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Print ISSN: 1792-1074 Online ISSN: 1792-1082
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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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Journal Cover
June-2021 Volume 21 Issue 6

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Journal Metrics

Impact Factor: 2.2

CiteScore: 4.6

CiteScore Rank: Q2: #178/415 Oncology

Source Normalized Impact per Paper (SNIP): 0.568

SCImago Journal Rank (SJR): 0.663

Article Open Access

MicroRNA‑665 regulates the proliferation, apoptosis and adhesion of gastric cancer cells by binding to cadherin 3

Xinhui Fang, Yangqiu Bai, Lida Zhang, Songze Ding
Article Number: 494
Published online on: 26 April 2021

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Article Open Access

HOXA11‑AS induces cisplatin resistance by modulating the microRNA‑98/PBX3 axis in nasopharyngeal carcinoma

Haineng Li, Jia Huang, Sa Yu, Hangbo Li, Yan Zhou, Qingwei Wu
Article Number: 493
Published online on: 26 April 2021

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Article Open Access

Silymarin inhibits proliferation of human breast cancer cells via regulation of the MAPK signaling pathway and induction of apoptosis

Sung-Hyun Kim, Gang-Sik Choo, Eun-Seon Yoo, Joong-Seok Woo, Jae-Han Lee, So-Hee Han, Soo-Hyun Jung, Hyeong-Jin Kim, Ji-Youn Jung
Article Number: 492
Published online on: 26 April 2021

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Article Open Access

Expression pattern of histone lysine‑specific demethylase 6B in gastric cancer

Shujun Wang, Yiping Wang, Hui Zhu, Miaohui Chen, Liang Zhang
Article Number: 491
Published online on: 26 April 2021

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Article Open Access

Oncolytic virotherapy with human telomerase reverse transcriptase promoter regulation enhances cytotoxic effects against gastric cancer Retraction in /10.3892/ol.2021.13061

Tomoya Kato, Mikihito Nakamori, Shuichi Matsumura, Masaki Nakamura, Toshiyasu Ojima, Hiroshi Fukuhara, Yasushi Ino, Tomoki Todo, Hiroki Yamaue
Article Number: 490
Published online on: 23 April 2021

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Article Open Access

The effectiveness of plasma miR‑33a‑5p as a predictive biomarker for the efficacy of colorectal cancer chemotherapy

Megumi Sasaki, Toshiaki Ishikawa, Megumi Ishiguro, Satoshi Okazaki, Shinichi Yamauchi, Akifumi Kikuchi, Takatoshi Matsuyama, Kenro Kawada, Masanori Tokunaga, Hiroyuki Uetake, Yusuke Kinugasa
Article Number: 489
Published online on: 22 April 2021

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Article Open Access

Upregulation of glucosamine‑phosphate N‑acetyltransferase 1 is a promising diagnostic and predictive indicator for poor survival in patients with lung adenocarcinoma

Pengyuan Zhu, Shaorui Gu, Haitao Huang, Chongjun Zhong, Zhenchuan Liu, Xin Zhang, Wenli Wang, Shiliang Xie, Kaiqin Wu, Tiancheng Lu, Yongxin Zhou
Article Number: 488
Published online on: 22 April 2021

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Article Open Access

Predictive effects of preoperative serum CA125 and AFP levels on post‑hepatectomy survival in patients with hepatitis B‑related hepatocellular carcinoma

Chuang Qin, Yan Gao, Jiangfa Li, Chao Huang, Songqing He
Article Number: 487
Published online on: 22 April 2021

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Article Open Access

Circular RNA UBAP2 promotes the proliferation of prostate cancer cells via the miR‑1244/MAP3K2 axis

Xiaodong Li, Baihetiya Azhati, Wenguang Wang, Mulati Rexiati, Chen Xing, Yujie Wang
Article Number: 486
Published online on: 21 April 2021

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Article Open Access

SPARC promotes pancreatic cancer cell proliferation and migration through autocrine secretion into the extracellular milieu

Kehua Pan, Xince Huang, Xiufen Jia
Article Number: 485
Published online on: 21 April 2021

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Article Open Access

Krüppel‑like factor 5 is upregulated and induces cell proliferation in endometrial cancer

Tetsuya Moritake, Junya Kojima, Kaiyu Kubota, Fumitoshi Terauchi, Keiichi Isaka, Hirotaka Nishi
Article Number: 484
Published online on: 21 April 2021

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Article Open Access

GAD1 expression and its methylation as indicators of malignant behavior in thymic epithelial tumors

Shiho Soejima, Kazuya Kondo, Mitsuhiro Tsuboi, Kyoka Muguruma, Bilguun Tegshee, Yukikiyo Kawakami, Koichiro Kajiura, Naoya Kawakita, Hiroaki Toba, Mitsuteru Yoshida, Hiromitsu Takizawa, Akira Tangoku
Article Number: 483
Published online on: 21 April 2021

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Article Open Access

MicroRNA‑204 plays a role as a tumor suppressor in Newcastle disease virus‑induced oncolysis in lung cancer A549 cells

Ying Liang, Wen-Yu Tian, Juan-Juan Huang, Ling-Xi Gao, Xiao-Hui Fan
Article Number: 482
Published online on: 21 April 2021

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Article

miR‑188‑5p promotes oxaliplatin resistance by targeting RASA1 in colon cancer cells

Xijia Zhu, Xishun Luo, Zhike Song, Shiyu Jiang, Xiangkai Long, Xueyuan Gao, Xinyang Xie, Laijian Zheng, Haipeng Wang
Article Number: 481
Published online on: 20 April 2021

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Correction Open Access

[Corrigendum] Chemopreventive effect of 4'‑hydroxychalcone on intestinal tumorigenesis in ApcMin mice

Qing Chen, Jiahong Lei, Jinzhe Zhou, Shaoze Ma, Qi Huang, Bujun Ge
Article Number: 480
Published online on: 20 April 2021

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Article Open Access

Oncogenic WIP1 phosphatase attenuates the DNA damage response and sensitizes p53 mutant Jurkat cells to apoptosis

Mehtap Kilic Eren, Nur Betül Kartal, Hatice Pi̇levneli̇
Article Number: 479
Published online on: 19 April 2021

