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Iron regulatory protein 1 promotes ferroptosis by sustaining cellular iron homeostasis in melanoma

  • Authors:
    • Fengping Yao
    • Xiaohong Cui
    • Ying Zhang
    • Zhuchun Bei
    • Hongquan Wang
    • Dongxu Zhao
    • Hong Wang
    • Yongfei Yang
  • View Affiliations / Copyright

    Affiliations: School of Life Science, Beijing Institute of Technology, Beijing 100081, P.R. China, Psychiatry Department, Shanxi Bethune Hospital, Taiyuan, Shanxi 030000, P.R. China, State Key Laboratory of Pathogens and Biosecurity, Beijing Institute of Microbiology and Epidemiology, Beijing 100071, P.R. China
    Copyright: © Yao et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 657
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    Published online on: July 12, 2021
       https://doi.org/10.3892/ol.2021.12918
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Abstract

Melanoma, the most aggressive skin cancer, is mainly treated with BRAF inhibitors or immunotheareapy. However, most patients who initially responded to BRAF inhibitors or immunotheareapy become resistant following relapse. Ferroptosis is a form of regulated cell death characterized by its dependence on iron ions and the accumulation of lipid reactive oxygen species (ROS). Recent studies have demonstrated that ferroptosis is a good method for tumor treatment, and iron homeostasis is closely associated with ferroptosis. Iron regulatory protein (IRP)1 and 2 play important roles in maintaining iron homeostasis, but their functions in ferroptosis have not been investigated. The present study reported that the expression of IRP1 and IRP2 was increased by the ferroptosis inducers erastin and RSL3 in melanoma cells. Depletion of IRP1 significantly suppressed erastin‑ and RSL3‑induced ferroptosis. IRP2 had a weak effect but could enhance the promoting function of IRP1 on ferroptosis. Further, erastin and RSL3 promoted the transition of aconitase 1 to IRP1, which regulated downstream iron metabolism proteins, including transferrin receptor (TFRC), ferroportin (FPN) and ferritin heavy chain 1 (FTH1). Moreover, overexpression of TFRC and knockdown of FPN and FTH1 significantly promoted erastin‑ and RSL3‑induced ferroptosis in IRP1 knockdown melanoma cells. Collectively, the present findings indicate that IRP1 plays an essential role in erastin‑ and RSL3‑induced ferroptosis by regulating iron homeostasis.
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1 

Hentze MW, Muckenthaler MU, Galy B and Camaschella C: Two to tango: Regulation of Mammalian iron metabolism. Cell. 142:24–38. 2010. View Article : Google Scholar : PubMed/NCBI

2 

Datz C, Müller E and Aigner E: Iron overload and non-alcoholic fatty liver disease. Minerva Endocrinol. 42:173–183. 2017. View Article : Google Scholar : PubMed/NCBI

3 

Babitt JL and Lin HY: Mechanisms of anemia in CKD. J Am Soc Nephrol. 23:1631–1634. 2012. View Article : Google Scholar : PubMed/NCBI

4 

Keith DS, Nichols GA, Gullion CM, Brown JB and Smith DH: Longitudinal follow-up and outcomes among a population with chronic kidney disease in a large managed care organization. Arch Intern Med. 164:659–663. 2004. View Article : Google Scholar : PubMed/NCBI

5 

Bush AI: The metallobiology of Alzheimer's disease. Trends Neurosci. 26:207–214. 2003. View Article : Google Scholar : PubMed/NCBI

6 

Singh A, Kukreti R, Saso L and Kukreti S: Oxidative Stress: A Key Modulator in Neurodegenerative Diseases. Molecules. 24:15832019. View Article : Google Scholar : PubMed/NCBI

7 

Zager RA: Parenteral iron compounds: Potent oxidants but mainstays of anemia management in chronic renal disease. Clin J Am Soc Nephrol. (Suppl 1):S24–S31. 2006. View Article : Google Scholar

