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Tumor suppressor RBM24 inhibits nuclear translocation of CTNNB1 and TP63 expression in liver cancer cells

  • Authors:
    • Sung Ung Moon
    • Jang Hyun Kim
    • Hyun Goo Woo
  • View Affiliations / Copyright

    Affiliations: Department of Physiology, Ajou University School of Medicine, Suwon, Gyeonggi 16499, Republic of Korea
    Copyright: © Moon et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 674
    |
    Published online on: July 19, 2021
       https://doi.org/10.3892/ol.2021.12935
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Abstract

RNA‑binding protein 24 (RBM24) has been shown to play tumor‑suppressive functions in various types of cancer. The present study aimed to investigate the role of RBM24 in liver cancers and its downstream mechanisms. The present study demonstrated that RBM24 functioned as a tumor suppressor in liver cancer cells, and inhibited nuclear translocation of β‑catenin and tumor protein 63 expression by immunocytochemistry. In addition, RBM24 could suppress sphere formation in a multicellular tumor spheroid model of liver cancer cells. In conclusion, it is hypothesized that RBM24 is a tumor suppressor of liver cancer cells, which could be a potential novel therapeutic target for treatment of patients with liver cancer.
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1 

Ferlay J, Colombet M, Soerjomataram I, Mathers C, Parkin DM, Piñeros M, Znaor A and Bray F: Estimating the global cancer incidence and mortality in 2018: GLOBOCAN sources and methods. Int J Cancer. 144:1941–1953. 2019. View Article : Google Scholar : PubMed/NCBI

2 

Finn RS: Emerging targeted strategies in advanced hepatocellular carcinoma. Semin Liver Dis. 33 (Suppl 1):S11–S19. 2013. View Article : Google Scholar : PubMed/NCBI

3 

Daher S, Massarwa M, Benson AA and Khoury T: Current and future treatment of hepatocellular carcinoma: An updated comprehensive review. J Clin Transl Hepatol. 6:69–78. 2018. View Article : Google Scholar : PubMed/NCBI

4 

Wei P, Yang J, Zhang D, Cui M and Li L: lncRNA HAND2-AS1 regulates prostate cancer cell growth through targeting the miR-106a-5p/RBM24 axis. OncoTargets Ther. 13:4523–4531. 2020. View Article : Google Scholar : PubMed/NCBI

5 

Hua WF, Zhong Q, Xia TL, Chen Q, Zhang MY, Zhou AJ, Tu ZW, Qu C, Li MZ, Xia YF, et al: RBM24 suppresses cancer progression by upregulating miR-25 to target MALAT1 in nasopharyngeal carcinoma. Cell Death Dis. 7:e23522016. View Article : Google Scholar : PubMed/NCBI

6 

Kiledjian M, Wang X and Liebhaber SA: Identification of two KH domain proteins in the alpha-globin mRNP stability complex. EMBO J. 14:4357–4364. 1995. View Article : Google Scholar : PubMed/NCBI

7 

Collier B, Goobar-Larsson L, Sokolowski M and Schwartz S: Translational inhibition in vitro of human papillomavirus type 16 L2 mRNA mediated through interaction with heterogenous ribonucleoprotein K and poly(rC)-binding proteins 1 and 2. J Biol Chem. 273:22648–22656. 1998. View Article : Google Scholar : PubMed/NCBI

8 

Krecic AM and Swanson MS: hnRNP complexes: Composition, structure, and function. Curr Opin Cell Biol. 11:363–371. 1999. View Article : Google Scholar : PubMed/NCBI

9 

Wurth L: Versatility of RNA-binding proteins in cancer. Comp Funct Genomics. 2012:1785252012. View Article : Google Scholar : PubMed/NCBI

10 

Zhang D, Ma Y, Ma Z, Liu S, Sun L, Li J, Zhao F, Li Y, Zhang J, Li S, et al: Circular RNA SMARCA5 suppressed non small cell lung cancer progression by regulating miR 670 5p/RBM24 axis. Acta Biochim Biophys Sin (Shanghai). 52:1071–1080. 2020. View Article : Google Scholar : PubMed/NCBI

