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IGF2 is a potential factor in RAI‑refractory differentiated thyroid cancer

  • Authors:
    • Thomas Crezee
    • Marika H. Tesselaar
    • Martin Jaeger
    • Katrin Rabold
    • Willem E. Corver
    • Hans Morreau
    • Adriana C.H. Van Engen‑Van Grunsven
    • Jan W.A. Smit
    • Romana T. Netea‑Maier
    • Theo S. Plantinga
  • View Affiliations / Copyright

    Affiliations: Department of Pathology, Radboud University Medical Center, 6500 HB Nijmegen, The Netherlands, Radboud Institute for Molecular Life Sciences, Radboud University Medical Center, 6500 HB Nijmegen, The Netherlands, Department of Internal Medicine, Radboud University Medical Center, 6500 HB Nijmegen, The Netherlands, Department of Pathology, Leiden University Medical Center, 2333 ZA Leiden, The Netherlands, Department of Internal Medicine, Division of Endocrinology, Radboud University Medical Center, 6500 HB Nijmegen, The Netherlands
    Copyright: © Crezee et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 590
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    Published online on: June 6, 2021
       https://doi.org/10.3892/ol.2021.12851
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Abstract

Differentiated thyroid cancer (DTC) is the most frequent endocrine tumor with a good prognosis after primary treatment in most cases. By contrast, 30‑40% of patients with metastatic DTC are unresponsive to 131I radioactive iodide (RAI) treatment due to tumor dedifferentiation. Currently, underlying molecular mechanisms of dedifferentiation remain elusive and predictive biomarkers are lacking. Therefore, the present study aimed to identify molecular biomarkers in primary tumors associated with RAI refractoriness. A retrospective cohort was gathered consisting of RAI‑sensitive patients with DTC and RAI‑refractory patients with poorly DTC. In all patients, extensive intratumoral mutation profiling, gene fusions analysis, telomerase reverse transcriptase (TERT) promoter mutation analysis and formalin‑fixed paraffin‑embedded‑compatible RNA sequencing were performed. Genetic analyses revealed an increased mutational load in RAI‑refractory DTC, including mutations in AKT1, PTEN, TP53 and TERT promoter. Transcriptomic analyses revealed profound differential expression of insulin‑like growth factor 2 (IGF2), with up to 100‑fold higher expression in RAI‑refractory DTC compared with in RAI‑sensitive DTC cases. ELISA revealed significant lower IGF2 plasma concentrations after surgery and subsequent 131I RAI therapy in patients with DTC compared with pretreatment baseline. Overall, the current findings suggested that the tumor‑promoting growth factor IGF2 may have a potential role in acquiring RAI refractoriness.
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1 

Xing M: Molecular pathogenesis and mechanisms of thyroid cancer. Nat Rev Cancer. 13:184–199. 2013. View Article : Google Scholar : PubMed/NCBI

2 

Fagin JA and Wells SA Jr: Biologic and clinical perspectives on thyroid cancer. N Engl J Med. 375:1054–1067. 2016. View Article : Google Scholar : PubMed/NCBI

3 

Durante C, Haddy N, Baudin E, Leboulleux S, Hartl D, Travagli JP, Caillou B, Ricard M, Lumbroso JD, De Vathaire F and Schlumberger M: Long-term outcome of 444 patients with distant metastases from papillary and follicular thyroid carcinoma: Benefits and limits of radioiodine therapy. J Clin Endocrinol Metab. 91:2892–2899. 2006. View Article : Google Scholar : PubMed/NCBI

4 

Song HJ, Qiu ZL, Shen CT, Wei WJ and Luo QY: Pulmonary metastases in differentiated thyroid cancer: Efficacy of radioiodine therapy and prognostic factors. Eur J Endocrinol. 173:399–408. 2015. View Article : Google Scholar : PubMed/NCBI

5 

Brose MS, Nutting CM, Jarzab B, Elisei R, Siena S, Bastholt L, de la Fouchardiere C, Pacini F, Paschke R, Shong YK, et al: Sorafenib in radioactive iodine-refractory, locally advanced or metastatic differentiated thyroid cancer: A randomised, double-blind, phase 3 trial. Lancet. 384:319–328. 2014. View Article : Google Scholar : PubMed/NCBI

6 

Pacini F, Castagna MG, Brilli L and Pentheroudakis G; ESMO Guidelines Working Group, : Thyroid cancer: ESMO clinical practice guidelines for diagnosis, treatment and follow-up. Ann Oncol. 23 (Suppl 7):vii110–vii119. 2012. View Article : Google Scholar : PubMed/NCBI

