Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Oncology Letters
      • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Biomedical Reports
      • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • Information for Authors
    • Information for Reviewers
    • Information for Librarians
    • Information for Advertisers
    • Conferences
  • Language Editing
Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • For Authors
    • For Reviewers
    • For Librarians
    • For Advertisers
    • Conferences
  • Language Editing
Login Register Submit
  • This site uses cookies
  • You can change your cookie settings at any time by following the instructions in our Cookie Policy. To find out more, you may read our Privacy Policy.

    I agree
Search articles by DOI, keyword, author or affiliation
Search
Advanced Search
presentation
Oncology Letters
Join Editorial Board Propose a Special Issue
Print ISSN: 1792-1074 Online ISSN: 1792-1082
Journal Cover
August-2021 Volume 22 Issue 2

Full Size Image

Sign up for eToc alerts
Recommend to Library

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
August-2021 Volume 22 Issue 2

Full Size Image

Sign up for eToc alerts
Recommend to Library

  • Article
  • Citations
    • Cite This Article
    • Download Citation
    • Create Citation Alert
    • Remove Citation Alert
    • Cited By
  • Similar Articles
    • Related Articles (in Spandidos Publications)
    • Similar Articles (Google Scholar)
    • Similar Articles (PubMed)
  • Download PDF
  • Download XML
  • View XML

  • Supplementary Files
    • Supplementary_Data.pdf
Article Open Access

Diagnostic potential of extracellular vesicle‑associated microRNA‑10b and tumor markers for lung adenocarcinoma

  • Authors:
    • Guangda Yuan
    • Hongya Xie
    • Tengteng Wei
    • Donglin Zhu
    • Chuanyu Zhang
    • Yong Yang
  • View Affiliations / Copyright

    Affiliations: Department of Thoracic Surgery, The Affiliated Suzhou Hospital of Nanjing Medical University, Suzhou, Jiangsu 215000, P.R. China
    Copyright: © Yuan et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 614
    |
    Published online on: June 23, 2021
       https://doi.org/10.3892/ol.2021.12875
  • Expand metrics +
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
Cited By (CrossRef): 0 citations Loading Articles...

This article is mentioned in:



Abstract

MicroRNAs (miRNAs/miRs) in extracellular vesicles (EVs) are potential diagnostic markers. The purpose of the present study was to investigate potential EV miRNA biomarkers for lung adenocarcinoma (LUAD). Potential miRNAs were identified by searching public databases and verified by examining clinical samples. The diagnostic value of EV‑associated miR‑10b, plasma miR‑10b and tumor markers (TMs), including α‑fetoprotein (AFP), neuron‑specific enolase, carcinoembryonic antigen (CEA), cytokeratin 19 fragment 21‑1 (CYFRA211), pro‑gastrin‑releasing‑peptide, carbohydrate antigen (CA)125, CA153, CA199 and CA724, was evaluated via receiver operating characteristic curve analysis. By searching the Gene Expression Omnibus and The Cancer Genome Atlas databases, miR‑10b was identified as a potential biomarker. The analysis of clinical samples suggested that EV‑associated miR‑10b from plasma was significantly differentially expressed between LUAD and control samples. EV‑associated miR‑10b could function as a diagnostic marker for LUAD, with an AUC of 0.998, which was higher than the AUCs for TMs such as AFP, CEA, CYFRA211, CA125, CA153, CA199, CA724, pro‑gastrin‑releasing‑peptide and neuron‑specific enolase. In conclusion, EV‑associated miR‑10b may be a potential diagnostic biomarker for LUAD that is superior to plasma miR‑10b and TMs.
View Figures

Figure 1

Figure 2

Figure 3

Figure 4

Figure 5

Figure 6

View References

1 

Siegel R, Ward E, Brawley O and Jemal A: Cancer statistics, 2011: The impact of eliminating socioeconomic and racial disparities on premature cancer deaths. CA Cancer J Clin. 61:212–236. 2011. View Article : Google Scholar : PubMed/NCBI

