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Article

Sphingosine kinases are involved in the regulation of all‑trans retinoic acid sensitivity of K562 chronic myeloid leukemia cells

  • Authors:
    • Defu Sun
    • Siping Wang
  • View Affiliations / Copyright

    Affiliations: Department of Bioengineering, School of Life Science, Yantai University, Yantai, Shandong 264005, P.R. China, Department of Gastroenterology, Yantai Shan Hospital, Yantai, Shandong 264005, P.R. China
  • Article Number: 581
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    Published online on: June 2, 2021
       https://doi.org/10.3892/ol.2021.12842
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Abstract

The efficacy of all‑trans retinoic acid (ATRA) for the treatment of chronic myeloid leukemia (CML) has been reported to be limited both as single‑drug treatment or in combination with other drugs. Our previous study demonstrated that sphingosine 1‑phosphate attenuated the effects of ATRA on human colon cancer cells by blocking the expression of retinoic acid receptor β. The aim of the present study was to investigate whether the ATRA‑dependent proliferation inhibition of K562 cells was regulated by sphingosine kinases (SphKs). The results of cell proliferation assay and reverse transcription‑PCR demonstrated that ATRA may exert synergistic effects with the SphK1 inhibitor SKI 5C or the pan‑SphK inhibitor SKI II to inhibit the proliferation of K562 cells and upregulate the expression levels of the ATRA‑inducible enzyme cytochrome P450 26A1 (CYP26A1). Knocking down the expression of SphK1 or SphK2 in K562 cells by small interfering RNA enhanced the inhibitory effects of ATRA and induced the expression of CYP26A1. Crude asterosaponins, which abrogated the expression of SphK2, also enhanced the effects of ATRA on K562 cells. In conclusion, the results of the present study demonstrated that SphKs may be involved in the regulation of the sensitivity of CML cells to ATRA.
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1 

Schwartz SI: Myeloproliferative disorders. Ann Surg. 182:464–471. 1975. View Article : Google Scholar : PubMed/NCBI

2 

Goldman JM: Chronic myeloid leukemia: A historical perspective. Semin Hematol. 47:302–311. 2010. View Article : Google Scholar : PubMed/NCBI

3 

Deininger MW, Goldman JM and Melo JV: The molecular biology of chronic myeloid leukemia. Blood. 96:3343–3356. 2000. View Article : Google Scholar : PubMed/NCBI

4 

Chen Y, Peng C, Sullivan C, Li D and Li S: Critical molecular pathways in cancer stem cells of chronic myeloid leukemia. Leukemia. 24:1545–1554. 2010. View Article : Google Scholar : PubMed/NCBI

5 

Zhang H and Li S: Molecular mechanisms for survival regulation of chronic myeloid leukemia stem cells. Protein Cell. 4:186–196. 2013. View Article : Google Scholar : PubMed/NCBI

6 

Kam RK, Deng Y, Chen Y and Zhao H: Retinoic acid synthesis and functions in early embryonic development. Cell Biosci. 2:112012. View Article : Google Scholar : PubMed/NCBI

7 

Zhang R, Wang Y, Li R and Chen G: Transcriptional factors mediating retinoic acid signals in the control of energy metabolism. Int J Mol Sci. 16:14210–14244. 2015. View Article : Google Scholar : PubMed/NCBI

8 

Theodosiou M, Laudet V and Schubert M: From carrot to clinic: An overview of the retinoic acid signaling pathway. Cell Mol Life Sci. 67:1423–1445. 2010. View Article : Google Scholar : PubMed/NCBI

9 

Connolly RM, Nguyen NK and Sukumar S: Molecular pathways: Current role and future directions of the retinoic acid pathway in cancer prevention and treatment. Clin Cancer Res. 19:1651–1659. 2013. View Article : Google Scholar : PubMed/NCBI

10 

Lotan R, Xu XC, Lippman SM, Ro JY, Lee JS, Lee JJ and Hong WK: Suppression of retinoic acid receptor-beta in premalignant oral lesions and its up-regulation by isotretinoin. N Engl J Med. 332:1405–1410. 1995. View Article : Google Scholar : PubMed/NCBI

11 

Arrieta O, Gonzalez-De la Rosa CH, Arechaga-Ocampo E, Villanueva-Rodriguez G, Ceron-Lizarraga TL, Martinez-Barrera L, Vázquez-Manríquez ME, Ríos-Trejo MA, Alvarez-Avitia MA, Hernández-Pedro N, et al: Randomized phase II trial of All-trans-retinoic acid with chemotherapy based on paclitaxel and cisplatin as first-line treatment in patients with advanced non-small-cell lung cancer. J Clin Oncol. 28:3463–3471. 2010. View Article : Google Scholar : PubMed/NCBI