11 

Jiang Y, Zhang M, Qian Y, Xu E, Zhang J and Chen X: Rbm24, an RNA-binding protein and a target of p53, regulates p21 expression via mRNA stability. J Biol Chem. 289:3164–3175. 2014. View Article : Google Scholar : PubMed/NCBI

12 

Xu E, Zhang J, Zhang M, Jiang Y, Cho SJ and Chen X: RNA-binding protein RBM24 regulates p63 expression via mRNA stability. Mol Cancer Res. 12:359–369. 2014. View Article : Google Scholar : PubMed/NCBI

13 

Ruptier C, De Gaspéris A, Ansieau S, Granjon A, Tanière P, Lafosse I, Shi H, Petitjean A, Taranchon-Clermont E, Tribollet V, et al: TP63 P2 promoter functional analysis identifies β-catenin as a key regulator of ΔNp63 expression. Oncogene. 30:4656–4665. 2011. View Article : Google Scholar : PubMed/NCBI

14 

Massion PP, Taflan PM, Jamshedur Rahman SM, Yildiz P, Shyr Y, Edgerton ME, Westfall MD, Roberts JR, Pietenpol JA, Carbone DP, et al: Significance of p63 amplification and overexpression in lung cancer development and prognosis. Cancer Res. 63:7113–7121. 2003.PubMed/NCBI

15 

Nekulova M, Holcakova J, Coates P and Vojtesek B: The role of p63 in cancer, stem cells and cancer stem cells. Cell Mol Biol Lett. 16:296–327. 2011. View Article : Google Scholar : PubMed/NCBI

16 

Liang Y, Chen J, Yu Q, Ji T, Zhang B, Xu J, Dai Y, Xie Y, Lin H, Liang X, et al: Phosphorylated ERK is a potential prognostic biomarker for Sorafenib response in hepatocellular carcinoma. Cancer Med. 6:2787–2795. 2017. View Article : Google Scholar : PubMed/NCBI

17 

Chaleshi V, Asadzadeh Aghdaei H, Nourian M, Iravani S, Jalaeikhoo H, Rajaeinejad M, Khoshdel AR and Naghoosi H: Association of MALAT1 expression in gastric carcinoma and the significance of its clinicopathologic features in an Iranian patient. Gastroenterol Hepatol Bed Bench. 14:108–114. 2021.PubMed/NCBI

18 

Seo HR: Roles of tumor microenvironment in hepatocellular carcinoma. Curr Med Chem. 11:82–93. 2015.

19 

Song Y, Kim SH, Kim KM, Choi EK, Kim J and Seo HR: Activated hepatic stellate cells play pivotal roles in hepatocellular carcinoma cell chemoresistance and migration in multicellular tumor spheroids. Sci Rep. 6:367502016. View Article : Google Scholar : PubMed/NCBI

20 

Carotenuto P, Fassan M, Pandolfo R, Lampis A, Vicentini C, Cascione L, Paulus-Hock V, Boulter L, Guest R, Quagliata L, et al: Wnt signalling modulates transcribed-ultraconserved regions in hepatobiliary cancers. Gut. 66:1268–1277. 2017. View Article : Google Scholar : PubMed/NCBI

21 

Oh JJ, Taschereau EO, Koegel AK, Ginther CL, Rotow JK, Isfahani KZ and Slamon DJ: RBM5/H37 tumor suppressor, located at the lung cancer hot spot 3p21.3, alters expression of genes involved in metastasis. Lung Cancer. 70:253–262. 2010. View Article : Google Scholar : PubMed/NCBI

22 

Sutherland LC, Wang K and Robinson AG: RBM5 as a putative tumor suppressor gene for lung cancer. J Thorac Oncol. 5:294–298. 2010. View Article : Google Scholar : PubMed/NCBI

