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Print ISSN: 1792-1074 Online ISSN: 1792-1082
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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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Journal Cover
June-2021 Volume 21 Issue 6

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Journal Metrics

Impact Factor: 2.2

CiteScore: 4.6

CiteScore Rank: Q2: #178/415 Oncology

Source Normalized Impact per Paper (SNIP): 0.568

SCImago Journal Rank (SJR): 0.663

Article Open Access

MicroRNA‑665 regulates the proliferation, apoptosis and adhesion of gastric cancer cells by binding to cadherin 3

Xinhui Fang, Yangqiu Bai, Lida Zhang, Songze Ding
Article Number: 494
Published online on: 26 April 2021

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Article Open Access

HOXA11‑AS induces cisplatin resistance by modulating the microRNA‑98/PBX3 axis in nasopharyngeal carcinoma

Haineng Li, Jia Huang, Sa Yu, Hangbo Li, Yan Zhou, Qingwei Wu
Article Number: 493
Published online on: 26 April 2021

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Article Open Access

Silymarin inhibits proliferation of human breast cancer cells via regulation of the MAPK signaling pathway and induction of apoptosis

Sung-Hyun Kim, Gang-Sik Choo, Eun-Seon Yoo, Joong-Seok Woo, Jae-Han Lee, So-Hee Han, Soo-Hyun Jung, Hyeong-Jin Kim, Ji-Youn Jung
Article Number: 492
Published online on: 26 April 2021

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Article Open Access

Expression pattern of histone lysine‑specific demethylase 6B in gastric cancer

Shujun Wang, Yiping Wang, Hui Zhu, Miaohui Chen, Liang Zhang
Article Number: 491
Published online on: 26 April 2021

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Article Open Access

Oncolytic virotherapy with human telomerase reverse transcriptase promoter regulation enhances cytotoxic effects against gastric cancer Retraction in /10.3892/ol.2021.13061

Tomoya Kato, Mikihito Nakamori, Shuichi Matsumura, Masaki Nakamura, Toshiyasu Ojima, Hiroshi Fukuhara, Yasushi Ino, Tomoki Todo, Hiroki Yamaue
Article Number: 490
Published online on: 23 April 2021

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Article Open Access

The effectiveness of plasma miR‑33a‑5p as a predictive biomarker for the efficacy of colorectal cancer chemotherapy

Megumi Sasaki, Toshiaki Ishikawa, Megumi Ishiguro, Satoshi Okazaki, Shinichi Yamauchi, Akifumi Kikuchi, Takatoshi Matsuyama, Kenro Kawada, Masanori Tokunaga, Hiroyuki Uetake, Yusuke Kinugasa
Article Number: 489
Published online on: 22 April 2021

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Article Open Access

Upregulation of glucosamine‑phosphate N‑acetyltransferase 1 is a promising diagnostic and predictive indicator for poor survival in patients with lung adenocarcinoma

Pengyuan Zhu, Shaorui Gu, Haitao Huang, Chongjun Zhong, Zhenchuan Liu, Xin Zhang, Wenli Wang, Shiliang Xie, Kaiqin Wu, Tiancheng Lu, Yongxin Zhou
Article Number: 488
Published online on: 22 April 2021

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Article Open Access

Predictive effects of preoperative serum CA125 and AFP levels on post‑hepatectomy survival in patients with hepatitis B‑related hepatocellular carcinoma

Chuang Qin, Yan Gao, Jiangfa Li, Chao Huang, Songqing He
Article Number: 487
Published online on: 22 April 2021

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Article Open Access

Circular RNA UBAP2 promotes the proliferation of prostate cancer cells via the miR‑1244/MAP3K2 axis

Xiaodong Li, Baihetiya Azhati, Wenguang Wang, Mulati Rexiati, Chen Xing, Yujie Wang
Article Number: 486
Published online on: 21 April 2021

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Article Open Access

SPARC promotes pancreatic cancer cell proliferation and migration through autocrine secretion into the extracellular milieu

Kehua Pan, Xince Huang, Xiufen Jia
Article Number: 485
Published online on: 21 April 2021

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Article Open Access

Krüppel‑like factor 5 is upregulated and induces cell proliferation in endometrial cancer

Tetsuya Moritake, Junya Kojima, Kaiyu Kubota, Fumitoshi Terauchi, Keiichi Isaka, Hirotaka Nishi
Article Number: 484
Published online on: 21 April 2021

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Article Open Access

GAD1 expression and its methylation as indicators of malignant behavior in thymic epithelial tumors

Shiho Soejima, Kazuya Kondo, Mitsuhiro Tsuboi, Kyoka Muguruma, Bilguun Tegshee, Yukikiyo Kawakami, Koichiro Kajiura, Naoya Kawakita, Hiroaki Toba, Mitsuteru Yoshida, Hiromitsu Takizawa, Akira Tangoku
Article Number: 483
Published online on: 21 April 2021

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Article Open Access

MicroRNA‑204 plays a role as a tumor suppressor in Newcastle disease virus‑induced oncolysis in lung cancer A549 cells

Ying Liang, Wen-Yu Tian, Juan-Juan Huang, Ling-Xi Gao, Xiao-Hui Fan
Article Number: 482
Published online on: 21 April 2021

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Article

miR‑188‑5p promotes oxaliplatin resistance by targeting RASA1 in colon cancer cells

Xijia Zhu, Xishun Luo, Zhike Song, Shiyu Jiang, Xiangkai Long, Xueyuan Gao, Xinyang Xie, Laijian Zheng, Haipeng Wang
Article Number: 481
Published online on: 20 April 2021

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Correction Open Access

[Corrigendum] Chemopreventive effect of 4'‑hydroxychalcone on intestinal tumorigenesis in ApcMin mice

Qing Chen, Jiahong Lei, Jinzhe Zhou, Shaoze Ma, Qi Huang, Bujun Ge
Article Number: 480
Published online on: 20 April 2021

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Article Open Access

Oncogenic WIP1 phosphatase attenuates the DNA damage response and sensitizes p53 mutant Jurkat cells to apoptosis

