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MIF promoter polymorphism increases peripheral blood expression levels, contributing to increased susceptibility and poor prognosis in hepatocellular carcinoma

  • Authors:
    • Lifeng Qin
    • Jinmei Qin
    • Xiaoping Lv
    • Caiqiao Yin
    • Qian'e Zhang
    • Jiqiao Zhang
  • View Affiliations / Copyright

    Affiliations: Department of Gastroenterology, Minda Hospital of Hubei Minzu University, Enshi, Hubei 445000, P.R. China, Department of Infectious Diseases, The First Affiliated Hospital of Guangxi Medical University, Nanning, Guangxi 530021, P.R. China, Department of Gastroenterology, The First Affiliated Hospital of Guangxi Medical University, Nanning, Guangxi 530021, P.R. China
    Copyright: © Qin et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 549
    |
    Published online on: May 24, 2021
       https://doi.org/10.3892/ol.2021.12810
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Abstract

Hepatocellular carcinoma (HCC) is one of the most common malignancies in the world. The etiology and pathogenesis of HCC remain unclear. Macrophage migration inhibitory factor (MIF) plays a critical role in the pathogenesis of hepatocellular carcinoma. The association between MIF polymorphisms and its expression level in HCC has rarely been demonstrated. In the present study, the peripheral blood of 202 patients with HCC (HCC group), 242 patients with chronic hepatitis B (CHB group), 215 patients with liver cirrhosis (LC group) and 227 healthy volunteers (normal group) were collected, DNA was extracted and the target fragment of MIF gene was amplified using PCR. The products were then sequenced, and the expression levels of MIF protein were tested using ELISA. The results showed that the MIF rs755622 polymorphism was associated with an increased susceptibility and metastasis of HCC, and that the genotypes GC and CC were associated with poor prognosis of HCC. Compared with the normal, CHB and LC groups, the expression of MIF in the peripheral blood of the HCC group was significantly increased, and the high expression was associated with to poor prognosis. In the HCC group, MIF protein levels for genotypes GC and CC were increased compared with those of genotype GG. The current study indicated that the MIF rs755622 polymorphism is associated with susceptibility and metastasis of HCC, and that the GC and CC genotypes may be indicators of poor prognosis, which may be ascribed to the MIF rs755622 polymorphism leading to elevated MIF protein expression in peripheral blood.
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1 

Kulik L and El-Serag HB: Epidemiology and management of hepatocellular carcinoma. Gastroenterology. 156:477–491.e1. 2019. View Article : Google Scholar : PubMed/NCBI

2 

Chen W, Zheng R, Baade PD, Zhang S, Zeng H, Bray F, Jemal A, Yu XQ and He J: Cancer statistics in China, 2015. CA Cancer J Clin. 66:115–132. 2016. View Article : Google Scholar : PubMed/NCBI

3 

Pal LR and Moult J: Genetic basis of common human disease: Insight into the role of missense SNPs from genome-wide association studies. J Mol Biol. 427:2271–2289. 2015. View Article : Google Scholar : PubMed/NCBI

4 

Nie S, Wang H and Wang X: Research progress on polymorphism of susceptibility genes in hepatocellular carcinoma. Int J Genet. 41:512–517. 2018.

5 

Nobre CC, de Araújo JM, Fernandes TA, Cobucci RN, Lanza DC, Andrade VS and Fernandes JV: Macrophage migration inhibitory factor (MIF): Biological activities and relation with cancer. Pathol Oncol Res. 23:235–244. 2017. View Article : Google Scholar : PubMed/NCBI

6 

Grieb G, Merk M, Bernhagen J and Bucala R: Macrophage migration inhibitory factor (MIF): A promising biomarker. Drug News Perspect. 23:257–264. 2010. View Article : Google Scholar : PubMed/NCBI

7 

Illescas O, Gomez-Verjan JC, Garcia-Velazquez L, Govezensky T and Rodriguez-Sosa M: Macrophage migration inhibitory factor-173 G/C polymorphism: A global meta-analysis across the disease spectrum. Front Genet. 9:552018. View Article : Google Scholar : PubMed/NCBI