12 

Sutton LM, Warmuth MA, Petros WP and Winer EP: Pharmacokinetics and clinical impact of all-trans retinoic acid in metastatic breast cancer: A phase II trial. Cancer Chemother Pharmacol. 40:335–341. 1997. View Article : Google Scholar : PubMed/NCBI

13 

Degos L and Wang ZY: All trans retinoic acid in acute promyelocytic leukemia. Oncogene. 20:7140–7145. 2001. View Article : Google Scholar : PubMed/NCBI

14 

Lo-Coco F, Avvisati G, Vignetti M, Thiede C, Orlando SM, Iacobelli S, Ferrara F, Fazi P, Cicconi L, Di Bona E, et al: Retinoic acid and arsenic trioxide for acute promyelocytic leukemia. N Engl J Med. 369:111–121. 2013. View Article : Google Scholar : PubMed/NCBI

15 

Borrow J, Goddard AD, Sheer D and Solomon E: Molecular analysis of acute promyelocytic leukemia breakpoint cluster region on chromosome 17. Science. 249:1577–1580. 1990. View Article : Google Scholar : PubMed/NCBI

16 

el-Deiry WS, Tokino T, Velculescu VE, Levy DB, Parsons R, Trent JM, Lin D, Mercer ME, Kinzler KW and Vogelstein B: WAF1, a potential mediator of p53 tumor suppression. Cell. 75:817–825. 1993. View Article : Google Scholar : PubMed/NCBI

17 

Choi Y, Kim SY, Kim SH, Yang J, Park K and Byun Y: Inhibition of tumor growth by biodegradable microspheres containing all-trans-retinoic acid in a human head-and-neck cancer xenograft. Int J Cancer. 107:145–148. 2003. View Article : Google Scholar : PubMed/NCBI

18 

Masetti R, Biagi C, Zama D, Vendemini F, Martoni A, Morello W, Gasperini P and Pession A: Retinoids in pediatric onco-hematology: The model of acute promyelocytic leukemia and neuroblastoma. Adv Ther. 29:747–762. 2012. View Article : Google Scholar : PubMed/NCBI

19 

Dayon A, Brizuela L, Martin C, Mazerolles C, Pirot N, Doumerc N, Nogueira L, Golzio M, Teissié J, Serre G, et al: Sphingosine kinase-1 is central to androgen-regulated prostate cancer growth and survival. PLoS One. 4:e80482009. View Article : Google Scholar : PubMed/NCBI

20 

Sukocheva O, Wang L, Verrier E, Vadas MA and Xia P: Restoring endocrine response in breast cancer cells by inhibition of the sphingosine kinase-1 signaling pathway. Endocrinology. 150:4484–4492. 2009. View Article : Google Scholar : PubMed/NCBI

21 

Liu H, Toman RE, Goparaju SK, Maceyka M, Nava VE, Sankala H, Payne SG, Bektas M, Ishii I, Chun J, et al: Sphingosine kinase type 2 is a putative BH3-only protein that induces apoptosis. J Biol Chem. 278:40330–40336. 2003. View Article : Google Scholar : PubMed/NCBI

22 

Sobue S, Iwasaki T, Sugisaki C, Nagata K, Kikuchi R, Murakami M, Takagi A, Kojima T, Banno Y, Akao Y, et al: Quantitative RT-PCR analysis of sphingolipid metabolic enzymes in acute leukemia and myelodysplastic syndromes. Leukemia. 20:2042–2046. 2006. View Article : Google Scholar : PubMed/NCBI

23 

Datta A, Loo SY, Huang B, Wong L, Tan SS, Tan TZ, Lee SC, Thiery JP, Lim YC, Yong WP, Lam Y, Kumar AP and Yap CT: SPHK1 regulates proliferation and survival responses in triple-negative breast cancer. Oncotarget. 5:5920–5933. 2014. View Article : Google Scholar : PubMed/NCBI

24 

Igarashi N, Okada T, Hayashi S, Fujita T, Jahangeer S and Nakamura S: Sphingosine kinase 2 is a nuclear protein and inhibits DNA synthesis. J Biol Chem. 278:46832–46839. 2003. View Article : Google Scholar : PubMed/NCBI

25 

Illuzzi G, Bernacchioni C, Aureli M, Prioni S, Frera G, Donati C, Valsecchi M, Chigorno V, Bruni P, Sonnino S and Prinetti A: Sphingosine kinase mediates resistance to the synthetic retinoid N-(4-hydroxyphenyl)retinamide in human ovarian cancer cells. J Biol Chem. 285:18594–18602. 2010. View Article : Google Scholar : PubMed/NCBI