Mehtap Kilic Eren, Nur Betül Kartal, Hatice Pi̇levneli̇
Article Number: 479
Published online on: 19 April 2021

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Article Open Access

Low CFB expression is independently associated with poor overall and disease‑free survival in patients with lung adenocarcinoma

Chenglu He, Ya Li, Ruixian Zhang, Jing Chen, Xingxing Feng, Yong Duan
Article Number: 478
Published online on: 19 April 2021

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Article Open Access

Incaspitolide A isolated from Carpesium cernuum L. inhibits the growth of prostate cancer cells and induces apoptosis via regulation of the PI3K/Akt/xIAP pathway

Yuanshe Huang, Jingxin Mao, Lai Zhang, Hongwei Guo, Chen Yan, Min Chen
Article Number: 477
Published online on: 19 April 2021

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Article Open Access

Curcumin induces apoptosis and inhibits the growth of adrenocortical carcinoma: Identification of potential candidate genes and pathways by transcriptome analysis

Xuemei Huang, Chunfeng Liang, Haiyan Yang, Xin Li, Xiujun Deng, Xinghuan Liang, Li Li, Zhenxing Huang, Decheng Lu, Yan Ma, Zuojie Luo
Article Number: 476
Published online on: 15 April 2021

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Article Open Access

Analysis of the association between KIN17 expression and the clinical features/prognosis of epithelial ovarian cancer, and the effects of KIN17 in SKOV3 cells

Junyu Chen, Yang Xia, Yuanqing Peng, Shan Wu, Wei Liu, Haoxian Zhang, Tian Wang, Zhaoyun Yang, Shuhua Zhao, Lijing Zhao
Article Number: 475
Published online on: 15 April 2021

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Article Open Access

MicroRNA‑1226‑3p has a tumor‑promoting role in osteosarcoma

Yong Li, Dai Song, Ting An, Jie Liu, Qian Yang, Shaokui Nan
Article Number: 474
Published online on: 15 April 2021

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Article Open Access

Novel brd4 inhibitors with a unique scaffold exhibit antitumor effects

Young Hun Kim, Minsung Kim, Ji Eun Kim, Miyoun Yoo, Heung Kyoung Lee, Chong Ock Lee, Minjin Yoo, Kwan-Young Jung, Yeongrin Kim, Sang Un Choi, Chi Hoon Park
Article Number: 473
Published online on: 14 April 2021

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Article Open Access

Long non‑coding RNA SNHG17 enhances the aggressiveness of C4‑2 human prostate cancer cells in association with β‑catenin signaling

Haijun Zhao, Haijing Dong, Peng Wang, Hai Zhu
Article Number: 472
Published online on: 13 April 2021

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Article Open Access

lncRNA PCAT6 facilitates cell proliferation and invasion via regulating the miR‑326/hnRNPA2B1 axis in liver cancer

Jun Luo, Jiaping Zheng, Weiyuan Hao, Hui Zeng, Zhewei Zhang, Guoliang Shao
Article Number: 471
Published online on: 13 April 2021

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Article Open Access

LACTB and LC3 could serve as potential biomarkers of gastric cancer to neoadjuvant chemotherapy with oxaliplatin plus S‑1

Fang Yang, Zhiqiang Yan, Wei Nie, Zeying Liu, Xingzhen Cheng, Wei Wang, Chunyan Shao, Gui Fu, Yanni Yu
Article Number: 470
Published online on: 13 April 2021

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Article Open Access

Effect of the circCDR1as/miR‑641/XIAP regulatory axis on the proliferation and invasion of the prostate cancer PC‑3 cell line

Yulin Niu, Jin Hua He, Yinglian Zhang, Kun Li, Chungen Xing
Article Number: 469
Published online on: 13 April 2021

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Article Open Access

DNA methylation variations in familial female and male breast cancer

Edoardo Abeni, Ilaria Grossi, Eleonora Marchina, Arianna Coniglio, Paolo Incardona, Pietro Cavalli, Fausto Zorzi, Pier Luigi Chiodera, Carlo Terenzio Paties, Marialuisa Crosatti, Giuseppina De Petro, Alessandro Salvi
Article Number: 468
Published online on: 12 April 2021

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Review Open Access

Current status of extended ‘D2 plus’ lymphadenectomy in advanced gastric cancer (Review)

Jing-Quan Li, Donglei He, Yue-Xiang Liang
Article Number: 467
Published online on: 12 April 2021

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Article

Comprehensive genomic analysis contrasting primary colorectal cancer and matched liver metastases

Akio Shiomi, Masatoshi Kusuhara, Takashi Sugino, Teiichi Sugiura, Keiichi Ohshima, Takeshi Nagashima, Kenichi Urakami, Masakuni Serizawa, Hideyuki Saya, Ken Yamaguchi
Article Number: 466
Published online on: 12 April 2021

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Review Open Access

Regulatory function of peroxiredoxin I on 4‑(methylnitrosamino)‑1‑(3‑pyridyl)‑1‑butanone‑induced lung cancer development (Review)

Hu-Nan Sun, Chen-Xi Ren, Yi-Xi Gong, Dan-Ping Xie, Taeho Kwon
Article Number: 465
Published online on: 12 April 2021

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Article Open Access

Upregulation of long‑noncoding RNA PTPRG‑AS1 can predict the poor prognosis and promote migration and invasion in patients with osteosarcoma

Rile Ge, Peng Yang, Bingtao Wen
Article Number: 464
Published online on: 12 April 2021

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Retraction Open Access

[Retracted] Biochanin A induces anticancer effects in SK‑Mel‑28 human malignant melanoma cells via induction of apoptosis, inhibition of cell invasion and modulation of NF‑κB and MAPK signaling pathways

Peng Xiao, Bowen Zheng, Jiaming Sun, Jia Yang
Article Number: 463
Published online on: 12 April 2021

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Correction Open Access

[Corrigendum] Ras‑related protein Rap2c promotes the migration and invasion of human osteosarcoma cells

Jinxia Wu, Wenqi Du, Xiucun Wang, Lulu Wei, Yaojie Pan, Xiaojin Wu, Jinling Zhang, Dongsheng Pei
Article Number: 462
Published online on: 12 April 2021

