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Print ISSN: 1792-1074 Online ISSN: 1792-1082
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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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Journal Cover
July-2021 Volume 22 Issue 1

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Journal Metrics

Impact Factor: 2.2

CiteScore: 4.6

CiteScore Rank: Q2: #178/415 Oncology

Source Normalized Impact per Paper (SNIP): 0.568

SCImago Journal Rank (SJR): 0.663

Article Open Access

Tenascin‑C promotes epithelial‑to‑mesenchymal transition and the mTOR signaling pathway in nasopharyngeal carcinoma

Xiang Cheng, Fen Li, Zezhang Tao
Article Number: 570
Published online on: 29 May 2021

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Article Open Access

Dacomitinib improves chemosensitivity of cisplatin‑resistant human ovarian cancer cells

Lei Xu, Ying Xu, Jianbing Zheng, Yun Zhao, Hongcai Wang, Yushu Qi
Article Number: 569
Published online on: 29 May 2021

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Article Open Access

Characterization of the small RNA transcriptomes of cell protrusions and cell bodies of highly metastatic hepatocellular carcinoma cells via RNA sequencing

Wenpin Cai, Jingzhang Ji, Biting Wu, Kaixuan Hao, Ping Ren, Yu Jin, Lihong Yang, Qingchao Tong, Zhifa Shen
Article Number: 568
Published online on: 29 May 2021

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Article Open Access

lncRNA IUR upregulates miR‑34a to inhibit pancreatic adenocarcinoma cell migratory and invasive abilities

Ren Li, Jian Zhang, Shiyang Ma, Gang Zhao, Jun Li, Jiangwei Li, Xiaoyi Wang, Bo Hui
Article Number: 567
Published online on: 29 May 2021

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Review Open Access

Effect of melanoma stem cells on melanoma metastasis (Review)

Qiliang Yin, Xiumin Shi, Shijie Lan, Haofan Jin, Di Wu
Article Number: 566
Published online on: 29 May 2021

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Article Open Access

lncRNA SNHG7 promotes cell proliferation in glioma by acting as a competing endogenous RNA and sponging miR‑138‑5p to regulate EZH2 expression

Yanyao Deng, Liuyang Cheng, Zhicheng Lv, Hongwei Zhu, Xiangrui Meng
Article Number: 565
Published online on: 29 May 2021

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Review Open Access

LZTR1: A promising adaptor of the CUL3 family (Review)

Hui Zhang, Xinyi Cao, Jian Wang, Qian Li, Yiting Zhao, Xiaofeng Jin
Article Number: 564
Published online on: 29 May 2021

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Article Open Access

circMTO1 sponges microRNA‑219a‑5p to enhance gallbladder cancer progression via the TGF‑β/Smad and EGFR pathways

Pingfan Wang, Chenggang Zhou, Donghai Li, Dongsheng Zhang, Long Wei, Ying Deng
Article Number: 563
Published online on: 27 May 2021

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Article Open Access

Triptolide inhibits matrix metalloproteinase-9 expression and invasion of breast cancer cells through the inhibition of NF-κB and AP-1 signaling pathways

On-Yu Hong, Hye-Yeon Jang, Kwang-Hyun Park, Young-Ju Jeong, Jong-Suk Kim, Hee Suk Chae
Article Number: 562
Published online on: 27 May 2021

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Article Open Access

Clinical value of color Doppler ultrasound combined with serum tumor markers for the diagnosis of medullary thyroid carcinoma

Xue Yang, Jinjuan Xu, Jilan Sun, Lizhi Yin, Rui Guo, Zhimei Yan
Article Number: 561
Published online on: 27 May 2021

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Article Open Access

MicroRNA expression profiling involved in doxorubicin‑induced cardiotoxicity using high‑throughput deep‑sequencing analysis

Ying Chen, Yingjie Xu, Zhoufeng Deng, Yin Wang, Ying Zheng, Weihua Jiang, Li Jiang
Article Number: 560
Published online on: 26 May 2021

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Case Report Open Access

Whole genome, exon mutation and transcriptomic profiling of acute myeloid leukemia: A case report

Si-Han Lai, Ye-Cheng Li, Shan Zhang, Rui Deng, Yan Deng, Fang-Yi Fan
Article Number: 559
Published online on: 25 May 2021

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Article Open Access

Enhanced G1 arrest and apoptosis via MDM4/MDM2 double knockdown and MEK inhibition in wild‑type TP53 colon and gastric cancer cells with aberrant KRAS signaling

Xiaoxuan Wang, Yoshiyuki Yamamoto, Mamiko Imanishi, Xiaochen Zhang, Masashi Sato, Akinori Sugaya, Mitsuaki Hirose, Shinji Endo, Yukikazu Natori, Toshikazu Moriwaki, Kenji Yamato, Ichinosuke Hyodo
Article Number: 558
Published online on: 25 May 2021

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Article Open Access

Upregulation of LINC00659 expression predicts a poor prognosis and promotes migration and invasion of gastric cancer cells Corrigendum in /10.3892/ol.2023.13785

Pihai Gong, Ying Xu, Min Liu, Xiaohui Shen, Yuhang Mao, Yiping Li, Kun Zhang, Shenling Yu, Hong Fan
Article Number: 557
Published online on: 24 May 2021

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Article Open Access

Integrin α5 promotes migration and invasion through the FAK/STAT3/AKT signaling pathway in icotinib‑resistant non‑small cell lung cancer cells

Yang Yang, Yizhe Wang, Xiaofang Che, Kezuo Hou, Jie Wu, Chunlei Zheng, Yang Cheng, Yunpeng Liu, Xuejun Hu, Jingdong Zhang
Article Number: 556
Published online on: 24 May 2021

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Article Open Access

Challenges in bioinformatics approaches to tumor mutation burden analysis

Francesca Fenizia, Raffaella Pasquale, Riziero Esposito Abate, Matilde Lambiase, Cristin Roma, Francesca Bergantino, Ruchi Chaudhury, Fiona Hyland, Christopher Allen, Nicola Normanno
Article Number: 555
Published online on: 24 May 2021

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Article Open Access

Effects of transarterial chemoembolization on the immunological function of patients with hepatocellular carcinoma

