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CRMP5 regulates cell proliferation and development of colorectal cancer via MAPK‑dependent signaling

  • Authors:
    • Fanghua Qiu
    • Lin Yu
    • Daoli Liu
    • Yujin Wu
    • Feng Qiu
  • View Affiliations / Copyright

    Affiliations: Department of Infection Control, Guangzhou Hospital of Traditional Chinese Medicine, Guangzhou, Guangdong 510130, P.R. China, Department of Clinical Laboratory, The First Affiliated Hospital of Guangzhou Medical University, Guangzhou 510120, P.R. China, Department of Clinical Laboratory, Guangzhou Hospital of Traditional Chinese Medicine, Guangzhou, Guangdong 510130, P.R. China, Department of Spleen and Gastroenterology, Guangzhou Hospital of Traditional Chinese Medicine, Guangzhou, Guangdong 510130, P.R. China, Department of Laboratory Medicine, Nanhai Hospital, Southern Medical University, Foshan, Guangdong, 528244, P.R. China
    Copyright: © Qiu et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 747
    |
    Published online on: August 24, 2021
       https://doi.org/10.3892/ol.2021.13008
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Abstract

Colorectal cancer (CRC) is one of the most common malignancies worldwide. Collapsin response mediator protein 5 (CRMP5) belongs to a family of five cytosolic proteins that serve a major role in neural development. CRMP5 has been identified as a biomarker of numerous cancer types, including lung cancer and glioblastoma. However, the role of CRMP5 in CRC remains unclear. In the present study, CRMP5 was characterized as a novel biomarker of poor survival in CRC. CRMP5‑overexpression in CRC cells promoted cell proliferation and migration while CPMP5‑knockdown decreased cell growth and migration. A novel mechanism was uncovered, by which CRMP5 regulates MAPK signaling to drive CRC cell proliferation and development. Furthermore, CRMP5‑overexpression induced chemotherapy resistance and tumor recurrence in CRC. Taken together, these results demonstrated the important role of CRMP5 in the development and proliferation of CRC cells and suggested that CRMP5 may be a novel therapeutic target for CRC.
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Copy and paste a formatted citation
Spandidos Publications style
Qiu F, Yu L, Liu D, Wu Y and Qiu F: CRMP5 regulates cell proliferation and development of colorectal cancer via MAPK‑dependent signaling. Oncol Lett 22: 747, 2021.
APA
Qiu, F., Yu, L., Liu, D., Wu, Y., & Qiu, F. (2021). CRMP5 regulates cell proliferation and development of colorectal cancer via MAPK‑dependent signaling. Oncology Letters, 22, 747. https://doi.org/10.3892/ol.2021.13008
MLA
Qiu, F., Yu, L., Liu, D., Wu, Y., Qiu, F."CRMP5 regulates cell proliferation and development of colorectal cancer via MAPK‑dependent signaling". Oncology Letters 22.5 (2021): 747.
Chicago
Qiu, F., Yu, L., Liu, D., Wu, Y., Qiu, F."CRMP5 regulates cell proliferation and development of colorectal cancer via MAPK‑dependent signaling". Oncology Letters 22, no. 5 (2021): 747. https://doi.org/10.3892/ol.2021.13008
Copy and paste a formatted citation
x
Spandidos Publications style
Qiu F, Yu L, Liu D, Wu Y and Qiu F: CRMP5 regulates cell proliferation and development of colorectal cancer via MAPK‑dependent signaling. Oncol Lett 22: 747, 2021.
APA
Qiu, F., Yu, L., Liu, D., Wu, Y., & Qiu, F. (2021). CRMP5 regulates cell proliferation and development of colorectal cancer via MAPK‑dependent signaling. Oncology Letters, 22, 747. https://doi.org/10.3892/ol.2021.13008
MLA
Qiu, F., Yu, L., Liu, D., Wu, Y., Qiu, F."CRMP5 regulates cell proliferation and development of colorectal cancer via MAPK‑dependent signaling". Oncology Letters 22.5 (2021): 747.
Chicago
Qiu, F., Yu, L., Liu, D., Wu, Y., Qiu, F."CRMP5 regulates cell proliferation and development of colorectal cancer via MAPK‑dependent signaling". Oncology Letters 22, no. 5 (2021): 747. https://doi.org/10.3892/ol.2021.13008
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