Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Oncology Letters
      • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Biomedical Reports
      • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • Information for Authors
    • Information for Reviewers
    • Information for Librarians
    • Information for Advertisers
    • Conferences
  • Language Editing
Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • For Authors
    • For Reviewers
    • For Librarians
    • For Advertisers
    • Conferences
  • Language Editing
Login Register Submit
  • This site uses cookies
  • You can change your cookie settings at any time by following the instructions in our Cookie Policy. To find out more, you may read our Privacy Policy.

    I agree
Search articles by DOI, keyword, author or affiliation
Search
Advanced Search
presentation
Oncology Letters
Join Editorial Board Propose a Special Issue
Print ISSN: 1792-1074 Online ISSN: 1792-1082
Journal Cover
August-2021 Volume 22 Issue 2

Full Size Image

Sign up for eToc alerts
Recommend to Library

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
August-2021 Volume 22 Issue 2

Full Size Image

Sign up for eToc alerts
Recommend to Library

  • Article
  • Citations
    • Cite This Article
    • Download Citation
    • Create Citation Alert
    • Remove Citation Alert
    • Cited By
  • Similar Articles
    • Related Articles (in Spandidos Publications)
    • Similar Articles (Google Scholar)
    • Similar Articles (PubMed)
  • Download PDF
  • Download XML
  • View XML
Article Open Access

Dose distribution effects of spot‑scanning proton beam therapy equipped with a multi‑leaf collimator for pediatric brain tumors

  • Authors:
    • Nobuyoshi Fukumitsu
    • Tomohiro Yamashita
    • Masayuki Mima
    • Yusuke Demizu
    • Takeshi Suzuki
    • Toshinori Soejima
  • View Affiliations / Copyright

    Affiliations: Department of Radiation Oncology, Kobe Proton Center, Kobe, Hyōgo 650‑0047, Japan, Division of Medical Physics, Kobe Proton Center, Kobe, Hyōgo 650‑0047, Japan, Department of Anesthesiology, Kobe Proton Center, Kobe, Hyōgo 650‑0047, Japan
    Copyright: © Fukumitsu et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 635
    |
    Published online on: July 1, 2021
       https://doi.org/10.3892/ol.2021.12896
  • Expand metrics +
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
Cited By (CrossRef): 0 citations Loading Articles...

This article is mentioned in:



Abstract

The present study simulated the effect of spot‑scanning proton beam therapy (PBT) performed using a device equipped with a multi‑leaf collimator (MLC) to calculate the dose distribution. Simulation studies using 18 pediatric patients with brain tumors in the posterior fossa were performed. Treatment plans were created for the MLC at different stages: Fully open (initial plan), fully closed to allow an irradiated area extending to 15 mm from the clinical target volume (CTV) (15‑mm plan), or closing only the leaves where an organ at risk (OAR) overlapped with a border at 10 or 5 mm from the CTV (10‑ and 5‑mm plans, respectively). The mean dose values for the brainstem, cervical cord, brain and cochlea in all MLC closure plans decreased as the MLC was closed (P=9.9x10‑10, P=1.3x10‑17, P=2.1x10‑16 and P=2.0x10‑5, respectively). The maximum dose (Dmax) values of the cervical cord and cochlea in all MLC closure plans were also decreased as the MLC was closed (P=3.0x10‑4 and P=1.1x10‑5, respectively). The dose to the CTV was almost unchanged. In 10 patients, the Dmax of the brain in all MLC‑closure plans was higher than that of the initial plan, but the maximum increase was only 0.8 gray relative biological effectiveness [Gy(RBE)]. In conclusion, the existing MLC installed in the treatment device can be used to decrease the OAR dose significantly using spot‑scanning PBT without a large capital investment. The dose from the scattered particles was small.
View Figures

Figure 1

Figure 2

Figure 3

Figure 4

View References

1 

Lawrence JH, Tobias CA, Born JL, Linfoot JA, Kling RP and Gottschalk A: Alpha and proton heavy particles and the bragg peak in therapy. Trans Am Clin Climatol Assoc. 75:111–116. 1964.PubMed/NCBI