Jingjing Guo, Saixia Wang, Yujing Han, Zhongyuan Jia, Runchao Wang
Article Number: 554
Published online on: 24 May 2021

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Article Open Access

PD‑L1 expression and immune cells in anaplastic carcinoma and poorly differentiated carcinoma of the human thyroid gland: A retrospective study

Soledad Cameselle‑García, Sámer Abdulkader‑Sande, María Sánchez‑Ares, Gemma Rodríguez‑Carnero, Jesús Garcia‑Gómez, Francisco Gude‑Sampedro, Ihab Abdulkader‑Nallib, José Manuel Cameselle‑Teijeiro
Article Number: 553
Published online on: 24 May 2021

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Article Open Access

Apatinib plus ifosfamide and etoposide for relapsed or refractory osteosarcoma: A retrospective study in two centres

Lu Xie, Jie Xu, Xin Sun, Xiaowei Li, Kuisheng Liu, Xin Liang, Zuli Zhou, Hongqing Zhuang, Kunkun Sun, Yiming Wu, Jin Gu, Wei Guo
Article Number: 552
Published online on: 24 May 2021

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Article Open Access

Changes in SLIT2 expression are associated with the migration of human ovarian clear cell carcinoma cells

Cuei-Jyuan Lin, Way-Ren Huang, Chia-Zhen Wu, Ruo-Chia Tseng
Article Number: 551
Published online on: 24 May 2021

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Article Open Access

Formosanin C promotes the curative efficacy of ultrasound‑guided radiofrequency ablation in a mouse model of breast cancer

Zhe Chen, Jing Li, Qianqian Cui, Fuyuan Li, Gaiying Zhang
Article Number: 550
Published online on: 24 May 2021

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Article Open Access

MIF promoter polymorphism increases peripheral blood expression levels, contributing to increased susceptibility and poor prognosis in hepatocellular carcinoma

Lifeng Qin, Jinmei Qin, Xiaoping Lv, Caiqiao Yin, Qian'e Zhang, Jiqiao Zhang
Article Number: 549
Published online on: 24 May 2021

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Review Open Access

Cytochrome P450: Implications for human breast cancer (Review)

Bin Luo, Dandan Yan, Honglin Yan, Jingping Yuan
Article Number: 548
Published online on: 24 May 2021

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Article Open Access

Glyoxalase 1 and protein kinase Cλ as potential therapeutic targets for late‑stage breast cancer

Hitomi Motomura, Ayaka Ozaki, Shoma Tamori, Chotaro Onaga, Yuka Nozaki, Yuko Waki, Ryoko Takasawa, Kazumi Yoshizawa, Yasunari Mano, Tsugumichi Sato, Kazunori Sasaki, Hitoshi Ishiguro, Yohei Miyagi, Yoji Nagashima, Kouji Yamamoto, Keiko Sato, Takehisa Hanawa, Sei-Ichi Tanuma, Shigeo Ohno, Kazunori Akimoto
Article Number: 547
Published online on: 24 May 2021

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Article Open Access

Six-transmembrane epithelial antigen of the prostate 1 accelerates cell proliferation by targeting c-Myc in liver cancer cells

Kazutaka Iijima, Hajime Nakamura, Kohichi Takada, Naotaka Hayasaka, Tomohiro Kubo, Yui Umeyama, Satoshi Iyama, Koji Miyanishi, Masayoshi Kobune, Junji Kato
Article Number: 546
Published online on: 24 May 2021

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Retraction Open Access

[Retracted] miR‑429 promotes the proliferation of non‑small cell lung cancer cells via targeting DLC‑1

Peng Xiao, Wenliang Liu, Hui Zhou
Article Number: 545
Published online on: 24 May 2021

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Article Open Access

Long non‑coding RNA CASC9/microRNA‑590‑3p axis participates in lutein‑mediated suppression of breast cancer cell proliferation

Yuxia Zhang, Jingzhi Chang, Weiwei Jiang, Xin Ye, Shanfeng Zhang
Article Number: 544
Published online on: 20 May 2021

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Article Open Access

Immune-related gene expression signatures in colorectal cancer

Zhenqing Sun, Wei Xia, Yali Lyu, Yanan Song, Min Wang, Ruirui Zhang, Guode Sui, Zhenlu Li, Li Song, Changliang Wu, Choong-Chin Liew, Lei Yu, Guang Cheng, Changming Cheng
Article Number: 543
Published online on: 20 May 2021

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Article Open Access

Generation of TIM3 inhibitory single‑domain antibodies to boost the antitumor activity of chimeric antigen receptor T cells

Liu Yang, Xin Chen, Qian Wang, Yuankui Zhu, Changfa Wu, Xuqian  Ma, Dianbao Zuo, Huixia He, Le Huang, Jingwen Li, Chunjiao  Xia, Sheng Hu, Xiaoqing Yang, Mingqian Feng
Article Number: 542
Published online on: 20 May 2021

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Article Open Access

Long non‑coding RNA LINC01018 inhibits the progression of acute myeloid leukemia by targeting miR‑499a‑5p to regulate PDCD4

Hong Zhou, Pengfei Shi, Xiaofeng Jia, Qianfu Xue
Article Number: 541
Published online on: 20 May 2021

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Article Open Access

Immune‑related genes and gene sets for predicting the response to anti‑programmed death 1 therapy in patients with primary or metastatic non‑small cell lung cancer

Bolin Chen, Min Yang, Kang Li, Jia Li, Li Xu, Fang Xu, Yan Xu, Dandan Ren, Jiao Zhang, Liyu Liu
Article Number: 540
Published online on: 19 May 2021

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Article Open Access

MicroRNA‑186‑3p attenuates tumorigenesis of cervical cancer by targeting MCM2

Xiurong Lu, Xiao Song, Xiaohui Hao, Xiaoyu Liu, Xianyu Zhang, Na Yuan, Huan Ma, Zhilin Zhang
Article Number: 539
Published online on: 19 May 2021

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Article Open Access

Novel prognostic implications of YTH domain family 2 in resected hepatocellular carcinoma