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Article Open Access

PKM2 regulates proliferation and apoptosis through the Hippo pathway in oral tongue squamous cell carcinoma

Jia Luo, Lei Zhang, Lijuan Guo, Sen Yang
Article Number: 461
Published online on: 11 April 2021

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Review Open Access

Role of aryl hydrocarbon receptor in central nervous system tumors: Biological and therapeutic implications (Review)

Montserrat Zaragoza‑Ojeda, Elisa Apatiga‑Vega, Francisco Arenas‑Huertero
Article Number: 460
Published online on: 11 April 2021

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Article Open Access

miR‑574‑5p mediates epithelial‑mesenchymal transition in small cell lung cancer by targeting vimentin via a competitive endogenous RNA network

Yanqin Sun, Yanmei Yi, Siyuan Gan, Ruifang Ye, Cailing Huang, Man Li, Jian Huang, Ying Guo
Article Number: 459
Published online on: 08 April 2021

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Article Open Access

Inhibition of aquaporins as a potential adjunct to breast cancer cryotherapy

Haifa Alkhalifa, Fatima Mohammed, Sebastien Taurin, Khaled Greish, Safa Taha, Salim Fredericks
Article Number: 458
Published online on: 08 April 2021

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Article

MicroRNA‑133a‑3p suppresses malignant behavior of non‑small cell lung cancer cells by negatively regulating ERBB2

Yanhui Xu, Lei Zhang, Lilong Xia, Xinhai Zhu
Article Number: 457
Published online on: 08 April 2021

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Article Open Access

Integrative analysis of the gastric cancer long non‑coding RNA‑associated competing endogenous RNA network

Yuyou Jiang, Xianqin Zhang, Li Rong, Yi Hou, Jing Song, Wanfeng Zhang, Min He, Yan Xie, Yue Li, Fangzhou Song
Article Number: 456
Published online on: 08 April 2021

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Article Open Access

lncRNA HAR1B has potential to be a predictive marker for pazopanib therapy in patients with sarcoma Corrigendum in /10.3892/ol.2021.12959

Hideharu Yamada, Masanobu Takahashi, Munenori Watanuki, Mika Watanabe, Sakura Hiraide, Ken Saijo, Keigo Komine, Chikashi Ishioka
Article Number: 455
Published online on: 08 April 2021

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Article Open Access

Prognosis of patients treated in a single neurosurgical reference centre for brain metastasis caused by dormant disseminated cells

Lorenzo Ferlini, Lorenzo Peluso, Valentina Lolli, Nicolas Gaspard, Florence Lefranc
Article Number: 454
Published online on: 08 April 2021

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Article Open Access

Daphnoretin induces reactive oxygen species‑mediated apoptosis in melanoma cells

Hui Wang, Xue Hu, Minjing Li, Zhaohai Pan, Defang Li, Qiusheng Zheng
Article Number: 453
Published online on: 08 April 2021

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Article

Ginsenoside Rg5 inhibits cancer cell migration by inhibiting the nuclear factor‑κB and erythropoietin‑producing hepatocellular receptor A2 signaling pathways

Leixin Song, Fan Yang, Zhengtao Wang, Li Yang, Yue Zhou
Article Number: 452
Published online on: 08 April 2021

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Review Open Access

Dual roles of SAMHD1 in tumor development and chemoresistance to anticancer drugs (Review)

Zhangming Chen, Jie Hu, Songcheng Ying, Aman Xu
Article Number: 451
Published online on: 08 April 2021

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Article Open Access

Excision repair cross‑complementing group 2 upregulation is a potential predictive biomarker for oral squamous cell carcinoma recurrence

Yen-Yun Wang, Pen-Tzu Fang, Chang-Wei Su, Yuk-Kwan Chen, Joh-Jong Huang, Ming-Yii Huang, Shyng-Shiou F. Yuan
Article Number: 450
Published online on: 07 April 2021

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Article Open Access

Impact of copy number variant and single nucleotide polymorphism of the programmed death‑ligand 1 gene, programmed death‑ligand 1 protein expression and therapy regimens on overall survival in a large group of Caucasian patients with non‑small cell lung carcinoma

Anna Grenda, Paweł Krawczyk, Tomasz Kucharczyk, Justyna Błach, Katarzyna Reszka, Izabela Chmielewska, Jarosław Buczkowski, Robert Kieszko, Jan Siwiec, Tomasz Kubiatowski, Aleksandra Bożyk, Kinga Krukowska, Bożena Jarosz, Iwona Paśnik, Juliusz Pankowski, Daria Świniuch, Katarzyna Stencel, Michał Gil, Kinga Lew, Rodryg Ramlau, Aleksandra Szczęsna, Sebastian Fidler, Andrzej Sieracki, Andrzej Każarnowicz, Piotr Serwatowski, Tomasz Grodzki, Janusz Milanowski
Article Number: 449
Published online on: 07 April 2021

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Article

Impact of EGFR and EGFR ligand expression on treatment response in patients with metastatic colorectal cancer

Fee Klupp, Malte Sass, Frank Bergmann, Elias Khajeh, Omid Ghamarnejad, Matthias Hassenpflug, Arianeb Mehrabi, Yakup Kulu
Article Number: 448
Published online on: 07 April 2021

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Article Open Access

Clinical value of lncRNA CCAT1 in serum extracellular vesicles as a potential biomarker for gastric cancer

Ke Xiao, Zhaogang Dong, Ding Wang, Min Liu, Juan Ding, Wendan Chen, Ziqi Shang, Congbo Yue, Yi Zhang
Article Number: 447
Published online on: 06 April 2021

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Article

Analysis of radiotherapy‑induced alteration of CD8+ T cells and PD‑L1 expression in patients with uterine cervical squamous cell carcinoma

