|
1
|
Kiselyuk A, Lee SH, Farber-Katz S, Zhang
M, Athavankar S, Cohen T, Pinkerton AB, Ye M, Bushway P, Richardson
AD, et al: HNF4α antagonists discovered by a high-throughput screen
for modulators of the human insulin promoter. Chem Biol.
19:806–818. 2012. View Article : Google Scholar : PubMed/NCBI
|
|
2
|
Duncan SA, Manova K, Chen WS, Hoodless P,
Weinstein DC, Bachvarova RF and Darnell JE Jr: Expression of
transcription factor HNF-4 in the extraembryonic endoderm, gut, and
nephrogenic tissue of the developing mouse embryo: HNF-4 is a
marker for primary endoderm in the implanting blastocyst. Proc Natl
Acad Sci USA. 91:7598–7602. 1994. View Article : Google Scholar : PubMed/NCBI
|
|
3
|
Huang J, Karakucuk V, Levitsky LL and
Rhoads DB: Expression of HNF4alpha variants in pancreatic islets
and Ins-1 beta cells. Diabetes Metab Res Rev. 24:533–543. 2008.
View Article : Google Scholar : PubMed/NCBI
|
|
4
|
Harries LW, Locke JM, Shields B, Hanley
NA, Hanley KP, Steele A, Njølstad PR, Ellard S and Hattersley AT:
The diabetic phenotype in HNF4A mutation carriers is moderated by
the expression of HNF4A isoforms from the P1 promoter during fetal
development. Diabetes. 57:1745–1752. 2008. View Article : Google Scholar : PubMed/NCBI
|
|
5
|
Hwang-Verslues WW and Sladek FM:
HNF4alpha-role in drug metabolism and potential drug target? Curr
Opin Pharmacol. 10:698–705. 2010. View Article : Google Scholar : PubMed/NCBI
|
|
6
|
Hertz R, Magenheim J, Berman I and
Bar-Tana J: Fatty acyl-CoA thioesters are ligands of hepatic
nuclear factor-4alpha. Nature. 392:512–516. 1998. View Article : Google Scholar : PubMed/NCBI
|
|
7
|
Bogan AA, Dallas-Yang Q, Ruse MD Jr, Maeda
Y, Jiang G, Nepomuceno L, Scanlan TS, Cohen FE and Sladek FM:
Analysis of protein dimerization and ligand binding of orphan
receptor HNF4alpha. J Mol Biol. 302:831–851. 2000. View Article : Google Scholar : PubMed/NCBI
|
|
8
|
Dhe-Paganon S, Duda K, Iwamoto M, Chi YI
and Shoelson SE: Crystal structure of the HNF4 alpha ligand binding
domain in complex with endogenous fatty acid ligand. J Biol Chem.
277:37973–37976. 2002. View Article : Google Scholar : PubMed/NCBI
|
|
9
|
Wisely GB, Miller AB, Davis RG, Thornquest
AD Jr, Johnson R, Spitzer T, Sefler A, Shearer B, Moore JT, Miller
AB, et al: Hepatocyte nuclear factor 4 is a transcription factor
that constitutively binds fatty acids. Structure. 10:1225–1234.
2002. View Article : Google Scholar : PubMed/NCBI
|
|
10
|
Benoit G, Malewicz M and Perlmann T:
Digging deep into the pockets of orphan nuclear receptors: Insights
from structural studies. Trends Cell Biol. 14:369–376. 2004.
View Article : Google Scholar : PubMed/NCBI
|
|
11
|
Sladek F: Desperately seeking…something.
Mol Cell. 10:219–221. 2002. View Article : Google Scholar : PubMed/NCBI
|
|
12
|
Yuan X, Ta TC, Lin M, Evans JR, Dong Y,
Bolotin E, Sherman MA, Forman BM and Sladek FM: Identification of
an endogenous ligand bound to a native orphan nuclear receptor.
PLoS One. 4:e56092009. View Article : Google Scholar : PubMed/NCBI
|
|
13
|
Lee SH, Piran R, Keinan E, Pinkerton A and
Levine F: Induction of beta-cell replication by a synthetic
HNF4alpha antagonist. Stem Cells. 31:2396–2407. 2013. View Article : Google Scholar : PubMed/NCBI
|
|
14
|
Kiselyuk A, Farber-Katz S, Cohen T, Lee
SH, Geron I, Azimi B, Heynen-Genel S, Singer O, Price J, Mercola M,
et al: Phenothiazine neuroleptics signal to the human insulin
promoter as revealed by a novel high-throughput screen. J Biomol
Screen. 15:663–670. 2010. View Article : Google Scholar : PubMed/NCBI
|
|
15
|
Fujimura T, Sakuma H, Konishi S, Oe T,
Hosogai N, Kimura C, Aramori I and Mutoh S: FK614, a novel
peroxisome proliferator-activated receptor gamma modulator, induces
differential transactivation through a unique ligand-specific
interaction with transcriptional coactivators. J Pharmacol Sci.