Nobuhiko Nakagawa, Fuminori Sonohara, Katsuhito Tanaka, Yuki Sunagawa, Yoshikuni Inokawa, Hideki Takami, Masamichi Hayashi, Suguru Yamada, Mitsuro Kanda, Chie Tanaka, Goro Nakayama, Masahiko Koike, Yasuhiro Kodera
Article Number: 538
Published online on: 19 May 2021

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Article Open Access

PDGF‑BB regulates the transformation of fibroblasts into cancer‑associated fibroblasts via the lncRNA LURAP1L‑AS1/LURAP1L/IKK/IκB/NF‑κB signaling pathway

Xiaobin Ren, Lei Li, Jianhua Wu, Ken Lin, Yongwen He, Li Bian
Article Number: 537
Published online on: 19 May 2021

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Article Open Access

MMP12 is a potential therapeutic target for Adamantinomatous craniopharyngioma: Conclusions from bioinformatics analysis and in vitro experiments

Minde Li, Lin Zhou, Shaoyang Li, Linchun Fang, Le Yang, Xiao Wu, Chenxing Yang, Youyuan Bao, Sihai Lan, Zhigao Tong, Suyue Zheng, Bin Tang, Erming Zeng, Shenhao Xie, Cheng Chen, Tao Hong
Article Number: 536
Published online on: 19 May 2021

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Article Open Access

HLA complex group 11 is involved in colorectal carcinoma cisplatin resistance via the miR‑214‑5p/SOX4 axis

Jianping Xie, Jiaping Zhu, Jie Pang, Yaping Ma
Article Number: 535
Published online on: 19 May 2021

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Article Open Access

PLEK2 promotes osteosarcoma tumorigenesis and metastasis by activating the PI3K/AKT signaling pathway

Yang Liu, Siting Yang, Feng Wang, Zheng Zhou, Wenjing Xu, Jingjing Xie, Linhui Qiao, Yanglin Gu
Article Number: 534
Published online on: 18 May 2021

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Article Open Access

Cyclooxygenase‑2 expression is associated with chemoresistance through cancer stemness property in hypopharyngeal carcinoma

Shin Saito, Hiroyuki Ozawa, Yorihisa Imanishi, Mariko Sekimizu, Yoshihiro Watanabe, Fumihiro Ito, Yuichi Ikari, Nana Nakahara, Kaori Kameyama, Kaoru Ogawa
Article Number: 533
Published online on: 17 May 2021

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Article Open Access

miR‑590‑5p targets RMND5A and promotes migration in pancreatic adenocarcinoma cell lines

Sixing Chen, Yu Chen, Yao Wen, Wanwan Cai, Ping Zhu, Wuzhou Yuan, Yongqing Li, Xiongwei Fan, Yongqi Wan, Fang Li, Jian Zhuang, Zhigang Jiang, Xiushan Wu, Yuequn Wang
Article Number: 532
Published online on: 17 May 2021

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Article Open Access

MCTS1 promotes the development of lung adenocarcinoma by regulating E2F1 expression

Cun Gao, Rui Dong, Yongmeng Li, Jinghui Liang, Hui Tian
Article Number: 531
Published online on: 17 May 2021

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Review Open Access

Cell fusion in cancer hallmarks: Current research status and future indications (Review)

Hao-Fei Wang, Wei Xiang, Bing-Zhou Xue, Yi-Hao Wang, Dong-Ye  Yi, Xiao-Bing Jiang, Hong-Yang Zhao, Peng Fu
Article Number: 530
Published online on: 16 May 2021

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Article Open Access

Long non‑coding RNA SLC25A25‑AS1 exhibits oncogenic roles in non‑small cell lung cancer by regulating the microRNA‑195‑5p/ITGA2 axis Retraction in /10.3892/ol.2024.14608

Jinqin Chen, Chengpeng Gao, Wei Zhu
Article Number: 529
Published online on: 16 May 2021

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Article Open Access

Human papillomavirus‑16 infection and p16 expression in oral squamous cell carcinoma

Norihiko Tokuzen, Koh-Ichi Nakashiro, Shin Tojo, Hiroyuki Goda, Nobuyuki Kuribayashi, Daisuke Uchida
Article Number: 528
Published online on: 14 May 2021

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Article Open Access

Downregulation of GLUT3 impairs STYK1/NOK‑mediated metabolic reprogramming and proliferation in NIH‑3T3 cells

Weiye Shi, Yu Fu, Yingze Wang
Article Number: 527
Published online on: 14 May 2021

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Article Open Access

Prognostic and immunological roles of Fc fragment of IgG binding protein in colorectal cancer

Qunchuan Zhuang, Aling Shen, Liya Liu, Meizhu Wu, Zhiqing Shen, Huixin Liu, Ying Cheng, Xiaoying Lin, Xiangyan Wu, Wei Lin, Jiapeng Li, Yuying Han, Xiaoping Chen, Qi Chen, Jun Peng
Article Number: 526
Published online on: 13 May 2021

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Article Open Access

Clinicopathological characteristics of pancreatic ductal adenocarcinoma with invasive micropapillary carcinoma component with emphasis on the usefulness of PKCζ immunostaining for detection of reverse polarity

Hironori Ryota, Mitsuaki Ishida, Yusuke Ebisu, Hiroaki Yanagimoto, Tomohisa Yamamoto, Hisashi Kosaka, Satoshi Hirooka, So Yamaki, Masaya Kotsuka, Yoichi Matsui, Koji Tsuta, Sohei Satoi
Article Number: 525
Published online on: 13 May 2021

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Article Open Access

Dynamin 3 overexpression suppresses the proliferation, migration and invasion of cervical cancer cells

Jing Fa
Article Number: 524
Published online on: 12 May 2021

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Article

Antitumor effects of Andrographis via ferroptosis‑associated genes in gastric cancer

Ruiya Ma, Tadanobu Shimura, Chengzeng Yin, Yoshinaga Okugawa, Takahito Kitajima, Yuhki Koike, Yoshiki Okita, Masaki Ohi, Keiichi Uchida, Ajay Goel, Li Yao, Xueming Zhang, Yuji Toiyama
Article Number: 523
Published online on: 12 May 2021

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Article Open Access

Novel circulating tumor cell‑detection chip combining conventional podoplanin and EGFR antibodies for all histological malignant pleural mesothelioma