Yasumasa Mori, Hiro Sato, Takuya Kumazawa, Tiara Bunga Mayang Permata, Yuya Yoshimoto, Kazutoshi Murata, Shin-Ei Noda, Takuya Kaminuma, Ken Ando, Takahiro Oike, Noriyuki Okonogi, Kohei Okada, Sangeeta Kakoti, Keiji Suzuki, Hayato Ikota, Hideaki Yokoo, Takashi Nakano, Tatsuya Ohno, Atsushi Shibata
Article Number: 446
Published online on: 06 April 2021

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Article Open Access

Stromal expression of cancer‑associated fibroblast‑related molecules, versican and lumican, is strongly associated with worse relapse‑free and overall survival times in patients with esophageal squamous cell carcinoma

Naoto Yamauchi, Yasuyuki Kanke, Katsuharu Saito, Hirokazu Okayama, Shoki Yamada, Shotaro Nakajima, Eisei Endo, Koji Kase, Leo Yamada, Hiroshi Nakano, Takuro Matsumoto, Hiroyuki Hanayama, Yohei Watanabe, Suguru Hayase, Motonobu Saito, Zenichiro Saze, Kosaku Mimura, Tomoyuki Momma, Shinji Oki, Yuko Hashimoto, Koji Kono
Article Number: 445
Published online on: 06 April 2021

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Article Open Access

Long non‑coding RNA HOTAIR promotes the progression of synovial sarcoma through microRNA‑126/stromal cell‑derived factor‑1 regulation

Qi Feng, Donglai Wang, Peng Guo, Zibo Zhang, Jiangang Feng
Article Number: 444
Published online on: 06 April 2021

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Article Open Access

Elevated XRCC5 expression level can promote temozolomide resistance and predict poor prognosis in glioblastoma

I-Neng Lee, Jen-Tsung Yang, Cheng Huang, Hsiu-Chen Huang, Yu-Ping Wu, Jui-Chieh Chen
Article Number: 443
Published online on: 06 April 2021

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Article Open Access

LEM domain containing 1 promotes thyroid cancer cell proliferation and migration by activating the Wnt/β‑catenin signaling pathway and epithelial‑mesenchymal transition

Min Xu, Bangyi Lin, Danni Zheng, Jialiang Wen, Wenjing Hu, Chunxue Li, Xianwei Zhang, Xiaohua Zhang, Jinmiao Qu
Article Number: 442
Published online on: 02 April 2021

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Article Open Access

Expression profiling of CPS1 in Correa's cascade and its association with gastric cancer prognosis

Xuqian Fang, Xiaoqiong Wu, Enfei Xiang, Fangxiu Luo, Qinqin Li, Qianchen Ma, Fei Yuan, Peizhan Chen
Article Number: 441
Published online on: 02 April 2021

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Article Open Access

DEK is highly expressed in breast cancer and is associated with malignant phenotype and progression

Mai-Qing Yang, Lin-Lin Bai, Zhao Wang, Lei Lei, Yi-Wen Zheng, Zhi-Han Li, Wen-Jing Huang, Chen-Chen Liu, Hong-Tao Xu
Article Number: 440
Published online on: 01 April 2021

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Review Open Access

Potential role of mitochondria in gastric cancer detection: Fission and glycolysis (Review)

Hang Yang, Yan Li, Bing Hu
Article Number: 439
Published online on: 01 April 2021

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Article Open Access

Recombinant protein TRAIL-Mu3 enhances the antitumor effects in pancreatic cancer cells by strengthening the apoptotic signaling pathway

Min Huang, Cheng Yi, Xian-Zhou Huang, Juan Yan, Li-Jia Wei, Wei-Ju Tang, Shou-Chun Chen, Ying Huang
Article Number: 438
Published online on: 01 April 2021

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Aquaporin 1 knockdown inhibits triple‑negative breast cancer cell proliferation and invasion in vitro and in vivo

Yinan Ji, Xiaoming Liao, Yi Jiang, Wei Wei, Huawei Yang
Article Number: 437
Published online on: 01 April 2021

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Ring finger 20/ring finger 40/WW domain‑containing adaptor with coiled‑coil complex interacts with p53 to regulate gene transcription in DNA damage response

Danni Meng, Kun Guo, Die Zhang, Cheng Zhao, Chuanwen Sun, Feng Zhang
Article Number: 436
Published online on: 01 April 2021

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β‑asarone suppresses HCT116 colon cancer cell proliferation and liver metastasis in part by activating the innate immune system

Min Chen, Yu-Wen Zhuang, Cun-En Wu, Hai-Yan Peng, Jun Qian, Jin-Yong Zhou
Article Number: 435
Published online on: 31 March 2021

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Epigenetic silencing of microRNA‑199a‑5p promotes the proliferation of non‑small cell lung cancer cells by increasing AKAP1 expression

Nengli Yang, Yafeng Liang, Tianqi Zhu, Yanxiao Long, Zhe Chen, Xuezheng Zhang, Liuming Jiang
Article Number: 434
Published online on: 31 March 2021

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Lentivirus‑mediated silencing of CNTN1 enhances gefitinib sensitivity by reversing epithelial‑mesenchymal transition in lung adenocarcinoma A549 cells

Chun-Sheng Hu, Jiu-Hong Huang, Dong-Lin Yang, Chuan Xu, Zhi-Gang Xu, Hong-Bo Tan, Zhong-Zhu Chen
Article Number: 433
Published online on: 31 March 2021

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Activation of GPER by E2 promotes proliferation, invasion and migration of breast cancer cells by regulating the miR‑124/CD151 pathway

Huaicheng Yang, Congyu Wang, Heqiang Liao, Qi Wang
Article Number: 432
Published online on: 31 March 2021

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Siomycin A induces reactive oxygen species‑mediated cytotoxicity in ovarian cancer cells

Xiulan Shao, Fengying Zhang, Xiang Gao, Fengying Xu
Article Number: 431
Published online on: 31 March 2021

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Characterization and clinical evaluation of microsatellite instability and loss of heterozygosity in tumor‑related genes in gastric cancer

Xueyun Huo, Xiaoqin Xiao, Shuangyue Zhang, Xiaoyan Du, Changlong Li, Zhigang Bai, Zhenwen Chen
Article Number: 430
Published online on: 30 March 2021