99:342–352. 2005. View Article : Google Scholar : PubMed/NCBI
|
|
16
|
Inoue Y, Yu AM, Yim SH, Ma X, Krausz KW,
Inoue J, Xiang CC, Brownstein MJ, Eggertsen G, Björkhem I and
Gonzalez FJ: Regulation of bile acid biosynthesis by hepatocyte
nuclear factor 4alpha. J Lipid Res. 47:215–227. 2006. View Article : Google Scholar : PubMed/NCBI
|
|
17
|
Chiang JY: Hepatocyte nuclear factor
4alpha regulation of bile acid and drug metabolism. Expert Opin
Drug Metab Toxicol. 5:137–147. 2009. View Article : Google Scholar : PubMed/NCBI
|
|
18
|
Nitta S, Kusakari Y, Yamada Y, Kubo T, Neo
S, Igarashi H and Hisasue M: Conversion of mesenchymal stem cells
into a canine hepatocyte-like cells by Foxa1 and Hnf4a. Regen Ther.
14:165–176. 2020. View Article : Google Scholar : PubMed/NCBI
|
|
19
|
Chen S, Lencinas A, Nunez M, Selmin OI and
Runyan RB: HNF4a transcription is a target of trichloroethylene
toxicity in the embryonic mouse heart. Environ Sci Process Impacts.
22:824–832. 2020. View Article : Google Scholar : PubMed/NCBI
|
|
20
|
Jover R, Moya M and Gomez-Lechon MJ:
Transcriptional regulation of cytochrome p450 genes by the nuclear
receptor hepatocyte nuclear factor 4-alpha. Curr Drug Metab.
10:508–519. 2009. View Article : Google Scholar : PubMed/NCBI
|
|
21
|
Tavares-Sanchez OL, Rodriguez C,
Gortares-Moroyoqui P and Estrada MI: Hepatocyte nuclear
factor-4alpha, a multifunctional nuclear receptor associated with
cardiovascular disease and cholesterol catabolism. Int J Environ
Health Res. 25:126–139. 2015. View Article : Google Scholar : PubMed/NCBI
|
|
22
|
Kyrmizi I, Hatzis P, Katrakili N, Tronche
F, Gonzalez FJ and Talianidis I: Plasticity and expanding
complexity of the hepatic transcription factor network during liver
development. Genes Dev. 20:2293–2305. 2006. View Article : Google Scholar : PubMed/NCBI
|
|
23
|
Li J, Ning G and Duncan SA: Mammalian
hepatocyte differentiation requires the transcription factor
HNF-4alpha. Genes Dev. 14:464–474. 2000.PubMed/NCBI
|
|
24
|
Hayhurst GP, Lee YH, Lambert G, Ward JM
and Gonzalez FJ: Hepatocyte nuclear factor 4alpha (nuclear receptor
2A1) is essential for maintenance of hepatic gene expression and
lipid homeostasis. Mol Cell Biol. 21:1393–1403. 2001. View Article : Google Scholar : PubMed/NCBI
|
|
25
|
Parviz F, Matullo C, Garrison WD, Savatski
L, Adamson JW, Ning G, Kaestner KH, Rossi JM, Zaret KS and Duncan
SA: Hepatocyte nuclear factor 4alpha controls the development of a
hepatic epithelium and liver morphogenesis. Nat Genet. 34:292–296.
2003. View
Article : Google Scholar : PubMed/NCBI
|
|
26
|
Lussier CR, Babeu JP, Auclair BA,
Perreault N and Boudreau F: Hepatocyte nuclear factor-4alpha
promotes differentiation of intestinal epithelial cells in a
coculture system. Am J Physiol Gastrointest Liver Physiol.
294:G418–G428. 2008. View Article : Google Scholar : PubMed/NCBI
|
|
27
|
Garrison WD, Battle MA, Yang C, Kaestner
KH, Sladek FM and Duncan SA: Hepatocyte nuclear factor 4alpha is
essential for embryonic development of the mouse colon.
