1
|
Hentze MW, Muckenthaler MU, Galy B and
Camaschella C: Two to tango: Regulation of Mammalian iron
metabolism. Cell. 142:24–38. 2010. View Article : Google Scholar : PubMed/NCBI
|
2
|
Datz C, Müller E and Aigner E: Iron
overload and non-alcoholic fatty liver disease. Minerva Endocrinol.
42:173–183. 2017. View Article : Google Scholar : PubMed/NCBI
|
3
|
Babitt JL and Lin HY: Mechanisms of anemia
in CKD. J Am Soc Nephrol. 23:1631–1634. 2012. View Article : Google Scholar : PubMed/NCBI
|
4
|
Keith DS, Nichols GA, Gullion CM, Brown JB
and Smith DH: Longitudinal follow-up and outcomes among a
population with chronic kidney disease in a large managed care
organization. Arch Intern Med. 164:659–663. 2004. View Article : Google Scholar : PubMed/NCBI
|
5
|
Bush AI: The metallobiology of Alzheimer's
disease. Trends Neurosci. 26:207–214. 2003. View Article : Google Scholar : PubMed/NCBI
|
6
|
Singh A, Kukreti R, Saso L and Kukreti S:
Oxidative Stress: A Key Modulator in Neurodegenerative Diseases.
Molecules. 24:15832019. View Article : Google Scholar : PubMed/NCBI
|
7
|
Zager RA: Parenteral iron compounds:
Potent oxidants but mainstays of anemia management in chronic renal
disease. Clin J Am Soc Nephrol. (Suppl 1):S24–S31. 2006. View Article : Google Scholar
|
8
|
Jin L, Wang J and Zhao L: Decreased serum
ceruloplasmin levels characteristically aggravate nigral iron
deposition in Parkinson's disease. Brain. 134:50–58. 2011.
View Article : Google Scholar : PubMed/NCBI
|
9
|
Britton LJ, Subramaniam VN and Crawford
DH: Iron and non-alcoholic fatty liver disease. World J
Gastroenterol. 22:8112–8122. 2016. View Article : Google Scholar : PubMed/NCBI
|
10
|
Jiang R, Manson JE, Meigs JB, Ma J, Rifai
N and Hu FB: Body iron stores in relation to risk of type 2
diabetes in apparently healthy women. JAMA. 291:711–717. 2004.
View Article : Google Scholar : PubMed/NCBI
|
11
|
Wilkinson N and Pantopoulos K: The IRP/IRE
system in vivo: Insights from mouse models. Front Pharmacol.
5:1762014. View Article : Google Scholar : PubMed/NCBI
|
12
|
Brown NM, Kennedy MC, Antholine WE,
Eisenstein RS and Walden WE: Detection of a [3Fe-4S] cluster
intermediate of cytosolic aconitase in yeast expressing iron
regulatory protein 1. Insights into the mechanism of Fe-S cluster
cycling. J Biol Chem. 277:7246–7254. 2002. View Article : Google Scholar : PubMed/NCBI
|
13
|
Lushchak OV, Piroddi M, Galli F and
Lushchak VI: Aconitase post-translational modification as a key in
linkage between Krebs cycle, iron homeostasis, redox signaling, and
metabolism of reactive oxygen species. Redox Rep. 19:8–15. 2014.
View Article : Google Scholar : PubMed/NCBI
|
14
|
Tong WH and Rouault TA: Metabolic
regulation of citrate and iron by aconitases: Role of iron-sulfur
cluster biogenesis. Biometals. 20:549–564. 2007. View Article : Google Scholar : PubMed/NCBI
|
15
|
Meyron-Holtz EG, Ghosh MC, Iwai K, LaVaute
T, Brazzolotto X, Berger UV, Land W, Ollivierre-Wilson H, Grinberg
A, Love P and Rouault TA: Genetic ablations of iron regulatory
proteins 1 and 2 reveal why iron regulatory protein 2 dominates
iron homeostasis. EMBO J. 23:386–395. 2004. View Article : Google Scholar : PubMed/NCBI
|
16
|
Meyron-Holtz EG, Ghosh MC and Rouault TA:
Mammalian tissue oxygen levels modulate iron-regulatory protein
activities in vivo. Science. 306:2087–2090. 2004. View Article : Google Scholar : PubMed/NCBI
|
17
|
Ghosh MC, Tong WH, Zhang D,
Ollivierre-Wilson H, Singh A, Krishna MC, Mitchell JB and Rouault
TA: Tempol-mediated activation of latent iron regulatory protein
activity prevents symptoms of neurodegenerative disease in IRP2
knockout mice. Proc Natl Acad Sci USA. 105:12028–12033. 2008.