7 

Romesser PB, Sherman EJ, Shaha AR, Lian M, Wong RJ, Sabra M, Rao SS, Fagin JA, Tuttle RM and Lee NY: External beam radiotherapy with or without concurrent chemotherapy in advanced or recurrent non-anaplastic non-medullary thyroid cancer. J Surg Oncol. 110:375–382. 2014. View Article : Google Scholar : PubMed/NCBI

8 

Schlumberger M, Tahara M, Wirth LJ, Robinson B, Brose MS, Elisei R, Habra MA, Newbold K, Shah MH, Hoff AO, et al: Lenvatinib versus placebo in radioiodine-refractory thyroid cancer. N Engl J Med. 372:621–630. 2015. View Article : Google Scholar : PubMed/NCBI

9 

de la Fouchardière C, Decaussin-Petrucci M, Berthiller J, Descotes F, Lopez J, Lifante JC, Peix JL, Giraudet AL, Delahaye A, Masson S, et al: Predictive factors of outcome in poorly differentiated thyroid carcinomas. Eur J Cancer. 92:40–47. 2018. View Article : Google Scholar

10 

Zheng L, Wang G, Guo W, Pan D, Xie L, He S, Luo C, Li H, Ran Y, Wu S, et al: NIS and epithelial-mesenchymal transition marker expression of circulating tumor cells for predicting and monitoring the radioactive iodine-131 therapy effect in differentiated thyroid cancers. Mol Biol Rep. 46:4201–4212. 2019. View Article : Google Scholar : PubMed/NCBI

11 

Sollini M, di Tommaso L, Kirienko M, Piombo C, Erreni M, Lania AG, Erba PA, Antunovic L and Chiti A: PSMA expression level predicts differentiated thyroid cancer aggressiveness and patient outcome. EJNMMI Res. 9:932019. View Article : Google Scholar : PubMed/NCBI

12 

Song E, Kim M, Kim EY, Kim BH, Shin DY, Kang HC, Ahn BC, Kim WB, Shong YK, Jeon MJ and Lim DJ: Lenvatinib for radioactive iodine-refractory differentiated thyroid carcinoma and candidate biomarkers associated with survival: A multicenter study in Korea. Thyroid. 30:732–738. 2020. View Article : Google Scholar : PubMed/NCBI

13 

Wang C, Zhang X, Li H, Li X and Lin Y: Quantitative thyroglobulin response to radioactive iodine treatment in predicting radioactive iodine-refractory thyroid cancer with pulmonary metastasis. PLoS One. 12:e01796642017. View Article : Google Scholar : PubMed/NCBI

14 

Giovanella L, Castellana M and Trimboli P: Unstimulated high-sensitive thyroglobulin is a powerful prognostic predictor in patients with thyroid cancer. Clin Chem Lab Med. 58:130–137. 2019. View Article : Google Scholar : PubMed/NCBI

15 

Tuttle RM, Haugen B and Perrier ND: Updated American joint committee on cancer/tumor-node-metastasis staging system for differentiated and anaplastic thyroid cancer (eighth edition): What changed and why? Thyroid. 27:751–756. 2017. View Article : Google Scholar : PubMed/NCBI

16 

Eijkelenboom A, Kamping EJ, Kastner-van Raaij AW, Hendriks-Cornelissen SJ, Neveling K, Kuiper RP, Hoischen A, Nelen MR, Ligtenberg MJ and Tops BB: Reliable next-generation sequencing of formalin-fixed, paraffin-embedded tissue using single molecule tags. J Mol Diagn. 18:851–863. 2016. View Article : Google Scholar : PubMed/NCBI

17 

Cancer Genome Atlas Research Network, . Integrated genomic characterization of papillary thyroid carcinoma. Cell. 159:676–690. 2014. View Article : Google Scholar : PubMed/NCBI

18 

Jin L, Chen E, Dong S, Cai Y, Zhang X, Zhou Y, Zeng R, Yang F, Pan C, Liu Y, et al: BRAF and TERT promoter mutations in the aggressiveness of papillary thyroid carcinoma: A study of 653 patients. Oncotarget. 7:18346–18355. 2016. View Article : Google Scholar : PubMed/NCBI

