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Ruxolitinib induces apoptosis of human colorectal cancer cells by downregulating the JAK1/2‑STAT1‑Mcl‑1 axis

  • Authors:
    • Xia Li
    • Zhe Wang
    • Shengjie Zhang
    • Qinghua Yao
    • Wei Chen
    • Feiyan Liu
  • View Affiliations / Copyright

    Affiliations: College of Life Sciences, Zhejiang University, Hangzhou, Zhejiang 310058, P.R. China, Institute of Cancer and Basic Medicine, Chinese Academy of Sciences, Hangzhou, Zhejiang 310022, P.R. China
    Copyright: © Li et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 352
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    Published online on: March 4, 2021
       https://doi.org/10.3892/ol.2021.12613
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Abstract

Under pathological conditions, the Janus kinase (JAK)/STAT signaling pathway can regulate the proliferation, differentiation and migration of tumor cells, including colorectal cancer (CRC). CRC is the third major types of cancer among males and the second among females worldwide. In China, CRC is the fifth common cancer among both males and females. Western blotting, flow cytometry, RNA interference, immunoprecipitation, xenografts models, and immunohistochemical staining were carried out to evaluate the possible mechanisms of acton of ruxolitinib. The present data suggested that ruxolitinib can suppress CRC cell proliferation by inducing apoptosis. Firstly, JAK1/2‑STAT1 was identified as the target of ruxolitinib. Then, ruxolitinib downregulated myeloid cell leukemia‑1 (Mcl‑1) mRNA level and decreased its protein level, which enabled Bak to trigger CRC apoptosis. Furthermore, ruxolitinib exerted potent activity against CRC xenograft growth in vivo. High expression of phosphorylated STAT1 (S727) was also confirmed in 44 pairs of human colon carcinoma and adjacent normal tissues. Taken together, the results showed that ruxolitinib decreased JAK1/2‑STAT1‑Mcl‑1 protein level and effectively suppressed CRC cell proliferation in vitro and in vivo. Therefore, ruxolitinib could be a promising anticancer agent for CRC treatment.
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1 

Siegel R, Naishadham D and Jemal A: Cancer statistics, 2013. CA Cancer J Clin. 63:11–30. 2013. View Article : Google Scholar : PubMed/NCBI

2 

Chen W, Zheng R, Baade PD, Zhang S, Zeng H, Bray F, Jemal A, Yu XQ and He J: Cancer statistics in China, 2015. CA Cancer J Clin. 66:115–132. 2016. View Article : Google Scholar : PubMed/NCBI

3 

Li X, Zhou Y, Luo Z, Gu Y, Chen Y, Yang C, Wang J, Xiao S, Sun Q, Qian M and Zhao G: The impact of screening on the survival of colorectal cancer in Shanghai, China: A population based study. BMC Public Health. 19:10162019. View Article : Google Scholar : PubMed/NCBI

4 

Meads MB, Gatenby RA and Dalton WS: Environment-mediated drug resistance: A major contributor to minimal residual disease. Nat Rev Cancer. 9:665–674. 2009. View Article : Google Scholar : PubMed/NCBI

5 

Zhao H, Zhang N, Ho V, Ding M, He W, Niu J, Yang M, Du XL, Zorzi D, Chavez-MacGregor M and Giordano SH: Adherence to treatment guidelines and survival for older patients with stage II or III colon cancer in Texas from 2001 through 2011. Cancer. 124:679–687. 2018. View Article : Google Scholar : PubMed/NCBI

6 

Lieberman DA, Rex DK, Winawer SJ, Giardiello FM, Johnson DA and Levin TR: Guidelines for colonoscopy surveillance after screening and polypectomy: A consensus update by the US multi-society task force on colorectal cancer. Gastroenterology. 143:844–857. 2012. View Article : Google Scholar : PubMed/NCBI

7 

Harada T, Yamamoto E, Yamano HO, Aoki H, Matsushita HO, Yoshikawa K, Takagi R, Harada E, Tanaka Y, Yoshida Y, et al: Surface microstructures are associated with mutational intratumoral heterogeneity in colorectal tumors. J Gastroenterol. 53:1241–1252. 2018. View Article : Google Scholar : PubMed/NCBI