Gastroenterology. 130:1207–1220. 2006. View Article : Google Scholar : PubMed/NCBI
|
|
28
|
DeLaForest A, Nagaoka M, Si-Tayeb K, Noto
FK, Konopka G, Battle MA and Duncan SA: HNF4A is essential for
specification of hepatic progenitors from human pluripotent stem
cells. Development. 138:4143–4153. 2011. View Article : Google Scholar : PubMed/NCBI
|
|
29
|
Grigo K, Wirsing A, Lucas B, Klein-Hitpass
L and Ryffel GU: HNF4 alpha orchestrates a set of 14 genes to
down-regulate cell proliferation in kidney cells. Biol Chem.
389:179–187. 2008. View Article : Google Scholar : PubMed/NCBI
|
|
30
|
Erdmann S, Senkel S, Arndt T, Lucas B,
Lausen J, Klein-Hitpass L, Ryffel GU and Thomas H: Tissue-specific
transcription factor HNF4alpha inhibits cell proliferation and
induces apoptosis in the pancreatic INS-1 beta-cell line. Biol
Chem. 388:91–106. 2007. View Article : Google Scholar : PubMed/NCBI
|
|
31
|
Santangelo L, Marchetti A, Cicchini C,
Conigliaro A, Conti B, Mancone C, Bonzo JA, Gonzalez FJ, Alonzi T,
Amicone L and Tripodi M: The stable repression of mesenchymal
program is required for hepatocyte identity: A novel role for
hepatocyte nuclear factor 4α. Hepatology. 53:2063–2074. 2011.
View Article : Google Scholar : PubMed/NCBI
|
|
32
|
Thiery JP and Sleeman JP: Complex networks
orchestrate epithelial-mesenchymal transitions. Nat Rev Mol Cell
Biol. 7:131–142. 2006. View Article : Google Scholar : PubMed/NCBI
|
|
33
|
Thiery JP, Acloque H, Huang RY and Nieto
MA: Epithelial-mesenchymal transitions in development and disease.
Cell. 139:871–890. 2009. View Article : Google Scholar : PubMed/NCBI
|
|
34
|
Ahn SH, Shah YM, Inoue J, Morimura K, Kim
I, Yim S, Lambert G, Kurotani R, Nagashima K, Gonzalez FJ and Inoue
Y: Hepatocyte nuclear factor 4alpha in the intestinal epithelial
cells protects against inflammatory bowel disease. Inflamm Bowel
Dis. 14:908–920. 2008. View Article : Google Scholar : PubMed/NCBI
|
|
35
|
Darsigny M, Babeu JP, Dupuis AA, Furth EE,
Seidman EG, Lévy E, Verdu EF, Gendron FP and Boudreau F: Loss of
hepatocyte-nuclear-factor-4alpha affects colonic ion transport and
causes chronic inflammation resembling inflammatory bowel disease
in mice. PLoS One. 4:e76092009. View Article : Google Scholar : PubMed/NCBI
|
|
36
|
Tanaka T, Jiang S, Hotta H, Takano K,
Iwanari H, Sumi K, Daigo K, Ohashi R, Sugai M, Ikegame C, et al:
Dysregulated expression of P1 and P2 promoter-driven hepatocyte
nuclear factor-4alpha in the pathogenesis of human cancer. J
Pathol. 208:662–672. 2006. View Article : Google Scholar : PubMed/NCBI
|
|
37
|
Oshima T, Kawasaki T, Ohashi R, Hasegawa
G, Jiang S, Umezu H, Aoyagi Y, Iwanari H, Tanaka T, Hamakubo T, et
al: Downregulated P1 promoter-driven hepatocyte nuclear
factor-4alpha expression in human colorectal carcinoma is a new
prognostic factor against liver metastasis. Pathol Int. 57:82–90.
2007. View Article : Google Scholar : PubMed/NCBI
|
|
38
|
Takano K, Hasegawa G, Jiang S, Kurosaki I,
Hatakeyama K, Iwanari H, Tanaka T, Hamakubo T, Kodama T and Naito
M: Immunohistochemical staining for P1 and P2 promoter-driven
hepatocyte nuclear factor-4alpha may complement mucin phenotype of
differentiated-type early gastric carcinoma. Pathol Int.
