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Article

Comprehensive genomic analysis contrasting primary colorectal cancer and matched liver metastases

  • Authors:
    • Akio Shiomi
    • Masatoshi Kusuhara
    • Takashi Sugino
    • Teiichi Sugiura
    • Keiichi Ohshima
    • Takeshi Nagashima
    • Kenichi Urakami
    • Masakuni Serizawa
    • Hideyuki Saya
    • Ken Yamaguchi
  • View Affiliations / Copyright

    Affiliations: Division of Colon and Rectal Surgery, Shizuoka Cancer Center, Shizuoka 411-8777, Japan, Regional Resources Division, Shizuoka Cancer Center Research Institute, Shizuoka 411-8777, Japan, Division of Pathology, Shizuoka Cancer Center, Shizuoka 411-8777, Japan, Division of Hepato-Biliary-Pancreatic Surgery, Shizuoka Cancer Center, Shizuoka 411-8777, Japan, Medical Genetics Division, Shizuoka Cancer Center Research Institute, Shizuoka 411-8777, Japan, Cancer Diagnostics Research Division, Shizuoka Cancer Center Research Institute, Shizuoka 411-8777, Japan, Drug Discovery and Development Division, Shizuoka Cancer Center Research Institute, Shizuoka 411-8777, Japan, Division of Gene Regulation Institute for Advanced Medical Research, Keio University School of Medicine, Tokyo 160-858, Japan, Shizuoka Cancer Center, Shizuoka 411-8777, Japan
  • Article Number: 466
    |
    Published online on: April 12, 2021
       https://doi.org/10.3892/ol.2021.12727
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Abstract

Recent studies have revealed that colorectal cancer (CRC) displays intratumor genetic heterogeneity, and that the cancer microenvironment plays an important role in the proliferation, invasion and metastasis of CRC. The present study performed genomic analysis on paired primary CRC and synchronous colorectal liver metastasis (CRLM) tissues collected from 22 patients using whole‑exome sequencing, cancer gene panels and microarray gene expression profiling. In addition, immunohistochemical analysis was used to confirm the protein expression levels of genes identified as highly expressed in CRLM by DNA microarray analysis. The present study identified 10 genes that were highly expressed in CRLM compared with in CRC, from 36,022 probes obtained from primary CRC, CRLM and normal liver tissues by gene expression analysis with DNA microarrays. Of the 10 genes identified, five were classified as encoding ‘matricellular proteins’ [(osteopontin, periostin, thrombospondin‑2, matrix Gla protein (MGP) and glycoprotein nonmetastatic melanoma protein B (GPNMB)] and were selected for immunohistochemical analysis. Osteopontin was strongly expressed in CRLM (6 of 22 cases: 27.3%), but not in CRC (0 of 22: 0%; P=0.02). Periostin also exhibited strong immunoreactivity in CRLM (17 of 22: 68.2%) compared with in CRC (7 of 22: 31.8%; P=0.006). Thrombospondin‑2 exhibited strong immunoreactivity in both CRC and CRLM (54.5% in CRC, 45.5% in CRLM; P=0.55). GPNMB and MGP were rarely positive for both CRC and CRLM. A comparison of immunoreactive positive factors for these five genes revealed the complexities of gene expression in CRLM. Of the cases examined, 16 (72.7%) cases of CRC showed zero or only one positive immunoreactive factor. By contrast, CRLM showed more frequent and multiple immunoreactive factors; for example, 16 cases (72.7%) shared two or more factors, which was statistically more frequent than in CRC (P=0.007). The present study revealed the genomic heterogeneity between paired primary CRC and CRLM, in terms of cancer cell microenvironment. This finding may lead to novel diagnostic and therapeutic targets in the era of genome‑guided personalized cancer treatment.
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1 

DeSantis CE, Lin CC, Mariotto AB, Siegel RL, Stein KD, Kramer JL, Alteri R, Robbins AS and Jemal A: Cancer treatment and survivorship statistics, 2014. CA Cancer J Clin. 64:252–271. 2014. View Article : Google Scholar : PubMed/NCBI

