Open Access

Current status of extended ‘D2 plus’ lymphadenectomy in advanced gastric cancer (Review)

  • Authors:
    • Jing-Quan Li
    • Donglei He
    • Yue-Xiang Liang
  • View Affiliations

  • Published online on: April 12, 2021     https://doi.org/10.3892/ol.2021.12728
  • Article Number: 467
  • Copyright: © Li et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

The extent of lymph node (LN) dissection has been a topic of interest in gastric cancer (GC) surgery. D2 lymphadenectomy is considered the standard surgical procedure for most resectable advanced GC cases. The value and indications of more extended lymphadenectomy than D2 remain unclear. Currently, the controversial stations beyond the D2 range are mainly focused on no. 14v, no. 16a2/b1 and no. 13 LN stations. The metastatic rate of no. 14v LN is relatively high in advanced distal GC, particularly in patients with suspicious no. 6 LN metastasis. D2 plus no. 14v LN dissection may be attributed to improved survival outcomes for patients with obvious no. 6 LN metastasis. Although GC with para‑aortic lymph node (PALN) metastases is considered an M1 disease beyond surgical cure, patients with limited PALN metastases may benefit from the treatment strategy of adjuvant chemotherapy followed by D2 plus no. 16a2‑b1 LN dissection. In addition, D2 plus no. 13 LN dissection may be an option in a potentially curative gastrectomy for GC with duodenal invasion. The present review discusses the current status and future perspectives of D2 plus lymphadenectomy.
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June-2021
Volume 21 Issue 6

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Spandidos Publications style
Li J, He D and Liang Y: Current status of extended ‘D2 plus’ lymphadenectomy in advanced gastric cancer (Review). Oncol Lett 21: 467, 2021
APA
Li, J., He, D., & Liang, Y. (2021). Current status of extended ‘D2 plus’ lymphadenectomy in advanced gastric cancer (Review). Oncology Letters, 21, 467. https://doi.org/10.3892/ol.2021.12728
MLA
Li, J., He, D., Liang, Y."Current status of extended ‘D2 plus’ lymphadenectomy in advanced gastric cancer (Review)". Oncology Letters 21.6 (2021): 467.
Chicago
Li, J., He, D., Liang, Y."Current status of extended ‘D2 plus’ lymphadenectomy in advanced gastric cancer (Review)". Oncology Letters 21, no. 6 (2021): 467. https://doi.org/10.3892/ol.2021.12728