26 

Sun DF, Gao ZH, Liu HP, Yuan Y and Qu XJ: Sphingosine 1-phosphate antagonizes the effect of all-trans retinoic acid (ATRA) in a human colon cancer cell line by modulation of RARβ expression. Cancer Lett. 319:182–189. 2012. View Article : Google Scholar : PubMed/NCBI

27 

Li QF, Huang WR, Duan HF, Wang H, Wu CT and Wang LS: Sphingosine kinase-1 mediates BCR/ABL-induced upregulation of Mcl-1 in chronic myeloid leukemia cells. Oncogene. 26:7904–7908. 2007. View Article : Google Scholar : PubMed/NCBI

28 

Salas A, Ponnusamy S, Senkal CE, Meyers-Needham M, Selvam SP, Saddoughi SA, Apohan E, Sentelle RD, Smith C, Gault CR, et al: Sphingosine kinase-1 and sphingosine 1-phosphate receptor 2 mediate Bcr-Abl1 stability and drug resistance by modulation of protein phosphatase 2A. Blood. 117:5941–5952. 2011. View Article : Google Scholar : PubMed/NCBI

29 

Kalle AM, Sachchidanand S and Pallu R: Bcr-Abl-independent mechanism of resistance to imatinib in K562 cells: Induction of cyclooxygenase-2 (COX-2) by histone deacetylases (HDACs). Leukemia Res. 34:1132–1138. 2010. View Article : Google Scholar : PubMed/NCBI

30 

Malyarenko TV, Kicha AA, Ivanchina NV, Kalinovsky AI, Popov RS, Vishchuk OS and Stonik VA: Asterosaponins from the Far Eastern starfish Leptasterias ochotensis and their anticancer activity. Steroids. 87:119–127. 2014. View Article : Google Scholar : PubMed/NCBI

31 

Kurie JM, Buck J, Eppinger TM, Moy D and Dmitrovsky E: 9-cis and all-trans retinoic acid induce a similar phenotype in human teratocarcinoma cells. Differentiation. 54:123–129. 1993. View Article : Google Scholar : PubMed/NCBI

32 

Ozpolat B, Mehta K, Tari AM and Lopez-Berestein G: All-trans-Retinoic acid-induced expression and regulation of retinoic acid 4-hydroxylase (CYP26) in human promyelocytic leukemia. Am J Hematol. 70:39–47. 2002. View Article : Google Scholar : PubMed/NCBI

33 

Pitson SM, Powell JA and Bonder CS: Regulation of sphingosine kinase in hematological malignancies and other cancers. Anticancer Agents Med Chem. 11:799–809. 2011. View Article : Google Scholar : PubMed/NCBI

34 

Sobue S, Nemoto S, Murakami M, Ito H, Kimura A, Gao S, Furuhata A, Takagi A, Kojima T, Nakamura M, et al: Implications of sphingosine kinase 1 expression level for the cellular sphingolipid rheostat: Relevance as a marker for daunorubicin sensitivity of leukemia cells. Int J Hematol. 87:266–275. 2008. View Article : Google Scholar : PubMed/NCBI

35 

Bonhoure E, Pchejetski D, Aouali N, Morjani H, Levade T, Kohama T and Cuvillier O: Overcoming MDR-associated chemoresistance in HL-60 acute myeloid leukemia cells by targeting shingosine kinase-1. Leukemia. 20:95–102. 2005. View Article : Google Scholar : PubMed/NCBI

36 

Powell JA, Lewis AC, Zhu W, Toubia J, Pitman MR, Wallington-Beddoe CT, Moretti PA, Iarossi D, Samaraweera SE, Cummings N, et al: Targeting sphingosine kinase 1 induces MCL1-dependent cell death in acute myeloid leukemia. Blood. 129:771–782. 2017. View Article : Google Scholar : PubMed/NCBI

37 

Pitson SM, Xia P, Leclercq TM, Moretti PA, Zebol JR, Lynn HE, Wattenberg BW and Vadas MA: Phosphorylation-dependent translocation of sphingosine kinase to the plasma membrane drives its oncogenic signalling. J Exp Med. 201:49–54. 2005. View Article : Google Scholar : PubMed/NCBI

38 

Recchia F, Saggio G, Nuzzo A, Biondi E, Di Blasio A, Cesta A, Candeloro G, Alesse E and Rea S: Multicenter phase 2 study of interleukin-2 and 13-cis retinoic acid as maintenance therapy in advanced non-small-cell lung cancer. J Immunother. 29:87–94. 2006. View Article : Google Scholar : PubMed/NCBI

