Lanatoside C inhibits human cervical cancer cell proliferation and induces cell apoptosis by a reduction of the JAK2/STAT6/SOCS2 signaling pathway

  • Authors:
    • Yingchun Duan
    • Li Chen
    • Juan Shao
    • Cui Jiang
    • Yingmei Zhao
    • Yanyi Li
    • Huihui Ke
    • Rui Zhang
    • Jianlong Zhu
    • Minghua Yu
  • View Affiliations

  • Published online on: August 17, 2021     https://doi.org/10.3892/ol.2021.13001
  • Article Number: 740
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Abstract

Cervical cancer is one of the leading causes of cancer‑associated mortality in gynecological diseases and ranks third among female cancers worldwide. Although early detection and vaccination have reduced incidence rates, cancer recurrence and metastasis lead to high mortality due to the lack of effective medicines. The present study aimed to identify novel drug candidates to treat cervical cancer. In the present study, lanatoside C, an FDA‑approved cardiac glycoside used for the treatment of heart failure, was demonstrated to have anti‑proliferative and cytotoxic effects on cervical cancer cells, with abrogation of cell migration in a dose‑dependent manner. Lanatoside C also triggered cell apoptosis by enhancing reactive oxygen species production and reducing the mitochondrial membrane potential, which induced cell cycle arrest at the S and G2/M phases. Furthermore, lanatoside C inhibited the phosphorylation of Janus kinase 2 (JAK2) and signal transducer and activator of transcription 6 (STAT6), while inducing the expression of suppressor of cytokine signaling 2, a negative regulator of JAK2‑STAT6 signaling. Taken together, the results of the present study suggest that lanatoside C suppresses cell proliferation and induces cell apoptosis by inhibiting JAK2‑STAT6 signaling, indicating that lanatoside C is a promising agent for the treatment of cervical cancer.
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October-2021
Volume 22 Issue 4

Print ISSN: 1792-1074
Online ISSN:1792-1082

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Spandidos Publications style
Duan Y, Chen L, Shao J, Jiang C, Zhao Y, Li Y, Ke H, Zhang R, Zhu J, Yu M, Yu M, et al: Lanatoside C inhibits human cervical cancer cell proliferation and induces cell apoptosis by a reduction of the JAK2/STAT6/SOCS2 signaling pathway. Oncol Lett 22: 740, 2021
APA
Duan, Y., Chen, L., Shao, J., Jiang, C., Zhao, Y., Li, Y. ... Yu, M. (2021). Lanatoside C inhibits human cervical cancer cell proliferation and induces cell apoptosis by a reduction of the JAK2/STAT6/SOCS2 signaling pathway. Oncology Letters, 22, 740. https://doi.org/10.3892/ol.2021.13001
MLA
Duan, Y., Chen, L., Shao, J., Jiang, C., Zhao, Y., Li, Y., Ke, H., Zhang, R., Zhu, J., Yu, M."Lanatoside C inhibits human cervical cancer cell proliferation and induces cell apoptosis by a reduction of the JAK2/STAT6/SOCS2 signaling pathway". Oncology Letters 22.4 (2021): 740.
Chicago
Duan, Y., Chen, L., Shao, J., Jiang, C., Zhao, Y., Li, Y., Ke, H., Zhang, R., Zhu, J., Yu, M."Lanatoside C inhibits human cervical cancer cell proliferation and induces cell apoptosis by a reduction of the JAK2/STAT6/SOCS2 signaling pathway". Oncology Letters 22, no. 4 (2021): 740. https://doi.org/10.3892/ol.2021.13001