Dual roles of SAMHD1 in tumor development and chemoresistance to anticancer drugs (Review)
- Authors:
- Zhangming Chen
- Jie Hu
- Songcheng Ying
- Aman Xu
-
Affiliations: Department of General Surgery, The Fourth Affiliated Hospital of Anhui Medical University, Hefei, Anhui 230001, P.R. China, Department of Immunology, School of Basic Medical Sciences, Anhui Medical University, Hefei, Anhui 230032, P.R. China - Published online on: April 8, 2021 https://doi.org/10.3892/ol.2021.12712
- Article Number: 451
-
Copyright: © Chen et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
This article is mentioned in:
Abstract
Li N, Zhang W and Cao X: Identification of human homologue of mouse IFN-gamma induced protein from human dendritic cells. Immunol Lett. 74:221–224. 2000. View Article : Google Scholar : PubMed/NCBI | |
Brandariz-Nuñez A, Valle-Casuso JC, White TE, Laguette N, Benkirane M, Brojatsch J and Diaz-Griffero F: Role of SAMHD1 nuclear localization in restriction of HIV-1 and SIVmac. Retrovirology. 9:492012. View Article : Google Scholar | |
Wei W, Guo H, Han X, Liu X, Zhou X, Zhang W and Yu XF: A novel DCAF1-binding motif required for Vpx-mediated degradation of nuclear SAMHD1 and Vpr-induced G2 arrest. Cell Microbiol. 14:1745–1756. 2012. View Article : Google Scholar : PubMed/NCBI | |
Rice GI, Bond J, Asipu A, Brunette RL, Manfield IW, Carr IM, Fuller JC, Jackson RM, Lamb T, Briggs TA, et al: Mutations involved in Aicardi-Goutieres syndrome implicate SAMHD1 as regulator of the innate immune response. Nat Genet. 41:829–832. 2009. View Article : Google Scholar : PubMed/NCBI | |
Laguette N, Sobhian B, Casartelli N, Ringeard M, Chable-Bessia C, Ségéral E, Yatim A, Emiliani S, Schwartz O and Benkirane M: SAMHD1 is the dendritic- and myeloid-cell-specific HIV-1 restriction factor counteracted by Vpx. Nature. 474:654–657. 2011. View Article : Google Scholar : PubMed/NCBI | |
Goldstone DC, Ennis-Adeniran V, Hedden JJ, Groom HC, Rice GI, Christodoulou E, Walker PA, Kelly G, Haire LF, Yap MW, et al: HIV-1 restriction factor SAMHD1 is a deoxynucleoside triphosphate triphosphohydrolase. Nature. 480:379–382. 2011. View Article : Google Scholar : PubMed/NCBI | |
Chen Z, Zhu M, Pan X, Zhu Y, Yan H, Jiang T, Shen Y, Dong X, Zheng N, Lu J, et al: Inhibition of Hepatitis B virus replication by SAMHD1. Biochem Biophys Res Commun. 450:1462–1468. 2014. View Article : Google Scholar : PubMed/NCBI | |
Jeong GU, Park IH, Ahn K and Ahn BY: Inhibition of hepatitis B virus replication by a dNTPase-dependent function of the host restriction factor SAMHD1. Virology. 495:71–78. 2016. View Article : Google Scholar : PubMed/NCBI | |
Kim ET, White TE, Brandariz-Núñez A, Diaz-Griffero F and Weitzman MD: SAMHD1 restricts herpes simplex virus 1 in macrophages by limiting DNA replication. J Virol. 87:12949–12956. 2013. View Article : Google Scholar : PubMed/NCBI | |
Buj R and Aird KM: Deoxyribonucleotide Triphosphate Metabolism in Cancer and Metabolic Disease. Front Endocrinol (Lausanne). 9:1772018. View Article : Google Scholar : PubMed/NCBI | |
