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MicroRNA profiles in five pairs of early gastric cancer tissues and adjacent non‑cancerous tissues

  • Authors:
    • Yuan Liang
    • Yongxun Zhao
    • Longquan Li
    • Hui Wei
    • Taobi Huang
    • Huiyun Zhang
    • Xia Chen
    • Heng Yun
    • Weiming Sun
    • Yuping Wang
  • View Affiliations / Copyright

    Affiliations: The First School of Clinical Medicine, Lanzhou University, Lanzhou, Gansu 730000, P.R. China, Department of Oncology Surgery, The First Hospital of Lanzhou University, Lanzhou, Gansu 730000, P.R. China, Department of General Surgery, Baiyin First People's Hospital, Baiyin, Gansu 730900, P.R. China, Department of Endocrinology, The First Hospital of Lanzhou University, Lanzhou, Gansu 730000, P.R. China, Department of Gastroenterology, The First Hospital of Lanzhou University, Lanzhou, Gansu 730000, P.R. China
    Copyright: © Liang et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 595
    |
    Published online on: June 7, 2021
       https://doi.org/10.3892/ol.2021.12856
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Abstract

Approximately half of the world's gastric cancer cases and deaths occur in China. In addition, the incidence and mortality rates of gastric cancer in Gansu province in China are much higher than the average nationwide levels. The present study investigated microRNA (miRNA/miR) profiles in early gastric cancer (EGC) without specific symptoms. miRNA expression levels in five pairs of EGC tissues and adjacent non‑cancerous mucosa tissues of patients from Gansu province in China were analyzed using a miRNA microarray. A total of 47 differentially expressed miRNAs (DEMs) were identified. Subsequently, mRNA expression profiles of three pairs of cancer tissues and adjacent non‑cancerous tissues from 3 Asian patients with stage I or stage II gastric cancer (stage I/II; American Joint Committee on Cancer classification, Eighth Edition) were obtained from The Cancer Genome Atlas database, and differentially expressed genes (DEGs) were identified. The target genes of DEMs were filtered from the DEGs using the miRDB database and a miRNA‑gene network was constructed. The functions of DEMs were evaluated using the tool for annotations of human miRNAs database, and via Gene Ontology analysis, Kyoto Encyclopedia of Genes and Genomes analysis and Gene Set Enrichment Analysis of the target genes. Finally, survival analyses of DEMs, which were in the miRNA‑gene network, was performed. The results suggested that a number of miRNAs, including hsa‑let‑7a‑5p, hsa‑miR‑27a‑3p, hsa‑miR‑126‑5p and hsa‑miR‑424‑5p, may serve critical roles in EGC. The present study could provide a basis for the identification of EGC screening biomarkers. Furthermore, the present study may provide a basis for the exploration of the cause of the high incidence of gastric cancer in Gansu province from the perspective of miRNAs.
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1 

Bray F, Ferlay J, Soerjomataram I, Siegel RL, Torre LA and Jemal A: Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA Cancer J Clin. 68:394–424. 2018. View Article : Google Scholar : PubMed/NCBI

2 

Liu Y, Zhang X, Chen L, Zhao Q and Xia X: Cancer incidence and mortality in Gansu province, 2012. Chin J Cancer Res. 28:301–310. 2016. View Article : Google Scholar : PubMed/NCBI

3 

Chen W, Zheng R, Zhang S, Zeng H, Zuo T, Jia M, Xia C, Zou X and He J: Report of cancer incidence and mortality in China, 2012. China Cancer. 25:1–8. 2016.

4 

Guo Q, Liu X, Lu L, Yuan H, Wang Y, Chen Z, Ji R and Zhou Y: Comprehensive evaluation of clinical efficacy and safety of celecoxib combined with chemotherapy in management of gastric cancer. Medicine (Baltimore). 96:e88572017. View Article : Google Scholar : PubMed/NCBI

5 

Ji R: Gastric cancer screening and related risk factors analysis in the Wuwei Natrual population cohort. Lanzhou University; 2018

6 

Pasechnikov V, Chukov S, Fedorov E, Kikuste I and Leja M: Gastric cancer: Prevention, screening and early diagnosis. World J Gastroenterol. 20:13842–13862. 2014. View Article : Google Scholar : PubMed/NCBI