View Article : Google Scholar : PubMed/NCBI
|
18
|
Stys A, Galy B, Starzynski RR, Smuda E,
Drapier JC, Lipiński P and Bouton C: Iron regulatory protein 1
outcompetes iron regulatory protein 2 in regulating cellular iron
homeostasis in response to nitric oxide. J Biol Chem.
286:22846–22854. 2011. View Article : Google Scholar : PubMed/NCBI
|
19
|
Dev S, Kumari S, Singh N, Kumar Bal S,
Seth P and Mukhopadhyay CK: Role of extracellular Hydrogen peroxide
in regulation of iron homeostasis genes in neuronal cells:
Implication in iron accumulation. Free Radic Biol Med. 86:78–89.
2015. View Article : Google Scholar : PubMed/NCBI
|
20
|
Dixon SJ, Lemberg KM, Lamprecht MR, Skouta
R, Zaitsev EM, Gleason CE, Patel DN, Bauer AJ, Cantley AM, Yang WS,
et al: Ferroptosis: An iron-dependent form of nonapoptotic cell
death. Cell. 149:1060–1072. 2012. View Article : Google Scholar : PubMed/NCBI
|
21
|
Dolma S, Lessnick SL, Hahn WC and
Stockwell BR: Identification of genotype-selective antitumor agents
using synthetic lethal chemical screening in engineered human tumor
cells. Cancer Cell. 3:285–296. 2003. View Article : Google Scholar : PubMed/NCBI
|
22
|
Yang WS and Stockwell BR: Synthetic lethal
screening identifies compounds activating iron-dependent,
nonapoptotic cell death in oncogenic-RAS-harboring cancer cells.
Chem Biol. 15:234–245. 2008. View Article : Google Scholar : PubMed/NCBI
|
23
|
Yang WS, SriRamaratnam R, Welsch ME,
Shimada K, Skouta R, Viswanathan VS, Cheah JH, Clemons PA, Shamji
AF, Clish CB, et al: Regulation of ferroptotic cancer cell death by
GPX4. Cell. 156:317–331. 2014. View Article : Google Scholar : PubMed/NCBI
|
24
|
Wang H, An P, Xie E, Wu Q, Fang X, Gao H,
Zhang Z, Li Y, Wang X, Zhang J, et al: Characterization of
ferroptosis in murine models of hemochromatosis. Hepatology.
66:449–465. 2017. View Article : Google Scholar : PubMed/NCBI
|
25
|
Geng N, Shi BJ, Li SL, Zhong ZY, Li YC,
Xua WL, Zhou H and Cai JH: Knockdown of ferroportin accelerates
erastin-induced ferroptosis in neuroblastoma cells. Eur Rev Med
Pharmacol Sci. 22:3826–3836. 2018.PubMed/NCBI
|
26
|
Gao M, Monian P, Quadri N, Ramasamy R and
Jiang X: Glutaminolysis and transferrin regulate ferroptosis. Mol
Cell. 59:298–308. 2015. View Article : Google Scholar : PubMed/NCBI
|
27
|
Mancias JD, Wang X, Gygi SP, Harper JW and
Kimmelman AC: Quantitative proteomics identifies NCOA4 as the cargo
receptor mediating ferritinophagy. Nature. 509:105–109. 2014.
View Article : Google Scholar : PubMed/NCBI
|
28
|
Zhang Z, Yao Z, Wang L, Ding H, Shao J,
Chen A, Zhang F and Zheng S: Activation of ferritinophagy is
required for the RNA-binding protein ELAVL1/HuR to regulate
ferroptosis in hepatic stellate cells. Autophagy. 14:2083–2103.
2018. View Article : Google Scholar : PubMed/NCBI
|
29
|
Lin LS, Song J, Song L, Ke K, Liu Y, Zhou
Z, Shen Z, Li J, Yang Z, Tang W, et al: Simultaneous Fenton-like
ion delivery and glutathione depletion by MnO2-based
nanoagent to enhance chemodynamic therapy. Angew Chem Int Ed Engl.
57:4902–4906. 2018. View Article : Google Scholar : PubMed/NCBI
|
30
|
Sui S, Zhang J, Xu S, Wang Q, Wang P and
Pang D: Ferritinophagy is required for the induction of ferroptosis
by the bromodomain protein BRD4 inhibitor (+)-JQ1 in cancer cells.
Cell Death Dis. 10:3312019. View Article : Google Scholar : PubMed/NCBI
|
31
|
Siegel RL, Miller KD and Jemal A: Cancer
statistics, 2020. CA: Cancer J Clin. 70:7–30. 2020.PubMed/NCBI
|
32
|
Brenner M and Hearing VJ: The protective
role of melanin against UV damage in human skin. Photochem
Photobiol. 84:539–549. 2008. View Article : Google Scholar : PubMed/NCBI
|
33
|
Armstrong JL, Corazzari M, Martin S,
Pagliarini V, Falasca L, Hill DS, Ellis N, Al Sabah S, Redfern CP,
Fimia GM, et al: Oncogenic B-RAF signaling in melanoma impairs the
therapeutic advantage of autophagy inhibition. Clin Cancer Res.