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Article Open Access

Low CFB expression is independently associated with poor overall and disease‑free survival in patients with lung adenocarcinoma

Chenglu He, Ya Li, Ruixian Zhang, Jing Chen, Xingxing Feng, Yong Duan
Article Number: 478
Published online on: 19 April 2021

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Article Open Access

Incaspitolide A isolated from Carpesium cernuum L. inhibits the growth of prostate cancer cells and induces apoptosis via regulation of the PI3K/Akt/xIAP pathway

Yuanshe Huang, Jingxin Mao, Lai Zhang, Hongwei Guo, Chen Yan, Min Chen
Article Number: 477
Published online on: 19 April 2021

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Article Open Access

Curcumin induces apoptosis and inhibits the growth of adrenocortical carcinoma: Identification of potential candidate genes and pathways by transcriptome analysis

Xuemei Huang, Chunfeng Liang, Haiyan Yang, Xin Li, Xiujun Deng, Xinghuan Liang, Li Li, Zhenxing Huang, Decheng Lu, Yan Ma, Zuojie Luo
Article Number: 476
Published online on: 15 April 2021

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Article Open Access

Analysis of the association between KIN17 expression and the clinical features/prognosis of epithelial ovarian cancer, and the effects of KIN17 in SKOV3 cells

Junyu Chen, Yang Xia, Yuanqing Peng, Shan Wu, Wei Liu, Haoxian Zhang, Tian Wang, Zhaoyun Yang, Shuhua Zhao, Lijing Zhao
Article Number: 475
Published online on: 15 April 2021

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Article Open Access

MicroRNA‑1226‑3p has a tumor‑promoting role in osteosarcoma

Yong Li, Dai Song, Ting An, Jie Liu, Qian Yang, Shaokui Nan
Article Number: 474
Published online on: 15 April 2021

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Article Open Access

Novel brd4 inhibitors with a unique scaffold exhibit antitumor effects

Young Hun Kim, Minsung Kim, Ji Eun Kim, Miyoun Yoo, Heung Kyoung Lee, Chong Ock Lee, Minjin Yoo, Kwan-Young Jung, Yeongrin Kim, Sang Un Choi, Chi Hoon Park
Article Number: 473
Published online on: 14 April 2021

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Article Open Access

Long non‑coding RNA SNHG17 enhances the aggressiveness of C4‑2 human prostate cancer cells in association with β‑catenin signaling

Haijun Zhao, Haijing Dong, Peng Wang, Hai Zhu
Article Number: 472
Published online on: 13 April 2021

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Article Open Access

lncRNA PCAT6 facilitates cell proliferation and invasion via regulating the miR‑326/hnRNPA2B1 axis in liver cancer

Jun Luo, Jiaping Zheng, Weiyuan Hao, Hui Zeng, Zhewei Zhang, Guoliang Shao
Article Number: 471
Published online on: 13 April 2021

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Article Open Access

LACTB and LC3 could serve as potential biomarkers of gastric cancer to neoadjuvant chemotherapy with oxaliplatin plus S‑1

Fang Yang, Zhiqiang Yan, Wei Nie, Zeying Liu, Xingzhen Cheng, Wei Wang, Chunyan Shao, Gui Fu, Yanni Yu
Article Number: 470
Published online on: 13 April 2021

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Article Open Access

Effect of the circCDR1as/miR‑641/XIAP regulatory axis on the proliferation and invasion of the prostate cancer PC‑3 cell line

Yulin Niu, Jin Hua He, Yinglian Zhang, Kun Li, Chungen Xing
Article Number: 469
Published online on: 13 April 2021

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Article Open Access

DNA methylation variations in familial female and male breast cancer

Edoardo Abeni, Ilaria Grossi, Eleonora Marchina, Arianna Coniglio, Paolo Incardona, Pietro Cavalli, Fausto Zorzi, Pier Luigi Chiodera, Carlo Terenzio Paties, Marialuisa Crosatti, Giuseppina De Petro, Alessandro Salvi
Article Number: 468
Published online on: 12 April 2021

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Review Open Access

Current status of extended ‘D2 plus’ lymphadenectomy in advanced gastric cancer (Review)

Jing-Quan Li, Donglei He, Yue-Xiang Liang
Article Number: 467
Published online on: 12 April 2021

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Article

Comprehensive genomic analysis contrasting primary colorectal cancer and matched liver metastases

Akio Shiomi, Masatoshi Kusuhara, Takashi Sugino, Teiichi Sugiura, Keiichi Ohshima, Takeshi Nagashima, Kenichi Urakami, Masakuni Serizawa, Hideyuki Saya, Ken Yamaguchi
Article Number: 466
Published online on: 12 April 2021

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Review Open Access

Regulatory function of peroxiredoxin I on 4‑(methylnitrosamino)‑1‑(3‑pyridyl)‑1‑butanone‑induced lung cancer development (Review)

Hu-Nan Sun, Chen-Xi Ren, Yi-Xi Gong, Dan-Ping Xie, Taeho Kwon
Article Number: 465
Published online on: 12 April 2021

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Article Open Access

Upregulation of long‑noncoding RNA PTPRG‑AS1 can predict the poor prognosis and promote migration and invasion in patients with osteosarcoma

Rile Ge, Peng Yang, Bingtao Wen
Article Number: 464
Published online on: 12 April 2021

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Retraction Open Access

[Retracted] Biochanin A induces anticancer effects in SK‑Mel‑28 human malignant melanoma cells via induction of apoptosis, inhibition of cell invasion and modulation of NF‑κB and MAPK signaling pathways

Peng Xiao, Bowen Zheng, Jiaming Sun, Jia Yang
Article Number: 463
Published online on: 12 April 2021

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Correction Open Access

[Corrigendum] Ras‑related protein Rap2c promotes the migration and invasion of human osteosarcoma cells

Jinxia Wu, Wenqi Du, Xiucun Wang, Lulu Wei, Yaojie Pan, Xiaojin Wu, Jinling Zhang, Dongsheng Pei
Article Number: 462
Published online on: 12 April 2021

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Article Open Access

PKM2 regulates proliferation and apoptosis through the Hippo pathway in oral tongue squamous cell carcinoma

