
Oncology Letters
Join Editorial Board Propose a Special Issue
Print ISSN: 1792-1074 Online ISSN: 1792-1082
Journal Cover
April-2021 Volume 21 Issue 4

Full Size Image

Sign up for eToc alerts
Recommend to Library

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
April-2021 Volume 21 Issue 4

Full Size Image

Sign up for eToc alerts
Recommend to Library

  • Article
  • Citations
    • Cite This Article
    • Download Citation
    • Create Citation Alert
    • Remove Citation Alert
    • Cited By
  • Similar Articles
    • Related Articles (in Spandidos Publications)
    • Similar Articles (Google Scholar)
    • Similar Articles (PubMed)
  • Download PDF
  • Download XML
  • View XML
Review Open Access

Genomics and transcriptomics in veterinary oncology (Review)

  • Authors:
    • Bridget Marie Harrison
    • Panayiotis Loukopoulos
  • View Affiliations / Copyright

    Affiliations: Melbourne Veterinary School, Faculty of Veterinary and Agricultural Sciences, University of Melbourne, Werribee, Victoria 3030, Australia
    Copyright: © Harrison et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 336
    |
    Published online on: February 26, 2021
       https://doi.org/10.3892/ol.2021.12597
  • Expand metrics +
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
Cited By (CrossRef): 0 citations Loading Articles...

This article is mentioned in:



Abstract

The sequencing of the canine genome, combined with additional genomic technologies, has created opportunities for research linking veterinary genomics with naturally occurring cancer in dogs. Also, as numerous canine cancers have features in common with human cancers, comparative studies can be performed to evaluate the use of cancers in dogs as models for human cancer. There have been several reviews of veterinary genomics but, to the best of our knowledge, there has been no comprehensive review of the literature of canine cancer genomics. PubMed and CAB Abstracts databases were searched to retrieve relevant literature using the search terms ‘veterinary’, ‘cancer’ or ‘oncology’, and ‘genomics’ or ‘transcriptomics’. Results were manually assessed and grouped based on the techniques used, the cancer type investigated and genomic lesions targeted. The search resulted in the retrieval of 44 genomic and transcriptomic studies, with the most common technique employed being comparative genomic hybridization. Across both fields, the most commonly studied cancer type was canine osteosarcoma. Genomic and transcriptomic aberrations in canine cancer often reflected those reported in the corresponding human cancers. Analysis of the literature indicated that employing genomic and transcriptomic technologies has been instrumental in developing the understanding of the origin, development and pathogenesis of several canine cancers. However, their use in canine oncology is at an early phase, and there appears to be comparatively little understanding of certain canine cancer types in contrast to their human forms. Aberrations detected in all tumors were tabulated, and the results for osteosarcoma, lymphoma and leukemia, mast cell tumor, transmissible venereal tumor and urothelial carcinoma discussed in detail.
View Figures
View References

1 

Adams V, Evans K, Sampson J and Wood J: Methods and mortality results of a health survey of purebred dogs in the UK. J Small Anim Pract. 51:512–524. 2010. View Article : Google Scholar : PubMed/NCBI

2 

Pinho SS, Carvalho S, Cabral J, Reis CA and Gärtner F: Canine tumors: A spontaneous animal model of human carcinogenesis. Transl Res. 159:165–172. 2012. View Article : Google Scholar : PubMed/NCBI

3 

Ostrander EA, Dreger DL and Evans JM: Canine cancer genomics: Lessons for canine and human health. Annu Rev Anim Biosci. 7:449–472. 2019. View Article : Google Scholar : PubMed/NCBI

4 

Davis BW and Ostrander EA: Domestic dogs and cancer research: A breed-based genomics approach. ILAR J. 55:59–68. 2014. View Article : Google Scholar : PubMed/NCBI