8 

Jin L, Wang J and Zhao L: Decreased serum ceruloplasmin levels characteristically aggravate nigral iron deposition in Parkinson's disease. Brain. 134:50–58. 2011. View Article : Google Scholar : PubMed/NCBI

9 

Britton LJ, Subramaniam VN and Crawford DH: Iron and non-alcoholic fatty liver disease. World J Gastroenterol. 22:8112–8122. 2016. View Article : Google Scholar : PubMed/NCBI

10 

Jiang R, Manson JE, Meigs JB, Ma J, Rifai N and Hu FB: Body iron stores in relation to risk of type 2 diabetes in apparently healthy women. JAMA. 291:711–717. 2004. View Article : Google Scholar : PubMed/NCBI

11 

Wilkinson N and Pantopoulos K: The IRP/IRE system in vivo: Insights from mouse models. Front Pharmacol. 5:1762014. View Article : Google Scholar : PubMed/NCBI

12 

Brown NM, Kennedy MC, Antholine WE, Eisenstein RS and Walden WE: Detection of a [3Fe-4S] cluster intermediate of cytosolic aconitase in yeast expressing iron regulatory protein 1. Insights into the mechanism of Fe-S cluster cycling. J Biol Chem. 277:7246–7254. 2002. View Article : Google Scholar : PubMed/NCBI

13 

Lushchak OV, Piroddi M, Galli F and Lushchak VI: Aconitase post-translational modification as a key in linkage between Krebs cycle, iron homeostasis, redox signaling, and metabolism of reactive oxygen species. Redox Rep. 19:8–15. 2014. View Article : Google Scholar : PubMed/NCBI

14 

Tong WH and Rouault TA: Metabolic regulation of citrate and iron by aconitases: Role of iron-sulfur cluster biogenesis. Biometals. 20:549–564. 2007. View Article : Google Scholar : PubMed/NCBI

15 

Meyron-Holtz EG, Ghosh MC, Iwai K, LaVaute T, Brazzolotto X, Berger UV, Land W, Ollivierre-Wilson H, Grinberg A, Love P and Rouault TA: Genetic ablations of iron regulatory proteins 1 and 2 reveal why iron regulatory protein 2 dominates iron homeostasis. EMBO J. 23:386–395. 2004. View Article : Google Scholar : PubMed/NCBI

16 

Meyron-Holtz EG, Ghosh MC and Rouault TA: Mammalian tissue oxygen levels modulate iron-regulatory protein activities in vivo. Science. 306:2087–2090. 2004. View Article : Google Scholar : PubMed/NCBI

17 

Ghosh MC, Tong WH, Zhang D, Ollivierre-Wilson H, Singh A, Krishna MC, Mitchell JB and Rouault TA: Tempol-mediated activation of latent iron regulatory protein activity prevents symptoms of neurodegenerative disease in IRP2 knockout mice. Proc Natl Acad Sci USA. 105:12028–12033. 2008. View Article : Google Scholar : PubMed/NCBI

18 

Stys A, Galy B, Starzynski RR, Smuda E, Drapier JC, Lipiński P and Bouton C: Iron regulatory protein 1 outcompetes iron regulatory protein 2 in regulating cellular iron homeostasis in response to nitric oxide. J Biol Chem. 286:22846–22854. 2011. View Article : Google Scholar : PubMed/NCBI

19 

Dev S, Kumari S, Singh N, Kumar Bal S, Seth P and Mukhopadhyay CK: Role of extracellular Hydrogen peroxide in regulation of iron homeostasis genes in neuronal cells: Implication in iron accumulation. Free Radic Biol Med. 86:78–89. 2015. View Article : Google Scholar : PubMed/NCBI

