Open Access

Effect of melanoma stem cells on melanoma metastasis (Review)

  • Authors:
    • Qiliang Yin
    • Xiumin Shi
    • Shijie Lan
    • Haofan Jin
    • Di Wu
  • View Affiliations

  • Published online on: May 29, 2021     https://doi.org/10.3892/ol.2021.12827
  • Article Number: 566
  • Copyright: © Yin et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Cancer stem cells (CSCs) are involved in the metastatic process, the resistance of many types of cancer to therapeutic treatments and consequently the onset of recurrences. The CSC concept therefore significantly extends our understanding of melanoma biology. More recently, melanoma stem cells (MSCs) have been described in melanoma as expressing specific biomarkers. These primitive melanoma cells are not only capable of self‑renewal and differentiation plasticity, but may also confer virulence via immune evasion and multidrug resistance, and potentially, via vasculogenic mimicry and transition to migratory and metastasizing derivatives. This review will present the specific biomarkers of MSCs, including CD133, ATP binding cassette subfamily B member 5, CD271, CD20 and aldehyde dehydrogenase, which can regulate the transduction of tumor‑related signals. These signal molecules can reversely act on tumor cells and regulate tumor angiogenesis, leading to the occurrence of melanoma metastasis. Targeting these specific biomarkers could inhibit the progression of melanoma and may help the development of novel therapeutic strategies for melanoma.
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July-2021
Volume 22 Issue 1

Print ISSN: 1792-1074
Online ISSN:1792-1082

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Copy and paste a formatted citation
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Spandidos Publications style
Yin Q, Shi X, Lan S, Jin H and Wu D: Effect of melanoma stem cells on melanoma metastasis (Review). Oncol Lett 22: 566, 2021
APA
Yin, Q., Shi, X., Lan, S., Jin, H., & Wu, D. (2021). Effect of melanoma stem cells on melanoma metastasis (Review). Oncology Letters, 22, 566. https://doi.org/10.3892/ol.2021.12827
MLA
Yin, Q., Shi, X., Lan, S., Jin, H., Wu, D."Effect of melanoma stem cells on melanoma metastasis (Review)". Oncology Letters 22.1 (2021): 566.
Chicago
Yin, Q., Shi, X., Lan, S., Jin, H., Wu, D."Effect of melanoma stem cells on melanoma metastasis (Review)". Oncology Letters 22, no. 1 (2021): 566. https://doi.org/10.3892/ol.2021.12827