8 

Rawlings JS, Rosler KM and Harrison DA: The JAK/STAT signaling pathway. J Cell Sci. 117:1281–1283. 2004. View Article : Google Scholar : PubMed/NCBI

9 

O'Shea JJ, Schwartz DM, Villarino AV, Gadina M, McInnes IB and Laurence A: The JAK-STAT pathway: Impact on human disease and therapeutic intervention. Annu Rev Med. 66:311–328. 2015. View Article : Google Scholar : PubMed/NCBI

10 

Sansone P and Bromberg J: Targeting the interleukin-6/Jak/stat pathway in human malignancies. J Clin Oncol. 30:1005–1014. 2012. View Article : Google Scholar : PubMed/NCBI

11 

Spano JP, Milano G, Rixe C and Fagard R: JAK/STAT signalling pathway in colorectal cancer: A new biological target with therapeutic implications. Eur J Cancer. 42:2668–2670. 2006. View Article : Google Scholar : PubMed/NCBI

12 

Wang SW and Sun YM: The IL-6/JAK/STAT3 pathway: Potential therapeutic strategies in treating colorectal cancer (Review). Int J Oncol. 44:1032–1040. 2014. View Article : Google Scholar : PubMed/NCBI

13 

Yamaguchi R, Lartigue L and Perkins G: Targeting Mcl-1 and other Bcl-2 family member proteins in cancer therapy. Pharmacol Ther. 195:13–20. 2019. View Article : Google Scholar : PubMed/NCBI

14 

Li X, Zeng X, Sun J, Li H, Wu P, Fung KP and Liu F: Imperatorin induces Mcl-1 degradation to cooperatively trigger Bax translocation and Bak activation to suppress drug-resistant human hepatoma. Cancer Lett. 348:146–155. 2014. View Article : Google Scholar : PubMed/NCBI

15 

Craig RW: MCL1 provides a window on the role of the BCL2 family in cell proliferation, differentiation and tumorigenesis. Leukemia. 16:444–454. 2002. View Article : Google Scholar : PubMed/NCBI

16 

Gomez-Bougie P, Halliez M, Moreau P, Pellat-Deceunynck C and Amiot M: Repression of Mcl-1 and disruption of the Mcl-1/Bak interaction in myeloma cells couple ER stress to mitochondrial apoptosis. Cancer Lett. 383:204–211. 2016. View Article : Google Scholar : PubMed/NCBI

17 

Verstovsek S, Kantarjian H, Mesa RA, Pardanani AD, Cortes-Franco J, Thomas DA, Estrov Z, Fridman JS, Bradley EC, Erickson-Viitanen S, et al: Safety and efficacy of INCB018424, a JAK1 and JAK2 inhibitor, in myelofibrosis. N Engl J Med. 363:1117–1127. 2010. View Article : Google Scholar : PubMed/NCBI

18 

Shilling AD, Nedza FM, Emm T, Diamond S, McKeever E, Punwani N, Williams W, Arvanitis A, Galya LG, Li M, et al: Metabolism, excretion, and pharmacokinetics of [14C]INCB018424, a selective Janus tyrosine kinase 1/2 inhibitor, in humans. Drug Metab Dispos. 38:2023–2031. 2010. View Article : Google Scholar : PubMed/NCBI

19 

Stover DG, Gil Del Alcazar CR, Brock J, Guo H, Overmoyer B, Balko J, Xu Q, Bardia A, Tolaney SM, Gelman R, et al: Phase II study of ruxolitinib, a selective JAK1/2 inhibitor, in patients with metastatic triple-negative breast cancer. NPJ Breast Cancer. 4:102018. View Article : Google Scholar : PubMed/NCBI

20 

Galvez Acosta S and Javalera Rincon M: Ruxolitinib as first-line therapy in secondary hemophagocytic lymphohistiocytosis and HIV infection. Int J Hematol. 112:418–421. 2020. View Article : Google Scholar : PubMed/NCBI