2 

Yan Y, Chen Y, Jia H, Liu J, Ding Y, Wang H, Hu Y, Ma J, Zhang X and Li S: Patterns of Life Lost to Cancers with High Risk of Death in China. Int J Environ Res Public Health. 16:2175–2193. 2019. View Article : Google Scholar : PubMed/NCBI

3 

Zheng RS, Sun KX, Zhang SW, Zeng HM, Zou XN, Chen R, Gu XY, Wei WW and He J: Report of cancer epidemiology in China, 2015. Zhonghua Zhong Liu Za Zhi. 41:19–28. 2019.(In Chinese). PubMed/NCBI

4 

Zhang H, Guo L and Chen J: Rationale for Lung Adenocarcinoma Prevention and Drug Development Based on Molecular Biology During Carcinogenesis. OncoTargets Ther. 13:3085–3091. 2020. View Article : Google Scholar : PubMed/NCBI

5 

Zhang X, Wu L, Xu Y, Zhang B, Wu X, Wang Y and Pang Z: Trends in the incidence rate of lung cancer by histological type and gender in Sichuan, China, 1995–2015: A single-center retrospective study. Thorac Cancer. 9:532–541. 2018. View Article : Google Scholar : PubMed/NCBI

6 

Dama E, Melocchi V, Mazzarelli F, Colangelo T, Cuttano R, Di Candia L, Ferretti GM, Taurchini M, Graziano P and Bianchi F: Non-Coding RNAs as Prognostic Biomarkers: A miRNA Signature Specific for Aggressive Early-Stage Lung Adenocarcinomas. Noncoding RNA. 6:482020.PubMed/NCBI

7 

Yang W, Qian F, Teng J, Wang H, Manegold C, Pilz LR, Voigt W, Zhang Y, Ye J, Chen Q, et al Written on behalf of the AME Thoracic Surgery Collaborative Group, : Community-based lung cancer screening with low-dose CT in China: Results of the baseline screening. Lung Cancer. 117:20–26. 2018. View Article : Google Scholar : PubMed/NCBI

8 

Liang F, Wu C, Gu H, Zhu M, Xuan Z, Jiang Y, Chen H, Fu C and Zheng Y: Lung cancer incidence in female rises significantly in urban sprawl of Shanghai after introduction of LDCT screening. Lung Cancer. 132:114–118. 2019. View Article : Google Scholar : PubMed/NCBI

9 

He D, Yu H and Chen Y: Equity in the distribution of CT and MRI in China: A panel analysis. Int J Equity Health. 12:39–53. 2013. View Article : Google Scholar : PubMed/NCBI

10 

Siravegna G, Mussolin B, Venesio T, Marsoni S, Seoane J, Dive C, Papadopoulos N, Kopetz S, Corcoran RB, Siu LL, et al: How liquid biopsies can change clinical practice in oncology. Ann Oncol. 30:1580–1590. 2019. View Article : Google Scholar : PubMed/NCBI

11 

Sell S: Cancer markers of the 1990s. Comparison of the new generation of markers defined by monoclonal antibodies and oncogene probes to prototypic markers. Clin Lab Med. 10:1–37. 1990. View Article : Google Scholar : PubMed/NCBI

12 

He Y, Lu H and Zhang L: Serum AFP levels in patients suffering from 47 different types of cancers and noncancer diseases. Prog Mol Biol Transl Sci. 162:199–212. 2019. View Article : Google Scholar : PubMed/NCBI

13 

Beauchemin N and Arabzadeh A: Carcinoembryonic antigen-related cell adhesion molecules (CEACAMs) in cancer progression and metastasis. Cancer Metastasis Rev. 32:643–671. 2013. View Article : Google Scholar : PubMed/NCBI

14 

Grunnet M and Sorensen JB: Carcinoembryonic antigen (CEA) as tumor marker in lung cancer. Lung Cancer. 76:138–143. 2012. View Article : Google Scholar : PubMed/NCBI

15 

Lei L, Chen Q, Wang Z, Han N, Chen B, Qin J and Lu HY: Usefulness of carcinoembryonic antigen in the diagnosis of small cell lung cancer combined with adenocarcinoma. Adv Clin Exp Med. 26:1091–1094. 2017. View Article : Google Scholar : PubMed/NCBI