Jia Luo, Lei Zhang, Lijuan Guo, Sen Yang
Article Number: 461
Published online on: 11 April 2021

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Review Open Access

Role of aryl hydrocarbon receptor in central nervous system tumors: Biological and therapeutic implications (Review)

Montserrat Zaragoza‑Ojeda, Elisa Apatiga‑Vega, Francisco Arenas‑Huertero
Article Number: 460
Published online on: 11 April 2021

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Article Open Access

miR‑574‑5p mediates epithelial‑mesenchymal transition in small cell lung cancer by targeting vimentin via a competitive endogenous RNA network

Yanqin Sun, Yanmei Yi, Siyuan Gan, Ruifang Ye, Cailing Huang, Man Li, Jian Huang, Ying Guo
Article Number: 459
Published online on: 08 April 2021

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Article Open Access

Inhibition of aquaporins as a potential adjunct to breast cancer cryotherapy

Haifa Alkhalifa, Fatima Mohammed, Sebastien Taurin, Khaled Greish, Safa Taha, Salim Fredericks
Article Number: 458
Published online on: 08 April 2021

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Article

MicroRNA‑133a‑3p suppresses malignant behavior of non‑small cell lung cancer cells by negatively regulating ERBB2

Yanhui Xu, Lei Zhang, Lilong Xia, Xinhai Zhu
Article Number: 457
Published online on: 08 April 2021

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Article Open Access

Integrative analysis of the gastric cancer long non‑coding RNA‑associated competing endogenous RNA network

Yuyou Jiang, Xianqin Zhang, Li Rong, Yi Hou, Jing Song, Wanfeng Zhang, Min He, Yan Xie, Yue Li, Fangzhou Song
Article Number: 456
Published online on: 08 April 2021

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Article Open Access

lncRNA HAR1B has potential to be a predictive marker for pazopanib therapy in patients with sarcoma Corrigendum in /10.3892/ol.2021.12959

Hideharu Yamada, Masanobu Takahashi, Munenori Watanuki, Mika Watanabe, Sakura Hiraide, Ken Saijo, Keigo Komine, Chikashi Ishioka
Article Number: 455
Published online on: 08 April 2021

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Article Open Access

Prognosis of patients treated in a single neurosurgical reference centre for brain metastasis caused by dormant disseminated cells

Lorenzo Ferlini, Lorenzo Peluso, Valentina Lolli, Nicolas Gaspard, Florence Lefranc
Article Number: 454
Published online on: 08 April 2021

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Article Open Access

Daphnoretin induces reactive oxygen species‑mediated apoptosis in melanoma cells

Hui Wang, Xue Hu, Minjing Li, Zhaohai Pan, Defang Li, Qiusheng Zheng
Article Number: 453
Published online on: 08 April 2021

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Article

Ginsenoside Rg5 inhibits cancer cell migration by inhibiting the nuclear factor‑κB and erythropoietin‑producing hepatocellular receptor A2 signaling pathways

Leixin Song, Fan Yang, Zhengtao Wang, Li Yang, Yue Zhou
Article Number: 452
Published online on: 08 April 2021

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Review Open Access

Dual roles of SAMHD1 in tumor development and chemoresistance to anticancer drugs (Review)

Zhangming Chen, Jie Hu, Songcheng Ying, Aman Xu
Article Number: 451
Published online on: 08 April 2021

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Article Open Access

Excision repair cross‑complementing group 2 upregulation is a potential predictive biomarker for oral squamous cell carcinoma recurrence

Yen-Yun Wang, Pen-Tzu Fang, Chang-Wei Su, Yuk-Kwan Chen, Joh-Jong Huang, Ming-Yii Huang, Shyng-Shiou F. Yuan
Article Number: 450
Published online on: 07 April 2021

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Article Open Access

Impact of copy number variant and single nucleotide polymorphism of the programmed death‑ligand 1 gene, programmed death‑ligand 1 protein expression and therapy regimens on overall survival in a large group of Caucasian patients with non‑small cell lung carcinoma

Anna Grenda, Paweł Krawczyk, Tomasz Kucharczyk, Justyna Błach, Katarzyna Reszka, Izabela Chmielewska, Jarosław Buczkowski, Robert Kieszko, Jan Siwiec, Tomasz Kubiatowski, Aleksandra Bożyk, Kinga Krukowska, Bożena Jarosz, Iwona Paśnik, Juliusz Pankowski, Daria Świniuch, Katarzyna Stencel, Michał Gil, Kinga Lew, Rodryg Ramlau, Aleksandra Szczęsna, Sebastian Fidler, Andrzej Sieracki, Andrzej Każarnowicz, Piotr Serwatowski, Tomasz Grodzki, Janusz Milanowski
Article Number: 449
Published online on: 07 April 2021

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Article

Impact of EGFR and EGFR ligand expression on treatment response in patients with metastatic colorectal cancer

Fee Klupp, Malte Sass, Frank Bergmann, Elias Khajeh, Omid Ghamarnejad, Matthias Hassenpflug, Arianeb Mehrabi, Yakup Kulu
Article Number: 448
Published online on: 07 April 2021

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Article Open Access

Clinical value of lncRNA CCAT1 in serum extracellular vesicles as a potential biomarker for gastric cancer

Ke Xiao, Zhaogang Dong, Ding Wang, Min Liu, Juan Ding, Wendan Chen, Ziqi Shang, Congbo Yue, Yi Zhang
Article Number: 447
Published online on: 06 April 2021

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Article

Analysis of radiotherapy‑induced alteration of CD8+ T cells and PD‑L1 expression in patients with uterine cervical squamous cell carcinoma

Yasumasa Mori, Hiro Sato, Takuya Kumazawa, Tiara Bunga Mayang Permata, Yuya Yoshimoto, Kazutoshi Murata, Shin-Ei Noda, Takuya Kaminuma, Ken Ando, Takahiro Oike, Noriyuki Okonogi, Kohei Okada, Sangeeta Kakoti, Keiji Suzuki, Hayato Ikota, Hideaki Yokoo, Takashi Nakano, Tatsuya Ohno, Atsushi Shibata
Article Number: 446
Published online on: 06 April 2021