8 

Fukui H, Saito H, Ueno Y, Uto H, Obara K, Sakaida I, Shibuya A, Seike M, Nagoshi S, Segawa M, et al: Evidence-based clinical practice guidelines for liver cirrhosis 2015. J Gastroenterol. 51:629–650. 2016. View Article : Google Scholar : PubMed/NCBI

9 

Hou J, Wang G, Wang F, Cheng J, Ren H, Zhuang H, Sun J, Li L, Li J, Meng Q, et al: Guideline of prevention and treatment for chronic hepatitis B (2015 Update). J Clin Transl Hepatol. 5:297–318. 2017. View Article : Google Scholar : PubMed/NCBI

10 

Zhou J, Sun H, Wang Z, Cong W, Wang J, Zeng M, Zhou W, Bie P, Liu L, Wen T, et al: Guidelines for the diagnosis and treatment of hepatocellular carcinoma (2019 edition). Liver Cancer. 9:682–720. 2020. View Article : Google Scholar : PubMed/NCBI

11 

Forner A, Reig ME, de Lope CR and Bruix J: Current strategy for staging and treatment: The BCLC update and future prospects. Semin Liver Dis. 30:61–74. 2010. View Article : Google Scholar : PubMed/NCBI

12 

Ayuso C, Rimola J, Vilana R, Burrel M, Darnell A, García-Criado Á, Bianchi L, Belmonte E, Caparroz C, Barrufet M, et al: Diagnosis and staging of hepatocellular carcinoma (HCC): Current guidelines. Eur J Radiol. 101:72–81. 2018. View Article : Google Scholar : PubMed/NCBI

13 

Meza-Romero R, Benedek G, Leng L, Bucala R and Vandenbark AA: Predicted structure of MIF/CD74 and RTL1000/CD74 complexes. Metab Brain Dis. 31:249–255. 2016. View Article : Google Scholar : PubMed/NCBI

14 

Jankauskas SS, Wong DWL, Bucala R, Djudjaj S and Boor P: Evolving complexity of MIF signaling. Cell Signal. 57:76–88. 2019. View Article : Google Scholar : PubMed/NCBI

15 

Conroy H. Mawhinney L and Donnelly SC: Inflammation and cancer: Macrophage migration inhibitory factor (MIF)-the potential missing link. QJM. 103:831–836. 2010. View Article : Google Scholar : PubMed/NCBI

16 

Jäger B, Klatt D, Plappert L, Golpon H, Lienenklaus S, Barbosa PD, Schambach A and Prasse A: CXCR4/MIF axis amplifies tumor growth and epithelial-mesenchymal interaction in non-small cell lung cancer. Cell Signal. 73:1096722020. View Article : Google Scholar

17 

Guda MR, Rashid MA, Asuthkar S, Jalasutram A, Caniglia JL, Tsung AJ and Velpula KK: Pleiotropic role of macrophage migration inhibitory factor in cancer. Am J Cancer Res. 9:2760–2773. 2019.PubMed/NCBI

18 

Penticuff JC, Woolbright BL, Sielecki TM, Weir SJ and Taylor JA: MIF family proteins in genitourinary cancer: Tumorigenic roles and therapeutic potential. Nat Rev Urol. 16:318–328. 2019. View Article : Google Scholar : PubMed/NCBI

19 

Hira E, Ono T, Dhar DK, El-Assal ON, Hishikawa Y, Yamanoi A and Nagasue N: Overexpression of macrophage migration inhibitory factor induces angiogenesis and deteriorates prognosis after radical resection for hepatocellular carcinoma. Cancer. 103:588–598. 2005. View Article : Google Scholar : PubMed/NCBI

20 

Li QT, Feng YM, Ke ZH, Qiu MJ and Xiong ZF: KCNN4 promotes invasion and metastasis through the MAPK/ERK pathway in hepatocellular carcinoma. J Investig Med. 68:68–74. 2019. View Article : Google Scholar : PubMed/NCBI

21 

Songlin M, Fei X, Long Y and Yang L: The effect of miRNA-451 on the proliferation and invasion capacity of human hepatocellular carcinoma cell lines via its regulation on COX-2 and other cytokines. Oncol Progress. 16:690–693. 2018.