Masatoshi Kanayama, Rintaro Oyama, Masataka Mori, Akihiro Taira, Shinji Shinohara, Taiji Kuwata, Masaru Takenaka, Kazue Yoneda, Koji Kuroda, Takashi Ohnaga, Yukinari Kato, Fumihiro Tanaka
Article Number: 522
Published online on: 11 May 2021

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Article Open Access

GFI‑1 overexpression promotes cell proliferation and apoptosis resistance in mycosis fungoides by repressing Bax and P21

Xiaoguang Gu, Yimeng Wang, Chunlei Zhang, Yongsheng Liu
Article Number: 521
Published online on: 11 May 2021

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Article Open Access

Potential of the cell‑free blood‑based biomarker uroplakin 2 RNA to detect recurrence after surgical resection of lung adenocarcinoma

Ji Zhu, Qijue Lu, Bin Li, Huafei Li, Cong Wu, Chunguang Li, Hai Jin
Article Number: 520
Published online on: 10 May 2021

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Correction Open Access

[Corrigendum] The expression of Wnt‑1 inducible signaling pathway protein‑2 in astrocytoma: Correlation between pathological grade and clinical outcome

Gelei Xiao, Zhi Tang, Xianrui Yuan, Jian Yuan, Jie  Zhao, Zhiping Zhang, Zhengwen He, Jingping  Liu
Article Number: 519
Published online on: 10 May 2021

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Article Open Access

Effect of trachea stiffness on tumor distribution in papillary thyroid microcarcinoma

Hua Zhang, Taiyang Li, Xilong Du, Qihang Li, Bo Huo, Rui Jin, Ping Li
Article Number: 518
Published online on: 07 May 2021

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Article Open Access

Downregulation of SOX9 suppresses breast cancer cell proliferation and migration by regulating apoptosis and cell cycle arrest

Yu-Feng Wang, Hui-Feng Dang, Xu Luo, Qian-Qian Wang, Chen Gao, Ying-Xia Tian
Article Number: 517
Published online on: 06 May 2021

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Article Open Access

Regulatory effect of microRNA‑223‑3p on breast cancer cell processes via the Hippo/Yap signaling pathway

Tonghua Du, Dan Wang, Xiaoyu Wan, Jingwei Xu, Qi Xiao, Bin Liu
Article Number: 516
Published online on: 06 May 2021

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Article

MicroRNA‑383‑5p predicts favorable prognosis and inhibits the progression of diffuse large B‑cell lymphoma

Li-Yan Chen, Bi-Qing Han, Xiao-Min Zhang, Xing-Bao Yu, Dan-Dan Yao, Li-Qian Yu
Article Number: 515
Published online on: 06 May 2021

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Review Open Access

Nasopharyngeal carcinoma among the Bidayuh of Sarawak, Malaysia: history and risk factors (Review)

Reagan Entigu Linton, Maelinda Daker, Alan Soo‑Beng Khoo, Diana Chung Yiing Choo, Mignon Viljoen, Paul M. Neilsen
Article Number: 514
Published online on: 06 May 2021

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Article

Differentiation‑related zinc finger protein 750 suppresses cell growth in esophageal squamous cell carcinoma

Sheyne Sta Ana Choi, Josephine Mun‑Yee Ko, Valen Zhuoyou Yu, Lvwen Ning, Maria Li Lung
Article Number: 513
Published online on: 05 May 2021

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Triple‑negative breast cancer: A run‑through of features, classification and current therapies (Review)

Meghana Manjunath, Bibha Choudhary
Article Number: 512
Published online on: 05 May 2021

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Correction Open Access

[Corrigendum] Trifluridine/tipiracil increases survival rates in peritoneal dissemination mouse models of human colorectal and gastric cancer

Norihiko Suzuki, Fumio Nakagawa, Teiji Takechi
Article Number: 511
Published online on: 05 May 2021

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Review

Multiple strategies to improve the therapeutic efficacy of oncolytic herpes simplex virus in the treatment of glioblastoma (Review)

Zhengjun Zhou, Junjie Tian, Wenyan Zhang, Wei Xiang, Yang Ming, Ligang Chen, Jie Zhou
Article Number: 510
Published online on: 03 May 2021

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Article Open Access

Arsenic trioxide‑induced cell apoptosis and cell cycle arrest are potentiated by 1,25‑dihydroxyvitamin D3 in human leukemia K562 cells

Ya-Li Zhang, Shu-Kai Qiao, Xiao-Nan Guo, Jin-Hai Ren, Jing-Nan Zhang
Article Number: 509
Published online on: 03 May 2021

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Suppression of circulating AP001429.1 long non‑coding RNA in obese patients with breast cancer

Hani Choudhry, Mohammed A. Hassan, Abdulrahman L. Al‑Malki, Kaltoom A. Al‑Sakkaf
Article Number: 508
Published online on: 03 May 2021

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Article Open Access

MicroRNA‑891a‑5p is a novel biomarker for non‑small cell lung cancer and targets HOXA5 to regulate tumor cell biological function

Nianqing Wan, Jianxiao Zheng
Article Number: 507
Published online on: 02 May 2021

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Article Open Access

Screening and potential role of tRFs and tiRNAs derived from tRNAs in the carcinogenesis and development of lung adenocarcinoma

Jinhua Zhang, Linhui Li, Lilin Luo, Xuantao Yang, Juanjuan Zhang, Yuxin Xie, Rui Liang, Wanpu Wang, Shuaiyao Lu
Article Number: 506
Published online on: 02 May 2021

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Article Open Access

Long non‑coding RNA USP30‑AS1 aggravates the malignant progression of cervical cancer by sequestering microRNA‑299‑3p and thereby overexpressing PTP4A1

Mengyue Chen, Yugang Chi, Hongwei Chen, Limei Zhao
Article Number: 505
Published online on: 29 April 2021

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Review

Role of the IL‑33/ST2 receptor axis in ovarian cancer progression (Review)

Ning Liu, Jintong Chen, Yinghua Zhao, Mingyue Zhang, Li Piao, Siqing Wang, Ying Yue
Article Number: 504
Published online on: 29 April 2021

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Article Open Access

HMGB1 knockdown increases the radiosensitivity of esophageal squamous cell carcinoma by regulating the expression of molecules involved in DNA repair