39 

Wakelee HA, Takimoto CH, Lopez-Anaya A, Chu Q, Middleton G, Dunlop D, Ramlau R, Leighl N, Rowinsky EK, Hao D, et al: The effect of bexarotene on atorvastatin pharmacokinetics: Results from a phase I trial of bexarotene plus chemotherapy in patients with advanced non-small cell lung cancer. Cancer Chemother. Pharmacol. 69:563–571. 2012.PubMed/NCBI

40 

Montesano R and Soulié P: Retinoids induce lumen morphogenesis in mammary epithelial cells. J Cell Sci. 115((Pt 23)): 4419–4431. 2002. View Article : Google Scholar : PubMed/NCBI

41 

de The H, Vivanco-Ruiz MM, Tiollais P, Stunnenberg H and Dejean A: Identification of a retinoic acid responsive element in the retinoic acid receptor beta gene. Nature. 343:177–180. 1990. View Article : Google Scholar : PubMed/NCBI

42 

Zhou T, Medeiros LJ and Hu S: Chronic myeloid leukemia: Beyond BCR-ABL1. Curr Hematol Malig Rep. 13:435–445. 2018. View Article : Google Scholar : PubMed/NCBI

43 

Caldemeyer L, Dugan M, Edwards J and Akard L: Long-term side effects of tyrosine kinase inhibitors in chronic myeloid leukemia. Curr Hematol Malig Rep. 11:71–79. 2016. View Article : Google Scholar : PubMed/NCBI

44 

Ren R: Mechanisms of BCR-ABL in the pathogenesis of chronic myelogenous leukaemia. Nat Rev Cancer. 5:172–183. 2005. View Article : Google Scholar : PubMed/NCBI

45 

Thao NP, Cuong NX, Luyen BT, Thanh NV, Nhiem NX, Koh YS, Ly BM, Nam NH, Kiem PV, Minh CV and Kim YH: Anti-inflammatory asterosaponins from the starfish Astropecten monacanthus. J Nat Prod. 76:1764–1770. 2013. View Article : Google Scholar : PubMed/NCBI

46 

Ngoan BT, HanhT T, Vien le T, Diep CN, Thao NP, Thao do T, Thanh NV, Cuong NX, Nam NH, Thung do C, et al: Asterosaponins and glycosylated polyhydroxysteroids from the starfish Culcita novaeguineae and their cytotoxic activities. J Asian Nat Prod Res. 17:1010–1017. 2015. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Sun D and Wang S: Sphingosine kinases are involved in the regulation of all‑trans retinoic acid sensitivity of K562 chronic myeloid leukemia cells. Oncol Lett 22: 581, 2021.
APA
Sun, D., & Wang, S. (2021). Sphingosine kinases are involved in the regulation of all‑trans retinoic acid sensitivity of K562 chronic myeloid leukemia cells. Oncology Letters, 22, 581. https://doi.org/10.3892/ol.2021.12842
MLA
Sun, D., Wang, S."Sphingosine kinases are involved in the regulation of all‑trans retinoic acid sensitivity of K562 chronic myeloid leukemia cells". Oncology Letters 22.2 (2021): 581.
Chicago
Sun, D., Wang, S."Sphingosine kinases are involved in the regulation of all‑trans retinoic acid sensitivity of K562 chronic myeloid leukemia cells". Oncology Letters 22, no. 2 (2021): 581. https://doi.org/10.3892/ol.2021.12842
Copy and paste a formatted citation
x
Spandidos Publications style
Sun D and Wang S: Sphingosine kinases are involved in the regulation of all‑trans retinoic acid sensitivity of K562 chronic myeloid leukemia cells. Oncol Lett 22: 581, 2021.
APA
Sun, D., & Wang, S. (2021). Sphingosine kinases are involved in the regulation of all‑trans retinoic acid sensitivity of K562 chronic myeloid leukemia cells. Oncology Letters, 22, 581. https://doi.org/10.3892/ol.2021.12842
MLA
Sun, D., Wang, S."Sphingosine kinases are involved in the regulation of all‑trans retinoic acid sensitivity of K562 chronic myeloid leukemia cells". Oncology Letters 22.2 (2021): 581.
Chicago
Sun, D., Wang, S."Sphingosine kinases are involved in the regulation of all‑trans retinoic acid sensitivity of K562 chronic myeloid leukemia cells". Oncology Letters 22, no. 2 (2021): 581. https://doi.org/10.3892/ol.2021.12842
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