7 

Everett SM and Axon AT: Early gastric cancer in Europe. Gut. 41:142–150. 1997. View Article : Google Scholar : PubMed/NCBI

8 

Suzuki H, Oda I, Abe S, Sekiguchi M, Mori G, Nonaka S, Yoshinaga S and Saito Y: High rate of 5-year survival among patients with early gastric cancer undergoing curative endoscopic submucosal dissection. Gastric Cancer. 19:198–205. 2016. View Article : Google Scholar : PubMed/NCBI

9 

Crew KD and Neugut AI: Epidemiology of gastric cancer. World J Gastroenterol. 12:354–362. 2006. View Article : Google Scholar : PubMed/NCBI

10 

Gong W, Luo S, Hu R, Wang H, Pan J, Fei F, Wu H and Yu M: Survival analysis of gastric cancer patients during 2005–2010 in Zhejiang Province, China. Zhonghua Zhong Liu Za Zhi. 36:636–639. 2014.(In Chinese). PubMed/NCBI

11 

Zheng L, Wu C, Xi P, Zhu M, Zhang L, Chen S, Li X, Gu J and Zheng Y: The survival and the long-term trends of patients with gastric cancer in Shanghai, China. BMC Cancer. 14:3002014. View Article : Google Scholar : PubMed/NCBI

12 

Hamashima C, Shabana M, Okada K, Okamoto M and Osaki Y: Mortality reduction from gastric cancer by endoscopic and radiographic screening. Cancer Sci. 106:1744–1749. 2015. View Article : Google Scholar : PubMed/NCBI

13 

So JBY, Kapoor R, Zhu F, Koh C, Zhou L, Zou R, Tang YC, Goo PCK, Rha SY, Chung HC, et al: Development and validation of a serum microRNA biomarker panel for detecting gastric cancer in a high-risk population. Gut. 70:829–837. 2021. View Article : Google Scholar : PubMed/NCBI

14 

Bartel DP: MicroRNAs: Genomics, biogenesis, mechanism, and function. Cell. 116:281–297. 2004. View Article : Google Scholar : PubMed/NCBI

15 

Calin GA, Sevignani C, Dumitru CD, Hyslop T, Noch E, Yendamuri S, Shimizu M, Rattan S, Bullrich F, Negrini M and Croce CM: Human microRNA genes are frequently located at fragile sites and genomic regions involved in cancers. Proc Natl Acad Sci USA. 101:2999–3004. 2004. View Article : Google Scholar : PubMed/NCBI

16 

Han J, Lee Y, Yeom KH, Kim YK, Jin H and Kim VN: The Drosha-DGCR8 complex in primary microRNA processing. Genes Dev. 18:3016–3027. 2004. View Article : Google Scholar : PubMed/NCBI

17 

Zheng GD, Xu ZY, Hu C, Lv H, Xie XH, Huang T, Zhang YQ, Chen GP, Fu YF and Cheng XD: Exosomal miR-590-5p in serum as a biomarker for the diagnosis and prognosis of gastric cancer front. Mol Biosci. 8:6365662021. View Article : Google Scholar : PubMed/NCBI

18 

Shi Y, Wang Z, Zhu X, Chen L, Ma Y, Wang J, Yang X and Liu Z: Exosomal miR-1246 in serum as a potential biomarker for early diagnosis of gastric cancer. Int J Clin Oncol. 25:89–99. 2020. View Article : Google Scholar : PubMed/NCBI

19 

Xia L, Zhang D, Du R, Pan Y, Zhao L, Sun S, Hong L, Liu J and Fan D: miR-15b and miR-16 modulate multidrug resistance by targeting BCL2 in human gastric cancer cells. Int J Cancer. 123:372–379. 2008. View Article : Google Scholar : PubMed/NCBI

20 

Shin VY and Chu KM: MiRNA as potential biomarkers and therapeutic targets for gastric cancer. World J Gastroenterol. 20:10432–10439. 2014. View Article : Google Scholar : PubMed/NCBI