Guohu Han, Rui Ling, Changchun Sun, Xuefeng Wang, Yuepeng Zhou, Lijiang Yu, Shenzha Liu
Article Number: 503
Published online on: 29 April 2021

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miR‑4417 targets lncRNA PSMG3‑AS1 to suppress cell invasion and migration in cervical squamous cell carcinoma

Shuhong Man, Xiaohan Li, Wei Zhu
Article Number: 502
Published online on: 29 April 2021

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Article Open Access

Antimicrobial peptide 17BIPHE2 inhibits the proliferation of lung cancer cells in vitro and in vivo by regulating the ERK signaling pathway

Tingting Yang, Jun Li, Qinqin Jia, Shisheng Zhan, Qiannan Zhang, Yarong Wang, Xiuqing Wang
Article Number: 501
Published online on: 28 April 2021

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Long non‑coding RNA TMPO‑AS1 facilitates chemoresistance and invasion in breast cancer by modulating the miR‑1179/TRIM37 axis

Xiaojie Ning, Jianguo Zhao, Fan He, Yuan Yuan, Bin Li, Jian Ruan
Article Number: 500
Published online on: 28 April 2021

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Expression and prognostic value of epithelial‑to‑mesenchymal transition and cancer stem cellmarkersin primary lesions and liver metastases of colorectal cancers

Cong Li, Ji-Yan Liu, Dan Jiang, Meng Qiu
Article Number: 499
Published online on: 27 April 2021

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Comprehensive co‑expression analysis reveals TMC8 as a prognostic immune‑associated gene in head and neck squamous cancer

Bo Lin, Shunji Wang, Youdan Yao, Yuehong Shen, Hongyu Yang
Article Number: 498
Published online on: 27 April 2021

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Article Open Access

SOX9 is associated with advanced T-stages of clinical stage II colon cancer in young Mexican patients

Erik Lizárraga-Verdugo, Tatiana Galicia Carmona, Rosalío Ramos-Payan, Mariana Avendaño-Félix, Mercedes Bermúdez, Maryelv Parra-Niebla, César López-Camarillo, Edith Fernandez-Figueroa, Leonardo Lino-Silva, Herminia Arvelo Saavedra, Itzel Vela-Sarmiento, Roberto Cárdenas Ovando, Erika Ruíz-García, Maribel Aguilar-Medina
Article Number: 497
Published online on: 27 April 2021

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Review Open Access

Possibility of inducing tumor cell senescence during therapy (Review)

Guohui Wang, Xianliang Cheng, Jingyi Zhang, Yuan Liao, Yinnong Jia, Chen Qing
Article Number: 496
Published online on: 27 April 2021

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Article

DUXAP8 knockdown inhibits the development of melanoma by regulating the miR‑3182/NUPR1 pathway

Xige Chen, Juan Gao, Ning Liang
Article Number: 495
Published online on: 27 April 2021

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Journal Cover
May-2026 Volume 31 Issue 5

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Journal Metrics

Impact Factor: 2.2

CiteScore: 4.6

CiteScore Rank: Q2: #178/415 Oncology

Source Normalized Impact per Paper (SNIP): 0.568

SCImago Journal Rank (SJR): 0.663

Article Open Access

TBX20 regulates epithelial‑mesenchymal transition, maintains tumor stemness and immune factor expression, and promotes immune escape in lung cancer

Chuncai Xu, Peng Zhou, Yanting Zhang, Lili Li, Guowen Wang
Article Number: 207
Published online on: 30 March 2026

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Article Open Access

Silencing of small nuclear ribonucleoprotein polypeptide B inhibits the progression of esophageal squamous cell carcinoma

Haiyang Guo, Ji Zuo, Guangbing Hu, Yong Tang, Liuyi Lu, Zichen Luo, Xinrui Chen, Xiaobo Wang, Xianfei Wang
Article Number: 206
Published online on: 30 March 2026

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Article

Prognostic and diagnostic significance of serum p53 antibody levels in patients with surgically treated pancreatic cancer

Rei Okada, Yuichiro Otsuka, Yoji Kajiwara, Yu Matsumoto, Yuko Ito, Hideaki Shimada
Article Number: 205
Published online on: 30 March 2026

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Update on the clinical features, treatment and histogenesis of combined hepatocellular-cholangiocarcinoma

Junwen Hu, Jiahao Chen, Chenglei Yang, Yapeng Qi, Jie Zhang, Rui Song, Jianhong Zhong, Bangde Xiang
Article Number: 204
Published online on: 30 March 2026

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Lung squamous cell carcinoma downregulates haptoglobin expression to inhibit M2 macrophage ferroptosis via the hemoglobin‑dependent CD163/HO‑1 pathway

Weijing Xie, Ying-Ying Lin, Guang-Hong Tan, Feng-Ying Huang
Article Number: 203
Published online on: 30 March 2026

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Article Open Access

Immune‑imaging biomarkers: Prognostic value of splenic volume and circulating lymphocytes in upper tract urothelial carcinoma

Chien-Hsiung Lo, Kun-Che Lin, Chu-An Wang, Che-Yuan Hu, Chien-Hui Ou, Hau-Chern Jan
Article Number: 202
Published online on: 30 March 2026

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Whole‑exome sequencing unveils novel potential gene mutations involved in primary renal small cell carcinoma

Yang Wang, Lizhi Zhang, Xueyan Xia, Xiancheng Li
Article Number: 201
Published online on: 30 March 2026

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Efficacy and safety of concurrent chemoradiotherapy following neoadjuvant chemoimmunotherapy in patients with stage III NSCLC who experienced neoadjuvant failure: A real-world study

Ruoxuan Li, Luping Pan, Fujuan Zeng, Jingyu Huang, Ziye Chen, Chengyi Liu, Zhimin Zeng
Article Number: 200
Published online on: 30 March 2026

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Article Open Access

Curcumin induces and enhances the PARP1‑mediated parthanatos in diffuse large B cell lymphoma

Yayun Wang, Ruili Qi, Xuanzhu Zhao, Hanwei Mei, Minghan Qiu, Fengting Liu, Huaqing Wang
Article Number: 199
Published online on: 30 March 2026