5 

Katoh H, Shibata T, Kokubu A, Ojima H, Loukopoulos P, Kanai Y, Kosuge T, Fukayama M, Kondo T, Sakamoto M, et al: Genetic profile of hepatocellular carcinoma revealed by array-based comparative genomic hybridization: Identification of genetic indicators to predict patient outcome. J Hepatol. 43:863–874. 2005. View Article : Google Scholar : PubMed/NCBI

6 

Loukopoulos P, Shibata T, Katoh H, Kokubu A, Sakamoto M, Yamazaki K, Kosuge T, Kanai Y, Hosoda F, Imoto I, et al: Genome-wide array-based comparative genomic hybridization analysis of pancreatic adenocarcinoma: Identification of genetic indicators that predict patient outcome. Cancer Sci. 98:392–400. 2007. View Article : Google Scholar : PubMed/NCBI

7 

O'Brien SJ: Pet project. Nature. 438:7402005. View Article : Google Scholar

8 

Theisen A: Microarray-based comparative genomic hybridization (aCGH). Nature Educ. 1:452008.

9 

Dhawan D, Paoloni M, Shukradas S, Choudhury DR, Craig BA, Ramos-Vara JA, Hahn N, Bonney PL, Khanna C and Knapp DW: Comparative gene expression analyses identify luminal and basal subtypes of canine invasive urothelial carcinoma that mimic patterns in human invasive bladder cancer. PLoS One. 10:e01366882015. View Article : Google Scholar : PubMed/NCBI

10 

Simpson S, Dunning MD, de Brot S, Grau-Roma L, Mongan NP and Rutland CS: Comparative review of human and canine osteosarcoma: Morphology, epidemiology, prognosis, treatment and genetics. Acta Vet Scand. 59:712017. View Article : Google Scholar : PubMed/NCBI

11 

Shao YW, Wood GA, Lu J, Tang QL, Liu J, Molyneux S, Chen Y, Fang H, Adissu H, McKee T, et al: Cross-species genomics identifies DLG2 as a tumor suppressor in osteosarcoma. Oncogene. 38:291–298. 2019. View Article : Google Scholar : PubMed/NCBI

12 

Phillips JC, Lembcke L and Chamberlin T: A novel locus for canine osteosarcoma (OSA1) maps to CFA34, the canine orthologue of human 3q26. Genomics. 96:220–227. 2010. View Article : Google Scholar : PubMed/NCBI

13 

Sapierzyński R and Czopowicz M: The animal-dependent risk factors in canine osteosarcomas. Pol J Vet Sci. 20:293–298. 2017. View Article : Google Scholar : PubMed/NCBI

14 

Loukopoulos P and Robinson WF: Clinicopathological relevance of tumour grading in canine osteosarcoma. J Comp Pathol. 136:65–73. 2007. View Article : Google Scholar : PubMed/NCBI

15 

Loukopoulos P, Rozmanec M and Sutton RH: Cytological versus histopathological diagnosis in canine osteosarcoma. Vet Rec. 157:7842005. View Article : Google Scholar : PubMed/NCBI

16 

Angstadt AY, Thayanithy V, Subramanian S, Modiano JF and Breen M: A genome-wide approach to comparative oncology: High-resolution oligonucleotide aCGH of canine and human osteosarcoma pinpoints shared microaberrations. Cancer Genet. 205:572–587. 2012. View Article : Google Scholar : PubMed/NCBI

17 

Thomas R, Scott A, Langford CF, Fosmire SP, Jubala CM, Lorentzen TD, Hitte C, Karlsson EK, Kirkness E, Ostrander EA, et al: Construction of a 2-Mb resolution BAC microarray for CGH analysis of canine tumors. Genome Res. 15:1831–1837. 2005. View Article : Google Scholar : PubMed/NCBI

18 

Phillips JC, Stephenson B, Hauck M and Dillberger J: Heritability and segregation analysis of osteosarcoma in the Scottish deerhound. Genomics. 90:354–363. 2007. View Article : Google Scholar : PubMed/NCBI