2 

Bortfeld T and Schlegel W: An analytical approximation of depth-dose distributions for therapeutic proton beams. Phys Med Biol. 41:1331–1339. 1996. View Article : Google Scholar : PubMed/NCBI

3 

Foote RL, Stafford SL, Petersen IA, Pulido JS, Clarke MJ, Schild SE, Garces YI, Olivier KR, Miller RC, Haddock MG, et al: The clinical case for proton beam therapy. Radiat Oncol. 7:1742012. View Article : Google Scholar : PubMed/NCBI

4 

Holliday EB and Frank SJ: Proton radiation therapy for head and neck cancer: A review of the clinical experience to date. Int J Radiat Oncol Biol Phys. 89:292–302. 2014. View Article : Google Scholar : PubMed/NCBI

5 

Royce TJ and Efstathiou JA: Proton therapy for prostate cancer: A review of the rationale, evidence, and current state. Urol Oncol. 37:628–636. 2019. View Article : Google Scholar : PubMed/NCBI

6 

Haas-Kogan D, Indelicato D, Paganetti H, Esiashvili N, Mahajan A, Yock T, Flampouri S, MacDonald S, Fouladi M, Stephen K, et al: National cancer institute workshop on proton therapy for children: Considerations regarding brainstem injury. Int J Radiat Oncol Biol Phys. 101:152–168. 2018. View Article : Google Scholar : PubMed/NCBI

7 

Klein J and Dawson LA: Hepatocellular carcinoma radiation therapy: Review of evidence and future opportunities. Int J Radiat Oncol Biol Phys. 87:22–32. 2013. View Article : Google Scholar : PubMed/NCBI

8 

Chuong MD, Hallemeier CL, Jabbour SK, Yu J, Badiyan S, Merrell KW, Mishra MV, Li H, Verma V and Lin SH: Improving outcomes for esophageal cancer using proton beam therapy. Int J Radiat Oncol Biol Phys. 95:488–497. 2016. View Article : Google Scholar : PubMed/NCBI

9 

Lomax A: Intensity modulation methods for proton radiotherapy. Phys Med Biol. 44:185–205. 1999. View Article : Google Scholar : PubMed/NCBI

10 

Hyer DE, Hill PM, Wang D, Smith BR and Flynn RT: A dynamic collimation system for penumbra reduction in spot-scanning proton therapy: Proof of concept. Med Phys. 41:0917012014. View Article : Google Scholar : PubMed/NCBI

11 

DeLaney TF: Proton therapy in the clinic. Front Radiat Ther Oncol. 43:465–485. 2011. View Article : Google Scholar : PubMed/NCBI

12 

Bert C and Durante M: Motion in radiotherapy: Particle therapy. Phys Med Biol. 56:R113–R144. 2011. View Article : Google Scholar : PubMed/NCBI

13 

Schippers JM and Lomax AJ: Emerging technologies in proton therapy. Acta Oncol. 50:838–850. 2011. View Article : Google Scholar : PubMed/NCBI

14 

Engelsman M, Schwarz M and Dong L: Physics controversies in proton therapy. Semin Radiat Oncol. 23:88–96. 2013. View Article : Google Scholar : PubMed/NCBI

15 

van de Water S, Kraan AC, Breedveld S, Schillemans W, Teguh DN, Kooy HM, Madden TM, Heijmen BJ and Hoogeman MS: Improved efficiency of multi-criteria IMPT treatment planning using iterative resampling of randomly placed pencil beams. Phys Med Biol. 58:6969–6983. 2013. View Article : Google Scholar : PubMed/NCBI

16 

van de Water S, Safai S, Schippers JM, Weber DC and Lomax AJ: Towards FLASH proton therapy: The impact of treatment planning and machine characteristics on achievable dose rates. Acta Oncol. 58:1463–1469. 2019. View Article : Google Scholar : PubMed/NCBI

17 

Rosas S, Belosi FM, Bizzocchi N, Böhlen T, Zepter S, Morach P, Lomax AJ, Weber DC and Hrbacek J: Benchmarking a commercial proton therapy solution: The Paul Scherrer Institut experience. Br J Radiol. 93:201909202020. View Article : Google Scholar : PubMed/NCBI