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lncRNA LINC00473 promotes proliferation, migration, invasion and inhibition of apoptosis of non‑small cell lung cancer cells by acting as a sponge of miR‑497‑5p

Shao-Hua Xu, Yu-Hong Bo, Han-Chen Ma, Hua-Nan Zhang, Ming-Ju Shao
Article Number: 429
Published online on: 30 March 2021

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Effects of a combined therapy of bortezomib and ionizing radiation on chondrosarcoma three-dimensional spheroid cultures

Birgit Lohberger, Dietmar Glaenzer, Nicole Eck, Bibiane Steinecker-Frohnwieser, Andreas Leithner, Beate Rinner, Sylvia Kerschbaum-Gruber, Dietmar Georg
Article Number: 428
Published online on: 30 March 2021

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January-2026 Volume 31 Issue 1

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Impact Factor: 2.2

CiteScore: 4.6

CiteScore Rank: Q2: #178/415 Oncology

Source Normalized Impact per Paper (SNIP): 0.568

SCImago Journal Rank (SJR): 0.663

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Predictive analysis of BRAF V600E mutation and central lymph node metastasis in papillary thyroid carcinoma

Junhui Peng, Zhihui Wu, Yujun Huang, Runhua Pan, Zhongdai Fu, Jianzhang Wang
Article Number: 44
Published online on: 24 November 2025

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Adverse events induced by the subcutaneous HER2-targeted antibody‑drug conjugate JSKN033 in a male patient with breast cancer: A case report

Rui Yang, Jian Zhang, Yang Wang
Article Number: 43
Published online on: 24 November 2025

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Prediction of solitary ≤3‑cm small adrenal metastasis based on 18F‑FDG PET/CT using a support vector machine model in lung cancer

Lin Zhao, Haifeng Cai, Jingwu Li, Wenzhe Zhao, Yongliang Liu, Lixiu Cao
Article Number: 42
Published online on: 24 November 2025

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Transferrin receptor serves a role in promoting PANoptosis in thyroid cancer

Shungao Ma, Zhiqiang Ma, Jingwei Shen, Hong Liu, Hua Yang, Yuqin Hu, Simeng Ying
Article Number: 41
Published online on: 24 November 2025

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Oxidative stress as a nexus: Integrating mitophagy and ferroptosis in endometrial carcinogenesis (Review)

Qixia Yu, Liangxin Ren, Feng Ren, Fengling Li
Article Number: 40
Published online on: 20 November 2025

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Astragalin: A promising herbal compound with broad anticancer potential (Review)

Yu-Qian Fu, Chan Li, Dan-Ni Ding, Fang-Yuan Liu, Yu-Fei Zhu, Feng-Juan Han
Article Number: 39
Published online on: 20 November 2025

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Analysis of prognostic factors influencing brain metastasis in EGFR‑mutant lung adenocarcinoma and comparison of prognostic assessment models

Junjun Miao, Jianwei Hu, Yongxia Zhang, Lei Gao, Xiangkun Yuan
Article Number: 38
Published online on: 18 November 2025

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Case Report

Fumarate hydratase-deficient renal cell carcinoma arising in acquired cystic kidney disease in a hemodialysis patient: Diagnostic clues from percutaneous renal mass core needle biopsy: A case report

Yuki Oba, Hisashi Kamido, Kei Kono, Katsuyuki Miki, Shinji Ito, Akinari Sekine, Shigekazu Kurihara, Masayuki Yamanouchi, Tatsuya Suwabe, Yutaka Takazawa, Kenichi Ohashi, Yoji Nagashima, Yuki Nakamura, Yoshifumi Ubara, Naoki Sawa
Article Number: 37
Published online on: 18 November 2025

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TIMP1 expression in colorectal cancer: Linking prognosis, tumor immunity and molecular pathways

Jiming Gu, Dongming Zhu, Fan Chen, Tongguo Shi, Suhua Xia
Article Number: 36
Published online on: 18 November 2025

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[Retracted] Exosomes from LNCaP cells promote osteoblast activity through miR‑375 transfer

Su-Liang Li, Na An, Bing Liu, Sheng-Yu Wang, Jian-Jun Wang, Yun Ye
Article Number: 35
Published online on: 17 November 2025

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Article

TAS‑102 plus bevacizumab as salvage treatment in colorectal cancer: A retrospective study

Keita Matsumoto, Ryoma Yokoi, Chika Mizutani, Ryuichi Asai, Jesse Yu Tajima, Masahide Endo, Yuji Hatanaka, Takeshi Horaguchi, Masahiro Fukada, Itaru Yasufuku, Yuta Sato, Yoshihiro Tanaka, Katsutoshi Murase, Nobuhisa Matsuhashi
Article Number: 34
Published online on: 14 November 2025

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Research progress on neutrophil extracellular traps and hepatitis‑to‑hepatocellular carcinoma transformation (Review)

Yiwei Wang, Chengyan Zhang, Haonan Wang, Yali Zhou, Yuanbo Yu, Hui Liu, Chuansha Gu
Article Number: 33
Published online on: 14 November 2025

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Remarkable response to Osimertinib plus Gumarontinib for EGFR mutation and concomitant MET exon 14 skipping in a patient with lung adenocarcinoma: A case report

Xuquan Jing, Li Li, Shuangqing Lu, Xiaoyang Zhai, Hui Zhu
Article Number: 32
Published online on: 12 November 2025

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Machine learning‑based signature for prognosis and drug sensitivity in hepatocellular carcinoma using glycolysis‑related gene

Yufan Zhou, Wei Liu, Zhixue Fang, Ke Zhou, Xing Huang, Shanzheng Lu, Weilin Zhang, Qiaocheng Wen, Xu Chen, Zhigang Xiao
Article Number: 31
Published online on: 12 November 2025

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Dual immune checkpoint inhibitor cardonilumab induces immune myocarditis in a patient with cancer‑related myocardial metastasis: A case report

Tianxing Liu, Qiang Li, Renya Zeng, Baidong Zhang, Zhichao Kang, Pengfei Zhang, Zhe Yang
Article Number: 30
Published online on: 12 November 2025