16 

Nakamura H and Nishimura T: History, molecular features, and clinical importance of conventional serum biomarkers in lung cancer. Surg Today. 47:1037–1059. 2017. View Article : Google Scholar : PubMed/NCBI

17 

Li X, Xu Y and Zhang L: Serum CA153 as biomarker for cancer and noncancer diseases. Prog Mol Biol Transl Sci. 162:265–276. 2019. View Article : Google Scholar : PubMed/NCBI

18 

Buccheri G and Ferrigno D: Lung tumor markers of cytokeratin origin: An overview. Lung Cancer. 34 (Suppl 2):S65–S69. 2001. View Article : Google Scholar : PubMed/NCBI

19 

Uenishi T, Kubo S, Hirohashi K, Tanaka H, Shuto T, Yamamoto T and Nishiguchi S: Cytokeratin-19 fragments in serum (CYFRA 21-1) as a marker in primary liver cancer. Br J Cancer. 88:1894–1899. 2003. View Article : Google Scholar : PubMed/NCBI

20 

Narita T, Funahashi H, Imai T, Takagi H and Kannagi R: Cytosol and serum concentration of cytokeratin subunit-19 fragment (cyfra-21-1) in breast-cancer. Oncol Rep. 1:747–750. 1994.PubMed/NCBI

21 

Kammer MN, Kussrow AK, Webster RL, Chen H, Hoeksema M, Christenson R, Massion PP and Bornhop DJ: Compensated Interferometry Measures of CYFRA 21-1 Improve Diagnosis of Lung Cancer. ACS Comb Sci. 21:465–472. 2019. View Article : Google Scholar : PubMed/NCBI

22 

Yang G, Xiao Z, Tang C, Deng Y, Huang H and He Z: Recent advances in biosensor for detection of lung cancer biomarkers. Biosens Bioelectron. 141:1114162019. View Article : Google Scholar : PubMed/NCBI

23 

Gu Y, Liu S, Zhang X, Chen G, Liang H, Yu M, Liao Z, Zhou Y, Zhang CY, Wang T, et al: Oncogenic miR-19a and miR-19b co-regulate tumor suppressor MTUS1 to promote cell proliferation and migration in lung cancer. Protein Cell. 8:455–466. 2017. View Article : Google Scholar : PubMed/NCBI

24 

Yuan L, Bing Z, Yan P, Li R, Wang C, Sun X, Yang J, Shi X, Zhang Y and Yang K: Integrative data mining and meta-analysis to investigate the prognostic role of microRNA-200 family in various human malignant neoplasms: A consideration on heterogeneity. Gene. 716:144025. 2019. View Article : Google Scholar : PubMed/NCBI

25 

Dai B, Kong D-L, Tian J, Liu T-W, Zhou H and Wang ZF: microRNA-1205 promotes cell growth by targeting APC2 in lung adenocarcinoma. Eur Rev Med Pharmacol Sci. 23:1125–1133. 2019.PubMed/NCBI

26 

Wang SS, Fang YY, Huang JC, Liang YY, Guo YN, Pan LJ and Chen G: Clinical value of microRNA-198-5p downregulation in lung adenocarcinoma and its potential pathways. Oncol Lett. 18:2939–2954. 2019.PubMed/NCBI

27 

Sheu-Gruttadauria J, Pawlica P, Klum SM, Wang S, Yario TA, Schirle Oakdale NT, Steitz JA and MacRae IJ: Structural Basis for Target-Directed MicroRNA Degradation. Mol Cell. 75:1243–1255.e7. 2019. View Article : Google Scholar : PubMed/NCBI

28 

Barile L and Vassalli G: Exosomes: Therapy delivery tools and biomarkers of diseases. Pharmacol Ther. 174:63–78. 2017. View Article : Google Scholar : PubMed/NCBI

29 

Kowal EJK, Ter-Ovanesyan D, Regev A and Church GM: Extracellular Vesicle Isolation and Analysis by Western Blotting. Methods Mol Biol. 1660:143–152. 2017. View Article : Google Scholar : PubMed/NCBI