2 

Bray F, Ferlay J, Soerjomataram I, Siegel RL, Torre LA and Jemal A: Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA Cancer J Clin. 68:394–424. 2018. View Article : Google Scholar : PubMed/NCBI

3 

Hashiguchi Y, Muro K, Saito Y, Ito Y, Ajioka Y, Hamaguchi T, Hasegawa K, Hotta K, Ishida H, Ishiguro M, et al Japanese Society for Cancer of the Colon Rectum, : Japanese Society for Cancer of the Colon and Rectum (JSCCR) guidelines 2019 for the treatment of colorectal cancer. Int J Clin Oncol. 25:1–42. 2020. View Article : Google Scholar : PubMed/NCBI

4 

Folprecht G, Gruenberger T, Bechstein WO, Raab HR, Lordick F, Hartmann JT, Lang H, Frilling A, Stoehlmacher J, Weitz J, et al: Tumour response and secondary resectability of colorectal liver metastases following neoadjuvant chemotherapy with cetuximab: The CELIM randomised phase 2 trial. Lancet Oncol. 11:38–47. 2010. View Article : Google Scholar : PubMed/NCBI

5 

Majeed AW: Surgery for colorectal liver metastases with hepatic lymph node involvement: A systematic review. Br J Surg. 87:17372000. View Article : Google Scholar : PubMed/NCBI

6 

Martin LW and Warren RS: Current management of colorectal liver metastases. Surg Oncol Clin N Am. 9:853–878. 2000. View Article : Google Scholar : PubMed/NCBI

7 

Penna C and Nordlinger B: Colorectal metastasis (liver and lung). Surg Clin North Am. 82:1075–1090, x-xi. 2002. View Article : Google Scholar : PubMed/NCBI

8 

Fidler IJ and Kripke ML: Metastasis results from preexisting variant cells within a malignant tumor. Science. 197:893–895. 1977. View Article : Google Scholar : PubMed/NCBI

9 

Futakuchi M, Nannuru KC, Varney ML, Sadanandam A, Nakao K, Asai K, Shirai T, Sato SY and Singh RK: Transforming growth factor-beta signaling at the tumor-bone interface promotes mammary tumor growth and osteoclast activation. Cancer Sci. 100:71–81. 2009. View Article : Google Scholar : PubMed/NCBI

10 

Nagashima T, Yamaguchi K, Urakami K, Shimoda Y, Ohnami S, Ohshima K, Tanabe T, Naruoka A, Kamada F, Serizawa M, et al: Japanese version of The Cancer Genome Atlas, JCGA, established using fresh frozen tumors obtained from 5143 cancer patients. Cancer Sci. 111:687–699. 2020. View Article : Google Scholar : PubMed/NCBI

11 

Japanese ethical guidelines for human genome/gene analysis research. https://www.mhlw.go.jp/general/seido/kousei/i-kenkyu/genome/0504sisin.htmlMarch 25–2021

12 

Ion Reporter Software User Guide, . Tumor-Normal pair workflow. https://tools.thermofisher.com/content/sfs/manuals/IonReporter_v50_Help.pdfMarch 25–2021

13 

Torrent Suite v4.4.3 User and Admin Guide, . https://assets.thermofisher.com/TFS-Assets/LSG/manuals/MAN0019144_TorrentSuite_5_14_UG.pdfMarch 25–2021

14 

Robinson JT, Thorvaldsdóttir H, Winckler W, Guttman M, Lander ES, Getz G and Mesirov JP: Integrative genomics viewer. Nat Biotechnol. 29:24–26. 2011. View Article : Google Scholar : PubMed/NCBI

15 

Bamford S, Dawson E, Forbes S, Clements J, Pettett R, Dogan A, Flanagan A, Teague J, Futreal PA, Stratton MR, et al: The COSMIC (Catalogue of Somatic Mutations in Cancer) database and website. Br J Cancer. 91:355–358. 2004. View Article : Google Scholar : PubMed/NCBI

