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Long non‑coding RNA LINC00173 enhances cisplatin resistance in hepatocellular carcinoma via the microRNA‑641/RAB14 axis

  • Authors:
    • Guangliang Zhao
    • Anhua Zhang
    • Shufang Sun
    • Yunlong Ding
  • View Affiliations / Copyright

    Affiliations: Department of Emergency General Surgery, Weifang People's Hospital, Weifang, Shandong 261000, P.R. China, Department of Gastrointestinal Surgery, Gaomi People's Hospital, Gaomi, Shandong 261500, P.R. China, Department of Anesthesia, Weifang Maternal and Child Health Hospital, Weifang, Shandong 261000, P.R. China
    Copyright: © Zhao et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 371
    |
    Published online on: March 13, 2021
       https://doi.org/10.3892/ol.2021.12632
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Abstract

A growing body of evidence indicates that long non‑coding RNAs (lncRNAs) play crucial roles in the chemoresistance of human cancers. However, the molecular mechanisms underlying the functions of certain lncRNAs in the chemotherapeutic resistance of hepatocellular carcinoma (HCC) remain unclear. The aim of the present study was to investigate the function and potential mechanism of action of lncRNA LINC00173 in HCC cisplatin (DDP) resistance. Reverse transcription‑quantitative PCR analysis indicated that LINC00173 was highly expressed in DDP‑resistant HCC tissues and cell lines, and high expression levels of LINC00173 were found to be associated with poor prognosis in patients with HCC. Moreover, LINC00173‑knockdown improved the DDP sensitivity of DDP‑resistant HCC cells. A luciferase reporter assay also demonstrated that microRNA (miR)‑641 was a direct target of LINC00173. miR‑641 inhibition restored the promoting effect of LINC00173 knockdown on DDP sensitivity in HCC cells. Furthermore, RAB14 was identified as a target of miR‑641, and RAB14 overexpression restrained the inducing effect of LINC00173 knockdown on HCC cell DDP sensitivity. The findings of the present study demonstrated that LINC00173 increased DDP resistance in HCC via the miR‑641/RAB14 axis, which may represent a promising therapeutic strategy for HCC.
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1 

Singal AG and El-Serag HB: Hepatocellular carcinoma from epidemiology to prevention: Translating knowledge into practice. Clin Gastroenterol Hepatol. 13:2140–2151. 2015. View Article : Google Scholar : PubMed/NCBI

2 

Fan ST, Mau Lo C, Poon RT, Yeung C, Leung Liu C, Yuen WK, Ming Lam C, Ng KK and Ching Chan S: Continuous improvement of survival outcomes of resection of hepatocellular carcinoma: A 20-year experience. Ann Surg. 253:745–758. 2011. View Article : Google Scholar : PubMed/NCBI

3 

Schmitt AM and Chang HY: Long noncoding RNAs in cancer pathways. Cancer Cell. 29:452–463. 2016. View Article : Google Scholar : PubMed/NCBI

4 

Gibb EA, Brown CJ and Lam WL: The functional role of long non-coding RNA in human carcinomas. Mol Cancer. 10:382011. View Article : Google Scholar : PubMed/NCBI

5 

Shi Y, Yang X, Xue X, Sun D, Cai P, Song Q, Zhang B and Qin L: HANR enhances autophagy-associated sorafenib resistance through miR-29b/ATG9A axis in hepatocellular carcinoma. Onco Targets Ther. 13:2127–2137. 2020. View Article : Google Scholar : PubMed/NCBI

6 

Guo Y, Bai M, Lin L, Huang J, An Y, Liang L, Liu Y and Huang W: LncRNA DLEU2 aggravates the progression of hepatocellular carcinoma through binding to EZH2. Biomed Pharmacother. 118:1092722019. View Article : Google Scholar : PubMed/NCBI

7 

Liu Z, Chen JY, Zhong Y, Xie L and Li JS: lncRNA MEG3 inhibits the growth of hepatocellular carcinoma cells by sponging miR-9-5p to upregulate SOX11. Braz J Med Biol Res. 52:e86312019. View Article : Google Scholar : PubMed/NCBI

8 

Yang X, Sun L, Wang L, Yao B, Mo H and Yang W: LncRNA SNHG7 accelerates the proliferation, migration and invasion of hepatocellular carcinoma cells via regulating miR-122-5p and RPL4. Biomed Pharmacother. 118:1093862019. View Article : Google Scholar : PubMed/NCBI

9 

Gu M, Zheng W, Zhang M, Dong X, Zhao Y, Wang S, Jiang H and Zheng X: LncRNA NONHSAT141924 promotes paclitaxel chemotherapy resistance through p-CREB/Bcl-2 apoptosis signaling pathway in breast cancer. J Cancer. 11:3645–3654. 2020. View Article : Google Scholar : PubMed/NCBI

