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miR‑4417 targets lncRNA PSMG3‑AS1 to suppress cell invasion and migration in cervical squamous cell carcinoma

  • Authors:
    • Shuhong Man
    • Xiaohan Li
    • Wei Zhu
  • View Affiliations / Copyright

    Affiliations: Department of Gynaecology, Weifang People's Hospital, Weifang, Shandong 261000, P.R. China, School of Public Health, Shandong University, Jinan, Shandong 250012, P.R. China, Nursing Department, Weifang People's Hospital, Weifang, Shandong 261000, P.R. China
    Copyright: © Man et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 502
    |
    Published online on: April 29, 2021
       https://doi.org/10.3892/ol.2021.12763
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Abstract

Although long non‑coding RNA (lncRNA) PSMG3‑AS1 has been reported to participate in cancer biology, its role in cervical squamous cell carcinoma (CSCC) is unknown. The present study aimed to investigate the role of the lncRNA PSMG3‑AS1 in CSCC. The expression levels of PSMG3‑AS1 in both CSCC and non‑tumor tissues from 64 patients with CSCC were measured by reverse transcription‑quantitative PCR. The potential interaction between miR‑4417 and PSMG3‑AS1 was predicted using IntaRNA 2.0. Overexpression of miR‑4417 and PSMG3‑AS1 were achieved in CSCC cells to further explore the potential interaction between them. The effects of overexpression of miR‑4417 and PSMG3‑AS1 on CSCC cell invasion and migration were assessed by Transwell assay. The results revealed that PSMG3‑AS1 expression was upregulated in CSCC tissues, and its high expression levels predicted a poor survival in patients with CSCC. miR‑4417 expression was downregulated in CSCC tissues and was inversely correlated with PSMG3‑AS1 expression. Moreover, miR‑4417 was predicted to interact with PSMG3‑AS1. In CSCC cells, overexpression of miR‑4417 decreased the expression levels of PSMG3‑AS1, while overexpression of PSMG3‑AS1 did not affect miR‑4417 expression. Transwell assay demonstrated that overexpression of PSMG3‑AS1 increased CSCC cell invasion and migration. However, overexpression of miR‑4417 inhibited CSCC cell invasion and migration, and attenuated the effects of PSMG3‑AS1 overexpression in CSCC cells. In conclusion, the present study indicated that miR‑4417 may target PSMG3‑AS1 to suppress cancer cell invasion and migration in CSCC.
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1 

Small W Jr, Bacon MA, Bajaj A, Chuang LT, Fisher BJ, Harkenrider MM, Jhingran A, Kitchener HC, Mileshkin LR, Viswanathan AN, et al: Cervical cancer: A global health crisis. Cancer. 123:2404–2412. 2017. View Article : Google Scholar : PubMed/NCBI

2 

Bray F, Ferlay J, Soerjomataram I, Siegel RL, Torre LA and Jemal A: Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA Cancer J Clin. 68:394–424. 2018. View Article : Google Scholar : PubMed/NCBI

3 

Wentzensen N, Schiffman M, Palmer T and Arbyn M: Triage of HPV positive women in cervical cancer screening. J Clin Virol. 76 (Suppl 1):S49–S55. 2016. View Article : Google Scholar : PubMed/NCBI

4 

Drews CM, Case S and Vande Pol SB: E6 proteins from high-risk HPV, low-risk HPV, and animal papillomaviruses activate the Wnt/β-catenin pathway through E6AP-dependent degradation of NHERF1. PLoS Pathog. 15:e10075752019. View Article : Google Scholar : PubMed/NCBI

5 

Basukala O, Mittal S, Massimi P, Bestagno M and Banks L: The HPV-18 E7 CKII phospho acceptor site is required for maintaining the transformed phenotype of cervical tumour-derived cells. PLoS Pathog. 15:e10077692019. View Article : Google Scholar : PubMed/NCBI

6 

Waggoner SE: Cervical cancer. Lancet. 361:2217–2225. 2003. View Article : Google Scholar : PubMed/NCBI

7 

Koh WJ, Greer BE, Abu-Rustum NR, Apte SM, Campos SM, Cho KR, Chu C, Cohn D, Crispens MA, Dorigo O, et al: Cervical cancer, version 2.2015. J Natl Compr Canc Netw. 13:395–404; quiz 404. 2015. View Article : Google Scholar : PubMed/NCBI

8 

Wang B, He M, Chao A, Engelgau MM, Saraiya M and Wang L and Wang L: Cervical cancer screening among adult women in China, 2010. Oncologist. 20:627–634. 2015. View Article : Google Scholar : PubMed/NCBI