18 

Meier G, Leiser D, Besson R, Mayor A, Safai S, Weber DC and Lomax AJ: Contour scanning for penumbra improvement in pencil beam scanned proton therapy. Phys Med Biol. 62:2398–2416. 2017. View Article : Google Scholar : PubMed/NCBI

19 

Bues M, Newhauser WD, Titt U and Smith AR: Therapeutic step and shoot proton beam spot-scanning with a multi-leaf collimator: A Monte Carlo study. Radiat Prot Dosimetry. 115:164–169. 2005. View Article : Google Scholar : PubMed/NCBI

20 

Sugiyama S, Katsui K, Tominaga Y, Waki T, Katayama N, Matsuzaki H, Kariya S, Kuroda M, Nishizaki K and Kanazawa S: Dose distribution of intensity-modulated proton therapy with and without a multi-leaf collimator for the treatment of maxillary sinus cancer: A comparative effectiveness study. Radiat Oncol. 14:2092019. View Article : Google Scholar : PubMed/NCBI

21 

Dowdell SJ, Clasie B, Depauw N, Metcalfe P, Rosenfeld AB, Kooy HM, Flanz JB and Paganetti H: Monte Carlo study of the potential reduction in out-of-field dose using a patient-specific aperture in pencil beam scanning proton therapy. Phys Med Biol. 57:2829–2842. 2012. View Article : Google Scholar : PubMed/NCBI

22 

Wang D, Smith BR, Gelover E, Flynn RT and Hyer DE: A method to select aperture margin in collimated spot scanning proton therapy. Phys Med Biol. 60:N109–N119. 2015. View Article : Google Scholar : PubMed/NCBI

23 

Yasui K, Toshito T, Omachi C, Hayashi K, Tanaka K, Asai K, Shimomura A, Muramatsu R and Hayashi N: Evaluation of dosimetric advantages of using patient-specific aperture system with intensity-modulated proton therapy for the shallow depth tumor. J Appl Clin Med Phys. 19:132–137. 2018. View Article : Google Scholar : PubMed/NCBI

24 

Smith B, Gelover E, Moignier A, Wang D, Flynn RT, Lin L, Kirk M, Solberg T and Hyer DE: Technical Note: A treatment plan comparison between dynamic collimation and a fixed aperture during spot scanning proton therapy for brain treatment. Med Phys. 43:46932016. View Article : Google Scholar : PubMed/NCBI

25 

Moignier A, Gelover E, Wang D, Smith B, Flynn R, Kirk M, Lin L, Solberg T, Lin A and Hyer D: Theoretical benefits of dynamic collimation in pencil beam scanning proton therapy for brain tumors: Dosimetric and radiobiological metrics. Int J Radiat Oncol Biol Phys. 95:171–180. 2016. View Article : Google Scholar : PubMed/NCBI

26 

Winterhalter C, Meier G, Oxley D, Weber DC, Lomax AJ and Safai S: Contour scanning, multi-leaf collimation and the combination thereof for proton pencil beam scanning. Phys Med Biol. 64:0150022018. View Article : Google Scholar : PubMed/NCBI

27 

Smith BR, Hyer DE, Hill PM and Culberson WS: Secondary neutron dose from a dynamic collimation system during intracranial pencil beam scanning proton therapy: A monte carlo investigation. Int J Radiat Oncol Biol Phys. 103:241–250. 2019. View Article : Google Scholar : PubMed/NCBI

28 

Kimstrand P, Traneus E, Ahnesjo A and Tilly N: Parametrization and application of scatter kernels for modelling scanned proton beam collimator scatter dose. Phys Med Biol. 53:3405–3429. 2008. View Article : Google Scholar : PubMed/NCBI

29 

Saini J, Traneus E, Maes D, Regmi R, Bowen SR, Bloch C and Wong T: Advanced Proton Beam Dosimetry Part I: Review and performance evaluation of dose calculation algorithms. Transl Lung Cancer Res. 7:171–179. 2018. View Article : Google Scholar : PubMed/NCBI

30 

Maes D, Saini J, Zeng J, Rengan R, Wong T and Bowen SR: Advanced proton beam dosimetry part II: Monte Carlo vs. Pencil beam-based planning for lung cancer. Transl Lung Cancer Res. 7:114–121. 2018. View Article : Google Scholar : PubMed/NCBI

31 

Gill P, Murray W and Saunders M: Software for large-scale nonlinear programming. User's guide for SNOPT Version. 7:1–116. 2008.