19 

Meyer FR, Steinborn R, Grausgruber H, Wolfesberger B and Walter I: Expression of platelet-derived growth factor BB, erythropoietin and erythropoietin receptor in canine and feline osteosarcoma. Vet J. 206:67–74. 2015. View Article : Google Scholar : PubMed/NCBI

20 

Wolfesberger B, Fuchs-Baumgartinger A, Hlavaty J, Meyer FR, Hofer M, Steinborn R, Gebhard C and Walter I: Stem cell growth factor receptor in canine vs feline osteosarcomas. Oncol Lett. 12:2485–2492. 2016. View Article : Google Scholar : PubMed/NCBI

21 

Dimopoulou M, Kirpensteijn J, Moens H and Kik M: Histologic prognosticators in feline osteosarcoma: A comparison with phenotypically similar canine osteosarcoma. Vet Surg. 37:466–471. 2008. View Article : Google Scholar : PubMed/NCBI

22 

Fowles JS, Brown KC, Hess AM, Duval DL and Gustafson DL: Intra- and interspecies gene expression models for predicting drug response in canine osteosarcoma. BMC Bioinformatics. 17:932016. View Article : Google Scholar : PubMed/NCBI

23 

Thomas R, Seiser EL, Motsinger-Reif A, Borst L, Valli VE, Kelley K, Suter SE, Argyle D, Burgess K, Bell J, et al: Refining tumor-associated aneuploidy through ‘genomic recoding’ of recurrent DNA copy number aberrations in 150 canine non-Hodgkin lymphomas. Leuk Lymphoma. 52:1321–1335. 2011. View Article : Google Scholar : PubMed/NCBI

24 

Levsky JM and Singer RH: Fluorescence in situ hybridization: Past, present and future. J Cell Sci. 116:2833–2838. 2003. View Article : Google Scholar : PubMed/NCBI

25 

Breen M and Modiano JF: Evolutionarily conserved cytogenetic changes in hematological malignancies of dogs and humans-man and his best friend share more than companionship. Chromosome Res. 16:145–154. 2008. View Article : Google Scholar : PubMed/NCBI

26 

Suenaga M, Tomiyasu H, Watanabe M, Ogawa K, Motegi T, Goto-Koshino Y, Ohno K, Sugano S, Skorupski KA and Tsujimoto H: Comprehensive analysis of gene expression profiles reveals novel candidates of chemotherapy resistant factors in canine lymphoma. Vet J. 228:18–21. 2017. View Article : Google Scholar : PubMed/NCBI

27 

Camus MS, Priest HL, Koehler JW, Driskell EA, Rakich PM, Ilha MR and Krimer PM: Cytologic criteria for mast cell tumor grading in dogs with evaluation of clinical outcome. Vet Pathol. 53:1117–1123. 2016. View Article : Google Scholar : PubMed/NCBI

28 

Sledge DG, Webster J and Kiupel M: Canine cutaneous mast cell tumors: A combined clinical and pathologic approach to diagnosis, prognosis, and treatment selection. Vet J. 215:43–54. 2016. View Article : Google Scholar : PubMed/NCBI

29 

Jark PC, Mundin DB, de Carvalho M, Ferioli RB, Anai LA, Marchi FA, Rogatto SR, Laufer-Amorim R and Tinucci-Costa M: Genomic copy number variation associated with clinical outcome in canine cutaneous mast cell tumors. Res Vet Sci. 111:26–30. 2017. View Article : Google Scholar : PubMed/NCBI

30 

Mochizuki H, Thomas R, Moroff S and Breen M: Genomic profiling of canine mast cell tumors identifies DNA copy number aberrations associated with KIT mutations and high histological grade. Chromosome Res. 25:129–143. 2017. View Article : Google Scholar : PubMed/NCBI

31 

Giantin M, Baratto C, Marconato L, Vascellari M, Mutinelli F, Dacasto M and Granato A: Transcriptomic analysis identified up-regulation of a solute carrier transporter and UDP glucuronosyltransferases in dogs with aggressive cutaneous mast cell tumours. Vet J. 212:36–43. 2016. View Article : Google Scholar : PubMed/NCBI