19 

Xing M, Liu R, Liu X, Murugan AK, Zhu G, Zeiger MA, Pai S and Bishop J: BRAF V600E and TERT promoter mutations cooperatively identify the most aggressive papillary thyroid cancer with highest recurrence. J Clin Oncol. 32:2718–2726. 2014. View Article : Google Scholar : PubMed/NCBI

20 

Baral K and Rotwein P: The insulin-like growth factor 2 gene in mammals: Organizational complexity within a conserved locus. PLoS One. 14:e02191552019. View Article : Google Scholar : PubMed/NCBI

21 

Bowers LW, Rossi EL, O'Flanagan CH, deGraffenried LA and Hursting SD: The role of the insulin/IGF system in cancer: Lessons learned from clinical trials and the energy balance-cancer link. Front Endocrinol (Lausanne). 6:772015. View Article : Google Scholar : PubMed/NCBI

22 

Brouwer-Visser J and Huang GS: IGF2 signaling and regulation in cancer. Cytokine Growth Factor Rev. 26:371–377. 2015. View Article : Google Scholar : PubMed/NCBI

23 

Djiogue S, Nwabo Kamdje AH, Vecchio L, Kipanyula MJ, Farahna M, Aldebasi Y and Seke Etet PF: Insulin resistance and cancer: The role of insulin and IGFs. Endocr Relat Cancer. 20:R1–R17. 2013. View Article : Google Scholar : PubMed/NCBI

24 

Frasca F, Pandini G, Scalia P, Sciacca L, Mineo R, Costantino A, Goldfine ID, Belfiore A and Vigneri R: Insulin receptor isoform A, a newly recognized, high-affinity insulin-like growth factor II receptor in fetal and cancer cells. Mol Cell Biol. 19:3278–3288. 1999. View Article : Google Scholar : PubMed/NCBI

25 

Livingstone C: IGF2 and cancer. Endocr Relat Cancer. 20:R321–R339. 2013. View Article : Google Scholar : PubMed/NCBI

26 

Manabe T, Yasuda H, Terai H, Kagiwada H, Hamamoto J, Ebisudani T, Kobayashi K, Masuzawa K, Ikemura S, Kawada I, et al: IGF2 autocrine-mediated IGF1R activation is a clinically relevant mechanism of osimertinib resistance in lung cancer. Mol Cancer Res. 18:549–559. 2020. View Article : Google Scholar : PubMed/NCBI

27 

Shimizu T, Sugihara E, Yamaguchi-Iwai S, Tamaki S, Koyama Y, Kamel W, Ueki A, Ishikawa T, Chiyoda T, Osuka S, et al: IGF2 preserves osteosarcoma cell survival by creating an autophagic state of dormancy that protects cells against chemotherapeutic stress. Cancer Res. 74:6531–6541. 2014. View Article : Google Scholar : PubMed/NCBI

28 

Steigen SE, Schaeffer DF, West RB and Nielsen TO: Expression of insulin-like growth factor 2 in mesenchymal neoplasms. Mod Pathol. 22:914–921. 2009. View Article : Google Scholar : PubMed/NCBI

29 

Kasprzak A and Adamek A: Insulin-like growth factor 2 (IGF2) signaling in colorectal cancer-from basic research to potential clinical applications. Int J Mol Sci. 20:49152019. View Article : Google Scholar : PubMed/NCBI

30 

Sanderson MP, Hofmann MH, Garin-Chesa P, Schweifer N, Wernitznig A, Fischer S, Jeschko A, Meyer R, Moll J, Pecina T, et al: The IGF1R/INSR inhibitor BI 885578 selectively inhibits growth of IGF2-overexpressing colorectal cancer tumors and potentiates the efficacy of anti-VEGF therapy. Mol Cancer Ther. 16:2223–2233. 2017. View Article : Google Scholar : PubMed/NCBI

31 

Unger C, Kramer N, Unterleuthner D, Scherzer M, Burian A, Rudisch A, Stadler M, Schlederer M, Lenhardt D, Riedl A, et al: Stromal-derived IGF2 promotes colon cancer progression via paracrine and autocrine mechanisms. Oncogene. 36:5341–5355. 2017. View Article : Google Scholar : PubMed/NCBI

32 

Sciacca L, Costantino A, Pandini G, Mineo R, Frasca F, Scalia P, Sbraccia P, Goldfine ID, Vigneri R and Belfiore A: Insulin receptor activation by IGF-II in breast cancers: Evidence for a new autocrine/paracrine mechanism. Oncogene. 18:2471–2479. 1999. View Article : Google Scholar : PubMed/NCBI

