The mechanism of non‑coding RNAs in medulloblastoma (Review)
- Ying-Nan Zhao
- Kun Li
- Xing-Sheng Han
- Ya-Wen Pan
Affiliations: The Second Medical College of Lanzhou University, Lanzhou, Gansu 730030, P.R. China
- Published online on: September 2, 2021 https://doi.org/10.3892/ol.2021.13019
Copyright: © Zhao
et al. This is an open access article distributed under the
terms of Creative
Commons Attribution License.
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Medulloblastoma (MB) is one of the most common malignant tumors of the central nervous system in children. Although surgery, radiotherapy and chemotherapy have resulted in considerable progress in the treatment of this disease, the prognosis of patients with MB remains very poor. Therefore, highly specific molecular targeted treatment, which can improve the therapeutic efficacy and reduce the side effects of MB, has become a research hotspot. In recent years, non‑coding RNAs (ncRNAs), which were initially considered to be transcriptional noise, have been shown to possess regulatory functions. A series of ncRNAs have been identified, including microRNAs and circular RNAs, which affect the expression of specific genes in a variety of tumors. These genes lead to the formation of a specific complex of proteins or they directly participate in protein synthesis in order to regulate the occurrence and development of tumors. The aim of the present review article was to summarize the recent research studies that have explored the ability of ncRNAs to regulate the occurrence and development of MB.