Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Oncology Letters
      • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Biomedical Reports
      • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • Information for Authors
    • Information for Reviewers
    • Information for Librarians
    • Information for Advertisers
    • Conferences
  • Language Editing
Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • For Authors
    • For Reviewers
    • For Librarians
    • For Advertisers
    • Conferences
  • Language Editing
Login Register Submit
  • This site uses cookies
  • You can change your cookie settings at any time by following the instructions in our Cookie Policy. To find out more, you may read our Privacy Policy.

    I agree
Search articles by DOI, keyword, author or affiliation
Search
Advanced Search
presentation
Oncology Letters
Join Editorial Board Propose a Special Issue
Print ISSN: 1792-1074 Online ISSN: 1792-1082
Journal Cover
November-2021 Volume 22 Issue 5

Full Size Image

Sign up for eToc alerts
Recommend to Library

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
November-2021 Volume 22 Issue 5

Full Size Image

Sign up for eToc alerts
Recommend to Library

  • Article
  • Citations
    • Cite This Article
    • Download Citation
    • Create Citation Alert
    • Remove Citation Alert
    • Cited By
  • Similar Articles
    • Related Articles (in Spandidos Publications)
    • Similar Articles (Google Scholar)
    • Similar Articles (PubMed)
  • Download PDF
  • Download XML
  • View XML
Review Open Access

The mechanism of non‑coding RNAs in medulloblastoma (Review)

  • Authors:
    • Ying-Nan Zhao
    • Kun Li
    • Xing-Sheng Han
    • Ya-Wen Pan
  • View Affiliations / Copyright

    Affiliations: The Second Medical College of Lanzhou University, Lanzhou, Gansu 730030, P.R. China
    Copyright: © Zhao et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 758
    |
    Published online on: September 2, 2021
       https://doi.org/10.3892/ol.2021.13019
  • Expand metrics +
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
Cited By (CrossRef): 0 citations Loading Articles...

This article is mentioned in:



Abstract

Medulloblastoma (MB) is one of the most common malignant tumors of the central nervous system in children. Although surgery, radiotherapy and chemotherapy have resulted in considerable progress in the treatment of this disease, the prognosis of patients with MB remains very poor. Therefore, highly specific molecular targeted treatment, which can improve the therapeutic efficacy and reduce the side effects of MB, has become a research hotspot. In recent years, non‑coding RNAs (ncRNAs), which were initially considered to be transcriptional noise, have been shown to possess regulatory functions. A series of ncRNAs have been identified, including microRNAs and circular RNAs, which affect the expression of specific genes in a variety of tumors. These genes lead to the formation of a specific complex of proteins or they directly participate in protein synthesis in order to regulate the occurrence and development of tumors. The aim of the present review article was to summarize the recent research studies that have explored the ability of ncRNAs to regulate the occurrence and development of MB.
View Figures

Figure 1

Figure 2

Figure 3

View References

1 

Ostrom QT, Gino C, Gittleman H, Patil N, Waite K, Kruchko C and Barnholtz-Sloan JS: CBTRUS statistical report: Primary brain and other central nervous system tumors diagnosed in the United States in 2012–2016. Neuro Oncol. 21 (Suppl 5):v1–v100. 2019. View Article : Google Scholar : PubMed/NCBI

2 

Louis D, Perry A, Reifenberger G, von Deimling A, Figarella-Branger D, Cavenee WK, Ohgaki H, Wiestler OD, Kleihues P and Ellison DW: The 2016 World Health Organization Classification of Tumors of the Central Nervous System: A summary. Acta Neuropathol. 131:803–820. 2016. View Article : Google Scholar : PubMed/NCBI

3 

Forbes K, Osborn, Salzman, Barkovich, et al: Diagnostic Imaging. Brain (2nd edition). Neuroradiology. 54:2692012.

4 

Gajjar A and Robinson G: Medulloblastoma-translating discoveries from the bench to the bedside. Nat Rev Clin Oncol. 11:714–722. 2014. View Article : Google Scholar : PubMed/NCBI

5 

Pollack IF and Jakacki RI: Childhood brain tumors: Epidemiology, current management and future directions. Nat Rev Neurol. 7:495–506. 2011. View Article : Google Scholar : PubMed/NCBI

6 

Merchant TE, Mulhern RK, Krasin MJ, Kun LE, Williams T, Li C, Xiong X, Khan RB, Lustig RH, Boop FA and Sanford RA: Preliminary results from a phase II trial of conformal radiation therapy and evaluation of radiation-related CNS effects for pediatric patients with localized ependymoma. J Clin Oncol. 22:3156–3162. 2004. View Article : Google Scholar : PubMed/NCBI

