Clinical significance of miR‑1298 in cervical cancer and its biological function <em>in vitro</em> Retraction in /10.3892/ol.2024.14283

Zhang,Haitao; Zhang,Ruihong; Zhang,Guiling; Liu,Wenjuan; Ma,Zhaoyuan; Yue,Caiyun; Yang,Min

doi:10.3892/ol.2021.12662

Clinical significance of miR‑1298 in cervical cancer and its biological function <em>in vitro</em>

Retraction in: /10.3892/ol.2024.14283

Authors:
- Haitao Zhang
- Ruihong Zhang
- Guiling Zhang
- Wenjuan Liu
- Zhaoyuan Ma
- Caiyun Yue
- Min Yang
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Affiliations: Department of Pathology, Chengwu People's Hospital, Heze, Shandong 274200, P.R. China, Department of Obstetrics, Chengwu People's Hospital, Heze, Shandong 274200, P.R. China, Department of Pathology, Linyi Hot Spring Sanatorium of Shandong Coal Industry Bureau, Linyi, Shandong 276032, P.R. China, Department of Pathology, The First Affiliated Hospital of Shandong First Medical University, Jinan, Shandong 250014, P.R. China
Published online on: March 18, 2021 https://doi.org/10.3892/ol.2021.12662
Article Number: 401
Copyright: © Zhang et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Cervical cancer is one of the most malignant tumors in women. miR‑1298 was reported to be abnormally expressed and serve crucial role in tumorigenesis of several types of cancer; however, the role of miR‑1298 in cervical cancer remains unknown. The present study aimed to evaluate the clinical and biological significance of miR‑1298 in cervical cancer. To do so, the expression level of miR‑1298 in cervical cancer tissues and cells was evaluated by reverse transcription quantitative PCR. Kaplan‑Meier survival analysis and Cox regression analysis were used to explore the prognostic significance of miR‑1298 in patients with cervical cancer. Cell Counting Kit‑8 and Transwell migration and invasion assays were used to evaluate the effect of miR‑1298 on the proliferative, migratory and invasive abilities of cervical cancer cells, respectively. The expression of miR‑1298 was lower in cancer tissues and cells compared with normal tissues and cells. Furthermore, miR‑1298 expression was associated with lymph node metastasis, tumor diameter and staging from the International Federation of Gynecology and Obstetrics. In addition, patients with low miR‑1298 expression had poorer overall survival. These findings suggested that miR‑1298 may be considered as an independent prognostic factor for patients with cervical cancer. Furthermore, the results demonstrated that miR‑1298 knockdown could promote tumor cell proliferation and migratory and invasive abilities. In addition, nucleus accumbens‑associated 1 (NACC1) was demonstrated to be a direct target of miR‑1298. Taken together, these findings indicated that miR‑1298 overexpression may be considered as a prognostic biomarker for cervical cancer and that miR‑1298 may play an inhibitor role in cervical cancer by targeting NACC1.