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Article Open Access

Stromal expression of cancer‑associated fibroblast‑related molecules, versican and lumican, is strongly associated with worse relapse‑free and overall survival times in patients with esophageal squamous cell carcinoma

Naoto Yamauchi, Yasuyuki Kanke, Katsuharu Saito, Hirokazu Okayama, Shoki Yamada, Shotaro Nakajima, Eisei Endo, Koji Kase, Leo Yamada, Hiroshi Nakano, Takuro Matsumoto, Hiroyuki Hanayama, Yohei Watanabe, Suguru Hayase, Motonobu Saito, Zenichiro Saze, Kosaku Mimura, Tomoyuki Momma, Shinji Oki, Yuko Hashimoto, Koji Kono
Article Number: 445
Published online on: 06 April 2021

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Article Open Access

Long non‑coding RNA HOTAIR promotes the progression of synovial sarcoma through microRNA‑126/stromal cell‑derived factor‑1 regulation

Qi Feng, Donglai Wang, Peng Guo, Zibo Zhang, Jiangang Feng
Article Number: 444
Published online on: 06 April 2021

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Article Open Access

Elevated XRCC5 expression level can promote temozolomide resistance and predict poor prognosis in glioblastoma

I-Neng Lee, Jen-Tsung Yang, Cheng Huang, Hsiu-Chen Huang, Yu-Ping Wu, Jui-Chieh Chen
Article Number: 443
Published online on: 06 April 2021

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Article Open Access

LEM domain containing 1 promotes thyroid cancer cell proliferation and migration by activating the Wnt/β‑catenin signaling pathway and epithelial‑mesenchymal transition

Min Xu, Bangyi Lin, Danni Zheng, Jialiang Wen, Wenjing Hu, Chunxue Li, Xianwei Zhang, Xiaohua Zhang, Jinmiao Qu
Article Number: 442
Published online on: 02 April 2021

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Article Open Access

Expression profiling of CPS1 in Correa's cascade and its association with gastric cancer prognosis

Xuqian Fang, Xiaoqiong Wu, Enfei Xiang, Fangxiu Luo, Qinqin Li, Qianchen Ma, Fei Yuan, Peizhan Chen
Article Number: 441
Published online on: 02 April 2021

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Article Open Access

DEK is highly expressed in breast cancer and is associated with malignant phenotype and progression

Mai-Qing Yang, Lin-Lin Bai, Zhao Wang, Lei Lei, Yi-Wen Zheng, Zhi-Han Li, Wen-Jing Huang, Chen-Chen Liu, Hong-Tao Xu
Article Number: 440
Published online on: 01 April 2021

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Review Open Access

Potential role of mitochondria in gastric cancer detection: Fission and glycolysis (Review)

Hang Yang, Yan Li, Bing Hu
Article Number: 439
Published online on: 01 April 2021

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Article Open Access

Recombinant protein TRAIL-Mu3 enhances the antitumor effects in pancreatic cancer cells by strengthening the apoptotic signaling pathway

Min Huang, Cheng Yi, Xian-Zhou Huang, Juan Yan, Li-Jia Wei, Wei-Ju Tang, Shou-Chun Chen, Ying Huang
Article Number: 438
Published online on: 01 April 2021

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Aquaporin 1 knockdown inhibits triple‑negative breast cancer cell proliferation and invasion in vitro and in vivo

Yinan Ji, Xiaoming Liao, Yi Jiang, Wei Wei, Huawei Yang
Article Number: 437
Published online on: 01 April 2021

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Ring finger 20/ring finger 40/WW domain‑containing adaptor with coiled‑coil complex interacts with p53 to regulate gene transcription in DNA damage response

Danni Meng, Kun Guo, Die Zhang, Cheng Zhao, Chuanwen Sun, Feng Zhang
Article Number: 436
Published online on: 01 April 2021

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β‑asarone suppresses HCT116 colon cancer cell proliferation and liver metastasis in part by activating the innate immune system

Min Chen, Yu-Wen Zhuang, Cun-En Wu, Hai-Yan Peng, Jun Qian, Jin-Yong Zhou
Article Number: 435
Published online on: 31 March 2021

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Epigenetic silencing of microRNA‑199a‑5p promotes the proliferation of non‑small cell lung cancer cells by increasing AKAP1 expression

Nengli Yang, Yafeng Liang, Tianqi Zhu, Yanxiao Long, Zhe Chen, Xuezheng Zhang, Liuming Jiang
Article Number: 434
Published online on: 31 March 2021

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Lentivirus‑mediated silencing of CNTN1 enhances gefitinib sensitivity by reversing epithelial‑mesenchymal transition in lung adenocarcinoma A549 cells

Chun-Sheng Hu, Jiu-Hong Huang, Dong-Lin Yang, Chuan Xu, Zhi-Gang Xu, Hong-Bo Tan, Zhong-Zhu Chen
Article Number: 433
Published online on: 31 March 2021

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Activation of GPER by E2 promotes proliferation, invasion and migration of breast cancer cells by regulating the miR‑124/CD151 pathway Retraction in /10.3892/ol.2025.15429

Huaicheng Yang, Congyu Wang, Heqiang Liao, Qi Wang
Article Number: 432
Published online on: 31 March 2021

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Siomycin A induces reactive oxygen species‑mediated cytotoxicity in ovarian cancer cells

Xiulan Shao, Fengying Zhang, Xiang Gao, Fengying Xu
Article Number: 431
Published online on: 31 March 2021

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Characterization and clinical evaluation of microsatellite instability and loss of heterozygosity in tumor‑related genes in gastric cancer

Xueyun Huo, Xiaoqin Xiao, Shuangyue Zhang, Xiaoyan Du, Changlong Li, Zhigang Bai, Zhenwen Chen
Article Number: 430
Published online on: 30 March 2021

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lncRNA LINC00473 promotes proliferation, migration, invasion and inhibition of apoptosis of non‑small cell lung cancer cells by acting as a sponge of miR‑497‑5p

Shao-Hua Xu, Yu-Hong Bo, Han-Chen Ma, Hua-Nan Zhang, Ming-Ju Shao
Article Number: 429
Published online on: 30 March 2021