32 

Strakova A, Ní Leathlobhair M, Wang GD, Yin TT, Airikkala-Otter I, Allen JL, Allum KM, Bansse-Issa L, Bisson JL, Castillo Domracheva A, et al: Mitochondrial genetic diversity, selection and recombination in a canine transmissible cancer. Elife. 5:e145522016. View Article : Google Scholar : PubMed/NCBI

33 

Decker B, Davis BW, Rimbault M, Long AH, Karlins E, Jagannathan V, Reiman R, Parker HG, Drögemüller C, Corneveaux JJ, et al: Comparison against 186 canid whole-genome sequences reveals survival strategies of an ancient clonally transmissible canine tumor. Genome Res. 25:1646–1655. 2015. View Article : Google Scholar : PubMed/NCBI

34 

Fulkerson CM, Dhawan D, Ratliff TL, Hahn NM and Knapp DW: Naturally occurring canine invasive urinary bladder cancer: A complementary animal model to improve the success rate in human clinical trials of new cancer drugs. Int J Genomics. 2017:65895292017. View Article : Google Scholar : PubMed/NCBI

35 

Shapiro SG, Raghunath S, Williams C, Motsinger-Reif AA, Cullen JM, Liu T, Albertson D, Ruvolo M, Bergstrom Lucas A, Jin J, et al: Canine urothelial carcinoma: Genomically aberrant and comparatively relevant. Chromosome Res. 23:311–331. 2015. View Article : Google Scholar : PubMed/NCBI

36 

Davis B, Schwartz M, Duchemin D, Barrett JC and Post G: Validation of a multiplexed gene signature assay for diagnosis of canine cancers from formalin-fixed paraffin-embedded tissues. J Vet Intern Med. 31:854–863. 2017. View Article : Google Scholar : PubMed/NCBI

37 

Granato A, Giantin M, Ariani P, Carminato A, Baratto C, Zorzan E, Vascellari M, Bozzato E, Dacasto M and Mutinelli F: DNA and RNA isolation from canine oncologic formalin-fixed, paraffin-embedded tissues for downstream ‘-omic’ analyses: Possible or not? J Vet Diagn Invest. 26:117–124. 2014. View Article : Google Scholar : PubMed/NCBI

38 

Breen M: Canine cytogenetics-from band to basepair. Cytogen Genome Res. 120:50–60. 2008. View Article : Google Scholar

39 

Breen M: Update on genomics in veterinary oncology. Topics Companion Anim Med. 24:113–121. 2009. View Article : Google Scholar

40 

Ceciliani F, Roccabianca P, Giudice C and Lecchi C: Application of post-genomic techniques in dog cancer research. Mol Biosyst. 12:2665–2679. 2016. View Article : Google Scholar : PubMed/NCBI

41 

Jones EA, Cheng Y and Belov K: The origin, dynamics, and molecular evolution of transmissible cancers. Adv Genom Genet. 5:317–326. 2015.

42 

Ferraresso S, Aricò A, Sanavia T, Da Ros S, Milan M, Cascione L, Comazzi S, Martini V, Giantin M, Di Camillo B, et al: DNA methylation profiling reveals common signatures of tumorigenesis and defines epigenetic prognostic subtypes of canine diffuse large B-cell lymphoma. Sci Rep. 7:115912017. View Article : Google Scholar : PubMed/NCBI

43 

Courtay-Cahen C, Platt SR, De Risio L and Starkey MP: Preliminary analysis of genomic abnormalities in canine meningiomas. Vet Comp Oncol. 6:182–192. 2008. View Article : Google Scholar : PubMed/NCBI

44 

Dickinson PJ, York D, Higgins RJ, LeCouteur RA, Joshi N and Bannasch D: Chromosomal aberrations in canine gliomas define candidate genes and common pathways in DOGS AND HUmans. J Neuropathol Exp Neurol. 75:700–710. 2016. View Article : Google Scholar : PubMed/NCBI