9 

Ibeanu OA: Molecular pathogenesis of cervical cancer. Cancer Biol Ther. 11:295–306. 2011. View Article : Google Scholar : PubMed/NCBI

10 

Crafton SM and Salani R: Beyond chemotherapy: An overview and review of targeted therapy in cervical cancer. Clin Ther. 38:449–458. 2016. View Article : Google Scholar : PubMed/NCBI

11 

Chandra Gupta S and Nandan Tripathi Y: Potential of long non-coding RNAs in cancer patients: From biomarkers to therapeutic targets. Int J Cancer. 140:1955–1967. 2017. View Article : Google Scholar : PubMed/NCBI

12 

Cui Y, Fan Y, Zhao G, Zhang Q, Bao Y, Cui Y, Ye Z, Chen G, Piao X, Guo F, et al: Novel lncRNA PSMG3 AS1 functions as a miR 143 3p sponge to increase the proliferation and migration of breast cancer cells. Oncol Rep. 43:229–239. 2020.PubMed/NCBI

13 

Wong CK, Gromisch C, Ozturk S, Papageorgis P, Abdolmaleky HM, Reinhard BM, Thiagalingam A and Thiagalingam S: MicroRNA-4417 is a tumor suppressor and prognostic biomarker for triple-negative breast cancer. Cancer Biol Ther. 20:1113–1120. 2019. View Article : Google Scholar : PubMed/NCBI

14 

Liu CS, Spirtos A, Khulpateea BR and Lea JS: AJCC versus FIGO staging of cervical cancer to predict disease severity. Gynecol Oncol. 149:1552018. View Article : Google Scholar

15 

Livak KJ and Schmittgen TD: Analysis of relative gene expression data using real-time quantitative PCR and the 2(−ΔΔC(T)) μethod. Methods. 25:402–408. 2001. View Article : Google Scholar : PubMed/NCBI

16 

Mann M, Wright PR and Backofen R: IntaRNA 2.0: Enhanced and customizable prediction of RNA-RNA interactions. Nucleic Acids Res. 45:W435–W439. 2017. View Article : Google Scholar : PubMed/NCBI

17 

Song L, Zhang W, Chang Z, Pan Y, Zong H, Fan Q and Wang L: miR-4417 targets tripartite motif-containing 35 (TRIM35) and regulates pyruvate kinase muscle 2 (PKM2) phosphorylation to promote proliferation and suppress apoptosis in hepatocellular carcinoma cells. Med Sci Monit. 23:1741–1750. 2017. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Man S, Li X and Zhu W: miR‑4417 targets lncRNA PSMG3‑AS1 to suppress cell invasion and migration in cervical squamous cell carcinoma. Oncol Lett 22: 502, 2021.
APA
Man, S., Li, X., & Zhu, W. (2021). miR‑4417 targets lncRNA PSMG3‑AS1 to suppress cell invasion and migration in cervical squamous cell carcinoma. Oncology Letters, 22, 502. https://doi.org/10.3892/ol.2021.12763
MLA
Man, S., Li, X., Zhu, W."miR‑4417 targets lncRNA PSMG3‑AS1 to suppress cell invasion and migration in cervical squamous cell carcinoma". Oncology Letters 22.1 (2021): 502.
Chicago
Man, S., Li, X., Zhu, W."miR‑4417 targets lncRNA PSMG3‑AS1 to suppress cell invasion and migration in cervical squamous cell carcinoma". Oncology Letters 22, no. 1 (2021): 502. https://doi.org/10.3892/ol.2021.12763
Copy and paste a formatted citation
x
Spandidos Publications style
Man S, Li X and Zhu W: miR‑4417 targets lncRNA PSMG3‑AS1 to suppress cell invasion and migration in cervical squamous cell carcinoma. Oncol Lett 22: 502, 2021.
APA
Man, S., Li, X., & Zhu, W. (2021). miR‑4417 targets lncRNA PSMG3‑AS1 to suppress cell invasion and migration in cervical squamous cell carcinoma. Oncology Letters, 22, 502. https://doi.org/10.3892/ol.2021.12763
MLA
Man, S., Li, X., Zhu, W."miR‑4417 targets lncRNA PSMG3‑AS1 to suppress cell invasion and migration in cervical squamous cell carcinoma". Oncology Letters 22.1 (2021): 502.
Chicago
Man, S., Li, X., Zhu, W."miR‑4417 targets lncRNA PSMG3‑AS1 to suppress cell invasion and migration in cervical squamous cell carcinoma". Oncology Letters 22, no. 1 (2021): 502. https://doi.org/10.3892/ol.2021.12763
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