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1	Schiffman M and Solomon D: Clinical practice. Cervical-cancer screening with human papillomavirus and cytologic cotesting. N Engl J Med. 369:2324–2331. 2013. View Article : Google Scholar : PubMed/NCBI
2	Cohen PA, Jhingran A, Oaknin A and Denny L: Cervical cancer. Lancet. 393:169–182. 2019. View Article : Google Scholar : PubMed/NCBI
3	Bray F, Ferlay J, Soerjomataram I, Siegel RL, Torre LA and Jemal A: Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA Cancer J Clin. 68:394–424. 2018. View Article : Google Scholar : PubMed/NCBI
4	Tsikouras P, Zervoudis S, Manav B, Tomara E, Iatrakis G, Romanidis C, Bothou A and Galazios G: Cervical cancer: Screening, diagnosis and staging. J BUON. 21:320–325. 2016.PubMed/NCBI
5	Feldman CH, Liu J, Feldman S, Solomon DH and Kim SC: Risk of high-grade cervical dysplasia and cervical cancer in women with systemic lupus erythematosus receiving immunosuppressive drugs. Lupus. 26:682–689. 2017. View Article : Google Scholar : PubMed/NCBI
6	Al-Mandeel HM, Sagr E, Sait K, Latifah HM, Al-Obaid A, Al-Badawi IA, Alkushi AO, Salem H, Massoudi NS, Schunemann H, et al: Clinical practice guidelines on the screening and treatment of precancerous lesions for cervical cancer prevention in Saudi Arabia. Ann Saudi Med. 36:313–320. 2016. View Article : Google Scholar : PubMed/NCBI
7	Rees CP, Brhlikova P and Pollock AM: Will HPV vaccination prevent cervical cancer? J R Soc Med. 113:64–78. 2020. View Article : Google Scholar : PubMed/NCBI
8	Liao W, He J, Disoma C, Hu Y, Li J, Chen G, Sheng Y, Cai X, Li C, Cheng K, et al: Hsa_circ_0107593 Suppresses the Progression of Cervical Cancer via Sponging hsa-miR-20a-5p/93-5p/106b-5p. Front Oncol. 10:5906272021. View Article : Google Scholar : PubMed/NCBI
9	Ke L, Chen Y, Li Y, Chen Z, He Y, Liu J and Zhuang Y: miR-142-5p promotes cervical cancer progression by targeting LMX1A through Wnt/β-catenin pathway. Open Med (Wars). 16:224–236. 2021. View Article : Google Scholar : PubMed/NCBI
10	Peng R, Cheng X, Zhang Y, Lu X and Hu Z: miR-214 down-regulates MKK3 and suppresses malignant phenotypes of cervical cancer cells. Gene. 724:1441462020. View Article : Google Scholar : PubMed/NCBI
11	Lu Y, Wei G, Liu L, Mo Y, Chen Q, Xu L, Liao R, Zeng D and Zhang K: Direct targeting of MAPK8IP1 by miR-10a-5p is a major mechanism for gastric cancer metastasis. Oncol Lett. 13:1131–1136. 2017. View Article : Google Scholar : PubMed/NCBI
12	Liu S, Gao G, Yan D, Chen X, Yao X, Guo S, Li G and Zhao Y: Effects of miR-145-5p through NRAS on the cell proliferation, apoptosis, migration, and invasion in melanoma by inhibiting MAPK and PI3K/AKT pathways. Cancer Med. 6:819–833. 2017. View Article : Google Scholar : PubMed/NCBI
13	Du Z, Wu J, Wang J, Liang Y, Zhang S, Shang Z and Zuo W: MicroRNA-1298 is downregulated in non-small cell lung cancer and suppresses tumor progression in tumor cells. Diagn Pathol. 14:1322019. View Article : Google Scholar : PubMed/NCBI
14	Lang B and Zhao S: miR-486 functions as a tumor suppressor in esophageal cancer by targeting CDK4/BCAS2. Oncol Rep. 39:71–80. 2018.PubMed/NCBI
15	Wang J, Zhao X, Shi J, Pan Y, Chen Q, Leng P and Wang Y: miR-451 suppresses bladder cancer cell migration and invasion via directly targeting c-Myc. Oncol Rep. 36:2049–2058. 2016. View Article : Google Scholar : PubMed/NCBI
16	Hua Y, Zhao K, Tao G, Dai C and Su Y: miR-25 promotes metastasis via targeting FBXW7 in esophageal squamous cell carcinoma. Oncol Rep. 38:3030–3038. 2017. View Article : Google Scholar : PubMed/NCBI
17	Zhou Y, Dang J, Chang KY, Yau E, Aza-Blanc P, Moscat J and Rana TM: miR-1298 inhibits mutant KRAS-Driven tumor growth by repressing FAK and LAMB3. Cancer Res. 76:5777–5787. 2016. View Article : Google Scholar : PubMed/NCBI
18	Chen S, Gao C, Wu Y and Huang Z: Identification of prognostic miRNA signature and lymph node metastasis-related key genes in cervical cancer. Front Pharmacol. 11:5442020. View Article : Google Scholar : PubMed/NCBI
19	Tsunoda K, Oikawa H, Tada H, Tatemichi Y, Muraoka S, Miura S, Shibazaki M, Maeda F, Takahashi K, Akasaka T, et al: Nucleus accumbens-associated 1 contributes to cortactin deacetylation and augments the migration of melanoma cells. J Invest Dermatol. 131:1710–1719. 2011. View Article : Google Scholar : PubMed/NCBI
20	Chen F, Yin Y, Yan Z, Cao K and Zhong K: NAC1 promotes the migration of prostate cancer cells and participates in osteoclastogenesis by negatively regulating IFNβ. Oncol Lett. 15:2921–2928. 2018.PubMed/NCBI
