Open Access

Tumor suppressor RBM24 inhibits nuclear translocation of CTNNB1 and TP63 expression in liver cancer cells

  • Authors:
    • Sung Ung Moon
    • Jang Hyun Kim
    • Hyun Goo Woo
  • View Affiliations

  • Published online on: July 19, 2021     https://doi.org/10.3892/ol.2021.12935
  • Article Number: 674
  • Copyright: © Moon et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

RNA‑binding protein 24 (RBM24) has been shown to play tumor‑suppressive functions in various types of cancer. The present study aimed to investigate the role of RBM24 in liver cancers and its downstream mechanisms. The present study demonstrated that RBM24 functioned as a tumor suppressor in liver cancer cells, and inhibited nuclear translocation of β‑catenin and tumor protein 63 expression by immunocytochemistry. In addition, RBM24 could suppress sphere formation in a multicellular tumor spheroid model of liver cancer cells. In conclusion, it is hypothesized that RBM24 is a tumor suppressor of liver cancer cells, which could be a potential novel therapeutic target for treatment of patients with liver cancer.
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September-2021
Volume 22 Issue 3

Print ISSN: 1792-1074
Online ISSN:1792-1082

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Copy and paste a formatted citation
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Spandidos Publications style
Moon SU, Kim JH and Woo HG: Tumor suppressor RBM24 inhibits nuclear translocation of CTNNB1 and TP63 expression in liver cancer cells. Oncol Lett 22: 674, 2021
APA
Moon, S.U., Kim, J.H., & Woo, H.G. (2021). Tumor suppressor RBM24 inhibits nuclear translocation of CTNNB1 and TP63 expression in liver cancer cells. Oncology Letters, 22, 674. https://doi.org/10.3892/ol.2021.12935
MLA
Moon, S. U., Kim, J. H., Woo, H. G."Tumor suppressor RBM24 inhibits nuclear translocation of CTNNB1 and TP63 expression in liver cancer cells". Oncology Letters 22.3 (2021): 674.
Chicago
Moon, S. U., Kim, J. H., Woo, H. G."Tumor suppressor RBM24 inhibits nuclear translocation of CTNNB1 and TP63 expression in liver cancer cells". Oncology Letters 22, no. 3 (2021): 674. https://doi.org/10.3892/ol.2021.12935