23 

Mourtada-Maarabouni M, Keen J, Clark J, Cooper CS and Williams GT: Candidate tumor suppressor LUCA-15/RBM5/H37 modulates expression of apoptosis and cell cycle genes. Exp Cell Res. 312:1745–1752. 2006. View Article : Google Scholar : PubMed/NCBI

24 

Shu L, Yan W and Chen X: RNPC1, an RNA-binding protein and a target of the p53 family, is required for maintaining the stability of the basal and stress-induced p21 transcript. Genes Dev. 20:2961–2972. 2006. View Article : Google Scholar : PubMed/NCBI

25 

Drewelus I, Göpfert C, Hippel C, Dickmanns A, Damianitsch K, Pieler T and Dobbelstein M: p63 antagonizes Wnt-induced transcription. Cell Cycle. 9:580–587. 2010. View Article : Google Scholar : PubMed/NCBI

26 

Katoh M and Katoh M: WNT signaling pathway and stem cell signaling network. Clin Cancer Res. 13:4042–4045. 2007. View Article : Google Scholar : PubMed/NCBI

27 

Zucchi I, Astigiano S, Bertalot G, Sanzone S, Cocola C, Pelucchi P, Bertoli G, Stehling M, Barbieri O, Albertini A, et al: Distinct populations of tumor-initiating cells derived from a tumor generated by rat mammary cancer stem cells. Proc Natl Acad Sci USA. 105:16940–16945. 2008. View Article : Google Scholar : PubMed/NCBI

28 

Cléry A, Blatter M and Allain FH: RNA recognition motifs: Boring? Not quite. Curr Opin Struct Biol. 18:290–298. 2008. View Article : Google Scholar

29 

Sayan BS, Sayan AE, Yang AL, Aqeilan RI, Candi E, Cohen GM, Knight RA, Croce CM and Melino G: Cleavage of the transactivation-inhibitory domain of p63 by caspases enhances apoptosis. Proc Natl Acad Sci USA. 104:10871–10876. 2007. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Moon SU, Kim JH and Woo HG: Tumor suppressor RBM24 inhibits nuclear translocation of CTNNB1 and TP63 expression in liver cancer cells. Oncol Lett 22: 674, 2021.
APA
Moon, S.U., Kim, J.H., & Woo, H.G. (2021). Tumor suppressor RBM24 inhibits nuclear translocation of CTNNB1 and TP63 expression in liver cancer cells. Oncology Letters, 22, 674. https://doi.org/10.3892/ol.2021.12935
MLA
Moon, S. U., Kim, J. H., Woo, H. G."Tumor suppressor RBM24 inhibits nuclear translocation of CTNNB1 and TP63 expression in liver cancer cells". Oncology Letters 22.3 (2021): 674.
Chicago
Moon, S. U., Kim, J. H., Woo, H. G."Tumor suppressor RBM24 inhibits nuclear translocation of CTNNB1 and TP63 expression in liver cancer cells". Oncology Letters 22, no. 3 (2021): 674. https://doi.org/10.3892/ol.2021.12935
Copy and paste a formatted citation
x
Spandidos Publications style
Moon SU, Kim JH and Woo HG: Tumor suppressor RBM24 inhibits nuclear translocation of CTNNB1 and TP63 expression in liver cancer cells. Oncol Lett 22: 674, 2021.
APA
Moon, S.U., Kim, J.H., & Woo, H.G. (2021). Tumor suppressor RBM24 inhibits nuclear translocation of CTNNB1 and TP63 expression in liver cancer cells. Oncology Letters, 22, 674. https://doi.org/10.3892/ol.2021.12935
MLA
Moon, S. U., Kim, J. H., Woo, H. G."Tumor suppressor RBM24 inhibits nuclear translocation of CTNNB1 and TP63 expression in liver cancer cells". Oncology Letters 22.3 (2021): 674.
Chicago
Moon, S. U., Kim, J. H., Woo, H. G."Tumor suppressor RBM24 inhibits nuclear translocation of CTNNB1 and TP63 expression in liver cancer cells". Oncology Letters 22, no. 3 (2021): 674. https://doi.org/10.3892/ol.2021.12935
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