16 

Landrum MJ, Lee JM, Riley GR, Jang W, Rubinstein WS, Church DM and Maglott DR: ClinVar: Public archive of relationships among sequence variation and human phenotype. Nucleic Acids Res. 42:D980–D985. 2014. View Article : Google Scholar

17 

Sherry ST, Ward MH, Kholodov M, Baker J, Phan L, Smigielski EM and Sirotkin K: dbSNP: The NCBI database of genetic variation. Nucleic Acids Res. 308–311. 2001. View Article : Google Scholar : PubMed/NCBI

18 

UniProt Consortium: UniProt: A hub for protein information. Nucleic Acids Res. 43:D204–D212. 2015. View Article : Google Scholar

19 

Wishart DS, Knox C, Guo AC, Shrivastava S, Hassanali M, Stothard P, Chang Z and Woolsey J: DrugBank: A comprehensive resource for in silico drug discovery and exploration. Nucleic Acids Res. 34:D668–D672. 2006. View Article : Google Scholar

20 

Nagashima T, Shimoda Y, Tanabe T, Naruoka A, Saito J, Serizawa M, Ohshima K, Urakami K, Ohnami S, Ohnami S, et al: Optimizing an ion semiconductor sequencing data analysis method to identify somatic mutations in the genomes of cancer cells in clinical tissue samples. Biomed Res. 37:359–366. 2016. View Article : Google Scholar : PubMed/NCBI

21 

Shimoda Y, Nagashima T, Urakami K, Tanabe T, Saito J, Naruoka A, Serizawa M, Mochizuki T, Ohshima K, Ohnami S, et al: Integrated next-generation sequencing analysis of whole exome and 409 cancer-related genes. Biomed Res. 37:367–379. 2016. View Article : Google Scholar : PubMed/NCBI

22 

Urakami K, Shimoda Y, Ohshima K, Nagashima T, Serizawa M, Tanabe T, Saito J, Usui T, Watanabe Y, Naruoka A, et al: Next generation sequencing approach for detecting 491 fusion genes from human cancer. Biomed Res. 37:51–62. 2016. View Article : Google Scholar : PubMed/NCBI

23 

Guinney J, Dienstmann R, Wang X, de Reyniès A, Schlicker A, Soneson C, Marisa L, Roepman P, Nyamundanda G, Angelino P, et al: The consensus molecular subtypes of colorectal cancer. Nat Med. 21:1350–1356. 2015. View Article : Google Scholar : PubMed/NCBI

24 

Sadanandam A, Lyssiotis CA, Homicsko K, Collisson EA, Gibb WJ, Wullschleger S, Ostos LC, Lannon WA, Grotzinger C, Del Rio M, et al: A colorectal cancer classification system that associates cellular phenotype and responses to therapy. Nat Med. 19:619–625. 2013. View Article : Google Scholar : PubMed/NCBI

25 

Le DT, Uram JN, Wang H, Bartlett BR, Kemberling H, Eyring AD, Skora AD, Luber BS, Azad NS, Laheru D, et al: PD-1 blockade in tumors with mismatch-repair deficiency. N Engl J Med. 372:2509–2520. 2015. View Article : Google Scholar : PubMed/NCBI

26 

Le DT, Durham JN, Smith KN, Wang H, Bartlett BR, Aulakh LK, Lu S, Kemberling H, Wilt C, Luber BS, et al: Mismatch repair deficiency predicts response of solid tumors to PD-1 blockade. Science. 357:409–413. 2017. View Article : Google Scholar : PubMed/NCBI

27 

Polanska UM and Orimo A: Carcinoma-associated fibroblasts: Non-neoplastic tumour-promoting mesenchymal cells. J Cell Physiol. 228:1651–1657. 2013. View Article : Google Scholar : PubMed/NCBI

