Open Access

MicroRNA‑4491 enhances cell proliferation and inhibits cell apoptosis in non‑small cell lung cancer via targeting TRIM7

  • Authors:
    • Fei Han
    • Gang Chen
    • Yi Guo
    • Bo Li
    • Yanlong Sun
    • Xiangqian Qi
    • Hanji Tian
    • Xinfei Zhao
    • Hongguang Zhang
  • View Affiliations

  • Published online on: June 7, 2021     https://doi.org/10.3892/ol.2021.12852
  • Article Number: 591
  • Copyright: © Han et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

MicroRNAs (miRNAs) are involved in the development of non‑small cell lung cancer (NSCLC). However, the biological roles of several aberrantly expressed miRNAs have not been explored yet. In the present study, miR‑4491 was identified as a novel upregulated miRNA in NSCLC tissues and cell lines. Downregulation of miR‑4491 by a miR‑4491 inhibitor inhibited the proliferation and triggered the apoptosis of NSCLC cells. Tripartite motif containing 7 (TRIM7), a tumor suppressor gene expressed in NSCLC, was demonstrated in the present study to be directly targeted by miR‑4491. This finding was verified by bioinformatics analysis, reverse transcription‑quantitative PCR, western blotting and dual luciferase reporter assays. Furthermore, downregulation of miR‑4491 inactivated nuclear factor‑κB signaling via induction of TRIM7. In addition, TRIM7 silencing attenuated the effect of miR‑4491 inhibitor in NSCLC cells. The decreased TRIM7 level in NSCLC tissues was negatively correlated with miR‑4491 expression in NSCLC tissues. In conclusion, the findings from this study demonstrated that miR‑4491 expression was upregulated in NSCLC tissues and cells and that miR‑4491 may promote NSCLC progression via targeting TRIM7.
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August-2021
Volume 22 Issue 2

Print ISSN: 1792-1074
Online ISSN:1792-1082

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Spandidos Publications style
Han F, Chen G, Guo Y, Li B, Sun Y, Qi X, Tian H, Zhao X and Zhang H: MicroRNA‑4491 enhances cell proliferation and inhibits cell apoptosis in non‑small cell lung cancer via targeting TRIM7. Oncol Lett 22: 591, 2021
APA
Han, F., Chen, G., Guo, Y., Li, B., Sun, Y., Qi, X. ... Zhang, H. (2021). MicroRNA‑4491 enhances cell proliferation and inhibits cell apoptosis in non‑small cell lung cancer via targeting TRIM7. Oncology Letters, 22, 591. https://doi.org/10.3892/ol.2021.12852
MLA
Han, F., Chen, G., Guo, Y., Li, B., Sun, Y., Qi, X., Tian, H., Zhao, X., Zhang, H."MicroRNA‑4491 enhances cell proliferation and inhibits cell apoptosis in non‑small cell lung cancer via targeting TRIM7". Oncology Letters 22.2 (2021): 591.
Chicago
Han, F., Chen, G., Guo, Y., Li, B., Sun, Y., Qi, X., Tian, H., Zhao, X., Zhang, H."MicroRNA‑4491 enhances cell proliferation and inhibits cell apoptosis in non‑small cell lung cancer via targeting TRIM7". Oncology Letters 22, no. 2 (2021): 591. https://doi.org/10.3892/ol.2021.12852