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Tenascin‑C promotes epithelial‑to‑mesenchymal transition and the mTOR signaling pathway in nasopharyngeal carcinoma

  • Authors:
    • Xiang Cheng
    • Fen Li
    • Zezhang Tao
  • View Affiliations / Copyright

    Affiliations: Department of Otolaryngology‑Head and Neck Surgery, Renmin Hospital of Wuhan University, Wuhan, Hubei 430060, P.R. China
    Copyright: © Cheng et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 570
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    Published online on: May 29, 2021
       https://doi.org/10.3892/ol.2021.12831
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Abstract

Tenascin‑C (TNC) is a large extracellular matrix glycoprotein that promotes cell adhesion and tissue remodeling, and is involved in the transduction of cellular signaling pathways. The present study aimed to investigate the role of TNC and determine its effect in nasopharyngeal carcinoma (NPC). TNC gene transcription and expression were analyzed using the NPC dataset and immunohistochemistry analysis of NPC tissues. Weighted gene co‑expression network and gene enrichment analyses were performed to determine the potential molecular mechanisms underlying the effects of TNC in NPC. TNC expression was suppressed in NPC cells, and the effects were determined both in vitro and in vivo. The results demonstrated that TNC gene transcription and expression were high in NPC tissues compared with normal tissues. Notably, TNC knockdown inhibited NPC cell proliferation, migration and invasion. In addition, TNC knockdown inhibited tumor growth in mice. In vitro, TNC knockdown inhibited epithelial‑to‑mesenchymal transition (EMT) and decreased activity of the PI3K/AKT/mTOR signaling pathway in NPC cells. Taken together, these results suggest that TNC promotes cell proliferation, EMT and activity of the PI3K/AKT/mTOR signaling pathway in NPC cells, and thus functions as an oncogene.
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Copy and paste a formatted citation
Spandidos Publications style
Cheng X, Li F and Tao Z: Tenascin‑C promotes epithelial‑to‑mesenchymal transition and the mTOR signaling pathway in nasopharyngeal carcinoma. Oncol Lett 22: 570, 2021.
APA
Cheng, X., Li, F., & Tao, Z. (2021). Tenascin‑C promotes epithelial‑to‑mesenchymal transition and the mTOR signaling pathway in nasopharyngeal carcinoma. Oncology Letters, 22, 570. https://doi.org/10.3892/ol.2021.12831
MLA
Cheng, X., Li, F., Tao, Z."Tenascin‑C promotes epithelial‑to‑mesenchymal transition and the mTOR signaling pathway in nasopharyngeal carcinoma". Oncology Letters 22.1 (2021): 570.
Chicago
Cheng, X., Li, F., Tao, Z."Tenascin‑C promotes epithelial‑to‑mesenchymal transition and the mTOR signaling pathway in nasopharyngeal carcinoma". Oncology Letters 22, no. 1 (2021): 570. https://doi.org/10.3892/ol.2021.12831
Copy and paste a formatted citation
x
Spandidos Publications style
Cheng X, Li F and Tao Z: Tenascin‑C promotes epithelial‑to‑mesenchymal transition and the mTOR signaling pathway in nasopharyngeal carcinoma. Oncol Lett 22: 570, 2021.
APA
Cheng, X., Li, F., & Tao, Z. (2021). Tenascin‑C promotes epithelial‑to‑mesenchymal transition and the mTOR signaling pathway in nasopharyngeal carcinoma. Oncology Letters, 22, 570. https://doi.org/10.3892/ol.2021.12831
MLA
Cheng, X., Li, F., Tao, Z."Tenascin‑C promotes epithelial‑to‑mesenchymal transition and the mTOR signaling pathway in nasopharyngeal carcinoma". Oncology Letters 22.1 (2021): 570.
Chicago
Cheng, X., Li, F., Tao, Z."Tenascin‑C promotes epithelial‑to‑mesenchymal transition and the mTOR signaling pathway in nasopharyngeal carcinoma". Oncology Letters 22, no. 1 (2021): 570. https://doi.org/10.3892/ol.2021.12831
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