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Retrospective analysis of clinical characteristics, treatment outcomes and prognosis of patients with natural killer/T‑cell lymphoma

Pengye Li, Geraldine Esther Awakossa, Lu Zhou, Qiuhui Li, Xinxiu Liu, Fang Zhu, Tao Liu, Liling Zhang
Article Number: 29
Published online on: 11 November 2025

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From mechanism to targeted therapy: Advances in histone lactylation‑driven cancer progression (Review)

Zhe Jia, Shan Lu, Zhenchuan Wang, Pengfei Ge
Article Number: 28
Published online on: 11 November 2025

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Retraction Open Access

[Retracted] Upregulation of cervical carcinoma expressed PCNA regulatory long non‑coding RNA promotes esophageal squamous cell carcinoma progression

Xiaojun Wang, Liangfen Zhou, Huiyun Zhang, Hui Ou, Wenxing Long, Xiaobao Liu
Article Number: 27
Published online on: 10 November 2025

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Biology of PEST‑containing nuclear proteins as potential targets in ovarian cancer (Review)

Hao Liu, Zhi-Liang Jiang, Yi Liu, Yong-Hao Zhu, Muhammad Usman Akbar, Saadullah Khattak, Zhendong Lu, Muhammad Babar Khawar, Yue Zhang, Umair Ali Khan Saddozai, Xin-Ying Ji
Article Number: 26
Published online on: 07 November 2025

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Article

Survival outcomes and prognostic factors in temporal bone malignancies: A retrospective cohort of 20 patients

Liming Gao, Wenyang Zhang, Ting Ye, Rui Guo, Yin Xia
Article Number: 25
Published online on: 06 November 2025

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Real‑world performance of the machine learning‑based prediction of chemotherapy‑associated adverse effects in lung cancer

Sha Huang, Zhengwei Huang, Zhoujian Sun, Tianao Xie, Xingyu Zhu, Sheng Lu, Zhengxing Huang, Jian Hu, Zhengfu He
Article Number: 24
Published online on: 06 November 2025

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Long non‑coding RNA RP11‑196G11.6 inhibits neuroblastoma progression by regulating the miR‑376a‑3p/RYBP signaling axis

Jie Zhang, Kai Huang, Jianwu Zhou, Wenge Liao, Fei Li, Zhenzhen Zhao, Shan Wang
Article Number: 23
Published online on: 06 November 2025

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Review

Cervical cancer immune microenvironment: Mechanisms of HPV‑mediated immune evasion and advances in immunotherapy (Review)

Xiaojing Zhou, Ren An, Xiangjuan Li
Article Number: 22
Published online on: 05 November 2025

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Mesenchymal stem cell‑derived exosomes: Regulators of progression and suppression in pancreatic cancer (Review)

Haoyan Zhuang, Xuewen Shi
Article Number: 21
Published online on: 04 November 2025

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Advancements in research regarding the influence of the tumor microenvironment on the proliferation and metastasis of osteosarcoma (Review)

Tao Shi, Jianping Kang, Qiyang Wang, Jiamei Song, Xiaofeng He
Article Number: 20
Published online on: 04 November 2025

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Enhanced expression of CXCL1 in renal cell carcinoma facilitates tumor cell malignancy via PI3K/AKT‑dependent mechanisms

Shiliang Gui, Hongrui Zhang, Huiting Xiao, Chen Liu, Yuhang Wang, Baotian Wang, Hongbin Qiu
Article Number: 19
Published online on: 03 November 2025

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Case Report Open Access

Photodynamic therapy with local‑targeted perfusion for recurrent tracheal adenoid cystic carcinoma achieving 12‑year survival: A case report

Luoqi Yang, Lu Wang, Hongwu Wang, Heng Zou
Article Number: 18
Published online on: 03 November 2025

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Retraction Open Access

[Retracted] Tunicamycin inhibits progression of glioma cells through downregulation of the MEG‑3‑regulated wnt/β‑catenin signaling pathway

Xin Li, Lei Xue, Qin Peng
Article Number: 17
Published online on: 03 November 2025

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Non‑targeted metabolomics reveals diagnostic biomarker in the plasma of patients with lung cancer

Yan Liu, Yangmin Li, Haijun Hou, Yanyan Dong, Haitong Tian, Yanan Zhao, Ke Li, Jiayuan Zhou, Fujie Song, Yan Li
Article Number: 16
Published online on: 31 October 2025

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Primary pulmonary angiosarcoma: A case study with genetic insights and potential therapeutic targets

Yanling Zhu, Chunfang Guo
Article Number: 15
Published online on: 31 October 2025

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Progress in the treatment of esophageal neuroendocrine carcinoma (Review)

Jie Shi, Bin He, Heng Di Zhang, Chao Yang Jiang, Ling Zhang
Article Number: 14
Published online on: 31 October 2025

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Sensitive cell‑free DNA assay for accurate detection of RAS and BRAF mutations in liquid biopsies of patients with metastatic colorectal cancer: Final results of the multicentric ColoBEAM study

Alexandre Harlé, Céline Gavoille, Olivier Bouché, Meher Ben Abdelghani, Jérome Plaza, Dominique Spaeth, Axelle Boudrant, François Ghiringhelli, Anne-Laure Villing, Christophe Borg, Marie Rouyer, Marie Husson, Pauline Gilson, Julia Salleron, Aurélien Lambert, Jean-Louis Merlin
Article Number: 13
Published online on: 30 October 2025

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Article

Single‑center retrospective study of factors associated with early discontinuation of tumor‑treating fields therapy in glioblastoma

Kohei Suzuki, Koichiro Sato, Shohei Nagasaka, Ryo Miyaoka, Takeshi Saito, Yoshiteru Nakano, Nayuta Higa, Toshiaki Akahane, Akihide Tanimoto, Ryosuke Hanaya, Junkoh Yamamoto
Article Number: 12
Published online on: 29 October 2025

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Clinical value of emerging peripheral blood protein biomarkers in prostate cancer (Review)

