Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Oncology Letters
      • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Biomedical Reports
      • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • Information for Authors
    • Information for Reviewers
    • Information for Librarians
    • Information for Advertisers
    • Conferences
  • Language Editing
Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • For Authors
    • For Reviewers
    • For Librarians
    • For Advertisers
    • Conferences
  • Language Editing
Login Register Submit
  • This site uses cookies
  • You can change your cookie settings at any time by following the instructions in our Cookie Policy. To find out more, you may read our Privacy Policy.

    I agree
Search articles by DOI, keyword, author or affiliation
Search
Advanced Search
presentation
Oncology Letters
Join Editorial Board Propose a Special Issue
Print ISSN: 1792-1074 Online ISSN: 1792-1082
Journal Cover
November-2021 Volume 22 Issue 5

Full Size Image

Sign up for eToc alerts
Recommend to Library

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
November-2021 Volume 22 Issue 5

Full Size Image

Sign up for eToc alerts
Recommend to Library

  • Article
  • Citations
    • Cite This Article
    • Download Citation
    • Create Citation Alert
    • Remove Citation Alert
    • Cited By
  • Similar Articles
    • Related Articles (in Spandidos Publications)
    • Similar Articles (Google Scholar)
    • Similar Articles (PubMed)
  • Download PDF
  • Download XML
  • View XML
Article Open Access

Knockdown of lncRNA C5orf66‑AS1 inhibits osteosarcoma cell proliferation and invasion via miR‑149‑5p upregulation

Corrigendum in: /10.3892/ol.2025.15000
  • Authors:
    • Hui Zhang
    • Jie Song
  • View Affiliations / Copyright

    Affiliations: Department of Orthopedics, Huangshi Central Hospital, Affiliated Hospital of Hubei Polytechnic University, Edong Healthcare Group, Huangshi, Hubei 435000, P.R. China, Department of Geriatrics, Huangshi Central Hospital, Affiliated Hospital of Hubei Polytechnic University, Edong Healthcare Group, Huangshi, Hubei 435000, P.R. China
    Copyright: © Zhang et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 757
    |
    Published online on: September 2, 2021
       https://doi.org/10.3892/ol.2021.13018
  • Expand metrics +
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
Cited By (CrossRef): 0 citations Loading Articles...

This article is mentioned in:



Abstract

Osteosarcoma (OS) is the most common primary malignant bone tumor in the pediatric age group. Despite the various potential treatments for OS, the cure rate of patients with OS remains very low. An increasing number of long non‑coding RNAs (lncRNAs) have been identified as key regulators of the progression of malignant human tumors. However, the biological functions of the lncRNA C5orf66‑antisense 1 (C5orf66‑AS1) in OS are yet to be fully elucidated. The present study aimed to investigate the functions and underlying mechanisms of C5orf66‑AS1 in OS tissues and cell lines. Expression levels of C5orf66‑AS1 and microRNA (miRNA/miR)‑149‑5p in tissues from patients with OS and OS cells lines were evaluated using reverse transcription quantitative (RT‑q)PCR. The miRNA target interaction between C5orf66‑AS1 and miR‑149‑5p was predicted and verified using StarBase and dual‑luciferase reporter assays. Cell viability, migration, invasion and apoptosis were analyzed using Cell Counting Kit‑8, Transwell assays and flow cytometry, respectively. In addition, the expression levels of migration‑ and apoptosis‑associated proteins [matrix metalloproteinase‑9 (MMP‑9), Bcl‑2 and Bax] were determined using western blotting and RT‑qPCR. The results demonstrated that C5orf66‑AS1 was significantly upregulated and miR‑149‑5p was significantly downregulated in OS tissues and cells (MG63 and U2OS). Bioinformatics analysis further confirmed that miR‑149‑5p could directly bind to C5orf66‑AS1. Furthermore, it was revealed that C5orf66‑AS1 negatively regulated the expression of miR‑149‑5p in OS cells, as confirmed by the inhibition of C5orf66‑AS1 expression and miR‑149‑5p upregulation in cells transfected with small interfering (si RNA targeting C5orf66‑AS1. In addition, C5orf66‑AS1 silencing significantly inhibited the proliferation, invasion and migration of U2OS cells, and stimulated cell apoptosis. These findings were reversed using miR‑149‑5p inhibitor. Increased Bax expression and decreased Bcl‑2 and MMP‑9 expression were also observed in C5orf66‑AS1‑siRNA transfected U2OS cells, compared with the control group. In summary, the results from the present study indicated that C5orf66‑AS1 knockdown inhibits OS cell proliferation and invasion via the upregulation of miR‑149‑5p. This findings may provide a promising novel target for the treatment of OS.
View Figures