21 

Lu M, Hu C, Wu F, Shu L, Pan Y, Liu X, Liu P, Ma F, Deng C and Huang M: MiR-320a is associated with cisplatin resistance in lung adenocarcinoma and its clinical value in non-small cell lung cancer: A comprehensive analysis based on microarray data. Lung Cancer. 147:193–197. 2020. View Article : Google Scholar : PubMed/NCBI

22 

Amin MB, Edge SB, Greene FI, Byrd DR, Brookland RK, Washington MK, Gershenwald JE, Compton CC, Hess KR, Sullivan DC, et al: AJCC cancer staging manual. Springer-Verlag New York, the United States: 2016

23 

Ritchie ME, Phipson B, Wu D, Hu Y, Law CW, Shi W and Smyth GK: Limma powers differential expression analyses for RNA-sequencing and microarray studies. Nucleic Acids Res. 43:e472015. View Article : Google Scholar : PubMed/NCBI

24 

Barrett T, Wilhite SE, Ledoux P, Evangelista C, Kim IF, Tomashevsky M, Marshall KA, Phillippy KH, Sherman PM, Holko M, et al: NCBI GEO: Archive for functional genomics data sets-update. Nucleic Acids Res. 41:D991–D995. 2013. View Article : Google Scholar : PubMed/NCBI

25 

Li J, Han X, Wan Y, Zhang S, Zhao Y, Fan R, Cui Q and Zhou Y: TAM 2.0: Tool for MicroRNA set analysis. Nucleic Acids Res. 46:W180–W185. 2018. View Article : Google Scholar : PubMed/NCBI

26 

Love MI, Huber W and Anders S: Moderated estimation of fold change and dispersion for RNA-seq data with DESeq2. Genome Biol. 15:5502014. View Article : Google Scholar : PubMed/NCBI

27 

Gaudet P and Dessimoz C: Gene ontology: Pitfalls, biases, and remedies. Methods Mol Biol. 1446:189–205. 2017. View Article : Google Scholar : PubMed/NCBI

28 

Kanehisa M, Furumichi M, Tanabe M, Sato Y and Morishima K: KEGG: New perspectives on genomes, pathways, diseases and drugs. Nucleic Acids Res. 45:D353–D361. 2017. View Article : Google Scholar : PubMed/NCBI

29 

Subramanian A, Tamayo P, Mootha VK, Mukherjee S, Ebert BL, Gillette MA, Paulovich A, Pomeroy SL, Golub TR, Lander ES and Mesirov JP: Gene set enrichment analysis: A knowledge-based approach for interpreting genome-wide expression profiles. Proc Natl Acad Sci USA. 102:15545–15550. 2005. View Article : Google Scholar : PubMed/NCBI

30 

Yu G, Wang LG, Han Y and He QY: clusterProfiler: An R package for comparing biological themes among gene clusters. OMICS. 16:284–287. 2012. View Article : Google Scholar : PubMed/NCBI

31 

Wickham H: ggplot2: Elegant Graphics for Data Analysis. Springer-Verlag; New York, NY: 2016

32 

Chen Y and Wang X: miRDB: An online database for prediction of functional microRNA targets. Nucleic Acids Res. 48:D127–D131. 2020. View Article : Google Scholar : PubMed/NCBI

33 

Shannon P, Markiel A, Ozier O, Baliga NS, Wang JT, Ramage D, Amin N, Schwikowski B and Ideker T: Cytoscape: A software environment for integrated models of biomolecular interaction networks. Genome Res. 13:2498–2504. 2003. View Article : Google Scholar : PubMed/NCBI

34 

Szklarczyk D, Gable AL, Lyon D, Junge A, Wyder S, Huerta-Cepas J, Simonovic M, Doncheva NT, Morris JH, Bork P, et al: STRING v11: Protein-protein association networks with increased coverage, supporting functional discovery in genome-wide experimental datasets. Nucleic Acids Res. 47:D607–D613. 2019. View Article : Google Scholar : PubMed/NCBI

35 

Bader GD and Hogue CW: An automated method for finding molecular complexes in large protein interaction networks. BMC Bioinformatics. 4:22003. View Article : Google Scholar : PubMed/NCBI