Ji X, Wu Y, Yan J, Mehrens J, Yang H, DeLucia M, Hao C, Gronenborn AM, Skowronski J, Ahn J and Xiong Y: Mechanism of allosteric activation of SAMHD1 by dGTP. Nat Struct Mol Biol. 20:1304–1309. 2013. View Article : Google Scholar : PubMed/NCBI | |
Franzolin E, Pontarin G, Rampazzo C, Miazzi C, Ferraro P, Palumbo E, Reichard P and Bianchi V: The deoxynucleotide triphosphohydrolase SAMHD1 is a major regulator of DNA precursor pools in mammalian cells. Proc Natl Acad Sci USA. 110:14272–14277. 2013. View Article : Google Scholar : PubMed/NCBI | |
Clifford R, Louis T, Robbe P, Ackroyd S, Burns A, Timbs AT, Wright Colopy G, Dreau H, Sigaux F, et al: SAMHD1 is mutated recurrently in chronic lymphocytic leukemia and is involved in response to DNA damage. Blood. 123:1021–1031. 2014. View Article : Google Scholar : PubMed/NCBI | |
Wang JL, Lu FZ, Shen XY, Wu Y and Zhao LT: SAMHD1 is down regulated in lung cancer by methylation and inhibits tumor cell proliferation. Biochem Biophys Res Commun. 455:229–233. 2014. View Article : Google Scholar : PubMed/NCBI | |
Rentoft M, Lindell K, Tran P, Chabes AL, Buckland RJ, Watt DL, Marjavaara L, Nilsson AK, Melin B, Trygg J, et al: Heterozygous colon cancer-associated mutations of SAMHD1 have functional significance. Proc Natl Acad Sci USA. 113:4723–4728. 2016. View Article : Google Scholar : PubMed/NCBI | |
Lee EJ, Seo JH, Park JH, Vo TTL, An S, Bae SJ, Le H, Lee HS, Wee HJ, Lee D, et al: SAMHD1 acetylation enhances its deoxynucleotide triphosphohydrolase activity and promotes cancer cell proliferation. Oncotarget. 8:68517–68529. 2017. View Article : Google Scholar : PubMed/NCBI | |
Tramentozzi E, Ferraro P, Hossain M, Stillman B, Bianchi V and Pontarin G: The dNTP triphosphohydrolase activity of SAMHD1 persists during S-phase when the enzyme is phosphorylated at T592. Cell Cycle. 17:1102–1114. 2018. View Article : Google Scholar : PubMed/NCBI | |
Coquel F, Silva MJ, Técher H, Zadorozhny K, Sharma S, Nieminuszczy J, Mettling C, Dardillac E, Barthe A, Schmitz AL, et al: SAMHD1 acts at stalled replication forks to prevent interferon induction. Nature. 557:57–61. 2018. View Article : Google Scholar : PubMed/NCBI | |
Zhao K, Du J, Han X, Goodier JL, Li P, Zhou X, Wei W, Evans SL, Li L, Zhang W, et al: Modulation of LINE-1 and Alu/SVA retrotransposition by Aicardi-Goutieres syndrome-related SAMHD1. Cell Rep. 4:1108–1115. 2013. View Article : Google Scholar : PubMed/NCBI | |
Gao W, Li G, Bian X, Rui Y, Zhai C, Liu P, Su J, Wang H, Zhu C, Du Y, et al: Defective modulation of LINE-1 retrotransposition by cancer-associated SAMHD1 mutants. Biochem Biophys Res Commun. 519:213–219. 2019. View Article : Google Scholar : PubMed/NCBI | |
Herold N, Rudd SG, Ljungblad L, Sanjiv K, Myrberg IH, Paulin CB, Heshmati Y, Hagenkort A, Kutzner J, Page BD, et al: Targeting SAMHD1 with the Vpx protein to improve cytarabine therapy for hematological malignancies. Nat Med. 23:256–263. 2017. View Article : Google Scholar : PubMed/NCBI | |
Herold N, Rudd SG, Sanjiv K, Kutzner J, Bladh J, Paulin CBJ, Helleday T, Henter JI and Schaller T: SAMHD1 protects cancer cells from various nucleoside-based antimetabolites. Cell Cycle. 16:1029–1038. 2017. View Article : Google Scholar : PubMed/NCBI | |