7 

Kortmann RD, Kühl J, Timmermann B, Mittler U, Urban C, Budach V, Richter E, Willich N, Flentje M, Berthold F, et al: Postoperative neoadjuvant chemotherapy before radiotherapy as compared to immediate radiotherapy followed by maintenance chemotherapy in the treatment of medulloblastoma in childhood: Results of the german prospective randomized trial hit '91. Int J Radiat Oncol Biol Phys. 46:269–279. 2000. View Article : Google Scholar : PubMed/NCBI

8 

Gerber NU, Mynarek M, Von Hoff K, Friedrich C, Resch A and Rutkowski S: Recent developments and current concepts in medulloblastoma. Cancer Treat Rev. 40:356–365. 2014. View Article : Google Scholar : PubMed/NCBI

9 

ENCODE Project Consortium, . An Integrated Encyclopedia of DNA Elements in the Human Genome. Nature. 489:57–74. 2012. View Article : Google Scholar : PubMed/NCBI

10 

Pennisi E: ENCODE project writes eulogy for junk DNA. Science. 337:1159–1161. 2012. View Article : Google Scholar : PubMed/NCBI

11 

Ramasamy P, Malhotra M and Massoud TF: The protean world of non-coding RNAs in glioblastoma. J Mol Med (Berl). 97:909–925. 2019. View Article : Google Scholar : PubMed/NCBI

12 

Nie L, Wu HJ, Hsu JM, Chang SS, Labaff AM, Li CW, Wang Y, Hsu JL and Hung MC: Long non-coding RNAs: Versatile master regulators of gene expression and crucial players in cancer. Am J Transl Res. 4:127–150. 2012.PubMed/NCBI

13 

Barrett SP and Salzman J: Circular RNAs: Analysis, expression and potential functions. Development. 143:1838–1847. 2016. View Article : Google Scholar : PubMed/NCBI

14 

Peng Y and Croce CM: The role of MicroRNAs in human cancer. Signal Transduct Target Ther. 1:150042016. View Article : Google Scholar : PubMed/NCBI

15 

Kristensen LS, Hansen TB, Venø MT and Kjems J: Circular RNAs in cancer: Opportunities and challenges in the field. Oncogene. 37:555–565. 2018. View Article : Google Scholar : PubMed/NCBI

16 

Trimarchi T, Bilal E, Ntziachristos P, Fabbri G, Dalla-Favera R, Tsirigos A and Aifantis I: Genome-wide mapping and characterization of Notch-regulated long noncoding RNAs in acute leukemia. Cell. 158:593–606. 2014. View Article : Google Scholar : PubMed/NCBI

17 

Xia X, Li X, Li F, Wu X, Zhang M, Zhou H, Huang N, Yang X, Xiao F, Liu D, et al: A novel tumor suppressor protein encoded by circular AKT3 RNA inhibits glioblastoma tumorigenicity by competing with active phosphoinositide-dependent Kinase-1. Mol Cancer. 18:1312019. View Article : Google Scholar : PubMed/NCBI

18 

Gao X, Xia X, Li F, Zhang M, Zhou H, Wu X, Zhong J, Zhao Z, Zhao K, Liu D, et al: Circular RNA-encoded oncogenic E-cadherin variant promotes glioblastoma tumorigenicity through activation of EGFR-STAT3 signalling. Nat Cell Biol. 23:278–291. 2021. View Article : Google Scholar : PubMed/NCBI

19 

Morlando M, Di Timoteo G, Rossi F, Morlando M, Briganti F, Sthandier O, Fatica A, Santini T, Andronache A, Wade M, et al: Circ-ZNF609 is a circular RNA that Can Be translated and functions in myogenesis. Mol Cell. 66:22–37.e9. 2017. View Article : Google Scholar : PubMed/NCBI

20 

Diederichs S: Non-coding RNA in malignant tumors. A new world of tumor biomarkers and target structures in cancer cells. Pathologe. 31 (Suppl 2):S258–S262. 2010.(In German). View Article : Google Scholar : PubMed/NCBI

21 

Julia L, Grabowska A, Zarębska Ż, Kuczyński K, Kuczyńska B and Rolle K: Non-coding RNAs in Brain Tumors, the Contribution of lncRNAs, circRNAs, and snoRNAs to cancer development-their diagnostic and therapeutic potential. Int J Mol Scie. 21:70012020. View Article : Google Scholar

22 

Joshi P, Katsushima K, Zhou R, Meoded A, Stapleton S, Jallo G, Raabe E, Eberhart CG and Perera RJ: The therapeutic and diagnostic potential of regulatory noncoding RNAs in medulloblastoma. Neurooncol Adv. 1:vdz0232019.PubMed/NCBI