28 

Ishii G, Ochiai A and Neri S: Phenotypic and functional heterogeneity of cancer-associated fibroblast within the tumor microenvironment. Adv Drug Deliv Rev. 99:186–196. 2016. View Article : Google Scholar : PubMed/NCBI

29 

Kyutoku M, Taniyama Y, Katsuragi N, Shimizu H, Kunugiza Y, Iekushi K, Koibuchi N, Sanada F, Oshita Y and Morishita R: Role of periostin in cancer progression and metastasis: Inhibition of breast cancer progression and metastasis by anti-periostin antibody in a murine model. Int J Mol Med. 28:181–186. 2011.PubMed/NCBI

30 

Erkan M, Kleeff J, Gorbachevski A, Reiser C, Mitkus T, Esposito I, Giese T, Büchler MW, Giese NA and Friess H: Periostin creates a tumor-supportive microenvironment in the pancreas by sustaining fibrogenic stellate cell activity. Gastroenterology. 132:1447–1464. 2007. View Article : Google Scholar : PubMed/NCBI

31 

Kudo Y, Ogawa I, Kitajima S, Kitagawa M, Kawai H, Gaffney PM, Miyauchi M and Takata T: Periostin promotes invasion and anchorage-independent growth in the metastatic process of head and neck cancer. Cancer Res. 66:6928–6935. 2006. View Article : Google Scholar : PubMed/NCBI

32 

Puglisi F, Puppin C, Pegolo E, Andreetta C, Pascoletti G, D'Aurizio F, Pandolfi M, Fasola G, Piga A, Damante G, et al: Expression of periostin in human breast cancer. J Clin Pathol. 61:494–498. 2008. View Article : Google Scholar : PubMed/NCBI

33 

Moniuszko T, Wincewicz A, Koda M, Domysławska I and Sulkowski S: Role of periostin in esophageal, gastric and colon cancer. Oncol Lett. 12:783–787. 2016. View Article : Google Scholar : PubMed/NCBI

34 

Sodek J, Ganss B and McKee MD: Osteopontin. Crit Rev Oral Biol Med. 11:279–303. 2000. View Article : Google Scholar : PubMed/NCBI

35 

Zhang J, Takahashi K, Takahashi F, Shimizu K, Ohshita F, Kameda Y, Maeda K, Nishio K and Fukuchi Y: Differential osteopontin expression in lung cancer. Cancer Lett. 171:215–222. 2001. View Article : Google Scholar : PubMed/NCBI

36 

Song G, Cai QF, Mao YB, Ming YL, Bao SD and Ouyang GL: Osteopontin promotes ovarian cancer progression and cell survival and increases HIF-1alpha expression through the PI3-K/Akt pathway. Cancer Sci. 99:1901–1907. 2008.PubMed/NCBI

37 

Kim JY, Bae BN, Kim KS, Shin E and Park K: Osteopontin, CD44, and NFkappaB expression in gastric adenocarcinoma. Cancer Res Treat. 41:29–35. 2009. View Article : Google Scholar : PubMed/NCBI

38 

Likui W, Hong W and Shuwen Z: Clinical significance of the upregulated osteopontin mRNA expression in human colorectal cancer. J Gastrointest Surg. 14:74–81. 2010. View Article : Google Scholar : PubMed/NCBI

39 

Bramwell VH, Tuck AB, Chapman JA, Anborgh PH, Postenka CO, Al-Katib W, Shepherd LE, Han L, Wilson CF, Pritchard KI, et al: Assessment of osteopontin in early breast cancer: Correlative study in a randomised clinical trial. Breast Cancer Res. 16:R82014. View Article : Google Scholar : PubMed/NCBI

40 

Zhao M, Liang F, Zhang B, Yan W and Zhang J: The impact of osteopontin on prognosis and clinicopathology of colorectal cancer patients: A systematic meta-analysis. Sci Rep. 5:127132015. View Article : Google Scholar : PubMed/NCBI