de Silva S, Hoy H, Hake TS, Wong HK, Porcu P and Wu L: Promoter methylation regulates SAMHD1 gene expression in human CD4+ T cells. J Biol Chem. 288:9284–9292. 2013. View Article : Google Scholar : PubMed/NCBI | |
de Silva S, Wang F, Hake TS, Porcu P, Wong HK and Wu L: Downregulation of SAMHD1 expression correlates with promoter DNA methylation in Sezary syndrome patients. J Invest Dermatol. 134:562–565. 2014. View Article : Google Scholar : PubMed/NCBI | |
Chen W, Cheng P, Jiang J, Ren Y, Wu D and Xue D: Epigenomic and genomic analysis of transcriptome modulation in skin cutaneous melanoma. Aging (Albany NY). 12:12703–12725. 2020. View Article : Google Scholar : PubMed/NCBI | |
Oellerich T, Schneider C, Thomas D, Knecht KM, Buzovetsky O, Kaderali L, Schliemann C, Bohnenberger H, Angenendt L, Hartmann W, et al: Selective inactivation of hypomethylating agents by SAMHD1 provides a rationale for therapeutic stratification in AML. Nat Commun. 10:34752019. View Article : Google Scholar : PubMed/NCBI | |
White TE, Brandariz-Nuñez A, Valle-Casuso JC, Amie S, Nguyen LA, Kim B, Tuzova M and Diaz-Griffero F: The retroviral restriction ability of SAMHD1, but not its deoxynucleotide triphosphohydrolase activity, is regulated by phosphorylation. Cell Host Microbe. 13:441–451. 2013. View Article : Google Scholar : PubMed/NCBI | |
Welbourn S, Dutta SM, Semmes OJ and Strebel K: Restriction of virus infection but not catalytic dNTPase activity is regulated by phosphorylation of SAMHD1. J Virol. 87:11516–11524. 2013. View Article : Google Scholar : PubMed/NCBI | |
Hochegger H, Takeda S and Hunt T: Cyclin-dependent kinases and cell-cycle transitions: Does one fit all? Nat Rev Mol Cell Biol. 9:910–916. 2008. View Article : Google Scholar : PubMed/NCBI | |
Takeda DY, Wohlschlegel JA and Dutta A: A bipartite substrate recognition motif for cyclin-dependent kinases. J Biol Chem. 276:1993–1997. 2001. View Article : Google Scholar : PubMed/NCBI | |
Cribier A, Descours B, Valadão AL, Laguette N and Benkirane M: Phosphorylation of SAMHD1 by cyclin A2/CDK1 regulates its restriction activity toward HIV-1. Cell Rep. 3:1036–1043. 2013. View Article : Google Scholar : PubMed/NCBI | |
Kretschmer S, Wolf C, König N, Staroske W, Guck J, Häusler M, Luksch H, Nguyen LA, Kim B, Alexopoulou D, et al: SAMHD1 prevents autoimmunity by maintaining genome stability. Ann Rheum Dis. 74:e172015. View Article : Google Scholar : PubMed/NCBI | |
Yan J, Hao C, DeLucia M, Swanson S, Florens L, Washburn MP, Ahn J and Skowronski J: CyclinA2-cyclin-dependent kinase regulates SAMHD1 protein phosphohydrolase domain. J Biol Chem. 290:13279–13292. 2015. View Article : Google Scholar : PubMed/NCBI | |
Hu J, Qiao M, Chen Y, Tang H, Zhang W, Tang D, Pi S, Dai J, Tang N, Huang A and Hu Y: Cyclin E2-CDK2 mediates SAMHD1 phosphorylation to abrogate its restriction of HBV replication in hepatoma cells. FEBS Lett. 592:1893–1904. 2018. View Article : Google Scholar : PubMed/NCBI | |