59:462–470. 2009. View Article : Google Scholar : PubMed/NCBI
|
|
39
|
Lambert E, Babeu JP, Simoneau J, Raisch J,
Lavergne L, Lévesque D, Jolibois É, Avino M, Scott MS, Boudreau F
and Boisvert FM: Human hepatocyte nuclear factor 4-alpha encodes
isoforms with distinct transcriptional functions. Mol Cell
Proteomics. 19:808–827. 2020. View Article : Google Scholar : PubMed/NCBI
|
|
40
|
Vuong LM, Chellappa K, Dhahbi JM, Deans
JR, Fang B, Bolotin E, Titova NV, Hoverter NP, Spindler SR,
Waterman ML and Sladek FM: Differential effects of hepatocyte
nuclear factor 4alpha isoforms on tumor growth and T-cell factor
4/AP-1 interactions in human colorectal cancer cells. Mol Cell
Biol. 35:3471–3490. 2015. View Article : Google Scholar : PubMed/NCBI
|
|
41
|
Babeu JP, Jones C, Geha S, Carrier JC and
Boudreau F: P1 promoter-driven HNF4alpha isoforms are specifically
repressed by beta-catenin signaling in colorectal cancer cells. J
Cell Sci. 131:jcs2147342018. View Article : Google Scholar : PubMed/NCBI
|
|
42
|
Hoadley KA, Yau C, Hinoue T, Wolf DM,
Lazar AJ, Drill E, Shen R, Taylor AM, Cherniack AD, Thorsson V, et
al: Cell-of-origin patterns dominate the molecular classification
of 10,000 tumors from 33 types of cancer. Cell. 173:291–304.e6.
2018. View Article : Google Scholar : PubMed/NCBI
|
|
43
|
Zhou B and Guo R: Genomic and regulatory
characteristics of significant transcription factors in colorectal
cancer metastasis. Sci Rep. 8:178362018. View Article : Google Scholar : PubMed/NCBI
|
|
44
|
Chellappa K, Deol P, Evans JR, Vuong LM,
Chen G, Briançon N, Bolotin E, Lytle C, Nair MG and Sladek FM:
Opposing roles of nuclear receptor HNF4α isoforms in colitis and
colitis-associated colon cancer. Elife. 5:e109032016. View Article : Google Scholar : PubMed/NCBI
|
|
45
|
Yao HS, Wang J, Zhang XP, Wang LZ, Wang Y,
Li XX, Jin KZ, Hu ZQ and Wang WJ: Hepatocyte nuclear factor 4α
suppresses the aggravation of colon carcinoma. Mol Carcinog.
55:458–472. 2016. View Article : Google Scholar : PubMed/NCBI
|
|
46
|
Babeu JP, Wilson SD, Lambert E, Levesque
D, Boisvert FM and Boudreau F: Quantitative proteomics identifies
DNA repair as a novel biological function for hepatocyte nuclear
factor 4α in colorectal cancer cells. Cancers (Basel). 11:6262019.
View Article : Google Scholar
|
|
47
|
Yokoyama A, Katsura S, Ito R, Hashiba W,
Sekine H, Fujiki R and Kato S: Multiple post-translational
modifications in hepatocyte nuclear factor 4alpha. Biochem Biophys
Res Commun. 410:749–753. 2011. View Article : Google Scholar : PubMed/NCBI
|
|
48
|
Zhou W, Hannoun Z, Jaffray E, Medine CN,
Black JR, Greenhough S, Zhu L, Ross JA, Forbes S, Wilmut I, et al:
SUMOylation of HNF4α regulates protein stability and hepatocyte
function. J Cell Sci. 125:3630–3635. 2012. View Article : Google Scholar : PubMed/NCBI
|
|
49
|
Daigo K, Kawamura T, Ohta Y, Ohashi R,
Katayose S, Tanaka T, Aburatani H, Naito M, Kodama T, Ihara S and
Hamakubo T: Proteomic analysis of native hepatocyte nuclear
factor-4α (HNF4α) isoforms, phosphorylation status, and interactive
cofactors. J Biol Chem. 286:674–686. 2011. View Article : Google Scholar : PubMed/NCBI
|
|
50
|
Lazarevich NL, Cheremnova OA, Varga EV,
Ovchinnikov DA, Kudrjavtseva EI, Morozova OV, Fleishman DI,
Engelhardt NV and Duncan SA: Progression of HCC in mice is
associated with a downregulation in the expression of hepatocyte
nuclear factors. Hepatology. 39:1038–1047. 2004. View Article : Google Scholar : PubMed/NCBI
|
|
51
|
Xu L, Hui L, Wang S, Gong J, Jin Y, Wang
Y, Ji Y, Wu X, Han Z and Hu G: Expression profiling suggested a
regulatory role of liver-enriched transcription factors in human
hepatocellular carcinoma. Cancer Res. 61:3176–3181. 2001.PubMed/NCBI
|
|
52
|
Wu N, Zhang YL, Wang HT, Li DW, Dai HJ,
Zhang QQ, Zhang J, Ma Y, Xia Q, Bian JM and Hang HL: Overexpression
of hepatocyte nuclear factor 4α in human mesenchymal stem cells
suppresses hepatocellular carcinoma development through
Wnt/β-catenin signaling pathway downregulation. Cancer Biol Ther.