10 

Zhang J, Zhao B, Chen X, Wang Z, Xu H and Huang B: Silence of long noncoding RNA NEAT1 inhibits malignant biological behaviors and chemotherapy resistance in gastric cancer. Pathol Oncol Res. 24:109–113. 2018. View Article : Google Scholar : PubMed/NCBI

11 

Zhang J, Zhou M, Zhao X, Wang G and Li J: Long noncoding RNA LINC00173 is downregulated in cervical cancer and inhibits cell proliferation and invasion by modulating the miR-182-5p/FBXW7 axis. Pathol Res Pract. 216:1529942020. View Article : Google Scholar : PubMed/NCBI

12 

Fan H, Yuan J and Li X, Ma Y, Wang X, Xu B and Li X: LncRNA LINC00173 enhances triple-negative breast cancer progression by suppressing miR-490-3p expression. Biomed Pharmacother. 125:1099872020. View Article : Google Scholar : PubMed/NCBI

13 

Yang F, Lei P, Zeng W, Gao J and Wu N: Long noncoding RNA LINC00173 promotes the malignancy of melanoma by promoting the expression of IRS4 through competitive binding to microRNA-493. Cancer Manag Res. 12:3131–3144. 2020. View Article : Google Scholar : PubMed/NCBI

14 

Xiao F, Li Y, Wan Y and Xue M: MircroRNA-139 sensitizes ovarian cancer cell to cisplatin-based chemotherapy through regulation of ATP7A/B. Cancer Chemother Pharmacol. 81:935–947. 2018. View Article : Google Scholar : PubMed/NCBI

15 

Niu YC, Tong J, Shi XF and Zhang T: MicroRNA-654-3p enhances cisplatin sensitivity by targeting QPRT and inhibiting the PI3K/AKT signaling pathway in ovarian cancer cells. Exp Ther Med. 20:1467–1479. 2020. View Article : Google Scholar : PubMed/NCBI

16 

Yang S, Wang P, Wang S, Cong A, Zhang Q, Shen W, Li X, Zhang W and Han G: miRNA-181a-5p enhances the sensitivity of cells to cisplatin in esophageal adenocarcinoma by targeting CBLB. Cancer Manag Res. 12:4981–4990. 2020. View Article : Google Scholar : PubMed/NCBI

17 

Zhao Y, Zheng R, Chen J and Ning D: CircRNA CDR1as/miR-641/HOXA9 pathway regulated stemness contributes to cisplatin resistance in non-small cell lung cancer (NSCLC). Cancer Cell Int. 20:2892020. View Article : Google Scholar : PubMed/NCBI

18 

van Persijn van Meerten EL, Gelderblom H and Bloem JL: RECIST revised: Implications for the radiologist. A review article on the modified RECIST guideline. Eur Radiol. 20:1456–1467. 2010. View Article : Google Scholar : PubMed/NCBI

19 

Livak KJ and Schmittgen TD: Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) method. Methods. 25:402–408. 2001. View Article : Google Scholar : PubMed/NCBI

20 

Wang SY, Wang X and Zhang CY: LncRNA SNHG7 enhances chemoresistance in neuroblastoma through cisplatin-induced autophagy by regulating miR-329-3p/MYO10 axis. Eur Rev Med Pharmacol Sci. 24:3805–3817. 2020.PubMed/NCBI

21 

Xu Q, Lin YB, Li L and Liu J: LncRNA TLR8-AS1 promotes metastasis and chemoresistance of ovarian cancer through enhancing TLR8 mRNA stability. Biochem Biophys Res Commun. 526:857–864. 2020. View Article : Google Scholar : PubMed/NCBI

22 

Yu Y, Lu X, Yang C and Yin F: Long noncoding RNA LINC00173 contributes to the growth, invasiveness and chemo-resistance of colorectal cancer through regulating miR-765/PLP2 axis. Cancer Manag Res. 12:3363–3369. 2020. View Article : Google Scholar : PubMed/NCBI

23 

Zeng F, Wang Q, Wang S, Liang S, Huang W, Guo Y, Peng J, Li M, Zhu W and Guo L: Linc00173 promotes chemoresistance and progression of small cell lung cancer by sponging miR-218 to regulate Etk expression. Oncogene. 39:293–307. 2020. View Article : Google Scholar : PubMed/NCBI

24 

Wang Y, Hou J, He D, Sun M, Zhang P, Yu Y and Chen Y: The emerging function and mechanism of ceRNAs in cancer. Trends Genet. 32:211–224. 2016. View Article : Google Scholar : PubMed/NCBI