22 

Sun B, Nishihira J, Yoshiki T, Kondo M, Sato Y, Sasaki F and Todo S: Macrophage migration inhibitory factor promotes tumor invasion and metastasis via the Rho-dependent pathway. Clin Cancer Res. 11:1050–1058. 2005.PubMed/NCBI

23 

Pei XJ, Wu TT, Li B, Tian XY, Li Z and Yang QX: Increased expression of macrophage migration inhibitory factor and DJ-1 contribute to cell invasion and metastasis of nasopharyngeal carcinoma. Int J Med Sci. 11:106–115. 2014. View Article : Google Scholar : PubMed/NCBI

24 

Liu J, Zhang C, Hu W and Feng Z: Tumor suppressor p53 and its mutants in cancer metabolism. Cancer Lett. 356:197–203. 2015. View Article : Google Scholar : PubMed/NCBI

25 

Mathumai K: Treating p53 mutant aggregation-associated cancer. Cancers. 10:1542018. View Article : Google Scholar

26 

Ubby I, Krueger C, Rosato R, Qian W, Chang J and Sabapathy K: Cancer therapeutic targeting using mutant-p53-specific siRNAs. Oncogene. 38:3415–3427. 2019. View Article : Google Scholar : PubMed/NCBI

27 

Fukaya R, Ohta S, Yaguchi T, Matsuzaki Y, Sugihara E, Okano H, Saya H, Kawakami Y, Kawase T, Yoshida K and Toda M: MIF maintains the tumorigenic capacity of brain tumor-initiating cells by directly inhibiting p53. Cancer Res. 76:2813–2823. 2016. View Article : Google Scholar : PubMed/NCBI

28 

Kong F, Xuan D, Kong X, Du Y, Li L, Zhu H, Wang Y, Xie D, Guha S, Li Z, et al: ZFPM2-AS1, a Novel lncRNA, attenuates the p53 pathway and promotes gastric carcinogenesis by stabilizing MIF. Oncogene. 37:5982–5996. 2018. View Article : Google Scholar : PubMed/NCBI

29 

Ramireddy L, Chen WT, Peng CT, Hu RM, Ke TW, Chiang HC, Chang SC, Tsai FJ and Lo WY: Association between genetic polymorphism of the MIF gene and colorectal cancer in Taiwan. J Clin Lab Anal. 29:268–274. 2015. View Article : Google Scholar : PubMed/NCBI

30 

Lin S, Wang M, Liu X, Zhu W, Guo Y, Dai Z, Yang P, Tian T, Dai C, Zheng Y, et al: Association of genetic polymorphisms in MIF with breast cancer risk in Chinese women. Clin Exp Med. 17:395–401. 2017. View Article : Google Scholar : PubMed/NCBI

31 

Ding GX, Zhou SQ, Xu Z, Feng NH, Song NH, Wang XJ, Yang J, Zhang W, Wu HF and Hua LX: The association between MIF-173 G>C polymorphism and prostate cancer in southern Chinese. J Surg Oncol. 100:106–110. 2009. View Article : Google Scholar : PubMed/NCBI

32 

Xiang T, Bing Z, Tong Q, Liu S, Peng S, Yang X and Fan H: The MIF-173G/C gene polymorphism increase gastrointestinal cancer and hematological malignancy risk: Evidence from a meta-analysis and FPRP test. Int J Clin Exp Med. 8:15949–15957. 2015.PubMed/NCBI

33 

Yuan T, Tang C, Chen M, Deng S and Chen P: Influence of the human MIF promoter polymorphism on hepatocellular carcinoma prognosis. Genet Mol Res. 12:6629–6635. 2013. View Article : Google Scholar : PubMed/NCBI

34 

O'Reilly C, Doroudian M, Mawhinney L and Donnelly SC: Targeting MIF in cancer: Therapeutic strategies, current developments, and future opportunities. Med Res Rev. 36:440–460. 2016. View Article : Google Scholar

35 

Wang D, Luo L, Chen W, Chen LZ, Zeng WT, Li W and Huang XH: Significance of the vascular endothelial growth factor and the macrophage migration inhibitory factor in the progression of hepatocellular carcinoma. Oncol Rep. 31:1199–1204. 2014. View Article : Google Scholar : PubMed/NCBI