36 

Therneau TM and Grambsch PM: Modeling Survival Data: Extending the Cox Model. Springer-Verlag; New York, NY: 2000, View Article : Google Scholar

37 

Brusselaers N, Maret-Ouda J, Konings P, El-Serag HB and Lagergren J: Menopausal hormone therapy and the risk of esophageal and gastric cancer. Int J Cancer. 140:1693–1699. 2017. View Article : Google Scholar : PubMed/NCBI

38 

Lu M, Zhu J, Ling Y, Shi W, Zhang C and Wu H: The lower expression of gonadotropin-releasing hormone receptor associated with poor prognosis in gastric cancer. Int J Clin Exp Med. 8:13365–13370. 2015.PubMed/NCBI

39 

Yang S, Liu W, Wen J, Zhu M and Xu S: Corticotropin releasing hormone is correlated with tumorigenesis of gastric cancer. Cancer Invest. 31:167–171. 2013. View Article : Google Scholar : PubMed/NCBI

40 

Frycz BA, Murawa D, Borejsza-Wysocki M, Wichtowski M, Spychała A, Marciniak R, Murawa P, Drews M and Jagodziński PP: mRNA expression of steroidogenic enzymes, steroid hormone receptors and their coregulators in gastric cancer. Oncol Lett. 13:3369–3378. 2017. View Article : Google Scholar : PubMed/NCBI

41 

Gan J, Ke X, Jiang J, Dong H, Yao Z, Lin Y, Lin W, Wu X, Yan S, Zhuang Y, et al: Growth hormone-releasing hormone receptor antagonists inhibit human gastric cancer through downregulation of PAK1-STAT3/NF-κB signaling. Proc Natl Acad Sci USA. 113:14745–14750. 2016. View Article : Google Scholar : PubMed/NCBI

42 

Yamada T, Yoshikawa T, Taguri M, Hayashi T, Aoyama T, Sue-Ling HM, Bonam K, Hayden JD and Grabsch HI: The survival difference between gastric cancer patients from the UK and Japan remains after weighted propensity score analysis considering all background factors. Gastric Cancer. 19:479–489. 2016. View Article : Google Scholar : PubMed/NCBI

43 

Kerckhoffs KGP, Liu DHW, Saragoni L, van der Post RS, Langer R, Bencivenga M, Iglesias M, Gallo G, Hewitt LC, Fazzi GE, et al: Mucin expression in gastric- and gastro-oesophageal signet-ring cell cancer: Results from a comprehensive literature review and a large cohort study of Caucasian and Asian gastric cancer. Gastric Cancer. 23:765–779. 2020. View Article : Google Scholar : PubMed/NCBI

44 

Zhang ZL, Li ZR, Li JS and Wang SR: Calcium-sensing receptor antagonist NPS-2143 suppresses proliferation and invasion of gastric cancer cells. Cancer Gene Ther. 27:548–557. 2020. View Article : Google Scholar : PubMed/NCBI

45 

Tang B, Wu J, Zhu MX, Sun X, Liu J, Xie R, Dong TX, Xiao Y, Carethers JM, Yang S and Dong H: VPAC1 couples with TRPV4 channel to promote calcium-dependent gastric cancer progression via a novel autocrine mechanism. Oncogene. 38:3946–3961. 2019. View Article : Google Scholar : PubMed/NCBI

46 

Ge C, Li Q, Wang L and Xu X: The role of axon guidance factor semaphorin 6B in the invasion and metastasis of gastric cancer. J Int Med Res. 41:284–292. 2013. View Article : Google Scholar : PubMed/NCBI

47 

Pan G, Zhang X, Ren J, Lu J, Li W, Fu H, Zhang S and Li J: Semaphorin 5A, an axon guidance molecule, enhances the invasion and metastasis of human gastric cancer through activation of MMP9. Pathol Oncol Res. 19:11–18. 2013. View Article : Google Scholar : PubMed/NCBI

48 

Park T, Lee YJ, Jeong SH, Choi SK, Jung EJ, Ju YT, Jeong CY, Park M, Hah YS, Yoo J, et al: Overexpression of neuron-specific enolase as a prognostic factor in patients with gastric cancer. J Gastric Cancer. 17:228–236. 2017. View Article : Google Scholar : PubMed/NCBI