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Effects of a combined therapy of bortezomib and ionizing radiation on chondrosarcoma three-dimensional spheroid cultures

Birgit Lohberger, Dietmar Glaenzer, Nicole Eck, Bibiane Steinecker-Frohnwieser, Andreas Leithner, Beate Rinner, Sylvia Kerschbaum-Gruber, Dietmar Georg
Article Number: 428
Published online on: 30 March 2021

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May-2026 Volume 31 Issue 5

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Journal Metrics

Impact Factor: 2.2

CiteScore: 4.6

CiteScore Rank: Q2: #178/415 Oncology

Source Normalized Impact per Paper (SNIP): 0.568

SCImago Journal Rank (SJR): 0.663

Article Open Access

TBX20 regulates epithelial‑mesenchymal transition, maintains tumor stemness and immune factor expression, and promotes immune escape in lung cancer

Chuncai Xu, Peng Zhou, Yanting Zhang, Lili Li, Guowen Wang
Article Number: 207
Published online on: 30 March 2026

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Silencing of small nuclear ribonucleoprotein polypeptide B inhibits the progression of esophageal squamous cell carcinoma

Haiyang Guo, Ji Zuo, Guangbing Hu, Yong Tang, Liuyi Lu, Zichen Luo, Xinrui Chen, Xiaobo Wang, Xianfei Wang
Article Number: 206
Published online on: 30 March 2026

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Prognostic and diagnostic significance of serum p53 antibody levels in patients with surgically treated pancreatic cancer

Rei Okada, Yuichiro Otsuka, Yoji Kajiwara, Yu Matsumoto, Yuko Ito, Hideaki Shimada
Article Number: 205
Published online on: 30 March 2026

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Update on the clinical features, treatment and histogenesis of combined hepatocellular-cholangiocarcinoma

Junwen Hu, Jiahao Chen, Chenglei Yang, Yapeng Qi, Jie Zhang, Rui Song, Jianhong Zhong, Bangde Xiang
Article Number: 204
Published online on: 30 March 2026

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Lung squamous cell carcinoma downregulates haptoglobin expression to inhibit M2 macrophage ferroptosis via the hemoglobin‑dependent CD163/HO‑1 pathway

Weijing Xie, Ying-Ying Lin, Guang-Hong Tan, Feng-Ying Huang
Article Number: 203
Published online on: 30 March 2026

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Immune‑imaging biomarkers: Prognostic value of splenic volume and circulating lymphocytes in upper tract urothelial carcinoma

Chien-Hsiung Lo, Kun-Che Lin, Chu-An Wang, Che-Yuan Hu, Chien-Hui Ou, Hau-Chern Jan
Article Number: 202
Published online on: 30 March 2026

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Whole‑exome sequencing unveils novel potential gene mutations involved in primary renal small cell carcinoma

Yang Wang, Lizhi Zhang, Xueyan Xia, Xiancheng Li
Article Number: 201
Published online on: 30 March 2026

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Efficacy and safety of concurrent chemoradiotherapy following neoadjuvant chemoimmunotherapy in patients with stage III NSCLC who experienced neoadjuvant failure: A real-world study

Ruoxuan Li, Luping Pan, Fujuan Zeng, Jingyu Huang, Ziye Chen, Chengyi Liu, Zhimin Zeng
Article Number: 200
Published online on: 30 March 2026

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Curcumin induces and enhances the PARP1‑mediated parthanatos in diffuse large B cell lymphoma

Yayun Wang, Ruili Qi, Xuanzhu Zhao, Hanwei Mei, Minghan Qiu, Fengting Liu, Huaqing Wang
Article Number: 199
Published online on: 30 March 2026

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Immunotherapy‑based treatment patterns and clinical outcomes across lines of therapy in microsatellite stable metastatic colorectal cancer: A real‑world study

Wen-Si Zhao, Shi-Jing Ma, Tao Zhang, De-Dong Cao
Article Number: 198
Published online on: 27 March 2026

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Efficacy and safety of blinatumomab combination therapy in high‑risk B‑cell acute lymphoblastic leukemia: A systematic review and meta‑analysis

Mei Wang, Xinlin Yu, Zhongqing Zou, Yan He, Lvlin Chen, Ying Lan
Article Number: 197
Published online on: 26 March 2026

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Schisandrin B suppresses cholangiocarcinoma by targeting the ROS/p38 MAPK/NF‑κB axis

Junhao Yang, Wenying Long, Xiaoxiao Wu, Xiaohui Yang, Qiang Hong, Shuai Wang
Article Number: 196
Published online on: 26 March 2026

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Review Open Access

Role of non‑coding RNAs in O6‑methylguanine‑DNA methyltransferase‑positive glioblastoma (Review)

Yunyan Guo, Jun Guo, Wenyan Xiao, Yanxin Lu
Article Number: 195
Published online on: 26 March 2026

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Case Report Open Access

A rare case of uterine carcinosarcoma in a 21‑year‑old woman with hereditary breast and ovarian cancer syndrome: A case report

Yasushi Iida, Ayane Kosuge, Yoko Saito, Taichi Irie, Jun Matsushima, Makoto Iizuka, Satoshi Takakura
Article Number: 194
Published online on: 26 March 2026

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Metformin enhances survival with immune checkpoint inhibitors in cancer patients: A meta‑analysis

Yu Qiao, Huiyao Li, Yanping Feng, Shuai Liang, Dong Hua
Article Number: 193
Published online on: 26 March 2026

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Review Open Access

Dual role of exosomes in pancreatic cancer: Underlying mechanisms and research advances (Review)

Zhao Guo, Qingfeng Liu
Article Number: 192
Published online on: 26 March 2026

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Pomegranate peel‑derived exosome‑like nanoparticles: A discarded treasure trove for colorectal cancer treatment

Yifei Dong, Qin Yuan, Chao Chen, Zheng Zhang
Article Number: 191
Published online on: 26 March 2026

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SETD4 as a marker of disease burden and treatment response in childhood acute lymphoblastic leukemia

Luis Augusto Muniz Telles, Mariana Braccialli De Loyola, Luis Henrique Toshihiro Sakamoto, Doralina Do Amaral Ramos Rabello, Andrea Barretto Motoyama, Fabio Pittella‑Silva
Article Number: 190
Published online on: 24 March 2026