41 

Tokunaga T, Nakamura M, Oshika Y, Abe Y, Ozeki Y, Fukushima Y, Hatanaka H, Sadahiro S, Kijima H, Tsuchida T, et al: Thrombospondin 2 expression is correlated with inhibition of angiogenesis and metastasis of colon cancer. Br J Cancer. 79:354–359. 1999. View Article : Google Scholar : PubMed/NCBI

42 

de Fraipont F, Nicholson AC, Feige JJ and Van Meir EG: Thrombospondins and tumor angiogenesis. Trends Mol Med. 7:401–407. 2001. View Article : Google Scholar : PubMed/NCBI

43 

Kim H, Watkinson J, Varadan V and Anastassiou D: Multi-cancer computational analysis reveals invasion-associated variant of desmoplastic reaction involving INHBA, THBS2 and COL11A1. BMC Med Genomics. 3:512010. View Article : Google Scholar : PubMed/NCBI

44 

Tian Q, Liu Y, Zhang Y, Song Z, Yang J, Zhang J, Guo T, Gao W, Dai F and He C: THBS2 is a biomarker for AJCC stages and a strong prognostic indicator in colorectal cancer. J BUON. 23:1331–1336. 2018.PubMed/NCBI

45 

Rich JN, Shi Q, Hjelmeland M, Cummings TJ, Kuan CT, Bigner DD, Counter CM and Wang XF: Bone-related genes expressed in advanced malignancies induce invasion and metastasis in a genetically defined human cancer model. J Biol Chem. 278:15951–15957. 2003. View Article : Google Scholar : PubMed/NCBI

46 

Kuan CT, Wakiya K, Dowell JM, Herndon JE II, Reardon DA, Graner MW, Riggins GJ, Wikstrand CJ and Bigner DD: Glycoprotein nonmetastatic melanoma protein B, a potential molecular therapeutic target in patients with glioblastoma multiforme. Clin Cancer Res. 12:1970–1982. 2006. View Article : Google Scholar : PubMed/NCBI

47 

Rose AA, Pepin F, Russo C, Abou Khalil JE, Hallett M and Siegel PM: Osteoactivin promotes breast cancer metastasis to bone. Mol Cancer Res. 5:1001–1014. 2007. View Article : Google Scholar : PubMed/NCBI

48 

Rose AA, Annis MG, Dong Z, Pepin F, Hallett M, Park M and Siegel PM: ADAM10 releases a soluble form of the GPNMB/Osteoactivin extracellular domain with angiogenic properties. PLoS One. 5:e120932010. View Article : Google Scholar : PubMed/NCBI

49 

Rose AA, Grosset AA, Dong Z, Russo C, Macdonald PA, Bertos NR, St-Pierre Y, Simantov R, Hallett M, Park M, et al: Glycoprotein nonmetastatic B is an independent prognostic indicator of recurrence and a novel therapeutic target in breast cancer. Clin Cancer Res. 16:2147–2156. 2010. View Article : Google Scholar : PubMed/NCBI

50 

Taya M and Hammes SR: Glycoprotein non-metastatic melanoma protein B (GPNMB) and cancer: A novel potential therapeutic target. Steroids. 133:102–107. 2018. View Article : Google Scholar : PubMed/NCBI

51 

Zhou LT, Liu FY, Li Y, Peng YM, Liu YH and Li J: Gpnmb/osteoactivin, an attractive target in cancer immunotherapy. Neoplasma. 59:1–5. 2012. View Article : Google Scholar : PubMed/NCBI

52 

Selim AA: Osteoactivin bioinformatic analysis: Prediction of novel functions, structural features, and modes of action. Med Sci Monit. 15:MT19–MT33. 2009.

