Current status of the diagnosis and treatment of gastrointestinal schwannoma (Review)
- Zhiyong Qi
- Naixv Yang
- Mengqi Pi
- Wei Yu
Affiliations: Department of Gastrointestinal, Colorectal and Anal Surgery, China‑Japan Union Hospital of Jilin University, Changchun, Jilin 130033, P.R. China
- Published online on: March 16, 2021 https://doi.org/10.3892/ol.2021.12645
Copyright: © Qi
et al. This is an open access article distributed under the
terms of Creative
Commons Attribution License.
Views: 0 (Spandidos Publications: | PMC Statistics: )
Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
This article is mentioned in:
Gastrointestinal schwannoma is a rare, slow‑growing and benign tumor that mostly originates in the Auerbach myenteric nerve plexus in the gastrointestinal tract. The clinical manifestations may be associated with the location, size, differentiation type, and degree of malignancy of the tumor. Endoscopy, ultrasound and imaging examinations serve an important auxiliary role in the clinical identification, diagnosis and differential diagnosis of lesions; assessment of risk; and preparation for surgery. S‑100 positivity is a hallmark of schwannoma. CD34, CD117, discovered on GIST‑1, P53, ALK, β‑catenin, smooth muscle actin and Desmin negativity are helpful for the identification of other gastrointestinal stromal tumors. Surgical removal of the tumor is the main treatment for schwannoma. Benign gastrointestinal schwannoma has a good prognosis without recurrence and metastasis; malignant transformation is extremely rare and has a poor prognosis.