21 

Harrison C, Kiladjian JJ, Al-Ali HK, Gisslinger H, Waltzman R, Stalbovskaya V, McQuitty M, Hunter DS, Levy R, Knoops L, et al: JAK inhibition with ruxolitinib versus best available therapy for myelofibrosis. N Engl J Med. 366:787–798. 2012. View Article : Google Scholar : PubMed/NCBI

22 

Schonberg K, Rudolph J, Vonnahme M, Parampalli Yajnanarayana S, Cornez I, Hejazi M, Manser AR, Uhrberg M, Verbeek W, Koschmieder S, et al: JAK inhibition impairs NK cell function in myeloproliferative neoplasms. Cancer Res. 75:2187–2199. 2015. View Article : Google Scholar : PubMed/NCBI

23 

Klatte M and Bauer P: Accurate real-time reverse transcription quantitative PCR. Methods Mol Biol. 479:61–77. 2009. View Article : Google Scholar : PubMed/NCBI

24 

Li X, Wu J, Zhang X and Chen W: Glutathione reductase-mediated thiol oxidative stress suppresses metastasis of murine melanoma cells. Free Radic Biol Med. 129:256–267. 2018. View Article : Google Scholar : PubMed/NCBI

25 

Du H, Chen L, Luo F, Chen X, Li Y and Cheng Q: Beclin-1 expression is associated with prognosis in a Bcl-2-dependent manner in non-small cell lung cancer. Oncol Lett. 20:92020.PubMed/NCBI

26 

Yuan B, Hao J, Zhang Q, Wang Y and Zhu Y: Role of Bcl-2 on drug resistance in breast cancer polyploidy-induced spindle poisons. Oncol Lett. 19:1701–1710. 2020.PubMed/NCBI

27 

Zhou Y, Zhou Y, Yang M, Wang K, Liu Y, Zhang M, Yang Y, Jin C, Wang R and Hu R: Digoxin sensitizes gemcitabine-resistant pancreatic cancer cells to gemcitabine via inhibiting Nrf2 signaling pathway. Redox Biol. 22:1011312019. View Article : Google Scholar : PubMed/NCBI

28 

Timofeeva OA, Plisov S, Evseev AA, Peng S, Jose-Kampfner M, Lovvorn HN, Dome JS and Perantoni AO: Serine-phosphorylated STAT1 is a prosurvival factor in Wilms' tumor pathogenesis. Oncogene. 25:7555–7564. 2006. View Article : Google Scholar : PubMed/NCBI

29 

Reed JC: Proapoptotic multidomain Bcl-2/Bax-family proteins: Mechanisms, physiological roles, and therapeutic opportunities. Cell Death Differ. 13:1378–1386. 2006. View Article : Google Scholar : PubMed/NCBI

30 

Cuconati A, Mukherjee C, Perez D and White E: DNA damage response and MCL-1 destruction initiate apoptosis in adenovirus-infected cells. Genes Dev. 17:2922–2932. 2003. View Article : Google Scholar : PubMed/NCBI

31 

Chen S, Dai Y, Harada H, Dent P and Grant S: Mcl-1 down-regulation potentiates ABT-737 lethality by cooperatively inducing Bak activation and Bax translocation. Cancer Res. 67:782–791. 2007. View Article : Google Scholar : PubMed/NCBI

32 

Rane SG and Reddy EP: Janus kinases: Components of multiple signaling pathways. Oncogene. 19:5662–5679. 2000. View Article : Google Scholar : PubMed/NCBI

33 

Turkson J and Jove R: STAT proteins: Novel molecular targets for cancer drug discovery. Oncogene. 19:6613–6626. 2000. View Article : Google Scholar : PubMed/NCBI

34 

Meissl K, Macho-Maschler S, Muller M and Strobl B: The good and the bad faces of STAT1 in solid tumours. Cytokine. 89:12–20. 2017. View Article : Google Scholar : PubMed/NCBI

35 

Boisson-Dupuis S, Kong XF, Okada S, Cypowyj S, Puel A, Abel L and Casanova JL: Inborn errors of human STAT1: Allelic heterogeneity governs the diversity of immunological and infectious phenotypes. Curr Opin Immunol. 24:364–378. 2012. View Article : Google Scholar : PubMed/NCBI