53 

Singh M, Del Carpio-Cano F, Belcher JY, Crawford K, Frara N, Owen TA, Popoff SN and Safadi FF: Functional roles of osteoactivin in normal and disease processes. Crit Rev Eukaryot Gene Expr. 20:341–357. 2010. View Article : Google Scholar : PubMed/NCBI

54 

Mertsch S, Schurgers LJ, Weber K, Paulus W and Senner V: Matrix gla protein (MGP): An overexpressed and migration-promoting mesenchymal component in glioblastoma. BMC Cancer. 9:3022009. View Article : Google Scholar : PubMed/NCBI

55 

Kuzontkoski PM, Mulligan-Kehoe MJ, Harris BT and Israel MA: Inhibitor of DNA binding-4 promotes angiogenesis and growth of glioblastoma multiforme by elevating matrix GLA levels. Oncogene. 29:3793–3802. 2010. View Article : Google Scholar : PubMed/NCBI

56 

Gheorghe SR and Crăciun AM: Matrix Gla protein in tumoral pathology. Clujul Med. 89:319–321. 2016.PubMed/NCBI

57 

Caiado H, Conceição N, Tiago D, Marreiros A, Vicente S, Enriquez JL, Vaz AM, Antunes A, Guerreiro H, Caldeira P, et al: Evaluation of MGP gene expression in colorectal cancer. Gene. 723:1441202020. View Article : Google Scholar : PubMed/NCBI

58 

Hope NR and Murray GI: The expression profile of RNA-binding proteins in primary and metastatic colorectal cancer: Relationship of heterogeneous nuclear ribonucleoproteins with prognosis. Hum Pathol. 42:393–402. 2011. View Article : Google Scholar : PubMed/NCBI

59 

Vakiani E, Janakiraman M, Shen R, Sinha R, Zeng Z, Shia J, Cercek A, Kemeny N, D'Angelica M, Viale A, et al: Comparative genomic analysis of primary versus metastatic colorectal carcinomas. J Clin Oncol. 30:2956–2962. 2012. View Article : Google Scholar : PubMed/NCBI

60 

Schrijver WAME, Selenica P, Lee JY, Ng CKY, Burke KA, Piscuoglio S, Berman SH, Reis-Filho JS, Weigelt B, van Diest PJ, et al: Mutation profiling of key cancer genes in primary breast cancers and their distant metastases. Cancer Res. 78:3112–3121. 2018. View Article : Google Scholar : PubMed/NCBI

61 

Ding L, Ley TJ, Larson DE, Miller CA, Koboldt DC, Welch JS, Ritchey JK, Young MA, Lamprecht T, McLellan MD, et al: Clonal evolution in relapsed acute myeloid leukaemia revealed by whole-genome sequencing. Nature. 481:506–510. 2012. View Article : Google Scholar : PubMed/NCBI

62 

Johnson BE, Mazor T, Hong C, Barnes M, Aihara K, McLean CY, Fouse SD, Yamamoto S, Ueda H, Tatsuno K, et al: Mutational analysis reveals the origin and therapy-driven evolution of recurrent glioma. Science. 343:189–193. 2014. View Article : Google Scholar : PubMed/NCBI

63 

Harada K, Okamoto W, Mimaki S, Kawamoto Y, Bando H, Yamashita R, Yuki S, Yoshino T, Komatsu Y, Ohtsu A, et al: Comparative sequence analysis of patient-matched primary colorectal cancer, metastatic, and recurrent metastatic tumors after adjuvant FOLFOX chemotherapy. BMC Cancer. 19:2552019. View Article : Google Scholar : PubMed/NCBI

64 

Gagnière J, Dupré A, Gholami SS, Pezet D, Boerner T, Gönen M, Kingham TP, Allen PJ, Balachandran VP, De Matteo RP, et al: Is hepatectomy justified for BRAF mutant colorectal liver metastases?: A multi-institutional analysis of 1497 patients. Ann Surg. 271:147–154. 2020. View Article : Google Scholar

65 

Wu Y, Denhardt DT and Rittling SR: Osteopontin is required for full expression of the transformed phenotype by the ras oncogene. Br J Cancer. 83:156–163. 2000. View Article : Google Scholar : PubMed/NCBI