Figure 1

Figure 2

Figure 3

Figure 4

Figure 5

Figure 6

View References

1 

Yap FHX, Amanuel B, Van Vliet C, Thomas M and Wong D: Malignant transformation of fibrous dysplasia into osteosarcoma confirmed with TP53 somatic mutation and mutational analysis of GNAS gene. Pathology. 53:652–654. 2021. View Article : Google Scholar : PubMed/NCBI

2 

Geary RL, Corrigan LR, Carney DN and Higgins MJ: Osteosarcoma and second malignant neoplasms: A case series. Ir J Med Sci. 188:1163–1167. 2019. View Article : Google Scholar : PubMed/NCBI

3 

Wu ZJ, Tan JC, Qin X, Liu B and Yuan ZC: Significance of circulating tumor cells in osteosarcoma patients treated by neoadjuvant chemotherapy and surgery. Cancer Manag Res. 10:3333–3339. 2018. View Article : Google Scholar : PubMed/NCBI

4 

Hız M, Karaismailoglu B, Ulutas S, Camurdan VB, Gorgun B and Oner Dincbas F: The effect of preoperative radiotherapy on local control and prognosis in high-grade non-metastatic intramedullary osteosarcoma of the extremities. Arch Orthop Trauma Surg. 141:1083–1089. 2021. View Article : Google Scholar : PubMed/NCBI

5 

Zhang B and Zhang Y, Li R, Li J, Lu X and Zhang Y: The efficacy and safety comparison of first-line chemotherapeutic agents (high-dose methotrexate, doxorubicin, cisplatin, and ifosfamide) for osteosarcoma: A network meta-analysis. J Orthop Surg Res. 15:512020. View Article : Google Scholar : PubMed/NCBI

6 

Rainusso N, Wang LL and Yustein JT: The adolescent and young adult with cancer: State of the art - bone tumors. Curr Oncol Rep. 15:296–307. 2013. View Article : Google Scholar : PubMed/NCBI

7 

Liao YX, Yu HY, Lv JY, Cai YR, Liu F, He ZM and He SS: Targeting autophagy is a promising therapeutic strategy to overcome chemoresistance and reduce metastasis in osteosarcoma. Int J Oncol. 55:1213–1222. 2019.PubMed/NCBI

8 

Zhou B, Li L, Qiu X, Wu J, Xu L and Shao W: Long non-coding RNA ANRIL knockdown suppresses apoptosis and pro-inflammatory cytokines while enhancing neurite outgrowth via binding microRNA-125a in a cellular model of Alzheimer's disease. Mol Med Rep. 22:1489–1497. 2020. View Article : Google Scholar : PubMed/NCBI

9 

Long X, Li L, Zhou Q, Wang H, Zou D, Wang D, Lou M and Nian W: Long non-coding RNA LSINCT5 promotes ovarian cancer cell proliferation, migration and invasion by disrupting the CXCL12/CXCR4 signalling axis. Oncol Lett. 15:7200–7206. 2018.PubMed/NCBI

10 

Song B, Ye L, Wu S and Jing Z: Long non-coding RNA MEG3 regulates CSE-induced apoptosis and inflammation via regulating miR-218 in 16HBE cells. Biochem Biophys Res Commun. 521:368–374. 2020. View Article : Google Scholar : PubMed/NCBI