20 

Dixon SJ, Lemberg KM, Lamprecht MR, Skouta R, Zaitsev EM, Gleason CE, Patel DN, Bauer AJ, Cantley AM, Yang WS, et al: Ferroptosis: An iron-dependent form of nonapoptotic cell death. Cell. 149:1060–1072. 2012. View Article : Google Scholar : PubMed/NCBI

21 

Dolma S, Lessnick SL, Hahn WC and Stockwell BR: Identification of genotype-selective antitumor agents using synthetic lethal chemical screening in engineered human tumor cells. Cancer Cell. 3:285–296. 2003. View Article : Google Scholar : PubMed/NCBI

22 

Yang WS and Stockwell BR: Synthetic lethal screening identifies compounds activating iron-dependent, nonapoptotic cell death in oncogenic-RAS-harboring cancer cells. Chem Biol. 15:234–245. 2008. View Article : Google Scholar : PubMed/NCBI

23 

Yang WS, SriRamaratnam R, Welsch ME, Shimada K, Skouta R, Viswanathan VS, Cheah JH, Clemons PA, Shamji AF, Clish CB, et al: Regulation of ferroptotic cancer cell death by GPX4. Cell. 156:317–331. 2014. View Article : Google Scholar : PubMed/NCBI

24 

Wang H, An P, Xie E, Wu Q, Fang X, Gao H, Zhang Z, Li Y, Wang X, Zhang J, et al: Characterization of ferroptosis in murine models of hemochromatosis. Hepatology. 66:449–465. 2017. View Article : Google Scholar : PubMed/NCBI

25 

Geng N, Shi BJ, Li SL, Zhong ZY, Li YC, Xua WL, Zhou H and Cai JH: Knockdown of ferroportin accelerates erastin-induced ferroptosis in neuroblastoma cells. Eur Rev Med Pharmacol Sci. 22:3826–3836. 2018.PubMed/NCBI

26 

Gao M, Monian P, Quadri N, Ramasamy R and Jiang X: Glutaminolysis and transferrin regulate ferroptosis. Mol Cell. 59:298–308. 2015. View Article : Google Scholar : PubMed/NCBI

27 

Mancias JD, Wang X, Gygi SP, Harper JW and Kimmelman AC: Quantitative proteomics identifies NCOA4 as the cargo receptor mediating ferritinophagy. Nature. 509:105–109. 2014. View Article : Google Scholar : PubMed/NCBI

28 

Zhang Z, Yao Z, Wang L, Ding H, Shao J, Chen A, Zhang F and Zheng S: Activation of ferritinophagy is required for the RNA-binding protein ELAVL1/HuR to regulate ferroptosis in hepatic stellate cells. Autophagy. 14:2083–2103. 2018. View Article : Google Scholar : PubMed/NCBI

29 

Lin LS, Song J, Song L, Ke K, Liu Y, Zhou Z, Shen Z, Li J, Yang Z, Tang W, et al: Simultaneous Fenton-like ion delivery and glutathione depletion by MnO2-based nanoagent to enhance chemodynamic therapy. Angew Chem Int Ed Engl. 57:4902–4906. 2018. View Article : Google Scholar : PubMed/NCBI

30 

Sui S, Zhang J, Xu S, Wang Q, Wang P and Pang D: Ferritinophagy is required for the induction of ferroptosis by the bromodomain protein BRD4 inhibitor (+)-JQ1 in cancer cells. Cell Death Dis. 10:3312019. View Article : Google Scholar : PubMed/NCBI

31 

Siegel RL, Miller KD and Jemal A: Cancer statistics, 2020. CA: Cancer J Clin. 70:7–30. 2020.PubMed/NCBI

32 

Brenner M and Hearing VJ: The protective role of melanin against UV damage in human skin. Photochem Photobiol. 84:539–549. 2008. View Article : Google Scholar : PubMed/NCBI