36 

Zhao YM, Wang L, Dai Z, Wang DD, Hei ZY, Zhang N, Fu XT, Wang XL, Zhang SC, Qin LX, et al: Validity of plasma macrophage migration inhibitory factor for diagnosis and prognosis of hepatocellular carcinoma. Int J Cancer. 129:2463–2472. 2011. View Article : Google Scholar : PubMed/NCBI

37 

Han Y and Zhang C: Macrophage migration inhibitory factor plays a pivotal role in hepatocellular carcinoma and may be a noninvasive imaging target. Medical Hypotheses. 75:530–532. 2010. View Article : Google Scholar : PubMed/NCBI

38 

Oscar I, Gomez-Verjan JC, Lizbeth GV, Tzipe G and Miriam RS: Macrophage migration inhibitory factor-173 G/C polymorphism: A global meta-analysis across the disease spectrum. Front Genet. 9:552018. View Article : Google Scholar

39 

Gnoni A, Santini D, Scartozzi M, Russo A, Licchetta A, Palmieri V, Lupo L, Faloppi L, Palasciano G, Memeo V, et al: Hepatocellular carcinoma treatment over sorafenib: Epigenetics, microRNAs and microenvironment. Is there a light at the end of the tunnel? Expert Opin Ther Targets. 19:1623–1635. 2015. View Article : Google Scholar : PubMed/NCBI

40 

Zhang K, Pan X, Shu X, Cao H, Chen L, Zou Y, Deng H, Li G and Xu Q: Relationship between MIF-173 G/C polymorphism and susceptibility to chronic hepatitis B and HBV-induced liver cirrhosis. Cell Immunol. 282:113–116. 2013. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Qin L, Qin J, Lv X, Yin C, Zhang Q and Zhang J: MIF promoter polymorphism increases peripheral blood expression levels, contributing to increased susceptibility and poor prognosis in hepatocellular carcinoma. Oncol Lett 22: 549, 2021.
APA
Qin, L., Qin, J., Lv, X., Yin, C., Zhang, Q., & Zhang, J. (2021). MIF promoter polymorphism increases peripheral blood expression levels, contributing to increased susceptibility and poor prognosis in hepatocellular carcinoma. Oncology Letters, 22, 549. https://doi.org/10.3892/ol.2021.12810
MLA
Qin, L., Qin, J., Lv, X., Yin, C., Zhang, Q., Zhang, J."MIF promoter polymorphism increases peripheral blood expression levels, contributing to increased susceptibility and poor prognosis in hepatocellular carcinoma". Oncology Letters 22.1 (2021): 549.
Chicago
Qin, L., Qin, J., Lv, X., Yin, C., Zhang, Q., Zhang, J."MIF promoter polymorphism increases peripheral blood expression levels, contributing to increased susceptibility and poor prognosis in hepatocellular carcinoma". Oncology Letters 22, no. 1 (2021): 549. https://doi.org/10.3892/ol.2021.12810
Copy and paste a formatted citation
x
Spandidos Publications style
Qin L, Qin J, Lv X, Yin C, Zhang Q and Zhang J: MIF promoter polymorphism increases peripheral blood expression levels, contributing to increased susceptibility and poor prognosis in hepatocellular carcinoma. Oncol Lett 22: 549, 2021.
APA
Qin, L., Qin, J., Lv, X., Yin, C., Zhang, Q., & Zhang, J. (2021). MIF promoter polymorphism increases peripheral blood expression levels, contributing to increased susceptibility and poor prognosis in hepatocellular carcinoma. Oncology Letters, 22, 549. https://doi.org/10.3892/ol.2021.12810
MLA
Qin, L., Qin, J., Lv, X., Yin, C., Zhang, Q., Zhang, J."MIF promoter polymorphism increases peripheral blood expression levels, contributing to increased susceptibility and poor prognosis in hepatocellular carcinoma". Oncology Letters 22.1 (2021): 549.
Chicago
Qin, L., Qin, J., Lv, X., Yin, C., Zhang, Q., Zhang, J."MIF promoter polymorphism increases peripheral blood expression levels, contributing to increased susceptibility and poor prognosis in hepatocellular carcinoma". Oncology Letters 22, no. 1 (2021): 549. https://doi.org/10.3892/ol.2021.12810
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