Open Access

Patients with Helicobacter pylori‑positive gastric cancer with human cytomegalovirus infection have a low tendency of advanced lymphatic metastasis in a Chinese population

  • Authors:
    • Chao Chen
    • Sian Chen
    • Zheng Han
    • Wangkai Xie
    • Teming Zhang
    • Chenchen  Mao
    • Liang Zhang
    • Xiangwei Sun
    • Terry Kwok
    • Xian Shen
    • Xiangyang Xue
  • View Affiliations

  • Published online on: March 19, 2021     https://doi.org/10.3892/ol.2021.12663
  • Article Number: 402
  • Copyright: © Chen et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Recognized as a group I carcinogen for gastric cancer (GC) and a factor involved in the development of GC, Helicobacter pylori serves a major part in GC research. However, most studies have focused on H. pylori itself, ignoring the complicated pathogenic microbiological environment of GC and neglecting the synergistic or antagonistic effects of H. pylori with other pathogenic microorganisms. Increasing evidence has revealed that the human cytomegalovirus (HCMV) is present in several types of tumors and serves an important role in the neoplastic process of certain human malignant tumors, including GC. The aim of the present study was to explore the role of HCMV and H. pylori co‑infection in GC. HCMV and H. pylori infection was analyzed in paired gastric tumor and peri‑tumoral tissues from 134 (98 male and 36 female) patients using PCR. The results revealed that a total of 74 (55.2%) patients had H. pylori infection, 58 patients (43.3%) had HCMV infection, and 34 (25.4%) patients had both HCMV and H. pylori infection. Univariate and multivariate analyses demonstrated that H. pylori infection was independently associated with advanced lymphatic metastasis [P=0.007; odds ratio (OR)=3.51]. Furthermore, compared with HCMV/H. pylori, neither HCMV+/H. pylori nor HCMV+/H. pylori+ were associated with metastasis, but HCMV/H. pylori+ co‑infection status was an independent risk factor for advanced lymphatic metastasis (P=0.005; OR=6.00). In conclusion, GC co‑infected with HCMV and H. pylori exhibited a low tendency of lymph node metastasis. HCMV may interact with H. pylori to inhibit the process of lymphatic metastasis, and the mechanism requires further investigation.
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May-2021
Volume 21 Issue 5

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Copy and paste a formatted citation
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Spandidos Publications style
Chen C, Chen S, Han Z, Xie W, Zhang T, Mao C, Zhang L, Sun X, Kwok T, Shen X, Shen X, et al: Patients with <em>Helicobacter pylori</em>‑positive gastric cancer with human cytomegalovirus infection have a low tendency of advanced lymphatic metastasis in a Chinese population. Oncol Lett 21: 402, 2021
APA
Chen, C., Chen, S., Han, Z., Xie, W., Zhang, T., Mao, C. ... Xue, X. (2021). Patients with <em>Helicobacter pylori</em>‑positive gastric cancer with human cytomegalovirus infection have a low tendency of advanced lymphatic metastasis in a Chinese population. Oncology Letters, 21, 402. https://doi.org/10.3892/ol.2021.12663
MLA
Chen, C., Chen, S., Han, Z., Xie, W., Zhang, T., Mao, C., Zhang, L., Sun, X., Kwok, T., Shen, X., Xue, X."Patients with <em>Helicobacter pylori</em>‑positive gastric cancer with human cytomegalovirus infection have a low tendency of advanced lymphatic metastasis in a Chinese population". Oncology Letters 21.5 (2021): 402.
Chicago
Chen, C., Chen, S., Han, Z., Xie, W., Zhang, T., Mao, C., Zhang, L., Sun, X., Kwok, T., Shen, X., Xue, X."Patients with <em>Helicobacter pylori</em>‑positive gastric cancer with human cytomegalovirus infection have a low tendency of advanced lymphatic metastasis in a Chinese population". Oncology Letters 21, no. 5 (2021): 402. https://doi.org/10.3892/ol.2021.12663