17:558–565. 2016. View Article : Google Scholar : PubMed/NCBI
|
|
53
|
Ning BF, Ding J, Yin C, Zhong W, Wu K,
Zeng X, Yang W, Chen YX, Zhang JP, Zhang X, et al: Hepatocyte
nuclear factor 4 alpha suppresses the development of hepatocellular
carcinoma. Cancer Res. 70:7640–7651. 2010. View Article : Google Scholar : PubMed/NCBI
|
|
54
|
Saandi T, Baraille F, Derbal-Wolfrom L,
Cattin AL, Benahmed F, Martin E, Cardot P, Duclos B, Ribeiro A,
Freund JN and Duluc I: Regulation of the tumor suppressor homeogene
Cdx2 by HNF4α in intestinal cancer. Oncogene. 32:3782–3788. 2013.
View Article : Google Scholar : PubMed/NCBI
|
|
55
|
Chiba H, Itoh T, Satohisa S, Sakai N,
Noguchi H, Osanai M, Kojima T and Sawada N: Activation of
p21CIP1/WAF1 gene expression and inhibition of cell proliferation
by overexpression of hepatocyte nuclear factor-4alpha. Exp Cell
Res. 302:11–21. 2005. View Article : Google Scholar : PubMed/NCBI
|
|
56
|
Wang Z, Li Y, Wu D, Yu S, Wang Y and Leung
Chan F: Nuclear receptor HNF4alpha performs a tumor suppressor
function in prostate cancer via its induction of p21-driven
cellular senescence. Oncogene. 39:1572–1589. 2020. View Article : Google Scholar : PubMed/NCBI
|
|
57
|
Hwang-Verslues WW and Sladek FM: Nuclear
receptor hepatocyte nuclear factor 4alpha1 competes with
oncoprotein c-Myc for control of the p21/WAF1 promoter. Mol
Endocrinol. 22:78–90. 2008. View Article : Google Scholar : PubMed/NCBI
|
|
58
|
Lu JW, Hsia Y, Yang WY, Lin YI, Li CC,
Tsai TF, Chang KW, Shieh GS, Tsai SF, Wang HD and Yuh CH:
Identification of the common regulators for hepatocellular
carcinoma induced by hepatitis B virus X antigen in a mouse model.
Carcinogenesis. 33:209–219. 2012. View Article : Google Scholar : PubMed/NCBI
|
|
59
|
Walesky C, Edwards G, Borude P,
Gunewardena S, O'Neil M, Yoo B and Apte U: Hepatocyte nuclear
factor 4 alpha deletion promotes diethylnitrosamine-induced
hepatocellular carcinoma in rodents. Hepatology. 57:2480–2490.
2013. View Article : Google Scholar : PubMed/NCBI
|
|
60
|
Walesky C and Apte U: Role of hepatocyte
nuclear factor 4α (HNF4α) in cell proliferation and cancer. Gene
Expr. 16:101–108. 2015. View Article : Google Scholar : PubMed/NCBI
|
|
61
|
Hanse EA, Mashek DG, Becker JR, Solmonson
AD, Mullany LK, Mashek MT, Towle HC, Chau AT and Albrecht JH:
Cyclin D1 inhibits hepatic lipogenesis via repression of
carbohydrate response element binding protein and hepatocyte
nuclear factor 4α. Cell Cycle. 11:2681–2690. 2012. View Article : Google Scholar : PubMed/NCBI
|
|
62
|
Gao Y, Yan Y, Guo J, Zhang Q, Bi D, Wang
F, Chang Z, Lu L, Yao X and Wei Q: HNF4α downregulation promotes
tumor migration and invasion by regulating Ecadherin in renal cell
carcinoma. Oncol Rep. 42:1066–1074. 2019.PubMed/NCBI
|
|
63
|
Zhou H, Guo L, Yao W, Shi R, Yu G, Xu H
and Ye Z: Silencing of tumor-suppressive NR_023387 in renal cell
carcinoma via promoter hypermethylation and HNF4A deficiency. J
Cell Physiol. 235:2113–2128. 2020. View Article : Google Scholar : PubMed/NCBI
|
|
64
|
Lu J, Chen Z, Zhao H, Dong H, Zhu L, Zhang
Y, Wang J, Zhu H, Cui Q, Qi C, et al: ABAT and ALDH6A1, regulated
by transcription factor HNF4A, suppress tumorigenic capability in
clear cell renal cell carcinoma. J Transl Med. 18:1012020.