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Case Report Open Access

Comprehensive treatment for two patients with small cell neuroendocrine carcinoma of the liver: A case report and literature review

Ruizeng Feng, Hao Wang, Yang Zhao, Xue Zhang, Hongfang Tuo, Xing Xu
Article Number: 189
Published online on: 24 March 2026

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Expression of Concern Open Access

[Expression of Concern] Insulin‑like growth factor‑1 receptor knockdown enhances radiosensitivity via the HIF‑1α pathway and attenuates ATM/H2AX/53BP1 DNA repair activation in human lung squamous carcinoma cells

Xiaoxing Liu, Haiyan Chen, Xin Xu, Ming Ye, Hongbin Cao, Lei Xu, Yanli Hou, Jianmin Tang, Di Zhou, Yongrui Bai, Xiumei Ma
Article Number: 188
Published online on: 23 March 2026

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Case Report Open Access

Painless perianal mucinous adenocarcinoma: A case report and literature review

Jianping Shi, Xiaoying Wang, Junjie Yang, Guofeng Li, Yanjie Zhang
Article Number: 187
Published online on: 20 March 2026

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Methylglyoxal‑derived glycated albumin enhances the stemness potential of invasive ductal carcinoma‑derived breast cancer stem‑like cell line KAIMRC1

Maram Aldawood, Mariam K. Alamoudi, Abdulmonem A. Alsaleh, Nouf Alharbi, Sarah Huwaizi, Rehab Alroshody, Rizwan Ali, Rafa Almeer, Sabine Matou-Nasri
Article Number: 186
Published online on: 19 March 2026

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Proteomic and immunocytochemical analyses of squamous components in two‑ and three‑dimensional‑cultured pancreatic ductal adenocarcinoma cell lines

Yuuki Shichi, Hiroki Tsumoto, Masakazu Fujiwara, Keisuke Nonaka, Yasuko Hasegawa, Seiichi Shinji, Hirofumi Rokutan, Kimimasa Takahashi, Tomio Arai, Yuri Miura, Toshiyuki Ishiwata
Article Number: 185
Published online on: 19 March 2026

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Review Open Access

Metabolic reprogramming‑a breakthrough point in overcoming resistance to BRAF mutant melanoma targeted therapy (Review)

Xueting Zhao, Fang Chen, Huibin Li
Article Number: 184
Published online on: 18 March 2026

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Efficacy of induction chemotherapy combined with standard chemoradiotherapy vs. standard chemoradiotherapy monotherapy in locally advanced cervical cancer:  A systematic review and meta‑analysis

Xinyu Lu, Yaxu Su, Wentong Xu, Tianyou Tang, Fengjuan Zhou, Dehong Yu, Yilong Guo, Yong Xin
Article Number: 183
Published online on: 18 March 2026

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Predictive performance of image processing techniques in the diagnosis of bone metastasis: A meta‑analysis of a confusion matrix

Yupeng Hu, Wen Liao, Ying Er, Qifeng Tao
Article Number: 182
Published online on: 18 March 2026

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Expression of Concern Open Access

[Expression of Concern] Effect of overexpression of HOX genes on its invasive tendency in cerebral glioma 

Yun-Bao Guo, Yi-Meng Shao, Jing Chen, Song-Bai Xu, Xing-Dong Zhang, Mao-Ren Wang, Hai-Yan Liu
Article Number: 181
Published online on: 18 March 2026

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Optimizing safety and efficacy in radiotherapy for external auditory canal cancer

Yuto Imai, Taiki Takaoka, Natsuo Tomita, Mayu Kuno, Akifumi Miyakawa, Chikao Sugie, Shinya Otsuka, Kaoru Uchiyama, Dai Okazaki, Masanari Niwa, Akira Torii, Nozomi Kita, Masanosuke Oguri, Seiya Takano, Takuma Matoba, Daisuke Kawakita, Shinichi Iwasaki, Akio Hiwatashi
Article Number: 180
Published online on: 17 March 2026

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Correction Open Access

[Corrigendum] Inhibition of microRNA‑221‑5p induces osteogenic differentiation by directly targeting smad3 in myeloma bone disease mesenchymal stem cells   

Fang-Yi Fan, Rui Deng, Si-Han Lai, Qin Wen, Yunjing Zeng, Lei Gao, Yao Liu, Peiyan Kong, Jiangfan Zhong, Yi Su, Xi Zhang
Article Number: 179
Published online on: 17 March 2026

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Article

DNA hypermethylation of nonspecific cytotoxic cell receptor protein 1 and poor prognosis of pancreatic cancer

Mai Nakamura, Teruki Hagiwara, Kazuhiko Yamada, Toru Igari, Yuki Fukumura, Akio Saiura, Nobuyuki Takemura, Norihiro Kokudo, Yuki I. Kawamura
Article Number: 178
Published online on: 17 March 2026

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Case Report

Limbic encephalitis associated with anti‑Hu antibody induced by atezolizumab treatment for small cell lung cancer: A case report

Zhaohui Li, Hanping Wang
Article Number: 177
Published online on: 17 March 2026

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Case Report

Administration of tirabrutinib suspension in a patient with primary central nervous system lymphoma: A case report

Takeo Yasu, Hiroaki Ohta, Yoshito Gando, Masayuki Kobayashi
Article Number: 176
Published online on: 17 March 2026

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Review

Postoperative complications in patients with chemotherapy‑induced acute myeloid leukemia (Review)

Cen-Hung Lin, Hang-Tsung Liu, Ching-Hua Hsieh
Article Number: 175
Published online on: 17 March 2026

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Retraction Open Access

[Retracted] MicroRNA-27a functions as an oncogene in human osteosarcoma by targeting CCNG1  

Tao Lin, Quanping Ma, Yuefeng Zhang, Hongfei Zhang, Jiapeng Yan, Changhong Gao
Article Number: 174
Published online on: 16 March 2026

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Case Report Open Access

Bone marrow metastasis from gastric cancer: A case report

Xinyi Wei, Wenli Dai, Pengyi Deng
Article Number: 173
Published online on: 12 March 2026