33 

Tominaga K, Shimamura T, Kimura N, Murayama T, Matsubara D, Kanauchi H, Niida A, Shimizu S, Nishioka K, Tsuji EI, et al: Addiction to the IGF2-ID1-IGF2 circuit for maintenance of the breast cancer stem-like cells. Oncogene. 36:1276–1286. 2017. View Article : Google Scholar : PubMed/NCBI

34 

Wang Q, Shen Y, Ye B, Hu H, Fan C, Wang T, Zheng Y, Lv J, Ma Y and Xiang M: Gene expression differences between thyroid carcinoma, thyroid adenoma and normal thyroid tissue. Oncol Rep. 40:3359–3369. 2018.PubMed/NCBI

35 

Malaguarnera R, Frasca F, Garozzo A, Giani F, Pandini G, Vella V, Vigneri R and Belfiore A: Insulin receptor isoforms and insulin-like growth factor receptor in human follicular cell precursors from papillary thyroid cancer and normal thyroid. J Clin Endocrinol Metab. 96:766–774. 2011. View Article : Google Scholar : PubMed/NCBI

36 

Vella V and Malaguarnera R: The emerging role of insulin receptor isoforms in thyroid cancer: Clinical implications and new perspectives. Int J Mol Sci. 19:38142018. View Article : Google Scholar : PubMed/NCBI

37 

Vella V, Nicolosi ML, Cantafio P, Massimino M, Lappano R, Vigneri P, Ciuni R, Gangemi P, Morrione A, Malaguarnera R and Belfiore A: DDR1 regulates thyroid cancer cell differentiation via IGF-2/IR-A autocrine signaling loop. Endocr Relat Cancer. 26:197–214. 2019. View Article : Google Scholar : PubMed/NCBI

38 

Vella V, Pandini G, Sciacca L, Mineo R, Vigneri R, Pezzino V and Belfiore A: A novel autocrine loop involving IGF-II and the insulin receptor isoform-A stimulates growth of thyroid cancer. J Clin Endocrinol Metab. 87:245–254. 2002. View Article : Google Scholar : PubMed/NCBI

39 

Wang Y, Gan G, Wang B, Wu J, Cao Y, Zhu D, Xu Y, Wang X, Han H, Li X, et al: Cancer-associated fibroblasts promote irradiated cancer cell recovery through autophagy. EBioMedicine. 17:45–56. 2017. View Article : Google Scholar : PubMed/NCBI

40 

Zhang Q, Yang J, Bai J and Ren J: Reverse of non-small cell lung cancer drug resistance induced by cancer-associated fibroblasts via a paracrine pathway. Cancer Sci. 109:944–955. 2018. View Article : Google Scholar : PubMed/NCBI

41 

Li T, Wang J, Liu P, Chi J, Yan H, Lei L, Li Z, Yang B and Wang X: Insulin-like growth factor 2 axis supports the serum-independent growth of malignant rhabdoid tumor and is activated by microenvironment stress. Oncotarget. 8:47269–47283. 2017. View Article : Google Scholar : PubMed/NCBI

42 

El Tayebi HM, Salah W, El Sayed IH, Salam EM, Zekri AR, Zayed N, Salem ES, Esmat G and Abdelaziz AI: Expression of insulin-like growth factor-II, matrix metalloproteinases, and their tissue inhibitors as predictive markers in the peripheral blood of HCC patients. Biomarkers. 16:346–354. 2011. View Article : Google Scholar : PubMed/NCBI

43 

Peters G, Gongoll S, Langner C, Mengel M, Piso P, Klempnauer J, Rüschoff J, Kreipe H and von Wasielewski R: IGF-1R, IGF-1 and IGF-2 expression as potential prognostic and predictive markers in colorectal-cancer. Virchows Arch. 443:139–145. 2003. View Article : Google Scholar : PubMed/NCBI

44 

Van Arsdale AR, Arend RC, Cossio MJ, Erickson BK, Wang Y, Doo DW, Leath CA, Goldberg GL and Huang GS: Insulin-like growth factor 2: A poor prognostic biomarker linked to racial disparity in women with uterine carcinosarcoma. Cancer Med. 7:616–625. 2018. View Article : Google Scholar : PubMed/NCBI

45 

Ewing GP and Goff LW: The insulin-like growth factor signaling pathway as a target for treatment of colorectal carcinoma. Clin Colorectal Cancer. 9:219–223. 2010. View Article : Google Scholar : PubMed/NCBI