32 

Hyer DE, Hill PM, Wang D, Smith BR and Flynn RT: Effects of spot size and spot spacing on lateral penumbra reduction when using a dynamic collimation system for spot scanning proton therapy. Phys Med Biol. 59:N187–N196. 2014. View Article : Google Scholar : PubMed/NCBI

33 

Moteabbed M, Yock TI, Depauw N, Madden TM, Kooy HM and Paganetti H: Impact of spot size and beam-shaping devices on the treatment plan quality for pencil beam scanning proton therapy. Int J Radiat Oncol Biol Phys. 95:190–198. 2016. View Article : Google Scholar : PubMed/NCBI

Related Articles

  • Abstract
  • View
  • Download
  • Twitter
Copy and paste a formatted citation
Spandidos Publications style
Fukumitsu N, Yamashita T, Mima M, Demizu Y, Suzuki T and Soejima T: Dose distribution effects of spot‑scanning proton beam therapy equipped with a multi‑leaf collimator for pediatric brain tumors. Oncol Lett 22: 635, 2021.
APA
Fukumitsu, N., Yamashita, T., Mima, M., Demizu, Y., Suzuki, T., & Soejima, T. (2021). Dose distribution effects of spot‑scanning proton beam therapy equipped with a multi‑leaf collimator for pediatric brain tumors. Oncology Letters, 22, 635. https://doi.org/10.3892/ol.2021.12896
MLA
Fukumitsu, N., Yamashita, T., Mima, M., Demizu, Y., Suzuki, T., Soejima, T."Dose distribution effects of spot‑scanning proton beam therapy equipped with a multi‑leaf collimator for pediatric brain tumors". Oncology Letters 22.2 (2021): 635.
Chicago
Fukumitsu, N., Yamashita, T., Mima, M., Demizu, Y., Suzuki, T., Soejima, T."Dose distribution effects of spot‑scanning proton beam therapy equipped with a multi‑leaf collimator for pediatric brain tumors". Oncology Letters 22, no. 2 (2021): 635. https://doi.org/10.3892/ol.2021.12896
Copy and paste a formatted citation
x
Spandidos Publications style
Fukumitsu N, Yamashita T, Mima M, Demizu Y, Suzuki T and Soejima T: Dose distribution effects of spot‑scanning proton beam therapy equipped with a multi‑leaf collimator for pediatric brain tumors. Oncol Lett 22: 635, 2021.
APA
Fukumitsu, N., Yamashita, T., Mima, M., Demizu, Y., Suzuki, T., & Soejima, T. (2021). Dose distribution effects of spot‑scanning proton beam therapy equipped with a multi‑leaf collimator for pediatric brain tumors. Oncology Letters, 22, 635. https://doi.org/10.3892/ol.2021.12896
MLA
Fukumitsu, N., Yamashita, T., Mima, M., Demizu, Y., Suzuki, T., Soejima, T."Dose distribution effects of spot‑scanning proton beam therapy equipped with a multi‑leaf collimator for pediatric brain tumors". Oncology Letters 22.2 (2021): 635.
Chicago
Fukumitsu, N., Yamashita, T., Mima, M., Demizu, Y., Suzuki, T., Soejima, T."Dose distribution effects of spot‑scanning proton beam therapy equipped with a multi‑leaf collimator for pediatric brain tumors". Oncology Letters 22, no. 2 (2021): 635. https://doi.org/10.3892/ol.2021.12896
Follow us
  • Twitter
  • LinkedIn
  • Facebook
About
  • Spandidos Publications
  • Careers
  • Cookie Policy
  • Privacy Policy
How can we help?
  • Help
  • Live Chat
  • Contact
  • Email to our Support Team