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Article Open Access

Immunotherapy‑based treatment patterns and clinical outcomes across lines of therapy in microsatellite stable metastatic colorectal cancer: A real‑world study

Wen-Si Zhao, Shi-Jing Ma, Tao Zhang, De-Dong Cao
Article Number: 198
Published online on: 27 March 2026

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Article Open Access

Efficacy and safety of blinatumomab combination therapy in high‑risk B‑cell acute lymphoblastic leukemia: A systematic review and meta‑analysis

Mei Wang, Xinlin Yu, Zhongqing Zou, Yan He, Lvlin Chen, Ying Lan
Article Number: 197
Published online on: 26 March 2026

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Article Open Access

Schisandrin B suppresses cholangiocarcinoma by targeting the ROS/p38 MAPK/NF‑κB axis

Junhao Yang, Wenying Long, Xiaoxiao Wu, Xiaohui Yang, Qiang Hong, Shuai Wang
Article Number: 196
Published online on: 26 March 2026

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Review Open Access

Role of non‑coding RNAs in O6‑methylguanine‑DNA methyltransferase‑positive glioblastoma (Review)

Yunyan Guo, Jun Guo, Wenyan Xiao, Yanxin Lu
Article Number: 195
Published online on: 26 March 2026

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Case Report Open Access

A rare case of uterine carcinosarcoma in a 21‑year‑old woman with hereditary breast and ovarian cancer syndrome: A case report

Yasushi Iida, Ayane Kosuge, Yoko Saito, Taichi Irie, Jun Matsushima, Makoto Iizuka, Satoshi Takakura
Article Number: 194
Published online on: 26 March 2026

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Article Open Access

Metformin enhances survival with immune checkpoint inhibitors in cancer patients: A meta‑analysis

Yu Qiao, Huiyao Li, Yanping Feng, Shuai Liang, Dong Hua
Article Number: 193
Published online on: 26 March 2026

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Review Open Access

Dual role of exosomes in pancreatic cancer: Underlying mechanisms and research advances (Review)

Zhao Guo, Qingfeng Liu
Article Number: 192
Published online on: 26 March 2026

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Article Open Access

Pomegranate peel‑derived exosome‑like nanoparticles: A discarded treasure trove for colorectal cancer treatment

Yifei Dong, Qin Yuan, Chao Chen, Zheng Zhang
Article Number: 191
Published online on: 26 March 2026

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Article Open Access

SETD4 as a marker of disease burden and treatment response in childhood acute lymphoblastic leukemia

Luis Augusto Muniz Telles, Mariana Braccialli De Loyola, Luis Henrique Toshihiro Sakamoto, Doralina Do Amaral Ramos Rabello, Andrea Barretto Motoyama, Fabio Pittella‑Silva
Article Number: 190
Published online on: 24 March 2026

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Case Report Open Access

Comprehensive treatment for two patients with small cell neuroendocrine carcinoma of the liver: A case report and literature review

Ruizeng Feng, Hao Wang, Yang Zhao, Xue Zhang, Hongfang Tuo, Xing Xu
Article Number: 189
Published online on: 24 March 2026

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Expression of Concern Open Access

[Expression of Concern] Insulin‑like growth factor‑1 receptor knockdown enhances radiosensitivity via the HIF‑1α pathway and attenuates ATM/H2AX/53BP1 DNA repair activation in human lung squamous carcinoma cells

Xiaoxing Liu, Haiyan Chen, Xin Xu, Ming Ye, Hongbin Cao, Lei Xu, Yanli Hou, Jianmin Tang, Di Zhou, Yongrui Bai, Xiumei Ma
Article Number: 188
Published online on: 23 March 2026

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Case Report Open Access

Painless perianal mucinous adenocarcinoma: A case report and literature review

Jianping Shi, Xiaoying Wang, Junjie Yang, Guofeng Li, Yanjie Zhang
Article Number: 187
Published online on: 20 March 2026

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Article Open Access

Methylglyoxal‑derived glycated albumin enhances the stemness potential of invasive ductal carcinoma‑derived breast cancer stem‑like cell line KAIMRC1

Maram Aldawood, Mariam K. Alamoudi, Abdulmonem A. Alsaleh, Nouf Alharbi, Sarah Huwaizi, Rehab Alroshody, Rizwan Ali, Rafa Almeer, Sabine Matou-Nasri
Article Number: 186
Published online on: 19 March 2026

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Article Open Access

Proteomic and immunocytochemical analyses of squamous components in two‑ and three‑dimensional‑cultured pancreatic ductal adenocarcinoma cell lines

Yuuki Shichi, Hiroki Tsumoto, Masakazu Fujiwara, Keisuke Nonaka, Yasuko Hasegawa, Seiichi Shinji, Hirofumi Rokutan, Kimimasa Takahashi, Tomio Arai, Yuri Miura, Toshiyuki Ishiwata
Article Number: 185
Published online on: 19 March 2026

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Review Open Access

Metabolic reprogramming‑a breakthrough point in overcoming resistance to BRAF mutant melanoma targeted therapy (Review)

Xueting Zhao, Fang Chen, Huibin Li
Article Number: 184
Published online on: 18 March 2026

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Article Open Access

Efficacy of induction chemotherapy combined with standard chemoradiotherapy vs. standard chemoradiotherapy monotherapy in locally advanced cervical cancer:  A systematic review and meta‑analysis

Xinyu Lu, Yaxu Su, Wentong Xu, Tianyou Tang, Fengjuan Zhou, Dehong Yu, Yilong Guo, Yong Xin
Article Number: 183
Published online on: 18 March 2026

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Article Open Access

Predictive performance of image processing techniques in the diagnosis of bone metastasis: A meta‑analysis of a confusion matrix

Yupeng Hu, Wen Liao, Ying Er, Qifeng Tao
Article Number: 182
Published online on: 18 March 2026

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Expression of Concern Open Access

[Expression of Concern] Effect of overexpression of HOX genes on its invasive tendency in cerebral glioma 

Yun-Bao Guo, Yi-Meng Shao, Jing Chen, Song-Bai Xu, Xing-Dong Zhang, Mao-Ren Wang, Hai-Yan Liu
Article Number: 181
Published online on: 18 March 2026

