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Review Open Access

Cell fusion in cancer hallmarks: Current research status and future indications (Review)

  • Authors:
    • Hao-Fei Wang
    • Wei Xiang
    • Bing-Zhou Xue
    • Yi-Hao Wang
    • Dong-Ye  Yi
    • Xiao-Bing Jiang
    • Hong-Yang Zhao
    • Peng Fu
  • View Affiliations / Copyright

    Affiliations: Department of Neurosurgery, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei 430022, P.R. China
    Copyright: © Wang et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 530
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    Published online on: May 16, 2021
       https://doi.org/10.3892/ol.2021.12791
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Abstract

Cell fusion is involved in several physiological processes, such as reproduction, development and immunity. Although cell fusion in tumors was reported 130 years ago, it has recently attracted great interest, with recent progress in tumorigenesis research. However, the role of cell fusion in tumor progression remains unclear. The pattern of cell fusion and its role under physiological conditions are the basis for our understanding of the pathological role of cell fusion. However, the role of cell fusion in tumors and its functions are complicated. Cell fusion can directly increase tumor heterogeneity by forming polyploids or aneuploidies. Several studies have reported that cell fusion is associated with tumorigenesis, metastasis, recurrence, drug resistance and the formation of cancer stem cells. Given the diverse roles cell fusion plays in different tumor phenotypes, methods based on targeted cell fusion have been designed to treat tumors. Research on cell fusion in tumors may provide novel ideas for further treatment.
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Copy and paste a formatted citation
Spandidos Publications style
Wang H, Xiang W, Xue B, Wang Y, Yi D, Jiang X, Zhao H and Fu P: Cell fusion in cancer hallmarks: Current research status and future indications (Review). Oncol Lett 22: 530, 2021.
APA
Wang, H., Xiang, W., Xue, B., Wang, Y., Yi, D., Jiang, X. ... Fu, P. (2021). Cell fusion in cancer hallmarks: Current research status and future indications (Review). Oncology Letters, 22, 530. https://doi.org/10.3892/ol.2021.12791
MLA
Wang, H., Xiang, W., Xue, B., Wang, Y., Yi, D., Jiang, X., Zhao, H., Fu, P."Cell fusion in cancer hallmarks: Current research status and future indications (Review)". Oncology Letters 22.1 (2021): 530.
Chicago
Wang, H., Xiang, W., Xue, B., Wang, Y., Yi, D., Jiang, X., Zhao, H., Fu, P."Cell fusion in cancer hallmarks: Current research status and future indications (Review)". Oncology Letters 22, no. 1 (2021): 530. https://doi.org/10.3892/ol.2021.12791
Copy and paste a formatted citation
x
Spandidos Publications style
Wang H, Xiang W, Xue B, Wang Y, Yi D, Jiang X, Zhao H and Fu P: Cell fusion in cancer hallmarks: Current research status and future indications (Review). Oncol Lett 22: 530, 2021.
APA
Wang, H., Xiang, W., Xue, B., Wang, Y., Yi, D., Jiang, X. ... Fu, P. (2021). Cell fusion in cancer hallmarks: Current research status and future indications (Review). Oncology Letters, 22, 530. https://doi.org/10.3892/ol.2021.12791
MLA
Wang, H., Xiang, W., Xue, B., Wang, Y., Yi, D., Jiang, X., Zhao, H., Fu, P."Cell fusion in cancer hallmarks: Current research status and future indications (Review)". Oncology Letters 22.1 (2021): 530.
Chicago
Wang, H., Xiang, W., Xue, B., Wang, Y., Yi, D., Jiang, X., Zhao, H., Fu, P."Cell fusion in cancer hallmarks: Current research status and future indications (Review)". Oncology Letters 22, no. 1 (2021): 530. https://doi.org/10.3892/ol.2021.12791
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