Open Access

DEK is highly expressed in breast cancer and is associated with malignant phenotype and progression

  • Authors:
    • Mai-Qing Yang
    • Lin-Lin Bai
    • Zhao Wang
    • Lei Lei
    • Yi-Wen Zheng
    • Zhi-Han Li
    • Wen-Jing Huang
    • Chen-Chen Liu
    • Hong-Tao Xu
  • View Affiliations

  • Published online on: April 1, 2021     https://doi.org/10.3892/ol.2021.12701
  • Article Number: 440
  • Copyright: © Yang et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

DEK proto‑oncogene (DEK) has been demonstrated as an oncogene and is associated with the development of many types of tumor; however, the expression and role of DEK in breast cancer remain unknown. The present study aimed to determine the role of DEK in the progression of breast cancer. The expression of DEK in 110 breast cancer tissues and 50 adjacent normal breast tissues was examined using immunohistochemistry. Furthermore, DEK expression was upregulated by DEK transfection or downregulated by DEK shRNA interference in MCF7 cells. Proliferative and invasive abilities were examined in MCF7 cells using MTT assay, colony‑formation assay and transwell invasion assays. The results demonstrated that DEK expression level was significantly increased in breast cancer tissues compared with normal breast tissues. Furthermore, high DEK expression was associated with high histological grade, lymph node metastasis, advanced Tumor‑Node‑Metastasis stage and high Ki‑67 index; however, DEK expression was not associated with the expression level of estrogen receptor, progesterone receptor, and human epidermal growth factor receptor 2. High DEK expression indicated poor prognosis in patients with breast cancer. DEK overexpression upregulated the protein expression of β‑catenin and Wnt and increased the proliferative and invasive abilities of breast cancer cells. DEK downregulation had the opposite effect. Taken together, the results from the present study demonstrated that high expression of DEK was common in patients with breast cancer and was associated with progression of the disease and poor prognosis, and that DEK overexpression promoted the proliferative and invasive abilities of breast cancer cells.
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June-2021
Volume 21 Issue 6

Print ISSN: 1792-1074
Online ISSN:1792-1082

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Spandidos Publications style
Yang M, Bai L, Wang Z, Lei L, Zheng Y, Li Z, Huang W, Liu C and Xu H: DEK is highly expressed in breast cancer and is associated with malignant phenotype and progression. Oncol Lett 21: 440, 2021
APA
Yang, M., Bai, L., Wang, Z., Lei, L., Zheng, Y., Li, Z. ... Xu, H. (2021). DEK is highly expressed in breast cancer and is associated with malignant phenotype and progression. Oncology Letters, 21, 440. https://doi.org/10.3892/ol.2021.12701
MLA
Yang, M., Bai, L., Wang, Z., Lei, L., Zheng, Y., Li, Z., Huang, W., Liu, C., Xu, H."DEK is highly expressed in breast cancer and is associated with malignant phenotype and progression". Oncology Letters 21.6 (2021): 440.
Chicago
Yang, M., Bai, L., Wang, Z., Lei, L., Zheng, Y., Li, Z., Huang, W., Liu, C., Xu, H."DEK is highly expressed in breast cancer and is associated with malignant phenotype and progression". Oncology Letters 21, no. 6 (2021): 440. https://doi.org/10.3892/ol.2021.12701