View Article : Google Scholar : PubMed/NCBI
|
|
65
|
Saha SK, Parachoniak CA, Ghanta KS,
Fitamant J, Ross KN, Najem MS, Gurumurthy S, Akbay EA, Sia D,
Cornella H, et al: Mutant IDH inhibits HNF-4α to block hepatocyte
differentiation and promote biliary cancer. Nature. 513:110–114.
2014. View Article : Google Scholar : PubMed/NCBI
|
|
66
|
Yang G, Zhang M, Zhao Y, Pan Y, Kan M, Li
J, He K and Zhang X: HNF-4α inhibits hepatocellular carcinoma cell
proliferation through mir-122-adam17 pathway. PLoS One.
15:e02304502020. View Article : Google Scholar : PubMed/NCBI
|
|
67
|
Lv DD, Zhou LY and Tang H: Hepatocyte
nuclear factor 4α and cancer-related cell signaling pathways: A
promising insight into cancer treatment. Exp Mol Med. 53:8–18.
2021. View Article : Google Scholar : PubMed/NCBI
|
|
68
|
Wang Z and Burke PA: The role of microRNAs
in hepatocyte nuclear factor-4alpha expression and transactivation.
Biochim Biophys Acta. 1829:436–442. 2013. View Article : Google Scholar : PubMed/NCBI
|
|
69
|
Deng XG, Qiu RL, Wu YH, Li ZX, Xie P,
Zhang J, Zhou JJ, Zeng LX, Tang J, Maharjan A and Deng JM:
Overexpression of miR-122 promotes the hepatic differentiation and
maturation of mouse ESCs through a miR-122/FoxA1/HNF4a-positive
feedback loop. Liver Int. 34:281–295. 2014. View Article : Google Scholar : PubMed/NCBI
|
|
70
|
Ning BF, Ding J, Liu J, Yin C, Xu WP, Cong
WM, Zhang Q, Chen F, Han T, Deng X, et al: Hepatocyte nuclear
factor 4α-nuclear factor-κB feedback circuit modulates liver cancer
progression. Hepatology. 60:1607–1619. 2014. View Article : Google Scholar : PubMed/NCBI
|
|
71
|
Takagi S, Nakajima M, Kida K, Yamaura Y,
Fukami T and Yokoi T: MicroRNAs regulate human hepatocyte nuclear
factor 4alpha, modulating the expression of metabolic enzymes and
cell cycle. J Biol Chem. 285:4415–4422. 2010. View Article : Google Scholar : PubMed/NCBI
|
|
72
|
Salloum-Asfar S, Arroyo AB, Teruel-Montoya
R, García-Barberá N, Roldán V, Vicente V, Martínez C and
González-Conejero R: MiRNA-based regulation of hemostatic factors
through hepatic nuclear Factor-4 alpha. PLoS One. 11:e01547512016.
View Article : Google Scholar : PubMed/NCBI
|
|
73
|
Ramamoorthy A, Li L, Gaedigk A, Bradford
LD, Benson EA, Flockhart DA and Skaar TC: In silico and in vitro
identification of microRNAs that regulate hepatic nuclear factor 4α
expression. Drug Metab Dispos. 40:726–733. 2012. View Article : Google Scholar : PubMed/NCBI
|
|
74
|
Koh W, Sheng CT, Tan B, Lee QY, Kuznetsov
V, Kiang LS and Tanavde V: Analysis of deep sequencing microRNA
expression profile from human embryonic stem cells derived
mesenchymal stem cells reveals possible role of let-7 microRNA
family in downstream targeting of hepatic nuclear factor 4 alpha.
BMC Genomics. 11 (Suppl 1):S62010. View Article : Google Scholar : PubMed/NCBI
|
|
75
|
Zhang X, Xu Y, Qian Z, Zheng W, Wu Q, Chen
Y, Zhu G, Liu Y, Bian Z, Xu W, et al: circRNA_104075 stimulates
YAP-dependent tumorigenesis through the regulation of HNF4a and may
serve as a diagnostic marker in hepatocellular carcinoma. Cell
Death Dis. 9:10912018. View Article : Google Scholar : PubMed/NCBI
|
|
76
|
Moon RT and Miller JR: The APC tumor
suppressor protein in development and cancer. Trends Genet.