21	Yeasmin S, Nakayama K, Rahman MT, Rahman M, Ishikawa M, Katagiri A, Iida K, Nakayama N, Otuski Y, Kobayashi H, et al: Biological and clinical significance of NAC1 expression in cervical carcinomas: A comparative study between squamous cell carcinomas and adenocarcinomas/adenosquamous carcinomas. Hum Pathol. 43:506–519. 2012. View Article : Google Scholar : PubMed/NCBI
22	Livak KJ and Schmittgen TD: Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) method. Methods. 25:402–408. 2001. View Article : Google Scholar : PubMed/NCBI
23	Xi M and Tang W: Knockdown of Ezrin inhibited migration and invasion of cervical cancer cells in vitro. Int J Immunopathol Pharmacol. 34:20587384209308992020. View Article : Google Scholar : PubMed/NCBI
24	Johnson CA, James D, Marzan A and Armaos M: Cervical cancer: An overview of pathophysiology and management. Semin Oncol Nurs. 35:166–174. 2019. View Article : Google Scholar : PubMed/NCBI
25	Vu M, Yu J, Awolude OA and Chuang L: Cervical cancer worldwide. Curr Probl Cancer. 42:457–465. 2018. View Article : Google Scholar : PubMed/NCBI
26	Ha SY, Yu JI, Choi C, Kang SY, Joh JW, Paik SW, Kim S, Kim M, Park HC and Park CK: Prognostic significance of miR-122 expression after curative resection in patients with hepatocellular carcinoma. Sci Rep. 9:147382019. View Article : Google Scholar : PubMed/NCBI
27	Menbari MN, Rahimi K, Ahmadi A, Elyasi A, Darvishi N, Hosseini V, Mohammadi-Yeganeh S and Abdi M: miR-216b-5p inhibits cell proliferation in human breast cancer by down-regulating HDAC8 expression. Life Sci. 237:1169452019. View Article : Google Scholar : PubMed/NCBI
28	Liu S, Chen Q and Wang Y: miR-125b-5p suppresses the bladder cancer progression via targeting HK2 and suppressing PI3K/AKT pathway. Hum Cell. 33:185–194. 2020. View Article : Google Scholar : PubMed/NCBI
29	Hashemi ZS, Khalili S, Forouzandeh Moghadam M and Sadroddiny E: Lung cancer and miRNAs: A possible remedy for anti-metastatic, therapeutic and diagnostic applications. Expert Rev Respir Med. 11:147–157. 2017. View Article : Google Scholar : PubMed/NCBI
30	Zhu L, Tu H, Liang Y and Tang D: miR-218 produces anti-tumor effects on cervical cancer cells in vitro. World J Surg Oncol. 16:2042018. View Article : Google Scholar : PubMed/NCBI
31	Park S, Eom K, Kim J, Bang H, Wang HY, Ahn S, Kim G, Jang H, Kim S, Lee D, et al: miR-9, miR-21, and miR-155 as potential biomarkers for HPV positive and negative cervical cancer. BMC Cancer. 17:6582017. View Article : Google Scholar : PubMed/NCBI
32	Dong P, Xiong Y, Yu J, Chen L, Tao T, Yi S, Hanley SJB, Yue J, Watari H and Sakuragi N: Control of PD-L1 expression by miR-140/142/340/383 and oncogenic activation of the OCT4-miR-18a pathway in cervical cancer. Oncogene. 37:5257–5268. 2018. View Article : Google Scholar : PubMed/NCBI
33	Rupaimoole R and Slack FJ: MicroRNA therapeutics: Towards a new era for the management of cancer and other diseases. Nat Rev Drug Discov. 16:203–222. 2017. View Article : Google Scholar : PubMed/NCBI
34	Lee YS and Dutta A: MicroRNAs in cancer. Annu Rev Pathol. 4:199–227. 2009. View Article : Google Scholar : PubMed/NCBI
35	Liu X, Ju J, Liu Q, Zhu Z and Liu C: The Chinese medicine, shezhi huangling decoction, inhibits the growth and metastasis of glioma cells via the regulation of miR-1298-5p/TGIF1 axis. Cancer Manag Res. 12:5677–5687. 2020. View Article : Google Scholar : PubMed/NCBI
36	Xu X, Ban Y, Zhao Z, Pan Q and Zou J: MicroRNA-1298-3p inhibits proliferation and invasion of glioma cells by downregulating Nidogen-1. Aging (Albany NY). 12:7761–7773. 2020. View Article : Google Scholar : PubMed/NCBI
37	Wang CM, Cheng BH, Xue QJ, Chen J and Bai B: miR-1298 affects cell proliferation and apoptosis in C6 cells by targeting SET domain containing 7. Int J Immunopathol Pharmacol. 30:264–271. 2017. View Article : Google Scholar : PubMed/NCBI
38	Qiu ZK, Liu N, Zhao SF, Ding AP, Cheng G, Qiu WS and Qi WW: miR-1298 expression correlates with prognosis and inhibits cell proliferation and invasion of gastric cancer. Eur Rev Med Pharmacol Sci. 22:1672–1679. 2018.PubMed/NCBI
39	Hu W, Wang M, Yin H, Yao C, He Q, Yin L, Zhang C, Li W, Chang G and Wang S: MicroRNA-1298 is regulated by DNA methylation and affects vascular smooth muscle cell function by targeting connexin 43. Cardiovasc Res. 107:534–545. 2015. View Article : Google Scholar : PubMed/NCBI
40	Ishibashi M, Nakayama K, Yeasmin S, Katagiri A, Iida K, Nakayama N and Miyazaki K: Expression of a BTB/POZ protein, NAC1, is essential for the proliferation of normal cyclic endometrial glandular cells and is up-regulated by estrogen. Clin Cancer Res. 15:804–811. 2009. View Article : Google Scholar : PubMed/NCBI