Pauls E, Badia R, Torres-Torronteras J, Ruiz A, Permanyer M, Riveira-Muñoz E, Clotet B, Marti R, Ballana E and Esté JA: Palbociclib, a selective inhibitor of cyclin-dependent kinase4/6, blocks HIV-1 reverse transcription through the control of sterile alpha motif and HD domain-containing protein-1 (SAMHD1) activity. AIDS. 28:2213–2222. 2014. View Article : Google Scholar : PubMed/NCBI | |
Badia R, Angulo G, Riveira-Muñoz E, Pujantell M, Puig T, Ramirez C, Torres-Torronteras J, Martí R, Pauls E, Clotet B, et al: Inhibition of herpes simplex virus type 1 by the CDK6 inhibitor PD-0332991 (palbociclib) through the control of SAMHD1. J Antimicrob Chemother. 71:387–394. 2016. View Article : Google Scholar : PubMed/NCBI | |
Allouch A, David A, Amie SM, Lahouassa H, Chartier L, Margottin-Goguet F, Barré-Sinoussi F, Kim B, Sáez-Cirión A and Pancino G: p21-mediated RNR2 repression restricts HIV-1 replication in macrophages by inhibiting dNTP biosynthesis pathway. Proc Natl Acad Sci USA. 110:E3997–E4006. 2013. View Article : Google Scholar | |
Pauls E, Ruiz A, Riveira-Muñoz E, Permanyer M, Badia R, Clotet B, Keppler OT, Ballana E and Este JA: p21 regulates the HIV-1 restriction factor SAMHD1. Proc Natl Acad Sci USA. 111:E1322–E1324. 2014. View Article : Google Scholar | |
Osei Kuffour E, Schott K, Jaguva Vasudevan AA, Holler J, Schulz WA, Lang PA, Lang KS, Kim B, Häussinger D, König R and Münk C: USP18 (UBP43) abrogates p21-mediated inhibition of HIV-1. J Virol. 92:e00592–18. 2018. View Article : Google Scholar | |
Schott K, Fuchs NV, Derua R, Mahboubi B, Schnellbächer E, Seifried J, Tondera C, Schmitz H, Shepard C, Brandariz-Nuñez A, et al: Dephosphorylation of the HIV-1 restriction factor SAMHD1 is mediated by PP2A-B55alpha holoenzymes during mitotic exit. Nat Commun. 9:22272018. View Article : Google Scholar : PubMed/NCBI | |
Kueck T, Cassella E, Holler J, Kim B and Bieniasz PD: The aryl hydrocarbon receptor and interferon gamma generate antiviral states via transcriptional repression. Elife. 7:e388672018. View Article : Google Scholar : PubMed/NCBI | |
Bonifati S, Daly MB, St Gelais C, Kim SH, Hollenbaugh JA, Shepard C, Kennedy EM, Kim DH, Schinazi RF, Kim B and Wu L: SAMHD1 controls cell cycle status, apoptosis and HIV-1 infection in monocytic THP-1 cells. Virology. 495:92–100. 2016. View Article : Google Scholar : PubMed/NCBI | |
Kodigepalli KM, Li M, Liu SL and Wu L: Exogenous expression of SAMHD1 inhibits proliferation and induces apoptosis in cutaneous T-cell lymphoma-derived HuT78 cells. Cell Cycle. 16:179–188. 2017. View Article : Google Scholar : PubMed/NCBI | |
Welbourn S, Miyagi E, White TE, Diaz-Griffero F and Strebel K: Identification and characterization of naturally occurring splice variants of SAMHD1. Retrovirology. 9:862012. View Article : Google Scholar : PubMed/NCBI | |
Kodigepalli KM, Bonifati S, Tirumuru N and Wu L: SAMHD1 modulates in vitro proliferation of acute myeloid leukemia-derived THP-1 cells through the PI3K-Akt-p27 axis. Cell Cycle. 17:1124–1137. 2018. View Article : Google Scholar : PubMed/NCBI | |