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Article

Effect of apalutamide dosage on the incidence of cutaneous adverse events and prostate‑specific antigen reduction in patients with prostate cancer

Takuya Matsuyama, Michio Kimura, Makiko Go, Shiori Yamada, Mitsuhiro Nishimura, Hiromi Murase, Rina Matsuyama, Eiseki Usami
Article Number: 172
Published online on: 12 March 2026

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Correction Open Access

[Corrigendum] A potential diagnostic marker for ovarian cancer: Involvement of the histone acetyltransferase, human males absent on the first  

Ning Liu, Rui Zhang, Xiaoming Zhao, Jiaming Su, Xiaolei Bian, Jinsong Ni, Ying Yue, Yong Cai, Jingji Jin
Article Number: 171
Published online on: 12 March 2026

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Article Open Access

Skeletal muscle index at the third lumbar vertebra/BMI are positively associated with 1‑year overall survival in male patients with hepatocellular carcinoma treated with immune checkpoint inhibitors

Juan Li, Yang Wang, Songtao Liu, Huili Wu, Xin Hua, Qinghua Meng
Article Number: 170
Published online on: 11 March 2026

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Correction Open Access

[Corrigendum] Inhibition of Rac1 reverses enzalutamide resistance in castration‑resistant prostate cancer

Xiaoliang Chen, Lili Yin, Gan Qiao, Yanhua Li, Baoyuan Li, Yunfeng Bai, Feng Feng
Article Number: 169
Published online on: 11 March 2026

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Article Open Access

Integrated proteomic and metabolomic profiling reveals molecular signatures underlying invasiveness in non‑functioning pituitary adenomas

Jianyao Mao, Xi Chen, Wentao Zheng, Bosen Liu, Zhangyu Li, Yukui Li, Ping Zhong, Sifang Chen, Guowei Tan, Chen Wang, Jinli Sun
Article Number: 168
Published online on: 10 March 2026

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Retraction Open Access

[Retracted] MSK1 downregulation is associated with neuronal and astrocytic apoptosis following subarachnoid hemorrhage in rats

Bo Ning, Geng Guo, Hong Liu, Lei Ning, Bao-Liang Sun, Zhen Li, Shuo Wang, Zheng-Wen Lv, Cun-Dong Fan
Article Number: 167
Published online on: 09 March 2026

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Article Open Access

CANT1 as a novel prognostic biomarker in triple‑negative breast cancer

Doğan Bayram, Aysel Çolak, Şefi̇ka Karabulut, Sema Nur Özsan Çelebi̇, Emre Hafizoğlu, Duri̇ye Özer Türkay, Öznur Bal, Efnan Algin, Şebnem Yücel, Mehmet Ali̇ Nahi̇t Şendur, Burak Ci̇velek, Gökhan Uçar
Article Number: 166
Published online on: 09 March 2026

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Article Open Access

RNA methyltransferase NSUN2 enhances vasculogenic mimicry and malignant progression of cervical cancer through upregulation of MMP‑9

Jun Luo, Guang Li, Mei Ye, Xiaoqing Xu, Mengwen Qi, Jian Huang, Kong Shan, Lili Qu, Hengchuan Shi
Article Number: 165
Published online on: 06 March 2026

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Article Open Access

Long-term effects of using pegylated recombinant human granulocyte colony-stimulating factor following chemotherapy: A real-world study on patients with ovarian cancer

Weimin Zhang, Nenghuan Tang, Yiyue Wang, Tiantian Feng, Min Yong, Yuhua Zeng
Article Number: 164
Published online on: 06 March 2026

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Case Report Open Access

Primary clear‑cell carcinoma of the liver with gastric antrum metastasis: Integrated management with targeted therapy, immunotherapy and salvage surgery: A case report

Lianshan Zhan, Qianwei Li, Tian Tian, Long Wang
Article Number: 163
Published online on: 06 March 2026

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Case Report

Diagnostic and surgical challenges of a lymph node metastasis from occult gastric cancer mimicking a pancreatic head tumor: A case report

Takuya Ando, Yuki Hirose, Kazuyasu Takizawa, Jun Sakata, Hirosuke Ishikawa, Shun Abe, Yusuke Kawachi, Mae Nakano, Hiroshi Ichikawa, Yoshifumi Shimada, Toshifumi Wakai
Article Number: 162
Published online on: 05 March 2026

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Article Open Access

Integrated analysis of therapeutic strategies and prognostic factors in advanced lung adenocarcinoma: Retrospective study with emphasis on gene assays, multimodality treatment approaches and predictive machine learning models

Shingchern You, Shiuan-Wen Chen, Irene Chen, Wei-Teing Chen
Article Number: 161
Published online on: 05 March 2026

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Review Open Access

Tumor‑muscle communication in cancer‑associated cachexia (Review)

Lily Berríos‑Contreras, Matías Meza‑Valenzuela, Nelson Brown, Claudio Valenzuela, Silvia Busquets, Francisco Javier López‑Soriano, Andrew Fg Quest, Rodrigo Moore‑Carrasco
Article Number: 160
Published online on: 05 March 2026

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Case Report Open Access

Pseudocirrhosis due to liver metastasis from lung squamous cell carcinoma: A case report

Qian Liu, Yufeng Lu, Dan Wang, Juan Yao, Ying Liu
Article Number: 159
Published online on: 04 March 2026

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Case Report

Malignant mesothelioma of the tunica vaginalis testis: A case report

Yuanchen Lu, Junjun Miu, Zhongru Fan, Zheng Zhi, Lei He, Junpeng Deng, Xianhua Shao, Jingqi Hua, Yichen Qian, Jianjun Xie
Article Number: 158
Published online on: 04 March 2026

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Case Report Open Access

Metachronous primary non‑small cell lung cancer and mucinous tubular and spindle cell carcinoma of the left kidney: A case report

Jin-Xia Zhao, Wei Zhu, Jie-Bin Pan, Peng-Fei Sun
Article Number: 157
Published online on: 04 March 2026

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Article Open Access

Telomere maintenance mechanisms are activated in ganglioneuroblastoma and ganglioneuroma