33 

Armstrong JL, Corazzari M, Martin S, Pagliarini V, Falasca L, Hill DS, Ellis N, Al Sabah S, Redfern CP, Fimia GM, et al: Oncogenic B-RAF signaling in melanoma impairs the therapeutic advantage of autophagy inhibition. Clin Cancer Res. 17:2216–2226. 2011. View Article : Google Scholar : PubMed/NCBI

34 

Lang X, Green MD, Wang W, Yu J, Choi JE, Jiang L, Liao P, Zhou J, Zhang Q, Dow A, et al: Radiotherapy and immunotherapy promote tumoral lipid oxidation and ferroptosis via synergistic repression of SLC7A11. Cancer Discov. 9:1673–1685. 2019. View Article : Google Scholar : PubMed/NCBI

35 

Sato M, Onuma K, Domon M, Hasegawa S, Suzuki A, Kusumi R, Hino R, Kakihara N, Kanda Y, Osaki M, et al: Loss of the cystine/glutamate antiporter in melanoma abrogates tumor metastasis and markedly increases survival rates of mice. Int J Cancer. 147:3224–3235. 2020. View Article : Google Scholar : PubMed/NCBI

36 

Konieczkowski DJ, Johannessen CM, Abudayyeh O, Kim JW, Cooper ZA, Piris A, Frederick DT, Barzily-Rokni M, Straussman R, Haq R, et al: A melanoma cell state distinction influences sensitivity to MAPK pathway inhibitors. Cancer Discov. 4:816–827. 2014. View Article : Google Scholar : PubMed/NCBI

37 

Luo M, Wu L, Zhang K, Wang H, Zhang T, Gutierrez L, O'Connell D, Zhang P, Li Y, Gao T, et al: miR-137 regulates ferroptosis by targeting glutamine transporter SLC1A5 in melanoma. Cell Death Differ. 25:1457–1472. 2018. View Article : Google Scholar : PubMed/NCBI

38 

Tsoi J, Robert L, Paraiso K, Galvan C, Sheu KM, Lay J, Wong DJL, Atefi M, Shirazi R, Wang X, et al: Multi-stage differentiation defines melanoma subtypes with differential vulnerability to drug-induced iron-dependent oxidative stress. Cancer Cell. 33:890–904.e5. 2018. View Article : Google Scholar : PubMed/NCBI

39 

Miyazawa M, Bogdan AR and Tsuji Y: Perturbation of iron metabolism by cisplatin through inhibition of iron regulatory protein 2. Cell Chem Biol. 26:85–97.e4. 2019. View Article : Google Scholar : PubMed/NCBI

40 

Livak KJ and Schmittgen TD: Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) method. Methods. 25:402–408. 2001. View Article : Google Scholar : PubMed/NCBI

41 

Philpott CC, Klausner RD and Rouault TA: The bifunctional iron-responsive element binding protein/cytosolic aconitase: The role of active-site residues in ligand binding and regulation. Proc Natl Acad Sci USA. 91:7321–7325. 1994. View Article : Google Scholar : PubMed/NCBI

42 

Eisenstein RS: Iron regulatory proteins and the molecular control of mammalian iron metabolism. Annu Rev Nutr. 20:627–662. 2000. View Article : Google Scholar : PubMed/NCBI

43 

Wallander ML, Leibold EA and Eisenstein RS: Molecular control of vertebrate iron homeostasis by iron regulatory proteins. Biochim Biophys Acta. 1763:668–689. 2006. View Article : Google Scholar : PubMed/NCBI

44 

Hentze MW, Muckenthaler MU and Andrews NC: Balancing acts: Molecular control of mammalian iron metabolism. Cell. 117:285–297. 2004. View Article : Google Scholar : PubMed/NCBI

45 

LaVaute T, Smith S, Cooperman S, Iwai K, Land W, Meyron-Holtz E, Drake SK, Miller G, Abu-Asab M, Tsokos M, et al: Targeted deletion of the gene encoding iron regulatory protein-2 causes misregulation of iron metabolism and neurodegenerative disease in mice. Nat Genet. 27:209–214. 2001. View Article : Google Scholar : PubMed/NCBI