11 

Wang PS, Wang Z and Yang C: Dysregulations of long non-coding RNAs - The emerging ‘lnc’ in environmental carcinogenesis. Semin Cancer Biol. Apr 3–2021.(Epub ahead of print). doi: 10.1016/j.semcancer.2021.03.029. View Article : Google Scholar

12 

Bhan A, Soleimani M and Mandal SS: Long Noncoding RNA and Cancer: A New Paradigm. Cancer Res. 77:3965–3981. 2017. View Article : Google Scholar : PubMed/NCBI

13 

Rajagopal T, Talluri S, Akshaya RL and Dunna NR: HOTAIR lncRNA: A novel oncogenic propellant in human cancer. Clin Chim Acta. 503:1–18. 2020. View Article : Google Scholar : PubMed/NCBI

14 

Rui X, Xu Y, Jiang X, Ye W, Huang Y and Jiang J: Long non-coding RNA C5orf66-AS1 promotes cell proliferation in cervical cancer by targeting miR-637/RING1 axis. Cell Death Dis. 9:11752018. View Article : Google Scholar : PubMed/NCBI

15 

Lu T, Liu H and You G: Long non-coding RNA C5orf66-AS1 prevents oral squamous cell carcinoma through inhibiting cell growth and metastasis. Int J Mol Med. 42:3291–3299. 2018.PubMed/NCBI

16 

Tang XJ, Wang W and Hann SS: Interactions among lncRNAs, miRNAs and mRNA in colorectal cancer. Biochimie. 163:58–72. 2019. View Article : Google Scholar : PubMed/NCBI

17 

Wang Y, Shen S, Li Z, Li W and Weng X: MIR-140-5p affects chondrocyte proliferation, apoptosis, and inflammation by targeting HMGB1 in osteoarthritis. Inflamm Res. 69:63–73. 2020. View Article : Google Scholar : PubMed/NCBI

18 

Xu WX, Liu Z, Deng F, Wang DD, Li XW, Tian T, Zhang J and Tang JH: miR-145: A potential biomarker of cancer migration and invasion. Am J Transl Res. 11:6739–6753. 2019.PubMed/NCBI

19 

Gulino R, Forte S, Parenti R, Memeo L and Gulisano M: MicroRNA and pediatric tumors: Future perspectives. Acta Histochem. 117:339–354. 2015. View Article : Google Scholar : PubMed/NCBI

20 

Llobat L and Gourbault O: Role of microRNAs in human osteosarcoma: Future perspectives. Biomedicines. 9:4632021. View Article : Google Scholar : PubMed/NCBI

21 

Wang J, Liu S, Shi J, Li J, Wang S, Liu H, Zhao S, Duan K, Pan X and Yi Z: The Role of miRNA in the Diagnosis, Prognosis, and Treatment of Osteosarcoma. Cancer Biother Radiopharm. 34:605–613. 2019. View Article : Google Scholar : PubMed/NCBI

22 

Luo K, He J, Yu D and Açil Y: miR-149-5p regulates cisplatin chemosensitivity, cell growth, and metastasis of oral squamous cell carcinoma cells by targeting TGFβ2. Int J Clin Exp Pathol. 12:3728–3739. 2019.PubMed/NCBI

23 

Ye X and Chen X: miR-149-5p inhibits cell proliferation and invasion through targeting GIT1 in medullary thyroid carcinoma. Oncol Lett. 17:372–378. 2019.PubMed/NCBI

24 

Livak KJ and Schmittgen TD: Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) Method. Methods. 25:402–408. 2001. View Article : Google Scholar : PubMed/NCBI

25 

Zhang C, Ma K and Li WY: IL-6 promotes cancer stemness and oncogenicity in U2OS and MG-63 osteosarcoma cells by upregulating the OPN-STAT3 pathway. J Cancer. 10:6511–6525. 2019. View Article : Google Scholar : PubMed/NCBI

26 

Ozturk S, Gorgun C, Gokalp S, Vatansever S and Sendemir A: Development and characterization of cancer stem cell-based tumoroids as an osteosarcoma model. Biotechnol Bioeng. 117:2527–2539. 2020. View Article : Google Scholar : PubMed/NCBI