45 

Thomas R, Duke SE, Bloom SK, Breen TE, Young AC, Feiste E, Seiser EL, Tsai PC, Langford CF, Ellis P, et al: A cytogenetically characterized, genome-anchored 10-Mb BAC set and CGH array for the domestic dog. J Hered. 98:474–484. 2007. View Article : Google Scholar : PubMed/NCBI

46 

Wang G, Wu M, Maloneyhuss MA, Wojcik J, Durham AC, Mason NJ and Roth DB: Actionable mutations in canine hemangiosarcoma. PLoS One. 12:e01886672017. View Article : Google Scholar : PubMed/NCBI

47 

Laufer-Amorim R, Fonseca-Alves CE, Villacis RAR, Linde SAD, Carvalho M, Larsen SJ, Marchi FA and Rogatto SR: Comprehensive genomic profiling of androgen-receptor-negative canine prostate cancer. Int J Mol Sci. 20:15552019. View Article : Google Scholar

48 

Zapata I, Moraes LE, Fiala EM, Zaldivar-Lopez S, Couto CG, Rowell JL and Alvarez CE: Risk-modeling of dog osteosarcoma genome scans shows individuals with Mendelian-level polygenic risk are common. BMC Genomics. 20:2262019. View Article : Google Scholar : PubMed/NCBI

49 

Gardner HL, Sivaprakasam K, Briones N, Zismann V, Perdigones N, Drenner K, Facista S, Richholt R, Liang W, Aldrich J, et al: Canine osteosarcoma genome sequencing identifies recurrent mutations in DMD and the histone methyltransferase gene SETD2. Commun Biol. 2:2662019. View Article : Google Scholar : PubMed/NCBI

50 

Maués T, El-Jaick KB, Costa FB, Freitas PVS, Moreira AS, Castro L, Ferreira MLG and Ferreira AMR: Could polymorphisms in ABCB1 gene represent a genetic risk factor for the development of mammary tumors in dogs? Vet J. 248:58–63. 2019. View Article : Google Scholar : PubMed/NCBI

51 

Korpershoek E, Dieduksman DAER, Grinwis GCM, Day MJ, Reusch CE, Hilbe M, Fracassi F, Krol NMG, Uitterlinden AG, de Klein A, et al: Molecular alterations in dog pheochromocytomas and paragangliomas. Cancers (Basel). 11:6072019. View Article : Google Scholar

52 

Kosack L, Wingelhofer B, Popa A, Orlova A, Agerer B, Vilagos B, Majek P, Parapatics K, Lercher A, Ringler A, et al: The ERBB-STAT3 axis drives tasmanian devil facial tumor disease. Cancer Cell. 14:125–139.e9. 2019. View Article : Google Scholar

53 

Singer-Berk MH, Knickelbein KE, Lounsberry ZT, Crausaz M, Vig S, Joshi N, Britton M, Settles ML, Reilly CM, Bentley E, et al: Additional evidence for DDB2 T338M as a genetic risk factor for ocular squamous cell carcinoma in horses. Int J Genomics. 2019:36109652019. View Article : Google Scholar : PubMed/NCBI

54 

Megquier K, Turner-Maier J, Swofford R, Kim JH, Sarver AL, Wang C, Sakthikumar S, Johnson J, Koltookian M, Lewellen M, et al: Comparative genomics reveals shared mutational landscape in canine hemangiosarcoma and human angiosarcoma. Mol Cancer Res. 17:2410–2421. 2019. View Article : Google Scholar : PubMed/NCBI

55 

Amin SB, Anderson KJ, Boudreau CE, Martinez-Ledesma E, Kocakavuk E, Johnson KC, Barthel FP, Varn FS, Kassab C, Ling X, et al: Comparative molecular life history of spontaneous canine and human gliomas. Cancer Cell. 37:243–257.e7. 2020. View Article : Google Scholar : PubMed/NCBI