36 

Decker T and Kovarik P: Serine phosphorylation of STATs. Oncogene. 19:2628–2637. 2000. View Article : Google Scholar : PubMed/NCBI

37 

Chen J, Wang H, Wang J, Huang S and Zhang W: STAT1 inhibits human hepatocellular carcinoma cell growth through induction of p53 and Fbxw7. Cancer Cell Int. 15:1112015. View Article : Google Scholar : PubMed/NCBI

38 

Zhang Y, Molavi O, Su M and Lai R: The clinical and biological significance of STAT1 in esophageal squamous cell carcinoma. BMC Cancer. 14:7912014. View Article : Google Scholar : PubMed/NCBI

39 

Zhang X, Li X, Tan F, Yu N and Pei H: STAT1 inhibits MiR-181a expression to suppress colorectal cancer cell proliferation through PTEN/Akt. J Cell Biochem. 118:3435–3443. 2017. View Article : Google Scholar : PubMed/NCBI

40 

Sun Y, Yang S, Sun N and Chen J: Differential expression of STAT1 and p21 proteins predicts pancreatic cancer progression and prognosis. Pancreas. 43:619–623. 2014. View Article : Google Scholar : PubMed/NCBI

41 

Osborn JL and Greer SF: Metastatic melanoma cells evade immune detection by silencing STAT1. Int J Mol Sci. 16:4343–4361. 2015. View Article : Google Scholar : PubMed/NCBI

42 

Zhang N, Li F, Gao J, Zhang S and Wang Q: Osteopontin accelerates the development and metastasis of bladder cancer via activating JAK1/STAT1 pathway. Genes Genomics. 42:467–475. 2020. View Article : Google Scholar : PubMed/NCBI

43 

Wu J, Gao F, Xu T, Li J, Hu Z, Wang C, Long Y, He X, Deng X, Ren D, et al: CLDN1 induces autophagy to promote proliferation and metastasis of esophageal squamous carcinoma through AMPK/STAT1/ULK1 signaling. J Cell Physiol. 235:2245–2259. 2020. View Article : Google Scholar : PubMed/NCBI

44 

Malilas W, Koh SS, Kim S, Srisuttee R, Cho IR, Moon J, Yoo HS, Oh S, Johnston RN and Chung YH: Cancer upregulated gene 2, a novel oncogene, enhances migration and drug resistance of colon cancer cells via STAT1 activation. Int J Oncol. 43:1111–1116. 2013. View Article : Google Scholar : PubMed/NCBI

45 

Inoue-Yamauchi A, Jeng PS, Kim K, Chen HC, Han S, Ganesan YT, Ishizawa K, Jebiwott S, Dong Y, Pietanza MC, et al: Targeting the differential addiction to anti-apoptotic BCL-2 family for cancer therapy. Nat Commun. 8:160782017. View Article : Google Scholar : PubMed/NCBI

46 

Quinn BA, Dash R, Azab B, Sarkar S, Das SK, Kumar S, Oyesanya RA, Dasgupta S, Dent P, Grant S, et al: Targeting Mcl-1 for the therapy of cancer. Expert Opin Investig Drugs. 20:1397–1411. 2011. View Article : Google Scholar : PubMed/NCBI

47 

Radhakrishnan H, Ilm K, Walther W, Shirasawa S, Sasazuki T, Daniel PT, Gillissen B and Stein U: MACC1 regulates Fas mediated apoptosis through STAT1/3 - Mcl-1 signaling in solid cancers. Cancer Lett. 403:231–245. 2017. View Article : Google Scholar : PubMed/NCBI

48 

Jin X, Yu Y, Zou Q, Wang M, Cui Y, Xie J and Wang Z: MicroRNA-105 promotes epithelial-mesenchymal transition of nonsmall lung cancer cells through upregulating Mcl-1. J Cell Biochem. 120:5880–5888. 2019. View Article : Google Scholar : PubMed/NCBI

49 

Zhao C, Wang Y, Jin H and Yu T: Knockdown of microRNA-203 alleviates LPS-induced injury by targeting MCL-1 in C28/I2 chondrocytes. Exp Cell Res. 359:171–178. 2017. View Article : Google Scholar : PubMed/NCBI