27 

Anderson PM: Radiopharmaceuticals for treatment of osteosarcoma. Adv Exp Med Biol. 1257:45–53. 2020. View Article : Google Scholar : PubMed/NCBI

28 

Heng M, Gupta A, Chung PW, Healey JH, Vaynrub M, Rose PS, Houdek MT, Lin PP, Bishop AJ, Hornicek FJ, et al Japanese Musculoskeletal Oncology Group (JMOG); Soft Tissue Osteosarcoma International Collaborative (STOIC), : The role of chemotherapy and radiotherapy in localized extraskeletal osteosarcoma. Eur J Cancer. 125:130–141. 2020. View Article : Google Scholar : PubMed/NCBI

29 

Huang YF, Lu L, Shen HL and Lu XX: lncRNA SNHG4 promotes osteosarcoma proliferation and migration by sponging miR-377-3p. Mol Genet Genomic Med. 8:e13492020. View Article : Google Scholar : PubMed/NCBI

30 

Yang Y, Fei M, Zhou X, Li Y and Jin D: The potential value of lncRNA-BC050642 in osteosarcoma origination and outcomes. Artif Cells Nanomed Biotechnol. 47:1859–1866. 2019. View Article : Google Scholar : PubMed/NCBI

31 

Zhou Q, Li H, Jing J, Yuan Y and Sun L: Evaluation of C5orf66-AS1 as a potential biomarker for predicting early gastric cancer and its role in gastric carcinogenesis. OncoTargets Ther. 13:2795–2805. 2020. View Article : Google Scholar : PubMed/NCBI

32 

Yu G, Li C, Xie W, Wang Z, Gao H, Cao L, Hao L and Zhang Y: Long non-coding RNA C5orf66-AS1 is downregulated in pituitary null cell adenomas and is associated with their invasiveness. Oncol Rep. 38:1140–1148. 2017. View Article : Google Scholar : PubMed/NCBI

33 

Zhou Y, Yin L, Li H, Liu LH and Xiao T: The lncRNA LINC00963 facilitates osteosarcoma proliferation and invasion by suppressing miR-204-3p/FN1 axis. Cancer Biol Ther. 20:1141–1148. 2019. View Article : Google Scholar : PubMed/NCBI

34 

Xiaobo Z, Qizhi H, Zhiping W and Tao D: Down-regulated miR-149-5p contributes to preeclampsia via modulating endoglin expression. Pregnancy Hypertens. 15:201–208. 2019. View Article : Google Scholar : PubMed/NCBI

35 

Xu M, Xiao J, Chen M, Yuan L, Li J, Shen H and Yao S: miR-149-5p promotes chemotherapeutic resistance in ovarian cancer via the inactivation of the Hippo signaling pathway. Int J Oncol. 52:815–827. 2018.PubMed/NCBI

36 

Jiang J, Xie C, Liu Y, Shi Q and Chen Y: Up-regulation of miR-383-5p suppresses proliferation and enhances chemosensitivity in ovarian cancer cells by targeting TRIM27. Biomed Pharmacother. 109:595–601. 2019. View Article : Google Scholar : PubMed/NCBI

37 

Marín-Béjar O, Mas AM, González J, Martinez D, Athie A, Morales X, Galduroz M, Raimondi I, Grossi E, Guo S, Rouzaut A, Ulitsky I and Huarte M: The human lncRNA LINC-PINT inhibits tumor cell invasion through a highly conserved sequence element. Genome Biol. 18:1–15. 2017. View Article : Google Scholar : PubMed/NCBI

38 

Liu Y, Yang Y, Li L, Liu Y, Geng P, Li G and Song H: lncRNA SNHG1 enhances cell proliferation, migration, and invasion in cervical cancer. Biochem Cell Biol. 96:38–43. 2018. View Article : Google Scholar : PubMed/NCBI

