Open Access

Effect of eukaryotic translation initiation factor 4A3 in malignant tumors (Review)

  • Authors:
    • Yuanhang Zhu
    • Chenchen Ren
    • Li Yang
  • View Affiliations

  • Published online on: March 8, 2021     https://doi.org/10.3892/ol.2021.12619
  • Article Number: 358
  • Copyright: © Zhu et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Eukaryotic translation initiation factor 4A3 (EIF4A3), a key component of the exon junction complex, is widely involved in RNA splicing and nonsense‑mediated mRNA decay. EIF4A3 has also been reported to be involved in cell cycle regulation and apoptosis. Thus, EIF4A3 may serve as a pivotal regulatory factor involved in the occurrence and development of multiple diseases. Previous studies have demonstrated that EIF4A3 is mutated in neuromuscular degenerative lesions and is differentially expressed in several tumors, serving as a non‑coding RNA binding protein to regulate its expression. In addition, studies have reported that inhibiting EIF4A3 can prevent tumor cell proliferation, thus, several researchers are trying to design and synthesize potent and selective EIF4A3 inhibitors. The present review summarizes the function of EIF4A3 in cell cycle and discusses it underlying molecular mechanisms that contribute to the occurrence of malignant diseases. In addition, EIF4A3 selective inhibitors, and bioinformatics analyses performed to analyze the expression and mutations of EIF4A3 in gynecological tumors and breast cancer, are also discussed.
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May-2021
Volume 21 Issue 5

Print ISSN: 1792-1074
Online ISSN:1792-1082

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Spandidos Publications style
Zhu Y, Ren C and Yang L: Effect of eukaryotic translation initiation factor 4A3 in malignant tumors (Review). Oncol Lett 21: 358, 2021
APA
Zhu, Y., Ren, C., & Yang, L. (2021). Effect of eukaryotic translation initiation factor 4A3 in malignant tumors (Review). Oncology Letters, 21, 358. https://doi.org/10.3892/ol.2021.12619
MLA
Zhu, Y., Ren, C., Yang, L."Effect of eukaryotic translation initiation factor 4A3 in malignant tumors (Review)". Oncology Letters 21.5 (2021): 358.
Chicago
Zhu, Y., Ren, C., Yang, L."Effect of eukaryotic translation initiation factor 4A3 in malignant tumors (Review)". Oncology Letters 21, no. 5 (2021): 358. https://doi.org/10.3892/ol.2021.12619