17:2216–2226. 2011. View Article : Google Scholar : PubMed/NCBI
|
34
|
Lang X, Green MD, Wang W, Yu J, Choi JE,
Jiang L, Liao P, Zhou J, Zhang Q, Dow A, et al: Radiotherapy and
immunotherapy promote tumoral lipid oxidation and ferroptosis via
synergistic repression of SLC7A11. Cancer Discov. 9:1673–1685.
2019. View Article : Google Scholar : PubMed/NCBI
|
35
|
Sato M, Onuma K, Domon M, Hasegawa S,
Suzuki A, Kusumi R, Hino R, Kakihara N, Kanda Y, Osaki M, et al:
Loss of the cystine/glutamate antiporter in melanoma abrogates
tumor metastasis and markedly increases survival rates of mice. Int
J Cancer. 147:3224–3235. 2020. View Article : Google Scholar : PubMed/NCBI
|
36
|
Konieczkowski DJ, Johannessen CM,
Abudayyeh O, Kim JW, Cooper ZA, Piris A, Frederick DT,
Barzily-Rokni M, Straussman R, Haq R, et al: A melanoma cell state
distinction influences sensitivity to MAPK pathway inhibitors.
Cancer Discov. 4:816–827. 2014. View Article : Google Scholar : PubMed/NCBI
|
37
|
Luo M, Wu L, Zhang K, Wang H, Zhang T,
Gutierrez L, O'Connell D, Zhang P, Li Y, Gao T, et al: miR-137
regulates ferroptosis by targeting glutamine transporter SLC1A5 in
melanoma. Cell Death Differ. 25:1457–1472. 2018. View Article : Google Scholar : PubMed/NCBI
|
38
|
Tsoi J, Robert L, Paraiso K, Galvan C,
Sheu KM, Lay J, Wong DJL, Atefi M, Shirazi R, Wang X, et al:
Multi-stage differentiation defines melanoma subtypes with
differential vulnerability to drug-induced iron-dependent oxidative
stress. Cancer Cell. 33:890–904.e5. 2018. View Article : Google Scholar : PubMed/NCBI
|
39
|
Miyazawa M, Bogdan AR and Tsuji Y:
Perturbation of iron metabolism by cisplatin through inhibition of
iron regulatory protein 2. Cell Chem Biol. 26:85–97.e4. 2019.
View Article : Google Scholar : PubMed/NCBI
|
40
|
Livak KJ and Schmittgen TD: Analysis of
relative gene expression data using real-time quantitative PCR and
the 2(-Delta Delta C(T)) method. Methods. 25:402–408. 2001.
View Article : Google Scholar : PubMed/NCBI
|
41
|
Philpott CC, Klausner RD and Rouault TA:
The bifunctional iron-responsive element binding protein/cytosolic
aconitase: The role of active-site residues in ligand binding and
regulation. Proc Natl Acad Sci USA. 91:7321–7325. 1994. View Article : Google Scholar : PubMed/NCBI
|
42
|
Eisenstein RS: Iron regulatory proteins
and the molecular control of mammalian iron metabolism. Annu Rev
Nutr. 20:627–662. 2000. View Article : Google Scholar : PubMed/NCBI
|
43
|
Wallander ML, Leibold EA and Eisenstein
RS: Molecular control of vertebrate iron homeostasis by iron
regulatory proteins. Biochim Biophys Acta. 1763:668–689. 2006.
View Article : Google Scholar : PubMed/NCBI
|
44
|
Hentze MW, Muckenthaler MU and Andrews NC:
Balancing acts: Molecular control of mammalian iron metabolism.
Cell. 117:285–297. 2004. View Article : Google Scholar : PubMed/NCBI
|
45
|
LaVaute T, Smith S, Cooperman S, Iwai K,
Land W, Meyron-Holtz E, Drake SK, Miller G, Abu-Asab M, Tsokos M,
et al: Targeted deletion of the gene encoding iron regulatory
protein-2 causes misregulation of iron metabolism and
neurodegenerative disease in mice. Nat Genet. 27:209–214. 2001.
View Article : Google Scholar : PubMed/NCBI
|
46
|
Velsor LW, Kariya C, Kachadourian R and
Day BJ: Mitochondrial oxidative stress in the lungs of cystic
fibrosis transmembrane conductance regulator protein mutant mice.
Am J Respir Cell Mol Biol. 35:579–586. 2006. View Article : Google Scholar : PubMed/NCBI
|
47
|
Gardner PR: Aconitase: Sensitive target
and measure of superoxide. Methods Enzymol. 349:9–23. 2002.
