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Review

Pathways and role of MALAT1 in esophageal and gastric cancer (Review)

  • Authors:
    • Athanasios Syllaios
    • Dimitrios Moris
    • Georgia Sofia Karachaliou
    • Stratigoula Sakellariou
    • Ioannis Karavokyros
    • Maria Gazouli
    • Dimitrios Schizas
  • View Affiliations / Copyright

    Affiliations: First Department of Surgery, National and Kapodistrian University of Athens, Laikon General Hospital, Athens 11527, Greece, Department of Surgery, Duke University Medical Center, Durham, NC 27707, USA, Department of Medicine, Division of Hematology/Oncology, Duke University Medical Center, Durham, NC 27707, USA, First Department of Pathology, Medical School, National and Kapodistrian University of Athens, Athens 11527, Greece, Laboratory of Biology, Medical School, National and Kapodistrian University of Athens, Athens 11527, Greece
  • Article Number: 343
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    Published online on: March 2, 2021
       https://doi.org/10.3892/ol.2021.12604
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Abstract

Esophageal cancer (EC) and gastric cancer (GC) often have an unfavorable prognosis. Therefore, research is being conducted to identify the molecular mechanisms underlying the tumorigenesis and progression of GC and EC, and to indicate novel therapeutic targets and clinically applicable biomarkers. The dysregulations and roles of long non‑coding RNAs (lncRNAs) have been widely reported, and current published literature has shown that lncRNAs play important regulatory roles in the carcinogenesis and progression of EC and GC. The lncRNA metastasis‑associated lung adenocarcinoma transcript 1 (MALAT1) has been investigated in a number of studies with regard to its pathogenic pathways and association with the prognosis of gastric and esophageal malignancies. As literature on the topic of MALAT1 in EC and GC continues to emerge, the present review aims to summarize all current knowledge on the association between MALAT1 expression and esophagogastric malignancies and to describe the pathogenic pathways and possible prognostic role of MALAT1 in esophagogastric cancer. As research studies on MALAT1 pathways in esophagogastric malignancies are ongoing, new possibilities for the diagnosis, prognosis and therapy of GC and EC are likely to be identified.
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Copy and paste a formatted citation
Spandidos Publications style
Syllaios A, Moris D, Karachaliou GS, Sakellariou S, Karavokyros I, Gazouli M and Schizas D: Pathways and role of MALAT1 in esophageal and gastric cancer (Review). Oncol Lett 21: 343, 2021.
APA
Syllaios, A., Moris, D., Karachaliou, G.S., Sakellariou, S., Karavokyros, I., Gazouli, M., & Schizas, D. (2021). Pathways and role of MALAT1 in esophageal and gastric cancer (Review). Oncology Letters, 21, 343. https://doi.org/10.3892/ol.2021.12604
MLA
Syllaios, A., Moris, D., Karachaliou, G. S., Sakellariou, S., Karavokyros, I., Gazouli, M., Schizas, D."Pathways and role of MALAT1 in esophageal and gastric cancer (Review)". Oncology Letters 21.5 (2021): 343.
Chicago
Syllaios, A., Moris, D., Karachaliou, G. S., Sakellariou, S., Karavokyros, I., Gazouli, M., Schizas, D."Pathways and role of MALAT1 in esophageal and gastric cancer (Review)". Oncology Letters 21, no. 5 (2021): 343. https://doi.org/10.3892/ol.2021.12604
Copy and paste a formatted citation
x
Spandidos Publications style
Syllaios A, Moris D, Karachaliou GS, Sakellariou S, Karavokyros I, Gazouli M and Schizas D: Pathways and role of MALAT1 in esophageal and gastric cancer (Review). Oncol Lett 21: 343, 2021.
APA
Syllaios, A., Moris, D., Karachaliou, G.S., Sakellariou, S., Karavokyros, I., Gazouli, M., & Schizas, D. (2021). Pathways and role of MALAT1 in esophageal and gastric cancer (Review). Oncology Letters, 21, 343. https://doi.org/10.3892/ol.2021.12604
MLA
Syllaios, A., Moris, D., Karachaliou, G. S., Sakellariou, S., Karavokyros, I., Gazouli, M., Schizas, D."Pathways and role of MALAT1 in esophageal and gastric cancer (Review)". Oncology Letters 21.5 (2021): 343.
Chicago
Syllaios, A., Moris, D., Karachaliou, G. S., Sakellariou, S., Karavokyros, I., Gazouli, M., Schizas, D."Pathways and role of MALAT1 in esophageal and gastric cancer (Review)". Oncology Letters 21, no. 5 (2021): 343. https://doi.org/10.3892/ol.2021.12604
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