Feng Q, Moran JV, Kazazian HH Jr and Boeke JD: Human L1 retrotransposon encodes a conserved endonuclease required for retrotransposition. Cell. 87:905–916. 1996. View Article : Google Scholar : PubMed/NCBI | |
Burns KH: Transposable elements in cancer. Nat Rev Cancer. 17:415–424. 2017. View Article : Google Scholar : PubMed/NCBI | |
White TE, Brandariz-Nuñez A, Valle-Casuso JC, Knowlton C, Kim B, Sawyer SL and Diaz-Griffero F: Effects of human SAMHD1 polymorphisms on HIV-1 susceptibility. Virology. 460-461:34–44. 2014. View Article : Google Scholar : PubMed/NCBI | |
White TE, Brandariz-Nuñez A, Valle-Casuso JC, Amie S, Nguyen L, Kim B, Brojatsch J and Diaz-Griffero F: Contribution of SAM and HD domains to retroviral restriction mediated by human SAMHD1. Virology. 436:81–90. 2013. View Article : Google Scholar : PubMed/NCBI | |
Du J, Peng Y, Wang S, Hou J, Wang Y, Sun T and Zhao K: Nucleocytoplasmic shuttling of SAMHD1 is important for LINE-1 suppression. Biochem Biophys Res Commun. 510:551–557. 2019. View Article : Google Scholar : PubMed/NCBI | |
Herrmann A, Wittmann S, Thomas D, Shepard CN, Kim B, Ferreirós N and Gramberg T: The SAMHD1-mediated block of LINE-1 retroelements is regulated by phosphorylation. Mobile DNA. 9:112018. View Article : Google Scholar : PubMed/NCBI | |
Hu S, Li J, Xu F, Mei S, Le Duff Y, Yin L, Pang X, Cen S, Jin Q, Liang C and Guo F: SAMHD1 inhibits LINE-1 retrotransposition by promoting stress granule formation. PLoS Genetics. 11:e10053672015. View Article : Google Scholar : PubMed/NCBI | |
Ha°kansson P, Hofer A and Thelander L: Regulation of mammalian ribonucleotide reduction and dNTP pools after DNA damage and in resting cells. J Biol Chem. 281:7834–7841. 2006. View Article : Google Scholar | |
Jauregui P and Landau NR: DNA damage induces a SAMHD1-mediated block to the infection of macrophages by HIV-1. Sci Rep. 8:41532018. View Article : Google Scholar : PubMed/NCBI | |
Daddacha W, Koyen AE, Bastien AJ, Head PE, Dhere VR, Nabeta GN, Connolly EC, Werner E, Madden MZ, Daly MB, et al: SAMHD1 promotes DNA end resection to facilitate DNA repair by homologous recombination. Cell Rep. 20:1921–1935. 2017. View Article : Google Scholar : PubMed/NCBI | |
Ballana E, Badia R, Terradas G, Torres-Torronteras J, Ruiz A, Pauls E, Riveira-Muñoz E, Clotet B, Martí R and Esté JA: SAMHD1 specifically affects the antiviral potency of thymidine analog HIV reverse transcriptase inhibitors. Antimicrob Agents Chemother. 58:4804–4813. 2014. View Article : Google Scholar : PubMed/NCBI | |
Guièze R, Robbe P, Clifford R, de Guibert S, Pereira B, Timbs A, Dilhuydy MS, Cabes M, Ysebaert L, Burns A, et al: Presence of multiple recurrent mutations confers poor trial outcome of relapsed/refractory CLL. Blood. 126:2110–2117. 2015. View Article : Google Scholar | |
Grant S: Ara-C: Cellular and molecular pharmacology. Adv Cancer Res. 72:197–233. 1998. View Article : Google Scholar : PubMed/NCBI | |
Schneider C, Oellerich T, Baldauf HM, Schwarz SM, Thomas D, Flick R, Bohnenberger H, Kaderali L, Stegmann L, Cremer A, et al: SAMHD1 is a biomarker for cytarabine response and a therapeutic target in acute myeloid leukemia. Nat Med. 23:250–255. 2017. View Article : Google Scholar : PubMed/NCBI | |
