Open Access

Clinical significance of miR‑1298 in cervical cancer and its biological function in vitro

  • Authors:
    • Haitao Zhang
    • Ruihong Zhang
    • Guiling Zhang
    • Wenjuan Liu
    • Zhaoyuan Ma
    • Caiyun Yue
    • Min Yang
  • View Affiliations

  • Published online on: March 18, 2021     https://doi.org/10.3892/ol.2021.12662
  • Article Number: 401
  • Copyright: © Zhang et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Cervical cancer is one of the most malignant tumors in women. miR‑1298 was reported to be abnormally expressed and serve crucial role in tumorigenesis of several types of cancer; however, the role of miR‑1298 in cervical cancer remains unknown. The present study aimed to evaluate the clinical and biological significance of miR‑1298 in cervical cancer. To do so, the expression level of miR‑1298 in cervical cancer tissues and cells was evaluated by reverse transcription quantitative PCR. Kaplan‑Meier survival analysis and Cox regression analysis were used to explore the prognostic significance of miR‑1298 in patients with cervical cancer. Cell Counting Kit‑8 and Transwell migration and invasion assays were used to evaluate the effect of miR‑1298 on the proliferative, migratory and invasive abilities of cervical cancer cells, respectively. The expression of miR‑1298 was lower in cancer tissues and cells compared with normal tissues and cells. Furthermore, miR‑1298 expression was associated with lymph node metastasis, tumor diameter and staging from the International Federation of Gynecology and Obstetrics. In addition, patients with low miR‑1298 expression had poorer overall survival. These findings suggested that miR‑1298 may be considered as an independent prognostic factor for patients with cervical cancer. Furthermore, the results demonstrated that miR‑1298 knockdown could promote tumor cell proliferation and migratory and invasive abilities. In addition, nucleus accumbens‑associated 1 (NACC1) was demonstrated to be a direct target of miR‑1298. Taken together, these findings indicated that miR‑1298 overexpression may be considered as a prognostic biomarker for cervical cancer and that miR‑1298 may play an inhibitor role in cervical cancer by targeting NACC1.
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May-2021
Volume 21 Issue 5

Print ISSN: 1792-1074
Online ISSN:1792-1082

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Copy and paste a formatted citation
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Spandidos Publications style
Zhang H, Zhang R, Zhang G, Liu W, Ma Z, Yue C and Yang M: Clinical significance of miR‑1298 in cervical cancer and its biological function <em>in vitro</em>. Oncol Lett 21: 401, 2021
APA
Zhang, H., Zhang, R., Zhang, G., Liu, W., Ma, Z., Yue, C., & Yang, M. (2021). Clinical significance of miR‑1298 in cervical cancer and its biological function <em>in vitro</em>. Oncology Letters, 21, 401. https://doi.org/10.3892/ol.2021.12662
MLA
Zhang, H., Zhang, R., Zhang, G., Liu, W., Ma, Z., Yue, C., Yang, M."Clinical significance of miR‑1298 in cervical cancer and its biological function <em>in vitro</em>". Oncology Letters 21.5 (2021): 401.
Chicago
Zhang, H., Zhang, R., Zhang, G., Liu, W., Ma, Z., Yue, C., Yang, M."Clinical significance of miR‑1298 in cervical cancer and its biological function <em>in vitro</em>". Oncology Letters 21, no. 5 (2021): 401. https://doi.org/10.3892/ol.2021.12662