46 

Buck E, Gokhale PC, Koujak S, Brown E, Eyzaguirre A, Tao N, Rosenfeld-Franklin M, Lerner L, Chiu MI, Wild R, et al: Compensatory insulin receptor (IR) activation on inhibition of insulin-like growth factor-1 receptor (IGF-1R): Rationale for cotargeting IGF-1R and IR in cancer. Mol Cancer Ther. 9:2652–2664. 2010. View Article : Google Scholar : PubMed/NCBI

47 

Malaguarnera R and Belfiore A: The insulin receptor: A new target for cancer therapy. Front Endocrinol (Lausanne). 2:932011. View Article : Google Scholar : PubMed/NCBI

48 

Mulvihill MJ, Cooke A, Rosenfeld-Franklin M, Buck E, Foreman K, Landfair D, O'Connor M, Pirritt C, Sun Y, Yao Y, et al: Discovery of OSI-906: A selective and orally efficacious dual inhibitor of the IGF-1 receptor and insulin receptor. Future Med Chem. 1:1153–1171. 2009. View Article : Google Scholar : PubMed/NCBI

49 

Puzanov I, Lindsay CR, Goff L, Sosman J, Gilbert J, Berlin J, Poondru S, Simantov R, Gedrich R, Stephens A, et al: A phase I study of continuous oral dosing of OSI-906, a dual inhibitor of insulin-like growth factor-1 and insulin receptors, in patients with advanced solid tumors. Clin Cancer Res. 21:701–711. 2015. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Crezee T, Tesselaar MH, Jaeger M, Rabold K, Corver WE, Morreau H, Grunsven AC, Smit JW, Netea‑Maier RT, Plantinga TS, Plantinga TS, et al: IGF2 is a potential factor in RAI‑refractory differentiated thyroid cancer. Oncol Lett 22: 590, 2021.
APA
Crezee, T., Tesselaar, M.H., Jaeger, M., Rabold, K., Corver, W.E., Morreau, H. ... Plantinga, T.S. (2021). IGF2 is a potential factor in RAI‑refractory differentiated thyroid cancer. Oncology Letters, 22, 590. https://doi.org/10.3892/ol.2021.12851
MLA
Crezee, T., Tesselaar, M. H., Jaeger, M., Rabold, K., Corver, W. E., Morreau, H., Grunsven, A. C., Smit, J. W., Netea‑Maier, R. T., Plantinga, T. S."IGF2 is a potential factor in RAI‑refractory differentiated thyroid cancer". Oncology Letters 22.2 (2021): 590.
Chicago
Crezee, T., Tesselaar, M. H., Jaeger, M., Rabold, K., Corver, W. E., Morreau, H., Grunsven, A. C., Smit, J. W., Netea‑Maier, R. T., Plantinga, T. S."IGF2 is a potential factor in RAI‑refractory differentiated thyroid cancer". Oncology Letters 22, no. 2 (2021): 590. https://doi.org/10.3892/ol.2021.12851
Copy and paste a formatted citation
x
Spandidos Publications style
Crezee T, Tesselaar MH, Jaeger M, Rabold K, Corver WE, Morreau H, Grunsven AC, Smit JW, Netea‑Maier RT, Plantinga TS, Plantinga TS, et al: IGF2 is a potential factor in RAI‑refractory differentiated thyroid cancer. Oncol Lett 22: 590, 2021.
APA
Crezee, T., Tesselaar, M.H., Jaeger, M., Rabold, K., Corver, W.E., Morreau, H. ... Plantinga, T.S. (2021). IGF2 is a potential factor in RAI‑refractory differentiated thyroid cancer. Oncology Letters, 22, 590. https://doi.org/10.3892/ol.2021.12851
MLA
Crezee, T., Tesselaar, M. H., Jaeger, M., Rabold, K., Corver, W. E., Morreau, H., Grunsven, A. C., Smit, J. W., Netea‑Maier, R. T., Plantinga, T. S."IGF2 is a potential factor in RAI‑refractory differentiated thyroid cancer". Oncology Letters 22.2 (2021): 590.
Chicago
Crezee, T., Tesselaar, M. H., Jaeger, M., Rabold, K., Corver, W. E., Morreau, H., Grunsven, A. C., Smit, J. W., Netea‑Maier, R. T., Plantinga, T. S."IGF2 is a potential factor in RAI‑refractory differentiated thyroid cancer". Oncology Letters 22, no. 2 (2021): 590. https://doi.org/10.3892/ol.2021.12851
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