Open Access

Dual roles of SAMHD1 in tumor development and chemoresistance to anticancer drugs (Review)

  • Authors:
    • Zhangming Chen
    • Jie Hu
    • Songcheng Ying
    • Aman Xu
  • View Affiliations

  • Published online on: April 8, 2021     https://doi.org/10.3892/ol.2021.12712
  • Article Number: 451
  • Copyright: © Chen et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Human sterile alpha motif and HD‑domain‑­containing protein 1 (SAMHD1) has been identified as a GTP or dGTP‑dependent deoxynucleotide triphosphohydrolase (dNTPase) and acts as an antiviral factor against certain retroviruses and DNA viruses. Genetic mutation in SAMHD1 causes the inflammatory Aicardi‑Goutières Syndrome and abnormal intracellular deoxyribonucleoside triphosphates (dNTPs) pool. At present, the role of SAMHD1 in numerous types of cancer, such as chronic lymphocytic leukemia, lung cancer and colorectal cancer, is highly studied. Furthermore, it has been found that methylation, acetylation and phosphorylation are involved in the regulation of SAMHD1 expression, and that genetic mutations can cause changes in its activities, including dNTPase activity, long interspersed element type 1 (LINE‑1) suppression and DNA damage repair, which could lead to uncontrolled cell cycle progression and cancer development. In addition, SAMHD1 has been reported to have a negative regulatory role in the chemosensitivity to anticancer drugs through its dNTPase activity. The present review aimed to summarize the regulation of SAMHD1 expression in cancer and its function in tumor growth and chemotherapy sensitivity, and discussed controversial points and future directions.
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June-2021
Volume 21 Issue 6

Print ISSN: 1792-1074
Online ISSN:1792-1082

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Spandidos Publications style
Chen Z, Hu J, Ying S and Xu A: Dual roles of SAMHD1 in tumor development and chemoresistance to anticancer drugs (Review). Oncol Lett 21: 451, 2021
APA
Chen, Z., Hu, J., Ying, S., & Xu, A. (2021). Dual roles of SAMHD1 in tumor development and chemoresistance to anticancer drugs (Review). Oncology Letters, 21, 451. https://doi.org/10.3892/ol.2021.12712
MLA
Chen, Z., Hu, J., Ying, S., Xu, A."Dual roles of SAMHD1 in tumor development and chemoresistance to anticancer drugs (Review)". Oncology Letters 21.6 (2021): 451.
Chicago
Chen, Z., Hu, J., Ying, S., Xu, A."Dual roles of SAMHD1 in tumor development and chemoresistance to anticancer drugs (Review)". Oncology Letters 21, no. 6 (2021): 451. https://doi.org/10.3892/ol.2021.12712