13:256–258. 1997. View Article : Google Scholar : PubMed/NCBI
|
|
77
|
Yang M, Li SN, Anjum KM, Gui LX, Zhu SS,
Liu J, Chen JK, Liu QF, Ye GD, Wang WJ, et al: A double-negative
feedback loop between Wnt-β-catenin signaling and HNF4α regulates
epithelial-mesenchymal transition in hepatocellular carcinoma. J
Cell Sci. 126:5692–5703. 2013. View Article : Google Scholar : PubMed/NCBI
|
|
78
|
Battle MA, Konopka G, Parviz F, Gaggl AL,
Yang C, Sladek FM and Duncan SA: Hepatocyte nuclear factor 4alpha
orchestrates expression of cell adhesion proteins during the
epithelial transformation of the developing liver. Proc Natl Acad
Sci USA. 103:8419–8424. 2006. View Article : Google Scholar : PubMed/NCBI
|
|
79
|
Lazarevich NL, Shavochkina DA, Fleishman
DI, Kustova IF, Morozova OV, Chuchuev ES and Patyutko YI:
Deregulation of hepatocyte nuclear factor 4 (HNF4) as a marker of
epithelial tumors progression. Exp Oncol. 32:167–171.
2010.PubMed/NCBI
|
|
80
|
Yao D, Peng S and Dai C: The role of
hepatocyte nuclear factor 4alpha in metastatic tumor formation of
hepatocellular carcinoma and its close relationship with the
mesenchymal-epithelial transition markers. BMC Cancer. 13:4322013.
View Article : Google Scholar : PubMed/NCBI
|
|
81
|
Huang Q, Pu M, Zhao G, Dai B, Bian Z, Tang
H, Chen C, Liu W, Qu X, Shen L and Tao K: Tg737 regulates
epithelial-mesenchymal transition and cancer stem cell properties
via a negative feedback circuit between Snail and HNF4α during
liver stem cell malignant transformation. Cancer Lett. 402:52–60.
2017. View Article : Google Scholar : PubMed/NCBI
|
|
82
|
Yin C, Lin Y, Zhang X, Chen YX, Zeng X,
Yue HY, Hou JL, Deng X, Zhang JP, Han ZG and Xie WF:
Differentiation therapy of hepatocellular carcinoma in mice with
recombinant adenovirus carrying hepatocyte nuclear factor-4alpha
gene. Hepatology. 48:1528–1539. 2008. View Article : Google Scholar : PubMed/NCBI
|
|
83
|
Stumpf H, Senkel S, Rabes HM and Ryffel
GU: The DNA binding activity of the liver transcription factors
LFB1 (HNF1) and HNF4 varies coordinately in rat hepatocellular
carcinoma. Carcinogenesis. 16:143–145. 1995. View Article : Google Scholar : PubMed/NCBI
|
|
84
|
Flodby P, Liao DZ, Blanck A, Xanthopoulos
KG and Hallstrom IP: Expression of the liver-enriched transcription
factors C/EBP alpha, C/EBP beta, HNF-1, and HNF-4 in preneoplastic
nodules and hepatocellular carcinoma in rat liver. Mol Carcinog.
12:103–109. 1995. View Article : Google Scholar : PubMed/NCBI
|
|
85
|
Choi JK, Choi JY, Kim DG, Choi DW, Kim BY,
Lee KH, Yeom YI, Yoo HS, Yoo OJ and Kim S: Integrative analysis of
multiple gene expression profiles applied to liver cancer study.
FEBS Lett. 565:93–100. 2004. View Article : Google Scholar : PubMed/NCBI
|
|
86
|
Cai SH, Lu SX, Liu LL, Zhang CZ and Yun
JP: Increased expression of hepatocyte nuclear factor 4 alpha
transcribed by promoter 2 indicates a poor prognosis in
hepatocellular carcinoma. Therap Adv Gastroenterol. 10:761–771.
2017. View Article : Google Scholar : PubMed/NCBI
|
|
87
|
Zhang X, Du L, Qiao Y, Zhang X, Zheng W,
Wu Q, Chen Y, Zhu G, Liu Y, Bian Z, et al: Ferroptosis is governed
by differential regulation of transcription in liver cancer. Redox
Biol. 24:1012112019. View Article : Google Scholar : PubMed/NCBI
|
|
88
|
Darsigny M, Babeu JP, Seidman EG, Gendron
FP, Levy E, Carrier J, Perreault N and Boudreau F: Hepatocyte
nuclear Factor-4alpha promotes gut neoplasia in mice and protects
against the production of reactive oxygen species. Cancer Res.