39 

Russo A, Cardile V, Graziano ACE, Avola R, Bruno M and Rigano D: Involvement of Bax and Bcl-2 in induction of apoptosis by essential oils of three lebanese salvia species in human prostate cancer cells. Int J Mol Sci. 19:E2922018. View Article : Google Scholar

40 

Zhang W, Li JZ, Tai QY, Tang JJ, Huang YH and Gao SB: lncRNA DANCR regulates osteosarcoma migration and invasion by targeting miR-149/MSI2 axis. Eur Rev Med Pharmacol Sci. 24:6551–6560. 2020.PubMed/NCBI

41 

Chao Y, Hu K, Wang X and Wang L: MicroRNA-552 promotes migration and invasion of osteosarcoma through targeting TIMP2. Biochem Biophys Res Commun. 511:63–68. 2019. View Article : Google Scholar : PubMed/NCBI

42 

Chen T, Chen Z, Lian X, Wu W, Chu L, Zhang S and Wang L: MUC 15 Promotes osteosarcoma cell proliferation, migration and invasion through Livin, MMP-2/MMP-9 and Wnt/β-catenin signal pathway. J Cancer. 12:467–473. 2021. View Article : Google Scholar : PubMed/NCBI

Related Articles

  • Abstract
  • View
  • Download
  • Twitter
Copy and paste a formatted citation
Spandidos Publications style
Zhang H and Song J: Knockdown of lncRNA C5orf66‑AS1 inhibits osteosarcoma cell proliferation and invasion via miR‑149‑5p upregulation Corrigendum in /10.3892/ol.2025.15000. Oncol Lett 22: 757, 2021.
APA
Zhang, H., & Song, J. (2021). Knockdown of lncRNA C5orf66‑AS1 inhibits osteosarcoma cell proliferation and invasion via miR‑149‑5p upregulation Corrigendum in /10.3892/ol.2025.15000. Oncology Letters, 22, 757. https://doi.org/10.3892/ol.2021.13018
MLA
Zhang, H., Song, J."Knockdown of lncRNA C5orf66‑AS1 inhibits osteosarcoma cell proliferation and invasion via miR‑149‑5p upregulation Corrigendum in /10.3892/ol.2025.15000". Oncology Letters 22.5 (2021): 757.
Chicago
Zhang, H., Song, J."Knockdown of lncRNA C5orf66‑AS1 inhibits osteosarcoma cell proliferation and invasion via miR‑149‑5p upregulation Corrigendum in /10.3892/ol.2025.15000". Oncology Letters 22, no. 5 (2021): 757. https://doi.org/10.3892/ol.2021.13018
Copy and paste a formatted citation
x
Spandidos Publications style
Zhang H and Song J: Knockdown of lncRNA C5orf66‑AS1 inhibits osteosarcoma cell proliferation and invasion via miR‑149‑5p upregulation Corrigendum in /10.3892/ol.2025.15000. Oncol Lett 22: 757, 2021.
APA
Zhang, H., & Song, J. (2021). Knockdown of lncRNA C5orf66‑AS1 inhibits osteosarcoma cell proliferation and invasion via miR‑149‑5p upregulation Corrigendum in /10.3892/ol.2025.15000. Oncology Letters, 22, 757. https://doi.org/10.3892/ol.2021.13018
MLA
Zhang, H., Song, J."Knockdown of lncRNA C5orf66‑AS1 inhibits osteosarcoma cell proliferation and invasion via miR‑149‑5p upregulation Corrigendum in /10.3892/ol.2025.15000". Oncology Letters 22.5 (2021): 757.
Chicago
Zhang, H., Song, J."Knockdown of lncRNA C5orf66‑AS1 inhibits osteosarcoma cell proliferation and invasion via miR‑149‑5p upregulation Corrigendum in /10.3892/ol.2025.15000". Oncology Letters 22, no. 5 (2021): 757. https://doi.org/10.3892/ol.2021.13018
Follow us
  • Twitter
  • LinkedIn
  • Facebook
About
  • Spandidos Publications
  • Careers
  • Cookie Policy
  • Privacy Policy
How can we help?
  • Help
  • Live Chat
  • Contact
  • Email to our Support Team