Arnold LH, Kunzelmann S, Webb MR and Taylor IA: A continuous enzyme-coupled assay for triphosphohydrolase activity of HIV-1 restriction factor SAMHD1. Antimicrob Agents Chemother. 59:186–192. 2015. View Article : Google Scholar : PubMed/NCBI | |
Knecht KM, Buzovetsky O, Schneider C, Thomas D, Srikanth V, Kaderali L, Tofoleanu F, Reiss K, Ferreirós N, Geisslinger G, et al: The structural basis for cancer drug interactions with the catalytic and allosteric sites of SAMHD1. Proc Natl Acad Sci USA. 115:E10022–E10031. 2018. View Article : Google Scholar | |
Rassidakis GZ, Herold N, Myrberg IH, Tsesmetzis N, Rudd SG, Henter JI, Schaller T, Ng SB, Chng WJ, Yan B, et al: Low-level expression of SAMHD1 in acute myeloid leukemia (AML) blasts correlates with improved outcome upon consolidation chemotherapy with high-dose cytarabine-based regimens. Blood Cancer J. 8:982018. View Article : Google Scholar : PubMed/NCBI | |
Wang YT, Yuan B, Chen HD, Xu L, Tian YN, Zhang A, He JX and Miao ZH: Acquired resistance of phosphatase and tensin homolog-deficient cells to poly(ADP-ribose) polymerase inhibitor and Ara-C mediated by 53BP1 loss and SAMHD1 overexpression. Cancer Sci. 109:821–831. 2017. View Article : Google Scholar | |
Rudd SG, Tsesmetzis N, Sanjiv K, Paulin CB, Sandhow L, Kutzner J, Hed Myrberg I, Bunten SS, Axelsson H, Zhang SM, et al: Ribonucleotide reductase inhibitors suppress SAMHD1 ara-CTPase activity enhancing cytarabine efficacy. EMBO Mol Med. 12:e104192020. View Article : Google Scholar : PubMed/NCBI | |
Hollenbaugh JA, Shelton J, Tao S, Amiralaei S, Liu P, Lu X, Goetze RW, Zhou L, Nettles JH, Schinazi RF and Kim B: Substrates and Inhibitors of SAMHD1. PLoS One. 12:e01690522017. View Article : Google Scholar : PubMed/NCBI | |
Jones S, Zhang X, Parsons DW, Lin JC, Leary RJ, Angenendt P, Mankoo P, Carter H, Kamiyama H, Jimeno A, et al: Core signaling pathways in human pancreatic cancers revealed by global genomic analyses. Science. 321:1801–1806. 2008. View Article : Google Scholar : PubMed/NCBI | |
Kohnken R, Kodigepalli KM and Wu L: Regulation of deoxynucleotide metabolism in cancer: Novel mechanisms and therapeutic implications. Mol Cancer. 14:1762015. View Article : Google Scholar : PubMed/NCBI | |
James CD, Prabhakar AT, Otoa R, Evans MR, Wang X, Bristol ML, Zhang K, Li R and Morgan IM: SAMHD1 regulates human papillomavirus 16-induced cell proliferation and viral replication during differentiation of keratinocytes. mSphere. 4:e00448–19. 2019. View Article : Google Scholar | |
Stanland LJ and Luftig MA: The role of EBV-induced hypermethylation in gastric cancer tumorigenesis. Viruses. 12:12222020. View Article : Google Scholar : PubMed/NCBI | |
Cruz-Gregorio A, Aranda-Rivera AK and Pedraza-Chaverri J: Human papillomavirus-related cancers and mitochondria. Virus Res. 286:1980162020. View Article : Google Scholar : PubMed/NCBI | |
Cabello-Lobato MJ, Wang S and Schmidt CK: SAMHD1 sheds moonlight on DNA double-strand break repair. Trends Genet. 33:895–897. 2017. View Article : Google Scholar : PubMed/NCBI | |