30 

Shan B, Ai Z, Zeng S, Song Y, Song J, Zeng Q, Liao Z, Wang T, Huang C and Su D: Gut microbiome-derived lactate promotes to anxiety-like behaviors through GPR81 receptor-mediated lipid metabolism pathway. Psychoneuroendocrinology. 117:1046992020. View Article : Google Scholar : PubMed/NCBI

31 

Su D, Liao Z, Feng B, Wang T, Shan B, Zeng Q, Song J and Song Y: Pulsatilla chinensis saponins cause liver injury through interfering ceramide/sphingomyelin balance that promotes lipid metabolism dysregulation and apoptosis. Phytomedicine. 76:1532652020. View Article : Google Scholar : PubMed/NCBI

32 

Livak KJ and Schmittgen TD: Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)). Methods. 25:402–408. 2001. View Article : Google Scholar : PubMed/NCBI

33 

Nagy Á, Lánczky A, Menyhárt O and Győrffy B: Validation of miRNA prognostic power in hepatocellular carcinoma using expression data of independent datasets. Sci Rep. 8:9227–9235. 2018. View Article : Google Scholar : PubMed/NCBI

34 

Nigita G, Distefano R, Veneziano D, Romano G, Rahman M, Wang K, Pass H, Croce CM, Acunzo M and Nana-Sinkam P: Tissue and exosomal miRNA editing in Non-Small Cell Lung Cancer. Sci Rep. 8:10222–10229. 2018. View Article : Google Scholar : PubMed/NCBI

35 

Karagkouni D, Paraskevopoulou MD, Chatzopoulos S, Vlachos IS, Tastsoglou S, Kanellos I, Papadimitriou D, Kavakiotis I, Maniou S, Skoufos G, et al: DIANA-TarBase v8: A decade-long collection of experimentally supported miRNA-gene interactions. Nucleic Acids Res. 46D:D239–D245. 2018. View Article : Google Scholar : PubMed/NCBI

36 

Agarwal V, Bell GW, Nam JW and Bartel DP: Predicting effective microRNA target sites in mammalian mRNAs. eLife. 4:e05005–e05042. 2015. View Article : Google Scholar : PubMed/NCBI

37 

Paraskevopoulou MD, Georgakilas G, Kostoulas N, Vlachos IS, Vergoulis T, Reczko M, Filippidis C, Dalamagas T and Hatzigeorgiou AG: DIANA-microT web server v5.0: Service integration into miRNA functional analysis workflows. Nucleic Acids Res. 41W:W169–W173. 2013. View Article : Google Scholar : PubMed/NCBI

38 

Chandrashekar DS, Bashel B, Balasubramanya SAH, Creighton CJ, Ponce-Rodriguez I, Chakravarthi BVSK and Varambally S: UALCAN: A Portal for Facilitating Tumor Subgroup Gene Expression and Survival Analyses. Neoplasia. 19:649–658. 2017. View Article : Google Scholar : PubMed/NCBI

39 

Warde-Farley D, Donaldson SL, Comes O, Zuberi K, Badrawi R, Chao P, Franz M, Grouios C, Kazi F, Lopes CT, et al: The GeneMANIA prediction server: Biological network integration for gene prioritization and predicting gene function. Nucleic Acids Res. 38 (Suppl 2):W214–W220. 2010. View Article : Google Scholar : PubMed/NCBI

40 

Hong QY, Wu GM, Qian GS, Hu CP, Zhou JY, Chen LA, Li WM, Li SY, Wang K, Wang Q, et al Lung Cancer Group of Chinese Thoracic Society; Chinese Alliance Against Lung Cancer, : Prevention and management of lung cancer in China. Cancer. 121 (Suppl 17):3080–3088. 2015. View Article : Google Scholar : PubMed/NCBI

41 

Jiang ZF, Wang M and Xu JL: Thymidine kinase 1 combined with CEA, CYFRA21-1 and NSE improved its diagnostic value for lung cancer. Life Sci. 194:1–6. 2018. View Article : Google Scholar : PubMed/NCBI