49 

Eke I and Cordes N: Focal adhesion signaling and therapy resistance in cancer. Semin Cancer Biol. 31:65–75. 2015. View Article : Google Scholar : PubMed/NCBI

50 

Du M, Zheng R, Ma G, Chu H, Lu J, Li S, Xin J, Tong N, Zhang G, Wang W, et al: Remote modulation of lncRNA GCLET by risk variant at 16p13 underlying genetic susceptibility to gastric cancer. Sci Adv. 6:eaay55252020. View Article : Google Scholar : PubMed/NCBI

51 

Yang F, Chen X, Li X, Chen J, Tang Y, Cai Y, Wang Y, Chen Z, Li L, Li R and Deng Z: Long intergenic non-protein coding RNA 1089 suppresses cell proliferation and metastasis in gastric cancer by regulating miRNA-27a-3p/epithelial-mesenchymal transition (EMT) axis. Cancer Manag Res. 12:5587–5596. 2020. View Article : Google Scholar : PubMed/NCBI

52 

Geng G, Liu X, Xu A, Lu Z, Chen K, He J, Qi D and Yuan X: Low abundance of TFPI-2 by both promoter methylation and miR-27a-3p regulation is linked with poor clinical outcome in gastric cancer. J Gene Med. 22:e31662020. View Article : Google Scholar : PubMed/NCBI

53 

Zhou L, Liang X, Zhang L, Yang L, Nagao N, Wu H, Liu C, Lin S, Cai G and Liu J: MiR-27a-3p functions as an oncogene in gastric cancer by targeting BTG2. Oncotarget. 7:51943–51954. 2016. View Article : Google Scholar : PubMed/NCBI

54 

Zhang J, Liu H, Hou L, Wang G, Zhang R, Huang Y, Chen X and Zhu J: Circular RNA_LARP4 inhibits cell proliferation and invasion of gastric cancer by sponging miR-424-5p and regulating LATS1 expression. Mol Cancer. 16:1512017. View Article : Google Scholar : PubMed/NCBI

55 

Wei S, Li Q, Li Z, Wang L, Zhang L and Xu Z: Correction: miR-424-5p promotes proliferation of gastric cancer by targeting Smad3 through TGF-β signaling pathway. Oncotarget. 8:340182017. View Article : Google Scholar : PubMed/NCBI

56 

Wei S, Li Q, Li Z, Wang L, Zhang L and Xu Z: miR-424-5p promotes proliferation of gastric cancer by targeting Smad3 through TGF-β signaling pathway. Oncotarget. 7:75185–75196. 2016. View Article : Google Scholar : PubMed/NCBI

57 

Liang S, He L, Zhao X, Miao Y, Gu Y, Guo C, Xue Z, Dou W, Hu F, Wu K, et al: MicroRNA let-7f inhibits tumor invasion and metastasis by targeting MYH9 in human gastric cancer. PLoS One. 6:e184092011. View Article : Google Scholar : PubMed/NCBI

58 

Song C, Chen H, Wang T, Zhang W, Ru G and Lang J: Expression profile analysis of microRNAs in prostate cancer by next-generation sequencing. Prostate. 75:500–516. 2015. View Article : Google Scholar : PubMed/NCBI

59 

Queiroz AL, Zhang B, Comstock DE, Hao Y, Eriksson M, Hydbring P, Vakifahmetoglu-Norberg H and Norberg E: miR-126-5p targets Malate Dehydrogenase 1 in non-small cell lung carcinomas. Biochem Biophys Res Commun. 499:314–320. 2018. View Article : Google Scholar : PubMed/NCBI

60 

Wang C, Zhou B, Liu M, Liu Y and Gao R: miR-126-5p restoration promotes cell apoptosis in cervical cancer by targeting Bcl2l2. Oncol Res. 25:463–470. 2017. View Article : Google Scholar : PubMed/NCBI

61 

Mi Y, Zhang D, Jiang W, Weng J, Zhou C, Huang K, Tang H, Yu Y, Liu X, Cui W, et al: miR-181a-5p promotes the progression of gastric cancer via RASSF6-mediated MAPK signalling activation. Cancer Lett. 389:11–22. 2017. View Article : Google Scholar : PubMed/NCBI