66 

Nemoto H, Rittling SR, Yoshitake H, Furuya K, Amagasa T, Tsuji K, Nifuji A, Denhardt DT and Noda M: Osteopontin deficiency reduces experimental tumor cell metastasis to bone and soft tissues. J Bone Miner Res. 16:652–659. 2001. View Article : Google Scholar : PubMed/NCBI

67 

Wu XL, Lin KJ, Bai AP, Wang WX, Meng XK, Su XL, Hou MX, Dong PD, Zhang JJ, Wang ZY, et al: Osteopontin knockdown suppresses the growth and angiogenesis of colon cancer cells. World J Gastroenterol. 20:10440–10448. 2014. View Article : Google Scholar : PubMed/NCBI

68 

Wei R, Wong JPC and Kwok HF: Osteopontin - a promising biomarker for cancer therapy. J Cancer. 8:2173–2183. 2017. View Article : Google Scholar : PubMed/NCBI

69 

Rose AAN, Biondini M, Curiel R and Siegel PM: Targeting GPNMB with glembatumumab vedotin: Current developments and future opportunities for the treatment of cancer. Pharmacol Ther. 179:127–141. 2017. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Shiomi A, Kusuhara M, Sugino T, Sugiura T, Ohshima K, Nagashima T, Urakami K, Serizawa M, Saya H, Yamaguchi K, Yamaguchi K, et al: Comprehensive genomic analysis contrasting primary colorectal cancer and matched liver metastases. Oncol Lett 21: 466, 2021.
APA
Shiomi, A., Kusuhara, M., Sugino, T., Sugiura, T., Ohshima, K., Nagashima, T. ... Yamaguchi, K. (2021). Comprehensive genomic analysis contrasting primary colorectal cancer and matched liver metastases. Oncology Letters, 21, 466. https://doi.org/10.3892/ol.2021.12727
MLA
Shiomi, A., Kusuhara, M., Sugino, T., Sugiura, T., Ohshima, K., Nagashima, T., Urakami, K., Serizawa, M., Saya, H., Yamaguchi, K."Comprehensive genomic analysis contrasting primary colorectal cancer and matched liver metastases". Oncology Letters 21.6 (2021): 466.
Chicago
Shiomi, A., Kusuhara, M., Sugino, T., Sugiura, T., Ohshima, K., Nagashima, T., Urakami, K., Serizawa, M., Saya, H., Yamaguchi, K."Comprehensive genomic analysis contrasting primary colorectal cancer and matched liver metastases". Oncology Letters 21, no. 6 (2021): 466. https://doi.org/10.3892/ol.2021.12727
Copy and paste a formatted citation
x
Spandidos Publications style
Shiomi A, Kusuhara M, Sugino T, Sugiura T, Ohshima K, Nagashima T, Urakami K, Serizawa M, Saya H, Yamaguchi K, Yamaguchi K, et al: Comprehensive genomic analysis contrasting primary colorectal cancer and matched liver metastases. Oncol Lett 21: 466, 2021.
APA
Shiomi, A., Kusuhara, M., Sugino, T., Sugiura, T., Ohshima, K., Nagashima, T. ... Yamaguchi, K. (2021). Comprehensive genomic analysis contrasting primary colorectal cancer and matched liver metastases. Oncology Letters, 21, 466. https://doi.org/10.3892/ol.2021.12727
MLA
Shiomi, A., Kusuhara, M., Sugino, T., Sugiura, T., Ohshima, K., Nagashima, T., Urakami, K., Serizawa, M., Saya, H., Yamaguchi, K."Comprehensive genomic analysis contrasting primary colorectal cancer and matched liver metastases". Oncology Letters 21.6 (2021): 466.
Chicago
Shiomi, A., Kusuhara, M., Sugino, T., Sugiura, T., Ohshima, K., Nagashima, T., Urakami, K., Serizawa, M., Saya, H., Yamaguchi, K."Comprehensive genomic analysis contrasting primary colorectal cancer and matched liver metastases". Oncology Letters 21, no. 6 (2021): 466. https://doi.org/10.3892/ol.2021.12727
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