42 

Isgrò MA, Bottoni P and Scatena R: Neuron-Specific Enolase as a Biomarker: Biochemical and Clinical Aspects. Adv Exp Med Biol. 867:125–143. 2015. View Article : Google Scholar

43 

Papagiannakopoulos T, Bauer MR, Davidson SM, Heimann M, Subbaraj L, Bhutkar A, Bartlebaugh J, Vander Heiden MG and Jacks T: Circadian Rhythm Disruption Promotes Lung Tumorigenesis. Cell Metab. 24:324–331. 2016. View Article : Google Scholar : PubMed/NCBI

44 

Schier AC and Taatjes DJ: Structure and mechanism of the RNA polymerase II transcription machinery. Genes Dev. 34:465–488. 2020. View Article : Google Scholar : PubMed/NCBI

45 

Huang J, Sun C, Wang S, He Q and Li D: MicroRNA miR-10b inhibition reduces cell proliferation and promotes apoptosis in non-small cell lung cancer (NSCLC) cells. Mol Biosyst. 11:2051–2059. 2015. View Article : Google Scholar : PubMed/NCBI

Related Articles

  • Abstract
  • View
  • Download
  • Twitter
Copy and paste a formatted citation
Spandidos Publications style
Yuan G, Xie H, Wei T, Zhu D, Zhang C and Yang Y: Diagnostic potential of extracellular vesicle‑associated microRNA‑10b and tumor markers for lung adenocarcinoma. Oncol Lett 22: 614, 2021.
APA
Yuan, G., Xie, H., Wei, T., Zhu, D., Zhang, C., & Yang, Y. (2021). Diagnostic potential of extracellular vesicle‑associated microRNA‑10b and tumor markers for lung adenocarcinoma. Oncology Letters, 22, 614. https://doi.org/10.3892/ol.2021.12875
MLA
Yuan, G., Xie, H., Wei, T., Zhu, D., Zhang, C., Yang, Y."Diagnostic potential of extracellular vesicle‑associated microRNA‑10b and tumor markers for lung adenocarcinoma". Oncology Letters 22.2 (2021): 614.
Chicago
Yuan, G., Xie, H., Wei, T., Zhu, D., Zhang, C., Yang, Y."Diagnostic potential of extracellular vesicle‑associated microRNA‑10b and tumor markers for lung adenocarcinoma". Oncology Letters 22, no. 2 (2021): 614. https://doi.org/10.3892/ol.2021.12875
Copy and paste a formatted citation
x
Spandidos Publications style
Yuan G, Xie H, Wei T, Zhu D, Zhang C and Yang Y: Diagnostic potential of extracellular vesicle‑associated microRNA‑10b and tumor markers for lung adenocarcinoma. Oncol Lett 22: 614, 2021.
APA
Yuan, G., Xie, H., Wei, T., Zhu, D., Zhang, C., & Yang, Y. (2021). Diagnostic potential of extracellular vesicle‑associated microRNA‑10b and tumor markers for lung adenocarcinoma. Oncology Letters, 22, 614. https://doi.org/10.3892/ol.2021.12875
MLA
Yuan, G., Xie, H., Wei, T., Zhu, D., Zhang, C., Yang, Y."Diagnostic potential of extracellular vesicle‑associated microRNA‑10b and tumor markers for lung adenocarcinoma". Oncology Letters 22.2 (2021): 614.
Chicago
Yuan, G., Xie, H., Wei, T., Zhu, D., Zhang, C., Yang, Y."Diagnostic potential of extracellular vesicle‑associated microRNA‑10b and tumor markers for lung adenocarcinoma". Oncology Letters 22, no. 2 (2021): 614. https://doi.org/10.3892/ol.2021.12875
Follow us
  • Twitter
  • LinkedIn
  • Facebook
About
  • Spandidos Publications
  • Careers
  • Cookie Policy
  • Privacy Policy
How can we help?
  • Help
  • Live Chat
  • Contact
  • Email to our Support Team