Pathways and role of MALAT1 in esophageal and gastric cancer (Review)

Syllaios,Athanasios; Moris,Dimitrios; Karachaliou,Georgia Sofia; Sakellariou,Stratigoula; Karavokyros,Ioannis; Gazouli,Maria; Schizas,Dimitrios

doi:10.3892/ol.2021.12604

Pathways and role of MALAT1 in esophageal and gastric cancer (Review)

Authors:
- Athanasios Syllaios
- Dimitrios Moris
- Georgia Sofia Karachaliou
- Stratigoula Sakellariou
- Ioannis Karavokyros
- Maria Gazouli
- Dimitrios Schizas
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Affiliations: First Department of Surgery, National and Kapodistrian University of Athens, Laikon General Hospital, Athens 11527, Greece, Department of Surgery, Duke University Medical Center, Durham, NC 27707, USA, Department of Medicine, Division of Hematology/Oncology, Duke University Medical Center, Durham, NC 27707, USA, First Department of Pathology, Medical School, National and Kapodistrian University of Athens, Athens 11527, Greece, Laboratory of Biology, Medical School, National and Kapodistrian University of Athens, Athens 11527, Greece
Published online on: March 2, 2021 https://doi.org/10.3892/ol.2021.12604
Article Number: 343

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Abstract

Esophageal cancer (EC) and gastric cancer (GC) often have an unfavorable prognosis. Therefore, research is being conducted to identify the molecular mechanisms underlying the tumorigenesis and progression of GC and EC, and to indicate novel therapeutic targets and clinically applicable biomarkers. The dysregulations and roles of long non‑coding RNAs (lncRNAs) have been widely reported, and current published literature has shown that lncRNAs play important regulatory roles in the carcinogenesis and progression of EC and GC. The lncRNA metastasis‑associated lung adenocarcinoma transcript 1 (MALAT1) has been investigated in a number of studies with regard to its pathogenic pathways and association with the prognosis of gastric and esophageal malignancies. As literature on the topic of MALAT1 in EC and GC continues to emerge, the present review aims to summarize all current knowledge on the association between MALAT1 expression and esophagogastric malignancies and to describe the pathogenic pathways and possible prognostic role of MALAT1 in esophagogastric cancer. As research studies on MALAT1 pathways in esophagogastric malignancies are ongoing, new possibilities for the diagnosis, prognosis and therapy of GC and EC are likely to be identified.

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