46 

Velsor LW, Kariya C, Kachadourian R and Day BJ: Mitochondrial oxidative stress in the lungs of cystic fibrosis transmembrane conductance regulator protein mutant mice. Am J Respir Cell Mol Biol. 35:579–586. 2006. View Article : Google Scholar : PubMed/NCBI

47 

Gardner PR: Aconitase: Sensitive target and measure of superoxide. Methods Enzymol. 349:9–23. 2002. View Article : Google Scholar : PubMed/NCBI

48 

Gardner PR, Nguyen DD and White CW: Aconitase is a sensitive and critical target of oxygen poisoning in cultured mammalian cells and in rat lungs. Proc Natl Acad Sci USA. 91:12248–12252. 1994. View Article : Google Scholar : PubMed/NCBI

49 

Funauchi Y, Tanikawa C, Yi Lo PH, Mori J, Daigo Y, Takano A, Miyagi Y, Okawa A, Nakamura Y and Matsuda K: Regulation of iron homeostasis by the p53-ISCU pathway. Sci Rep. 5:164972015. View Article : Google Scholar : PubMed/NCBI

50 

Zhang F, Wang W, Tsuji Y, Torti SV and Torti FM: Post-transcriptional modulation of iron homeostasis during p53-dependent growth arrest. J Biol Chem. 283:33911–33918. 2008. View Article : Google Scholar : PubMed/NCBI

51 

Thompson LR, Oliveira TG, Hermann ER, Chowanadisai W, Clarke SL and Montgomery MR: Distinct TP53 mutation types exhibit increased sensitivity to ferroptosis independently of changes in iron regulatory protein activity. Int J Mol Sci. 21:67512020. View Article : Google Scholar : PubMed/NCBI

52 

Ou Y, Wang SJ, Li D, Chu B and Gu W: Activation of SAT1 engages polyamine metabolism with p53-mediated ferroptotic responses. Proc Natl Acad Sci USA. 113:E6806–E6812. 2016. View Article : Google Scholar : PubMed/NCBI

53 

Jiang L, Kon N, Li T, Wang SJ, Su T, Hibshoosh H, Baer R and Gu W: Ferroptosis as a p53-mediated activity during tumour suppression. Nature. 520:57–62. 2015. View Article : Google Scholar : PubMed/NCBI

54 

Jennis M, Kung CP, Basu S, Budina-Kolomets A, Leu JI, Khaku S, Scott JP, Cai KQ, Campbell MR, Porter DK, et al: An African-specific polymorphism in the TP53 gene impairs p53 tumor suppressor function in a mouse model. Genes Dev. 30:918–930. 2016. View Article : Google Scholar : PubMed/NCBI

55 

Wang SJ, Li D, Ou Y, Jiang L, Chen Y, Zhao Y and Gu W: Acetylation is crucial for p53-mediated ferroptosis and tumor suppression. Cell Rep. 17:366–373. 2016. View Article : Google Scholar : PubMed/NCBI

56 

Li J, Li J, Pu Y, Li S, Gao W and He B: PDT-Enhanced ferroptosis by a polymer nanoparticle with pH-activated singlet oxygen generation and superb biocompatibility for cancer therapy. Biomacromolecules. 22:1167–1176. 2021. View Article : Google Scholar : PubMed/NCBI

57 

Jasim KA and Gesquiere AJ: Ultrastable and biofunctionalizable conjugated polymer nanoparticles with encapsulated iron for ferroptosis assisted chemodynamic therapy. Mol Pharm. 16:4852–4866. 2019. View Article : Google Scholar : PubMed/NCBI