70:9423–9433. 2010. View Article : Google Scholar : PubMed/NCBI
|
|
89
|
Kriegsmann M, Harms A, Longuespée R, Muley
T, Winter H, Kriegsmann K, Kazdal D, Goeppert B, Pathil A and Warth
A: Role of conventional immunomarkers, HNF4-α and SATB2, in the
differential diagnosis of pulmonary and colorectal adenocarcinomas.
Histopathology. 72:997–1006. 2018. View Article : Google Scholar : PubMed/NCBI
|
|
90
|
Sugai M, Umezu H, Yamamoto T, Jiang S,
Iwanari H, Tanaka T, Hamakubo T, Kodama T and Naito M: Expression
of hepatocyte nuclear factor 4 alpha in primary ovarian mucinous
tumors. Pathol Int. 58:681–686. 2008. View Article : Google Scholar : PubMed/NCBI
|
|
91
|
Xiang X, Zhao X, Qu H, Li D, Yang D, Pu J,
Mei H, Zhao J, Huang K, Zheng L and Tong Q: Hepatocyte nuclear
factor 4 alpha promotes the invasion, metastasis and angiogenesis
of neuroblastoma cells via targeting matrix metalloproteinase 14.
Cancer Lett. 359:187–197. 2015. View Article : Google Scholar : PubMed/NCBI
|
|
92
|
Sugano M, Nagasaka T, Sasaki E, Murakami
Y, Hosoda W, Hida T, Mitsudomi T and Yatabe Y: HNF4α as a marker
for invasive mucinous adenocarcinoma of the lung. Am J Surg Pathol.
37:211–218. 2012. View Article : Google Scholar
|
|
93
|
Li Z and Chen H: miR-34a inhibits
proliferation, migration and invasion of paediatric neuroblastoma
cells via targeting HNF4α. Artif Cells Nanomed Biotechnol.
47:3072–3078. 2019. View Article : Google Scholar : PubMed/NCBI
|
|
94
|
Sun Q, Xu W, Ji S, Qin Y, Liu W, Hu Q,
Zhang Z, Liu M, Yu X and Xu X: Role of hepatocyte nuclear factor 4
alpha in cell proliferation and gemcitabine resistance in
pancreatic adenocarcinoma. Cancer Cell Int. 19:492019. View Article : Google Scholar : PubMed/NCBI
|
|
95
|
Xu C, Ooi WF, Qamra A, Tan J, Chua BY, Ho
SWT, Das K, Adam Isa ZF, Li Z, Yao X, et al: HNF4α pathway mapping
identifies wild-type IDH1 as a targetable metabolic node in gastric
cancer. Gut. 69:231–242. 2020. View Article : Google Scholar : PubMed/NCBI
|
|
96
|
Chang HR, Nam S, Kook MC, Kim KT, Liu X,
Yao H, Jung HR, Lemos R Jr, Seo HH, Park HS, et al: HNF4α is a
therapeutic target that links AMPK to WNT signalling in early-stage
gastric cancer. Gut. 65:19–32. 2016. View Article : Google Scholar : PubMed/NCBI
|
|
97
|
Ma Y, Wei X and Wu Z: HNF-4α promotes
multidrug resistance of gastric cancer cells through the modulation
of cell apoptosis. Oncol Lett. 14:6477–6484. 2017.PubMed/NCBI
|
|
98
|
Nakajima N, Yoshizawa A, Nakajima T,
Hirata M, Furuhata A, Sumiyoshi S, Rokutan-Kurata M, Sonobe M,
Menju T, Miyamoto E, et al: GATA6-positive lung adenocarcinomas are
associated with invasive mucinous adenocarcinoma morphology,
hepatocyte nuclear factor 4α expression, and KRAS mutations.
Histopathology. 73:38–48. 2018. View Article : Google Scholar : PubMed/NCBI
|
|
99
|
Chia NY, Deng N, Das K, Huang D, Hu L, Zhu
Y, Lim KH, Lee MH, Wu J, Sam XX, et al: Regulatory crosstalk
between lineage-survival oncogenes KLF5, GATA4 and GATA6
cooperatively promotes gastric cancer development. Gut. 64:707–719.
2015. View Article : Google Scholar : PubMed/NCBI
|
|
100
|
Wang Z, Wu D, Ng CF, Teoh JY, Yu S, Wang Y
and Chan FL: Nuclear receptor profiling in prostatospheroids and
castration-resistant prostate cancer. Endocr Relat Cancer.
25:35–50. 2018. View Article : Google Scholar : PubMed/NCBI
|