62 

Liu Z, Sun F, Hong Y, Liu Y, Fen M, Yin K, Ge X, Wang F, Chen X and Guan W: MEG2 is regulated by miR-181a-5p and functions as a tumour suppressor gene to suppress the proliferation and migration of gastric cancer cells. Mol Cancer. 16:1332017. View Article : Google Scholar : PubMed/NCBI

63 

Cui HW, Han WY, Hou LN, Yang L, Li X and Su XL: miR-1915-3p inhibits Bcl-2 expression in the development of gastric cancer. Biosci Rep. 39:BSR201823212019. View Article : Google Scholar : PubMed/NCBI

64 

Jin ML, Kim YW, Jin HL, Kang H, Lee EK, Stallcup MR and Jeong KW: Aberrant expression of SETD1A promotes survival and migration of estrogen receptor α-positive breast cancer cells. Int J Cancer. 143:2871–2883. 2018. View Article : Google Scholar : PubMed/NCBI

65 

Xu K, Liang X, Cui D, Wu Y, Shi W and Liu J: miR-1915 inhibits Bcl-2 to modulate multidrug resistance by increasing drug-sensitivity in human colorectal carcinoma cells. Mol Carcinog. 52:70–78. 2013. View Article : Google Scholar : PubMed/NCBI

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Liang Y, Zhao Y, Li L, Wei H, Huang T, Zhang H, Chen X, Yun H, Sun W, Wang Y, Wang Y, et al: MicroRNA profiles in five pairs of early gastric cancer tissues and adjacent non‑cancerous tissues. Oncol Lett 22: 595, 2021.
APA
Liang, Y., Zhao, Y., Li, L., Wei, H., Huang, T., Zhang, H. ... Wang, Y. (2021). MicroRNA profiles in five pairs of early gastric cancer tissues and adjacent non‑cancerous tissues. Oncology Letters, 22, 595. https://doi.org/10.3892/ol.2021.12856
MLA
Liang, Y., Zhao, Y., Li, L., Wei, H., Huang, T., Zhang, H., Chen, X., Yun, H., Sun, W., Wang, Y."MicroRNA profiles in five pairs of early gastric cancer tissues and adjacent non‑cancerous tissues". Oncology Letters 22.2 (2021): 595.
Chicago
Liang, Y., Zhao, Y., Li, L., Wei, H., Huang, T., Zhang, H., Chen, X., Yun, H., Sun, W., Wang, Y."MicroRNA profiles in five pairs of early gastric cancer tissues and adjacent non‑cancerous tissues". Oncology Letters 22, no. 2 (2021): 595. https://doi.org/10.3892/ol.2021.12856
Copy and paste a formatted citation
x
Spandidos Publications style
Liang Y, Zhao Y, Li L, Wei H, Huang T, Zhang H, Chen X, Yun H, Sun W, Wang Y, Wang Y, et al: MicroRNA profiles in five pairs of early gastric cancer tissues and adjacent non‑cancerous tissues. Oncol Lett 22: 595, 2021.
APA
Liang, Y., Zhao, Y., Li, L., Wei, H., Huang, T., Zhang, H. ... Wang, Y. (2021). MicroRNA profiles in five pairs of early gastric cancer tissues and adjacent non‑cancerous tissues. Oncology Letters, 22, 595. https://doi.org/10.3892/ol.2021.12856
MLA
Liang, Y., Zhao, Y., Li, L., Wei, H., Huang, T., Zhang, H., Chen, X., Yun, H., Sun, W., Wang, Y."MicroRNA profiles in five pairs of early gastric cancer tissues and adjacent non‑cancerous tissues". Oncology Letters 22.2 (2021): 595.
Chicago
Liang, Y., Zhao, Y., Li, L., Wei, H., Huang, T., Zhang, H., Chen, X., Yun, H., Sun, W., Wang, Y."MicroRNA profiles in five pairs of early gastric cancer tissues and adjacent non‑cancerous tissues". Oncology Letters 22, no. 2 (2021): 595. https://doi.org/10.3892/ol.2021.12856
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