Open Access

Current status of the diagnosis and treatment of gastrointestinal schwannoma (Review)

  • Authors:
    • Zhiyong Qi
    • Naixv Yang
    • Mengqi Pi
    • Wei Yu
  • View Affiliations

  • Published online on: March 16, 2021     https://doi.org/10.3892/ol.2021.12645
  • Article Number: 384
  • Copyright: © Qi et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Gastrointestinal schwannoma is a rare, slow‑growing and benign tumor that mostly originates in the Auerbach myenteric nerve plexus in the gastrointestinal tract. The clinical manifestations may be associated with the location, size, differentiation type, and degree of malignancy of the tumor. Endoscopy, ultrasound and imaging examinations serve an important auxiliary role in the clinical identification, diagnosis and differential diagnosis of lesions; assessment of risk; and preparation for surgery. S‑100 positivity is a hallmark of schwannoma. CD34, CD117, discovered on GIST‑1, P53, ALK, β‑catenin, smooth muscle actin and Desmin negativity are helpful for the identification of other gastrointestinal stromal tumors. Surgical removal of the tumor is the main treatment for schwannoma. Benign gastrointestinal schwannoma has a good prognosis without recurrence and metastasis; malignant transformation is extremely rare and has a poor prognosis.
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May-2021
Volume 21 Issue 5

Print ISSN: 1792-1074
Online ISSN:1792-1082

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Spandidos Publications style
Qi Z, Yang N, Pi M and Yu W: Current status of the diagnosis and treatment of gastrointestinal schwannoma (Review). Oncol Lett 21: 384, 2021
APA
Qi, Z., Yang, N., Pi, M., & Yu, W. (2021). Current status of the diagnosis and treatment of gastrointestinal schwannoma (Review). Oncology Letters, 21, 384. https://doi.org/10.3892/ol.2021.12645
MLA
Qi, Z., Yang, N., Pi, M., Yu, W."Current status of the diagnosis and treatment of gastrointestinal schwannoma (Review)". Oncology Letters 21.5 (2021): 384.
Chicago
Qi, Z., Yang, N., Pi, M., Yu, W."Current status of the diagnosis and treatment of gastrointestinal schwannoma (Review)". Oncology Letters 21, no. 5 (2021): 384. https://doi.org/10.3892/ol.2021.12645