Mengli Chen, Feng Wang, Weixi Wang, Kangle Feng, Kaihua Xiang, Xubo Gong, Zhihua Tao, Weiwei Liu
Article Number: 11
Published online on: 29 October 2025

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Intratumoral and peritumoral radiomics of MRI predict pathological differentiation in patients with rectal cancer

Huanhui Liu, Hanjing Zhang, Qian Zou, Jianquan Yang
Article Number: 10
Published online on: 29 October 2025

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Retraction Open Access

[Retracted] Peritumoral activated hepatic stellate cells are associated with hepatic recurrence for resectable colorectal adenocarcinoma liver metastasis following resection

Li Deng, Taiyuan Li, Yuanyuan Liao, Shuang Liu, Zhen Xie, Zhixiang Huang, Hua Dai, Jianfeng Li, Xiong Lei
Article Number: 9
Published online on: 27 October 2025

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Case Report Open Access

Combined BRAF/MEK inhibition for BRAF‑mutant melanoma brain metastases in pregnancy: A case report

Jaroslav Melus, Michaela Jezberova, Silvia Mikulajova, Katarina Komaromy Gerincova, Martin Karlik, Igor Straka, Marek Krivosik, Peter Valkovic, Gabriela Timarova
Article Number: 8
Published online on: 24 October 2025

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Case Report Open Access

Synchronous rectal and endometrial cancer: A case report and literature review

Zhuofan Li, Li Peng, Qing Su, Beige Zong
Article Number: 7
Published online on: 24 October 2025

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Article

Predictive significance of thoracic skeletal muscle nutritional status for radiotherapy survival in elderly patients with esophageal squamous cell carcinoma

Shuqin Liu, Qi Li, Dongmei Luo, Caixia Jia, Dingqiang Peng, Guihong Liu
Article Number: 6
Published online on: 24 October 2025

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Review Open Access

Ribosome‑binding protein 1: A multidimensional regulator of cancer progression and a novel target for precision therapy (Review)

Ho Huang, Jia Ouyang
Article Number: 5
Published online on: 23 October 2025

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Case Report Open Access

Brain metastasis of ovarian cancer >20 years after initial diagnosis: A case report

Chihiro Ishizawa, Kazunari Miyazawa, Misaki Tani, Kazuaki Neriishi, Yukari Kambe, Akira Tsuchiya
Article Number: 4
Published online on: 23 October 2025

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Investigating the roles of microRNAs associated with cancer stem cells, drug resistance, metastasis and recurrence in hepatocellular carcinoma: A systematic review, network analysis and experimental verification

Yuanyuan Jiang, Xiaoning Zhu, Qinghua Peng, Paniz Zarghami Dastjerdi, Mengyun Peng, Ding Zheng, Xiaodong Wang, Yoke Kqueen Cheah, Jing Wang
Article Number: 3
Published online on: 23 October 2025

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Case Report Open Access

Advanced dual primary male breast cancer and lung cancer: A case report and literature review

Xiaoxiao Xing, Junyi Li, Yue Wang, Shiyun Zhang, Jun Li, Yun Wang, Dongpo Zhang, Daixiang Liao
Article Number: 2
Published online on: 22 October 2025

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Retraction Open Access

[Retracted] Tumor necrosis factor‑related apoptosis‑inducing ligand inhibits proliferation and induces apoptosis of prostate and bladder cancer cells

Lin Hao, Yan Zhao, Zhi-Gang Li, Hou-Guang He, Qing Liang, Zhi-Guo Zhang, Zhen-Duo Shi, Pei-Ying Zhang, Cong-Hui Han
Article Number: 1
Published online on: 22 October 2025

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Journal Cover
February-2026 Volume 31 Issue 2

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Journal Metrics

Impact Factor: 2.2

CiteScore: 4.6

CiteScore Rank: Q2: #178/415 Oncology

Source Normalized Impact per Paper (SNIP): 0.568

SCImago Journal Rank (SJR): 0.663

Case Report Open Access

Primary bone marrow diffuse large B‑cell lymphoma with secondary myelofibrosis: A case report

Jing Yang, Sheng-Ke Tu, Hui Peng, Yuan-Yuan Peng, Min Li, Kui Song
Article Number: 70
Published online on: 05 December 2025

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Tanshinone IIA targets RNF123 to inhibit non‑small cell lung cancer cell proliferation, migration and invasion via KAT2B‑mediated H3K18ac modification

Yongjie He, Yingxin Zhang, Jiangsheng Zhang, Kaican Cai
Article Number: 69
Published online on: 04 December 2025

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Expression profiling reveals coordinated dysregulation of autophagy‑associated proteins in marginal zone lymphoma and therapeutic implications

Jingshu Ruan, Xin Zhou, Ai Li, Ningning Shan
Article Number: 68
Published online on: 03 December 2025

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Analysis of the TCRβ repertoire characteristics when combining radiotherapy and immunotherapy in cancer

Xueli Yang, Wujun Wei, Zhihui Feng, Biao Zhang, Yi Liu, Fei Yang, Chong Zhang, Minglin Ou, Songbai Liao, Xianliang Hou
Article Number: 67
Published online on: 03 December 2025

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Identification and validation of critical mitochondrial hub genes for prostate cancer

Sha Liu, Liang Huang, Li Lin, Hong Shan, Yueming Wan
Article Number: 66
Published online on: 03 December 2025

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Roles of minimally invasive techniques in the management of epithelial ovarian cancer (Review)

Ruibing Yang, Jiali Gao, Yunyun Cheng, Caihong Lu, Juan Li
Article Number: 65
Published online on: 03 December 2025

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Pregnancy with vitrified oocytes after fertility sparing surgery in a patient with fallopian tube cancer and a BRCA2 mutation: A case report and literature review

Guglielmo Stabile, Stefania Cicogna, Gabriella Zito, Anna Vido, Andrea Romano, Alessandro Mangogna, Luigi Nappi, Giuseppe Ricci
Article Number: 64
Published online on: 02 December 2025

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[Retracted] Clinical significance and effect of Sam68 expression in gastric cancer