56 

Grimes JA, Prasad N, Levy S, Cattley R, Lindley S, Boothe HW, Henderson RA and Smith BF: A comparison of microRNA expression profiles from splenic hemangiosarcoma, splenic nodular hyperplasia, and normal spleens of dogs. BMC Vet Res. 12:2722016. View Article : Google Scholar : PubMed/NCBI

57 

Mahoney JA, Fisher JC, Snyder SA and Hauck ML: Feasibility of using gene expression analysis to study canine soft tissue sarcomas. Mamm Genome. 21:577–582. 2010. View Article : Google Scholar : PubMed/NCBI

58 

Lee KH, Park HM, Son KH, Shin TJ and Cho JY: Transcriptome signatures of canine mammary gland tumors and its comparison to human breast cancers. Cancers (Basel). 10:3172018. View Article : Google Scholar

59 

Rahman M, Lai Y, Husna AA, Chen HW, Tanaka Y, Kawaguchi H, Hatai H, Miyoshi N, Nakagawa T, Fukushima R and Miura N: Transcriptome analysis of dog oral melanoma and its oncogenic analogy with human melanoma. Oncol Rep. 43:16–30. 2020.PubMed/NCBI

60 

Panchal K, Koringa P, Sabara P, Bhatia D, Jakhesara S and Joshi C: Expression profiling revealed keratins and interleukins as potential biomarkers in squamous cell carcinoma of horn in Indian bullocks (Bos indicus). 3 Biotech. 10:922020. View Article : Google Scholar : PubMed/NCBI

61 

Sabara PH, Jakhesara SJ, Panchal KJ, Joshi CG and Koringa PG: Transcriptomic analysis to affirm the regulatory role of long non-coding RNA in horn cancer of Indian zebu cattle breed Kankrej (Bos indicus). Funct Integr Genomics. 20:75–87. 2020. View Article : Google Scholar : PubMed/NCBI

Related Articles

  • Abstract
  • View
  • Download
  • Twitter
Copy and paste a formatted citation
Spandidos Publications style
Harrison BM and Loukopoulos P: Genomics and transcriptomics in veterinary oncology (Review). Oncol Lett 21: 336, 2021.
APA
Harrison, B.M., & Loukopoulos, P. (2021). Genomics and transcriptomics in veterinary oncology (Review). Oncology Letters, 21, 336. https://doi.org/10.3892/ol.2021.12597
MLA
Harrison, B. M., Loukopoulos, P."Genomics and transcriptomics in veterinary oncology (Review)". Oncology Letters 21.4 (2021): 336.
Chicago
Harrison, B. M., Loukopoulos, P."Genomics and transcriptomics in veterinary oncology (Review)". Oncology Letters 21, no. 4 (2021): 336. https://doi.org/10.3892/ol.2021.12597
Copy and paste a formatted citation
x
Spandidos Publications style
Harrison BM and Loukopoulos P: Genomics and transcriptomics in veterinary oncology (Review). Oncol Lett 21: 336, 2021.
APA
Harrison, B.M., & Loukopoulos, P. (2021). Genomics and transcriptomics in veterinary oncology (Review). Oncology Letters, 21, 336. https://doi.org/10.3892/ol.2021.12597
MLA
Harrison, B. M., Loukopoulos, P."Genomics and transcriptomics in veterinary oncology (Review)". Oncology Letters 21.4 (2021): 336.
Chicago
Harrison, B. M., Loukopoulos, P."Genomics and transcriptomics in veterinary oncology (Review)". Oncology Letters 21, no. 4 (2021): 336. https://doi.org/10.3892/ol.2021.12597
Follow us
  • Twitter
  • LinkedIn
  • Facebook
About
  • Spandidos Publications
  • Careers
  • Cookie Policy
  • Privacy Policy
How can we help?
  • Help
  • Live Chat
  • Contact
  • Email to our Support Team