View Article : Google Scholar : PubMed/NCBI
|
48
|
Gardner PR, Nguyen DD and White CW:
Aconitase is a sensitive and critical target of oxygen poisoning in
cultured mammalian cells and in rat lungs. Proc Natl Acad Sci USA.
91:12248–12252. 1994. View Article : Google Scholar : PubMed/NCBI
|
49
|
Funauchi Y, Tanikawa C, Yi Lo PH, Mori J,
Daigo Y, Takano A, Miyagi Y, Okawa A, Nakamura Y and Matsuda K:
Regulation of iron homeostasis by the p53-ISCU pathway. Sci Rep.
5:164972015. View Article : Google Scholar : PubMed/NCBI
|
50
|
Zhang F, Wang W, Tsuji Y, Torti SV and
Torti FM: Post-transcriptional modulation of iron homeostasis
during p53-dependent growth arrest. J Biol Chem. 283:33911–33918.
2008. View Article : Google Scholar : PubMed/NCBI
|
51
|
Thompson LR, Oliveira TG, Hermann ER,
Chowanadisai W, Clarke SL and Montgomery MR: Distinct TP53 mutation
types exhibit increased sensitivity to ferroptosis independently of
changes in iron regulatory protein activity. Int J Mol Sci.
21:67512020. View Article : Google Scholar : PubMed/NCBI
|
52
|
Ou Y, Wang SJ, Li D, Chu B and Gu W:
Activation of SAT1 engages polyamine metabolism with p53-mediated
ferroptotic responses. Proc Natl Acad Sci USA. 113:E6806–E6812.
2016. View Article : Google Scholar : PubMed/NCBI
|
53
|
Jiang L, Kon N, Li T, Wang SJ, Su T,
Hibshoosh H, Baer R and Gu W: Ferroptosis as a p53-mediated
activity during tumour suppression. Nature. 520:57–62. 2015.
View Article : Google Scholar : PubMed/NCBI
|
54
|
Jennis M, Kung CP, Basu S, Budina-Kolomets
A, Leu JI, Khaku S, Scott JP, Cai KQ, Campbell MR, Porter DK, et
al: An African-specific polymorphism in the TP53 gene impairs p53
tumor suppressor function in a mouse model. Genes Dev. 30:918–930.
2016. View Article : Google Scholar : PubMed/NCBI
|
55
|
Wang SJ, Li D, Ou Y, Jiang L, Chen Y, Zhao
Y and Gu W: Acetylation is crucial for p53-mediated ferroptosis and
tumor suppression. Cell Rep. 17:366–373. 2016. View Article : Google Scholar : PubMed/NCBI
|
56
|
Li J, Li J, Pu Y, Li S, Gao W and He B:
PDT-Enhanced ferroptosis by a polymer nanoparticle with
pH-activated singlet oxygen generation and superb biocompatibility
for cancer therapy. Biomacromolecules. 22:1167–1176. 2021.
View Article : Google Scholar : PubMed/NCBI
|
57
|
Jasim KA and Gesquiere AJ: Ultrastable and
biofunctionalizable conjugated polymer nanoparticles with
encapsulated iron for ferroptosis assisted chemodynamic therapy.
Mol Pharm. 16:4852–4866. 2019. View Article : Google Scholar : PubMed/NCBI
|
58
|
Kim SE, Zhang L, Ma K, Riegman M, Chen F,
Ingold I, Conrad M, Turker MZ, Gao M, Jiang X, et al: Ultrasmall
nanoparticles induce ferroptosis in nutrient-deprived cancer cells
and suppress tumour growth. Nat Nanotechnol. 11:977–985. 2016.
View Article : Google Scholar : PubMed/NCBI
|
59
|
Wang Y, Yu L, Ding J and Chen Y: Iron
metabolism in cancer. Int J Mol Sci. 20:952018. View Article : Google Scholar : PubMed/NCBI
|
60
|
Bian Z, Hann HW, Ye Z, Yin C, Wang Y, Fang
W, Wan S, Wang C and Tao K: Ferritin level prospectively predicts
hepatocarcinogenesis in patients with chronic hepatitis B virus
infection. Oncol Lett. 16:3499–3508. 2018.PubMed/NCBI
|
61
|
Song A, Eo W, Kim S, Shim B and Lee S:
Significance of serum ferritin as a prognostic factor in advanced
hepatobiliary cancer patients treated with Korean medicine: A
retrospective cohort study. BMC Complement Altern Med. 18:1762018.
View Article : Google Scholar : PubMed/NCBI
|
62
|
Guo W, Zhang S, Chen Y, Zhang D, Yuan L,
Cong H and Liu S: An important role of the hepcidin-ferroportin
signaling in affecting tumor growth and metastasis. Acta Biochim
Biophys Sin (Shanghai). 47:703–715. 2015. View Article : Google Scholar : PubMed/NCBI
|