Motoki Sugawara, Masayuki Haruta, Miki Ohira, Jesmin Akter, Ritsuko Onuki, Ryuichi P. Sugino, Kiyohiro Ando, Atsuko Nakazawa, Hajime Okita, Tetsuya Takimoto, Tomoko Iehara, Tsugumichi Koshinaga, Shuichiro Uehara, Takehiko Kamijo
Article Number: 156
Published online on: 04 March 2026

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Article Open Access

Leucovorin enhances curcumin‑induced inhibition of cell viability and ferroptosis in colorectal cancer cells

Rui Meng, Qianqian Xu, Xue Wang, Hongwei Xu
Article Number: 155
Published online on: 04 March 2026

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Correction Open Access

[Corrigendum] Effects of 17‑allylamino‑17‑demethoxygeldanamycin on the induction of apoptosis and cell cycle arrest in HCT‑116  cells

Xuerong Zhao, Jianping Wang, Lijun Xiao, Qian Xu, Enhong Zhao, Xin Zheng, Huachuan Zheng, Shuang Zhao, Shi Ding
Article Number: 154
Published online on: 03 March 2026

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Review

Application of carbonic anhydrase IX‑targeted radiopharmaceuticals in the diagnosis and treatment of clear cell renal cell carcinoma (Review)

Min Wang, Yuqin Li, Wenbo Yang, Bin Liu
Article Number: 153
Published online on: 02 March 2026

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Review Open Access

Targeting ICMT: A promising strategy in cancer treatment (Review)

Jinghong Hu, Ying Xiao, Jingyi Tang
Article Number: 152
Published online on: 02 March 2026

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Review Open Access

Orchestrating organotropism: miRNA‑driven mechanisms of site‑specific metastasis in triple‑negative breast cancer (Review)

Rigude Bu, Liu Bo
Article Number: 151
Published online on: 02 March 2026

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Retraction Open Access

[Retracted] EGFR expression is associated with cytoplasmic staining of CXCR4 and predicts poor prognosis in triple‑negative breast carcinomas

Rong-Hui Li, Wen-He Huang, Jun-Dong Wu, Cai-Wen Du, Guo-Jun Zhang
Article Number: 150
Published online on: 02 March 2026

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Case Report Open Access

Adenoid cystic carcinoma of the vulva: A case report and literature review

Zhiying Ding, Guiqiu Liu, Chuanshan Zhang
Article Number: 149
Published online on: 26 February 2026

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Journal Cover
June-2026 Volume 31 Issue 6

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Journal Metrics

Impact Factor: 2.2

CiteScore: 4.6

CiteScore Rank: Q2: #178/415 Oncology

Source Normalized Impact per Paper (SNIP): 0.568

SCImago Journal Rank (SJR): 0.663

Review Open Access

Lactylation enzymes in cancer: Mechanisms and novel therapeutic approaches (Review)

Guiyang Tang, Hanrong Zuo, Rou Long, Chaohui Zhang, Yufan Lv, Xinyu Luo, Jieya Qiu, Jianhong Zuo
Article Number: 217
Published online on: 02 April 2026

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Case Report Open Access

Comprehensive treatment for intracranial invasive sinonasal intestinal‑type adenocarcinoma with a focus on radiotherapy dosage and immunological combination therapy: A case report

Lianlian Yang, Qian Zhao, Fang Yi, Wenyan Guo, Qiongwen Zhang, Song Zhou, Dong Li, Zhihui Li
Article Number: 216
Published online on: 02 April 2026

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Review Open Access

Biological basis and clinical translation prospects of circulating cell‑free DNA in precision management of breast cancer (Review)

Li-Zhuang Fan, Ai-Lan Xu, Ya-Ru Xu, Luo Yang, Fang Yuan, Xin Nie
Article Number: 215
Published online on: 02 April 2026

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Review Open Access

Cutting‑edge advances in endocrine therapy for breast cancer (Review)

Yumei Dong, Lihua Shao, Qiong Li, Yuexiao Qi, Tingting Liu, Shihong Wei, Haiyan Qi
Article Number: 214
Published online on: 02 April 2026

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Case Report Open Access

Rapidly progressive squamous lung cancer with peripheral blood eosinophilia in a 25-year-old woman: A case report

Mingrui Zhang, Huanfang Fan, Chunxia Sun, Dehui Li, Jiangya Gan, Yun He, Jiaqi Chen
Article Number: 213
Published online on: 02 April 2026

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Article Open Access

Dynamic curve type serves as an effective tool for the diagnosis of benign or malignant non‑mass enhancements on breast MRI

Tara Farooq Kareem, Areege Mustafa Kamal, Munawar Al Nakash
Article Number: 212
Published online on: 02 April 2026

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Article Open Access

Clinical predictors of leptomeningeal metastasis from lung adenocarcinoma based on retrospective analysis

Yunyun Lu, Yi Lu, Yueyue Zhang, Hongyuan Du, Xuan Cao, Dexi Jin, Guofu Chen, Xiaohui Yang
Article Number: 211
Published online on: 01 April 2026

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Expression of Concern Open Access

[Expression of Concern] Delphinidin induces cell cycle arrest and apoptosis in HER‑2 positive breast cancer cell lines by regulating the NF‑κB and MAPK signaling pathways

Ailin Wu, Yanfeng Zhu, Bin Han, Jiayuan Peng, Xiaomin Deng, Wei Chen, Jingchang Du, Yu Ou, Xiaoli Peng, Xiaoping Yu
Article Number: 210
Published online on: 01 April 2026

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Case Report Open Access

Primary thoracic synovial sarcoma in a 45‑year‑old male: A case report and literature review

Baolei Liang, Jichun Zhang, Mingqiang Shen, Cuilian Li, Mingxiao Hou, Yunen Liu, Qingyong Cai
Article Number: 209
Published online on: 31 March 2026

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Expression of Concern Open Access

[Expression of Concern] Pseudomonas aeruginosa‑mannose‑sensitive hema-gglutinin inhibits proliferation and induces apoptosis in a caspase‑dependent manner in human bladder cancer cell lines

Yi-Ping Zhu, Xiao-Jie Bian, Ding-Wei Ye, Xu-Dong Yao, Shi-Lin Zhang, Bo Dai, Yi-Jun Shen
Article Number: 208
Published online on: 31 March 2026

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