58 

Kim SE, Zhang L, Ma K, Riegman M, Chen F, Ingold I, Conrad M, Turker MZ, Gao M, Jiang X, et al: Ultrasmall nanoparticles induce ferroptosis in nutrient-deprived cancer cells and suppress tumour growth. Nat Nanotechnol. 11:977–985. 2016. View Article : Google Scholar : PubMed/NCBI

59 

Wang Y, Yu L, Ding J and Chen Y: Iron metabolism in cancer. Int J Mol Sci. 20:952018. View Article : Google Scholar : PubMed/NCBI

60 

Bian Z, Hann HW, Ye Z, Yin C, Wang Y, Fang W, Wan S, Wang C and Tao K: Ferritin level prospectively predicts hepatocarcinogenesis in patients with chronic hepatitis B virus infection. Oncol Lett. 16:3499–3508. 2018.PubMed/NCBI

61 

Song A, Eo W, Kim S, Shim B and Lee S: Significance of serum ferritin as a prognostic factor in advanced hepatobiliary cancer patients treated with Korean medicine: A retrospective cohort study. BMC Complement Altern Med. 18:1762018. View Article : Google Scholar : PubMed/NCBI

62 

Guo W, Zhang S, Chen Y, Zhang D, Yuan L, Cong H and Liu S: An important role of the hepcidin-ferroportin signaling in affecting tumor growth and metastasis. Acta Biochim Biophys Sin (Shanghai). 47:703–715. 2015. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Yao F, Cui X, Zhang Y, Bei Z, Wang H, Zhao D, Wang H and Yang Y: Iron regulatory protein 1 promotes ferroptosis by sustaining cellular iron homeostasis in melanoma. Oncol Lett 22: 657, 2021.
APA
Yao, F., Cui, X., Zhang, Y., Bei, Z., Wang, H., Zhao, D. ... Yang, Y. (2021). Iron regulatory protein 1 promotes ferroptosis by sustaining cellular iron homeostasis in melanoma. Oncology Letters, 22, 657. https://doi.org/10.3892/ol.2021.12918
MLA
Yao, F., Cui, X., Zhang, Y., Bei, Z., Wang, H., Zhao, D., Wang, H., Yang, Y."Iron regulatory protein 1 promotes ferroptosis by sustaining cellular iron homeostasis in melanoma". Oncology Letters 22.3 (2021): 657.
Chicago
Yao, F., Cui, X., Zhang, Y., Bei, Z., Wang, H., Zhao, D., Wang, H., Yang, Y."Iron regulatory protein 1 promotes ferroptosis by sustaining cellular iron homeostasis in melanoma". Oncology Letters 22, no. 3 (2021): 657. https://doi.org/10.3892/ol.2021.12918
Copy and paste a formatted citation
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Spandidos Publications style
Yao F, Cui X, Zhang Y, Bei Z, Wang H, Zhao D, Wang H and Yang Y: Iron regulatory protein 1 promotes ferroptosis by sustaining cellular iron homeostasis in melanoma. Oncol Lett 22: 657, 2021.
APA
Yao, F., Cui, X., Zhang, Y., Bei, Z., Wang, H., Zhao, D. ... Yang, Y. (2021). Iron regulatory protein 1 promotes ferroptosis by sustaining cellular iron homeostasis in melanoma. Oncology Letters, 22, 657. https://doi.org/10.3892/ol.2021.12918
MLA
Yao, F., Cui, X., Zhang, Y., Bei, Z., Wang, H., Zhao, D., Wang, H., Yang, Y."Iron regulatory protein 1 promotes ferroptosis by sustaining cellular iron homeostasis in melanoma". Oncology Letters 22.3 (2021): 657.
Chicago
Yao, F., Cui, X., Zhang, Y., Bei, Z., Wang, H., Zhao, D., Wang, H., Yang, Y."Iron regulatory protein 1 promotes ferroptosis by sustaining cellular iron homeostasis in melanoma". Oncology Letters 22, no. 3 (2021): 657. https://doi.org/10.3892/ol.2021.12918
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