Jinzhang Xiao, Qiuhong Wang, Qichang Yang, Hua Wang, Fulin Qiang, Song He, Jin Cai, Lei Yang, Yingying Wang
Article Number: 63
Published online on: 02 December 2025

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Genome‑wide CRISPR screening identifies CLDN1 as a central node in the anticancer mechanisms of berberine and as a therapeutic target in lung cancer

Xiaogang Wang, Benzhong Mi, Jinfeng Lv, Xin Tang, Jingyu Huang, Fei Liu, Yajing Xing, Xingjian Wen, Yongde Wang, Yadong Zhong
Article Number: 62
Published online on: 01 December 2025

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Construction of a human epidermal growth factor receptor 2‑related gene risk model for predicting breast cancer prognosis

Limin Huang, Chunhong Xu, Yining Song, Furong Sun, Xuemei Sun, Hanyi Yao, Mingchen Liu, Nan Luo
Article Number: 61
Published online on: 01 December 2025

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Development of a machine learning model for preoperative prediction of spread through air spaces in resectable 
non‑small cell lung cancer: A single‑center retrospective study

Chong Yang, Guozheng Ding, Bicheng Zhan, Lanlan Xuan, Feifei Cheng, Yanguo Yang
Article Number: 60
Published online on: 01 December 2025

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Case Report Open Access

Integrated diagnostic evaluation of multiple malignant neoplasms via 99mTc‑MDP three‑phase bone imaging: A case report

Jing-Yi Lian, Jian-Lin Lu, Hui-Yu Zheng, Si-Xia Yuan, Jin-Shan Zhang
Article Number: 59
Published online on: 01 December 2025

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Article

Retrospective analysis of the association between monocyte percentage and outcomes in newly diagnosed diffuse large B‑cell lymphoma

Chaoqiang Zheng, Xiaoqin Xin
Article Number: 58
Published online on: 28 November 2025

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Role of HOXA transcript antisense RNA myeloid‑specific 1 in cancer (Review)

Yipei Jing, Xiaoqi Li, Ye Guo
Article Number: 57
Published online on: 28 November 2025

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Differential gene expression analysis reveals signaling pathways of proliferation, angiogenesis and metastasis is associated with interferon suppression in advanced hypopharyngeal cancer cells

Chia-Wei Kao, Yen-Ping Yeh, Ting-Wen Chen, Min-Ying Lin, Jyh-Der Leu, Yi-Jang Lee
Article Number: 56
Published online on: 27 November 2025

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Unicentric Castleman disease with paraneoplastic pemphigus and follicular dendritic cell sarcoma: A case report

Yukun Li, Fanchen Zeng, Zeyao Wang, Ganjian Zhao, Qi Zhou
Article Number: 55
Published online on: 27 November 2025

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CRISPR/Cas9‑mediated claudin‑2 knockout in HCT116 cells reveals its key role in colorectal cancer progression

Rana A. Alghamdi, Maryam H. Al‑zahrani
Article Number: 54
Published online on: 27 November 2025

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Comparative evaluation of microRNA detection in plasma, urine and liquid‑based cytology for high‑grade cervical intraepithelial neoplasia

Stéphanie Calfa, Ana Julia Aguiar De Freitas, Welinton Hirai, Júlio César Possati‑Resende, Rhafaela Lima Causin, Ricardo Dos Reis, Rui Manuel Reis, Márcia Maria Chiquitelli Marques
Article Number: 53
Published online on: 26 November 2025

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Case Report Open Access

Small intestinal SMARCA4‑deficient undifferentiated carcinoma with intussusception: A case report

Xiaoshan Cai, Shanshan Liu, Linqian Li, Yuming Zhang, Qin Guo, Ze Chen, Meihua Qu, Yubing Wang, Ben Yang, Xianwen Yue
Article Number: 52
Published online on: 26 November 2025

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SENP5 acts as a downstream target of androgen receptor and contributes to prostate cancer growth

Ximin Chen, Xubo Gong, Jingcheng Zhang, Weiwei Liu
Article Number: 51
Published online on: 26 November 2025

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Retraction Open Access

[Retracted] Scutellarein suppresses Aβ‑induced memory impairment via inhibition of the NF‑κB pathway in vivo and in vitro

Xiao-Wei Huang, Yan Xu, Xin Sui, He Lin, Jia-Ming Xu, Dong Han, Dou-Dan Ye, Guang-Fu Lv, Yue-Xin Liu, Xiao-Bo Qu, Ming-Hua Duan
Article Number: 50
Published online on: 26 November 2025

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Article Open Access

Prognostic analysis and expression patterns of programmed cell death ligand 1 and BRAF V600E in esophageal neuroendocrine carcinoma

Chengcheng Zhang, Li Zheng, Binwen Xu, Guidong Shi, Maoyong Fu
Article Number: 49
Published online on: 25 November 2025

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Article

Evaluating computer‑assisted mandibular reconstruction: Outsourced vs. in‑house approaches

Sho Katsura, Yoshihiro Morita, Ryotaro Kakimoto, Tetsuo Miyamoto, Kana Kashima, Emiko Ogasa, Yoshio Ueno, Ayano Tobe‑Nishimoto, Satoko Kishimoto, Yuka Matsumiya‑Matsumoto, Akinori Takeshita, Kazuhide Matsunaga, Narikazu Uzawa
Article Number: 48
Published online on: 25 November 2025

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Case Report Open Access

Multiple primary central nervous system lymphoma in the ventricular system and interpeduncular cistern: A case report

Qing Ouyang, Bing Sun, Haodong Sun, Jianing Luo, Zhen Xu, Yuan Ma
Article Number: 47
Published online on: 25 November 2025

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Review Open Access

Exploration of immunotherapy modalities in stage III unresectable non‑small cell lung cancer (Review)

Jiayun Ma, Jun Jiang
Article Number: 46
Published online on: 25 November 2025

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Case Report

Massive breast fat necrosis with invasive breast cancer: A case report

Anjie Zhang, Linfeng Song, Xiyao Yang, Xu Chen, Binlin Tian, Yongzhe Li, Guoyuan Jiang, Lin Jiang
Article Number: 45
Published online on: 25 November 2025

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