50 

Gong J, Zhang JP, Li B, Zeng C, You K, Chen MX, Yuan Y and Zhuang SM: MicroRNA-125b promotes apoptosis by regulating the expression of Mcl-1, Bcl-w and IL-6R. Oncogene. 32:3071–3079. 2013. View Article : Google Scholar : PubMed/NCBI

51 

Placzek WJ, Wei J, Kitada S, Zhai D, Reed JC and Pellecchia M: A survey of the anti-apoptotic Bcl-2 subfamily expression in cancer types provides a platform to predict the efficacy of Bcl-2 antagonists in cancer therapy. Cell Death Dis. 1:e402010. View Article : Google Scholar : PubMed/NCBI

52 

Zhang X, Zhang J, Wei H and Tian Z: STAT3-decoy oligodeoxynucleotide inhibits the growth of human lung cancer via down-regulating its target genes. Oncol Rep. 17:1377–1382. 2007.PubMed/NCBI

53 

Salazar-Montes A, Ruiz-Corro L, Sandoval-Rodriguez A, Lopez-Reyes A and Armendariz-Borunda J: Increased DNA binding activity of NF-kappaB, STAT-3, SMAD3 and AP-1 in acutely damaged liver. World J Gastroenterol. 12:5995–6001. 2006. View Article : Google Scholar : PubMed/NCBI

54 

Townsend PA, Scarabelli TM, Davidson SM, Knight RA, Latchman DS and Stephanou A: STAT-1 interacts with p53 to enhance DNA damage-induced apoptosis. J Biol Chem. 279:5811–5820. 2004. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Li X, Wang Z, Zhang S, Yao Q, Chen W and Liu F: Ruxolitinib induces apoptosis of human colorectal cancer cells by downregulating the JAK1/2‑STAT1‑Mcl‑1 axis. Oncol Lett 21: 352, 2021.
APA
Li, X., Wang, Z., Zhang, S., Yao, Q., Chen, W., & Liu, F. (2021). Ruxolitinib induces apoptosis of human colorectal cancer cells by downregulating the JAK1/2‑STAT1‑Mcl‑1 axis. Oncology Letters, 21, 352. https://doi.org/10.3892/ol.2021.12613
MLA
Li, X., Wang, Z., Zhang, S., Yao, Q., Chen, W., Liu, F."Ruxolitinib induces apoptosis of human colorectal cancer cells by downregulating the JAK1/2‑STAT1‑Mcl‑1 axis". Oncology Letters 21.5 (2021): 352.
Chicago
Li, X., Wang, Z., Zhang, S., Yao, Q., Chen, W., Liu, F."Ruxolitinib induces apoptosis of human colorectal cancer cells by downregulating the JAK1/2‑STAT1‑Mcl‑1 axis". Oncology Letters 21, no. 5 (2021): 352. https://doi.org/10.3892/ol.2021.12613
Copy and paste a formatted citation
x
Spandidos Publications style
Li X, Wang Z, Zhang S, Yao Q, Chen W and Liu F: Ruxolitinib induces apoptosis of human colorectal cancer cells by downregulating the JAK1/2‑STAT1‑Mcl‑1 axis. Oncol Lett 21: 352, 2021.
APA
Li, X., Wang, Z., Zhang, S., Yao, Q., Chen, W., & Liu, F. (2021). Ruxolitinib induces apoptosis of human colorectal cancer cells by downregulating the JAK1/2‑STAT1‑Mcl‑1 axis. Oncology Letters, 21, 352. https://doi.org/10.3892/ol.2021.12613
MLA
Li, X., Wang, Z., Zhang, S., Yao, Q., Chen, W., Liu, F."Ruxolitinib induces apoptosis of human colorectal cancer cells by downregulating the JAK1/2‑STAT1‑Mcl‑1 axis". Oncology Letters 21.5 (2021): 352.
Chicago
Li, X., Wang, Z., Zhang, S., Yao, Q., Chen, W., Liu, F."Ruxolitinib induces apoptosis of human colorectal cancer cells by downregulating the JAK1/2‑STAT1‑Mcl‑1 axis". Oncology Letters 21, no. 5 (2021): 352. https://doi.org/10.3892/ol.2021.12613
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