25 

Mercer TR, Dinger ME and Mattick JS: Long non-coding RNAs: Insights into functions. Nat Rev Genet. 10:155–159. 2009. View Article : Google Scholar : PubMed/NCBI

26 

Zhou J, Li H, Li N, Li X, Zhang H, Song Q and Peng M: MicroRNA-641 inhibits lung cancer cells proliferation, metastasis but promotes apoptosis in cells by targeting PDCD4. Int J Clin Exp Pathol. 10:8211–8221. 2017.PubMed/NCBI

27 

Yao R, Zheng H, Wu L and Cai P: miRNA-641 inhibits the proliferation, migration, and invasion and induces apoptosis of cervical cancer cells by directly targeting ZEB1. Onco Targets Ther. 11:8965–8976. 2018. View Article : Google Scholar : PubMed/NCBI

28 

Yang J, Liang B and Hou S: TMPO-AS1 promotes cervical cancer progression by upregulating RAB14 via sponging miR-577. J Gene Med. 21:e31252019. View Article : Google Scholar : PubMed/NCBI

29 

Guo B, Wang W, Zhao Z, Li Q, Zhou K, Zhao L, Wang L, Yang J and Huang C: Rab14 Act as oncogene and induce proliferation of gastric cancer cells via AKT signaling pathway. PLoS One. 12:e01706202017. View Article : Google Scholar : PubMed/NCBI

30 

Zhai Y, Liu M and Zheng Y: MicroRNA-451 dictates the anoikis resistance of osteosarcoma by targeting Rab14. Int J Clin Exp Pathol. 10:10989–10997. 2017.PubMed/NCBI

31 

Ge J and Ge C: Rab14 overexpression regulates gemcitabine sensitivity through regulation of Bcl-2 and mitochondrial function in pancreatic cancer. Virchows Arch. 474:59–69. 2019. View Article : Google Scholar : PubMed/NCBI

32 

Kim EA, Kim TG, Sung EG, Song IH, Kim JY, Doh KO and Lee TJ: miR-148a increases the sensitivity to cisplatin by targeting Rab14 in renal cancer cells. Int J Oncol. 50:984–992. 2017. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Zhao G, Zhang A, Sun S and Ding Y: Long non‑coding RNA LINC00173 enhances cisplatin resistance in hepatocellular carcinoma via the microRNA‑641/RAB14 axis. Oncol Lett 21: 371, 2021.
APA
Zhao, G., Zhang, A., Sun, S., & Ding, Y. (2021). Long non‑coding RNA LINC00173 enhances cisplatin resistance in hepatocellular carcinoma via the microRNA‑641/RAB14 axis. Oncology Letters, 21, 371. https://doi.org/10.3892/ol.2021.12632
MLA
Zhao, G., Zhang, A., Sun, S., Ding, Y."Long non‑coding RNA LINC00173 enhances cisplatin resistance in hepatocellular carcinoma via the microRNA‑641/RAB14 axis". Oncology Letters 21.5 (2021): 371.
Chicago
Zhao, G., Zhang, A., Sun, S., Ding, Y."Long non‑coding RNA LINC00173 enhances cisplatin resistance in hepatocellular carcinoma via the microRNA‑641/RAB14 axis". Oncology Letters 21, no. 5 (2021): 371. https://doi.org/10.3892/ol.2021.12632
Copy and paste a formatted citation
x
Spandidos Publications style
Zhao G, Zhang A, Sun S and Ding Y: Long non‑coding RNA LINC00173 enhances cisplatin resistance in hepatocellular carcinoma via the microRNA‑641/RAB14 axis. Oncol Lett 21: 371, 2021.
APA
Zhao, G., Zhang, A., Sun, S., & Ding, Y. (2021). Long non‑coding RNA LINC00173 enhances cisplatin resistance in hepatocellular carcinoma via the microRNA‑641/RAB14 axis. Oncology Letters, 21, 371. https://doi.org/10.3892/ol.2021.12632
MLA
Zhao, G., Zhang, A., Sun, S., Ding, Y."Long non‑coding RNA LINC00173 enhances cisplatin resistance in hepatocellular carcinoma via the microRNA‑641/RAB14 axis". Oncology Letters 21.5 (2021): 371.
Chicago
Zhao, G., Zhang, A., Sun, S., Ding, Y."Long non‑coding RNA LINC00173 enhances cisplatin resistance in hepatocellular carcinoma via the microRNA‑641/RAB14 axis". Oncology Letters 21, no. 5 (2021): 371. https://doi.org/10.3892/ol.2021.12632
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