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Article Open Access

Optimizing safety and efficacy in radiotherapy for external auditory canal cancer

Yuto Imai, Taiki Takaoka, Natsuo Tomita, Mayu Kuno, Akifumi Miyakawa, Chikao Sugie, Shinya Otsuka, Kaoru Uchiyama, Dai Okazaki, Masanari Niwa, Akira Torii, Nozomi Kita, Masanosuke Oguri, Seiya Takano, Takuma Matoba, Daisuke Kawakita, Shinichi Iwasaki, Akio Hiwatashi
Article Number: 180
Published online on: 17 March 2026

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Correction Open Access

[Corrigendum] Inhibition of microRNA‑221‑5p induces osteogenic differentiation by directly targeting smad3 in myeloma bone disease mesenchymal stem cells   

Fang-Yi Fan, Rui Deng, Si-Han Lai, Qin Wen, Yunjing Zeng, Lei Gao, Yao Liu, Peiyan Kong, Jiangfan Zhong, Yi Su, Xi Zhang
Article Number: 179
Published online on: 17 March 2026

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Article

DNA hypermethylation of nonspecific cytotoxic cell receptor protein 1 and poor prognosis of pancreatic cancer

Mai Nakamura, Teruki Hagiwara, Kazuhiko Yamada, Toru Igari, Yuki Fukumura, Akio Saiura, Nobuyuki Takemura, Norihiro Kokudo, Yuki I. Kawamura
Article Number: 178
Published online on: 17 March 2026

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Case Report

Limbic encephalitis associated with anti‑Hu antibody induced by atezolizumab treatment for small cell lung cancer: A case report

Zhaohui Li, Hanping Wang
Article Number: 177
Published online on: 17 March 2026

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Case Report

Administration of tirabrutinib suspension in a patient with primary central nervous system lymphoma: A case report

Takeo Yasu, Hiroaki Ohta, Yoshito Gando, Masayuki Kobayashi
Article Number: 176
Published online on: 17 March 2026

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Review

Postoperative complications in patients with chemotherapy‑induced acute myeloid leukemia (Review)

Cen-Hung Lin, Hang-Tsung Liu, Ching-Hua Hsieh
Article Number: 175
Published online on: 17 March 2026

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Retraction Open Access

[Retracted] MicroRNA-27a functions as an oncogene in human osteosarcoma by targeting CCNG1  

Tao Lin, Quanping Ma, Yuefeng Zhang, Hongfei Zhang, Jiapeng Yan, Changhong Gao
Article Number: 174
Published online on: 16 March 2026

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Case Report Open Access

Bone marrow metastasis from gastric cancer: A case report

Xinyi Wei, Wenli Dai, Pengyi Deng
Article Number: 173
Published online on: 12 March 2026

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Article

Effect of apalutamide dosage on the incidence of cutaneous adverse events and prostate‑specific antigen reduction in patients with prostate cancer

Takuya Matsuyama, Michio Kimura, Makiko Go, Shiori Yamada, Mitsuhiro Nishimura, Hiromi Murase, Rina Matsuyama, Eiseki Usami
Article Number: 172
Published online on: 12 March 2026

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Correction Open Access

[Corrigendum] A potential diagnostic marker for ovarian cancer: Involvement of the histone acetyltransferase, human males absent on the first  

Ning Liu, Rui Zhang, Xiaoming Zhao, Jiaming Su, Xiaolei Bian, Jinsong Ni, Ying Yue, Yong Cai, Jingji Jin
Article Number: 171
Published online on: 12 March 2026

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Article Open Access

Skeletal muscle index at the third lumbar vertebra/BMI are positively associated with 1‑year overall survival in male patients with hepatocellular carcinoma treated with immune checkpoint inhibitors

Juan Li, Yang Wang, Songtao Liu, Huili Wu, Xin Hua, Qinghua Meng
Article Number: 170
Published online on: 11 March 2026

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Correction Open Access

[Corrigendum] Inhibition of Rac1 reverses enzalutamide resistance in castration‑resistant prostate cancer

Xiaoliang Chen, Lili Yin, Gan Qiao, Yanhua Li, Baoyuan Li, Yunfeng Bai, Feng Feng
Article Number: 169
Published online on: 11 March 2026

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Article Open Access

Integrated proteomic and metabolomic profiling reveals molecular signatures underlying invasiveness in non‑functioning pituitary adenomas

Jianyao Mao, Xi Chen, Wentao Zheng, Bosen Liu, Zhangyu Li, Yukui Li, Ping Zhong, Sifang Chen, Guowei Tan, Chen Wang, Jinli Sun
Article Number: 168
Published online on: 10 March 2026

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Retraction Open Access

[Retracted] MSK1 downregulation is associated with neuronal and astrocytic apoptosis following subarachnoid hemorrhage in rats

Bo Ning, Geng Guo, Hong Liu, Lei Ning, Bao-Liang Sun, Zhen Li, Shuo Wang, Zheng-Wen Lv, Cun-Dong Fan
Article Number: 167
Published online on: 09 March 2026

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Article Open Access

CANT1 as a novel prognostic biomarker in triple‑negative breast cancer

Doğan Bayram, Aysel Çolak, Şefi̇ka Karabulut, Sema Nur Özsan Çelebi̇, Emre Hafizoğlu, Duri̇ye Özer Türkay, Öznur Bal, Efnan Algin, Şebnem Yücel, Mehmet Ali̇ Nahi̇t Şendur, Burak Ci̇velek, Gökhan Uçar
Article Number: 166
Published online on: 09 March 2026

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Article Open Access

RNA methyltransferase NSUN2 enhances vasculogenic mimicry and malignant progression of cervical cancer through upregulation of MMP‑9

Jun Luo, Guang Li, Mei Ye, Xiaoqing Xu, Mengwen Qi, Jian Huang, Kong Shan, Lili Qu, Hengchuan Shi
Article Number: 165
Published online on: 06 March 2026

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Article Open Access

Long-term effects of using pegylated recombinant human granulocyte colony-stimulating factor following chemotherapy: A real-world study on patients with ovarian cancer