Seamon KJ and Stivers JT: A high-throughput enzyme-coupled assay for SAMHD1 dNTPase. J Biomol Screen. 20:801–809. 2015. View Article : Google Scholar : PubMed/NCBI | |
Mauney CH, Perrino FW and Hollis T: Identification of inhibitors of the dNTP triphosphohydrolase SAMHD1 using a novel and direct high-throughput assay. Biochemistry. 57:6624–6636. 2018. View Article : Google Scholar : PubMed/NCBI | |
Jiang H, Li C, Liu Z and Shengjing Hospital; Hu: Expression and relationship of SAMHD1 with other apoptotic and autophagic genes in acute myeloid leukemia patients. Acta Haematol. 143:51–59. 2020. View Article : Google Scholar : PubMed/NCBI | |
Kodigepalli KM, Li M, Bonifati S, Panfil AR, Green PL, Liu SL and Wu L: SAMHD1 inhibits epithelial cell transformation in vitro and affects leukemia development in xenograft mice. Cell Cycle. 17:2564–2576. 2018. View Article : Google Scholar : PubMed/NCBI | |
Herold N, Rudd SG, Sanjiv K, Kutzner J, Myrberg IH, Paulin CBJ, Olsen TK, Helleday T, Henter JI and Schaller T: With me or against me: Tumor suppressor and drug resistance activities of SAMHD1. Exp Hematol. 52:32–39. 2017. View Article : Google Scholar : PubMed/NCBI | |
Rothenburger T, McLaughlin KM, Herold T, Schneider C, Oellerich T, Rothweiler F, Feber A, Fenton TR, Wass MN, Keppler OT, et al: SAMHD1 is a key regulator of the lineage-specific response of acute lymphoblastic leukaemias to nelarabine. Commun Biol. 3:3242020. View Article : Google Scholar : PubMed/NCBI | |
Yang CA, Huang HY, Chang YS, Lin CL, Lai IL and Chang JG: DNA-sensing and nuclease gene expressions as markers for colorectal cancer progression. Oncology. 92:115–124. 2017. View Article : Google Scholar : PubMed/NCBI | |
Shang Z, Qian L, Liu S, Niu X, Qiao Z, Sun Y, Zhang Y, Fan LY, Guan X, Cao CX and Xiao H: Graphene oxide-facilitated comprehensive analysis of cellular nucleic acid binding proteins for lung cancer. ACS Appl Mater Interfaces. 10:17756–17770. 2018. View Article : Google Scholar : PubMed/NCBI | |
Shi Y, Lv G, Chu Z, Piao L, Liu X, Wang T, Jiang Y and Zhang P: Identification of natural splice variants of SAMHD1 in virus-infected HCC. Oncol Rep. 31:687–692. 2014. View Article : Google Scholar : PubMed/NCBI | |
Merati M, Buethe DJ, Cooper KD, Honda KS, Wang H and Gerstenblith MR: Aggressive CD8(+) epidermotropic cutaneous T-cell lymphoma associated with homozygous mutation in SAMHD1. JAAD Case Rep. 1:227–229. 2015. View Article : Google Scholar : PubMed/NCBI | |
Amin NA, Seymour E, Saiya-Cork K, Parkin B, Shedden K and Malek SN: A quantitative analysis of subclonal and clonal gene mutations before and after therapy in chronic lymphocytic leukemia. Clin Cancer Res. 22:4525–4535. 2016. View Article : Google Scholar : PubMed/NCBI | |
Zhu KW, Chen P, Zhang DY, Yan H, Liu H, Cen LN, Liu YL, Cao S, Zhou G, Zeng H, et al: Association of genetic polymorphisms in genes involved in Ara-C and dNTP metabolism pathway with chemosensitivity and prognosis of adult acute myeloid leukemia (AML). J Transl Med. 16:902018. View Article : Google Scholar : PubMed/NCBI |