Weimin Zhang, Nenghuan Tang, Yiyue Wang, Tiantian Feng, Min Yong, Yuhua Zeng
Article Number: 164
Published online on: 06 March 2026

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Case Report Open Access

Primary clear‑cell carcinoma of the liver with gastric antrum metastasis: Integrated management with targeted therapy, immunotherapy and salvage surgery: A case report

Lianshan Zhan, Qianwei Li, Tian Tian, Long Wang
Article Number: 163
Published online on: 06 March 2026

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Case Report

Diagnostic and surgical challenges of a lymph node metastasis from occult gastric cancer mimicking a pancreatic head tumor: A case report

Takuya Ando, Yuki Hirose, Kazuyasu Takizawa, Jun Sakata, Hirosuke Ishikawa, Shun Abe, Yusuke Kawachi, Mae Nakano, Hiroshi Ichikawa, Yoshifumi Shimada, Toshifumi Wakai
Article Number: 162
Published online on: 05 March 2026

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Article Open Access

Integrated analysis of therapeutic strategies and prognostic factors in advanced lung adenocarcinoma: Retrospective study with emphasis on gene assays, multimodality treatment approaches and predictive machine learning models

Shingchern You, Shiuan-Wen Chen, Irene Chen, Wei-Teing Chen
Article Number: 161
Published online on: 05 March 2026

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Review Open Access

Tumor‑muscle communication in cancer‑associated cachexia (Review)

Lily Berríos‑Contreras, Matías Meza‑Valenzuela, Nelson Brown, Claudio Valenzuela, Silvia Busquets, Francisco Javier López‑Soriano, Andrew Fg Quest, Rodrigo Moore‑Carrasco
Article Number: 160
Published online on: 05 March 2026

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Case Report Open Access

Pseudocirrhosis due to liver metastasis from lung squamous cell carcinoma: A case report

Qian Liu, Yufeng Lu, Dan Wang, Juan Yao, Ying Liu
Article Number: 159
Published online on: 04 March 2026

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Case Report

Malignant mesothelioma of the tunica vaginalis testis: A case report

Yuanchen Lu, Junjun Miu, Zhongru Fan, Zheng Zhi, Lei He, Junpeng Deng, Xianhua Shao, Jingqi Hua, Yichen Qian, Jianjun Xie
Article Number: 158
Published online on: 04 March 2026

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Case Report Open Access

Metachronous primary non‑small cell lung cancer and mucinous tubular and spindle cell carcinoma of the left kidney: A case report

Jin-Xia Zhao, Wei Zhu, Jie-Bin Pan, Peng-Fei Sun
Article Number: 157
Published online on: 04 March 2026

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Article Open Access

Telomere maintenance mechanisms are activated in ganglioneuroblastoma and ganglioneuroma

Motoki Sugawara, Masayuki Haruta, Miki Ohira, Jesmin Akter, Ritsuko Onuki, Ryuichi P. Sugino, Kiyohiro Ando, Atsuko Nakazawa, Hajime Okita, Tetsuya Takimoto, Tomoko Iehara, Tsugumichi Koshinaga, Shuichiro Uehara, Takehiko Kamijo
Article Number: 156
Published online on: 04 March 2026

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Article Open Access

Leucovorin enhances curcumin‑induced inhibition of cell viability and ferroptosis in colorectal cancer cells

Rui Meng, Qianqian Xu, Xue Wang, Hongwei Xu
Article Number: 155
Published online on: 04 March 2026

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Correction Open Access

[Corrigendum] Effects of 17‑allylamino‑17‑demethoxygeldanamycin on the induction of apoptosis and cell cycle arrest in HCT‑116  cells

Xuerong Zhao, Jianping Wang, Lijun Xiao, Qian Xu, Enhong Zhao, Xin Zheng, Huachuan Zheng, Shuang Zhao, Shi Ding
Article Number: 154
Published online on: 03 March 2026

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Review

Application of carbonic anhydrase IX‑targeted radiopharmaceuticals in the diagnosis and treatment of clear cell renal cell carcinoma (Review)

Min Wang, Yuqin Li, Wenbo Yang, Bin Liu
Article Number: 153
Published online on: 02 March 2026

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Review Open Access

Targeting ICMT: A promising strategy in cancer treatment (Review)

Jinghong Hu, Ying Xiao, Jingyi Tang
Article Number: 152
Published online on: 02 March 2026

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Review Open Access

Orchestrating organotropism: miRNA‑driven mechanisms of site‑specific metastasis in triple‑negative breast cancer (Review)

Rigude Bu, Liu Bo
Article Number: 151
Published online on: 02 March 2026

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Retraction Open Access

[Retracted] EGFR expression is associated with cytoplasmic staining of CXCR4 and predicts poor prognosis in triple‑negative breast carcinomas

Rong-Hui Li, Wen-He Huang, Jun-Dong Wu, Cai-Wen Du, Guo-Jun Zhang
Article Number: 150
Published online on: 02 March 2026

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Case Report Open Access

Adenoid cystic carcinoma of the vulva: A case report and literature review

Zhiying Ding, Guiqiu Liu, Chuanshan Zhang
Article Number: 149
Published online on: 26 February 2026

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Journal Cover
June-2026 Volume 31 Issue 6

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Journal Metrics

Impact Factor: 2.2

CiteScore: 4.6

CiteScore Rank: Q2: #178/415 Oncology

Source Normalized Impact per Paper (SNIP): 0.568

SCImago Journal Rank (SJR): 0.663

Case Report Open Access

Primary thoracic synovial sarcoma in a 45‑year‑old male: A case report and literature review

Baolei Liang, Jichun Zhang, Mingqiang Shen, Cuilian Li, Mingxiao Hou, Yunen Liu, Qingyong Cai
Article Number: 209
Published online on: 31 March 2026

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Expression of Concern Open Access

[Expression of Concern] Pseudomonas aeruginosa‑mannose‑sensitive hema-gglutinin inhibits proliferation and induces apoptosis in a caspase‑dependent manner in human bladder cancer cell lines

Yi-Ping Zhu, Xiao-Jie Bian, Ding-Wei Ye, Xu-Dong Yao, Shi-Lin Zhang, Bo Dai, Yi-Jun Shen
Article Number: 208
Published online on: 31 March 2026

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