23 

Lee RC, Feinbaum RL and Ambros V: The C. elegans Heterochronic gene lin-4 encodes small RNAs with antisense complementarity to lin-14. Cell. 75:843–854. 1993. View Article : Google Scholar : PubMed/NCBI

24 

Browne BM, Stensland KD, Patel CK, Sullivan T, Burks EJ, Canes D, Raman JD, Warrick J and Reiger-Christ KM: MicroRNA expression profiles in upper tract urothelial carcinoma differentiate tumor grade, stage, and survival: Implications for clinical decision-making. Urology. 123:93–100. 2019. View Article : Google Scholar : PubMed/NCBI

25 

Magdalena Z, Fendler W, Zakrzewski K, Sikorska B, Grajkowska W, Dembowska-Bagińska B, Filipek I, Stefańczyk Ł and Liberski PP: Altered MicroRNA expression is associated with tumor grade, molecular background and outcome in childhood infratentorial ependymoma. PLoS One. 11:e01584642016. View Article : Google Scholar : PubMed/NCBI

26 

Rothé F, Ignatiadis M, Chaboteaux C, Haibe-Kains B, Kheddoumi N, Majjaj S, Badran B, Fayyad-Kazan H, Desmedt C, Harris AL, et al: Global microRNA expression profiling identifies MiR-210 associated with tumor proliferation, invasion and poor clinical outcome in breast cancer. PLoS One. 6:e209802011. View Article : Google Scholar : PubMed/NCBI

27 

Pierson J, Hostager B, Fan R and Vibhakar R: Regulation of cyclin dependent kinase 6 by microRNA 124 in medulloblastoma. J Neurooncol. 90:1–7. 2008. View Article : Google Scholar : PubMed/NCBI

28 

Ferretti E, De Smaele E, Po A, Di Marcotullio L, Tosi E, Espinola MS, Di Rocco C, Riccardi R, Giangaspero F, Farcomeni A, et al: MicroRNA profiling in human medulloblastoma. Int J Cancer. 124:568–577. 2010. View Article : Google Scholar : PubMed/NCBI

29 

Po A, Abballe L, Sabato C, Gianno F, Chiacchiarini M, Catanzaro G, De Smaele E, Giangaspero F, Ferretti E, Miele E and Besharat ZM: Sonic hedgehog medulloblastoma cancer stem cells mirnome and transcriptome highlight novel Functional Networks. Int J Mol Sci. 19:23262018. View Article : Google Scholar : PubMed/NCBI

30 

Dai J, Li Q, Bing Z, Zhang Y, Niu L, Yin H, Yuan G and Pan Y: Comprehensive analysis of a microRNA expression profile in pediatric medulloblastoma. Mol Med Rep. 15:4109–4115. 2017. View Article : Google Scholar : PubMed/NCBI

31 

Yogi K, Sridhar E, Goel N, Jalali R, Goel A, Moiyadi A, Thorat R, Panwalkar P, Khire A, Dasgupta A, et al: MiR-148a, a microRNA upregulated in the WNT subgroup tumors, inhibits invasion and tumorigenic potential of medulloblastoma cells by targeting Neuropilin 1. Oncoscience. 2:334–348. 2015. View Article : Google Scholar : PubMed/NCBI

32 

Northcott PA, Fernandez-L A, Hagan JP, Ellison DW, Grajkowska W, Gillespie Y, Grundy R, Van Meter T, Rutka JT, Croce CM, et al: The miR-17/92 polycistron is up-regulated in sonic hedgehog-driven medulloblastomas and induced by N-myc in sonic hedgehog-treated cerebellar neural precursors. Cancer Res. 69:3249–3255. 2009. View Article : Google Scholar : PubMed/NCBI

33 

Zhu LY, Wu XY, Liu XD, Zheng DF, Li HS, Yang B, Zhang J and Chang Q: Aggressive medulloblastoma-derived exosomal miRNAs promote in vitro invasion and migration of tumor cells via Ras/MAPK pathway. J Neuropathol Exp Neurol. 79:734–745. 2020. View Article : Google Scholar : PubMed/NCBI

34 

Gershanov S, Toledano H, Michowiz S, Barinfeld O, Pinhasov A, Goldenberg-Cohen N and Salmon-Divon M: MicroRNA-mRNA expression profiles associated with medulloblastoma subgroup 4. Cancer Manag Res. 10:339–352. 2018. View Article : Google Scholar : PubMed/NCBI

35 

Visani M, Marucci G, Biase D, Giangaspero F, Buttarelli FR, Brandes AA, Franceschi E, Acquaviva G, Ciarrocchi A, Rhoden KJ, et al: miR-196B-5P and miR-200B-3P are differentially expressed in medulloblastomas of adults and children. Diagnostics (Basel). 10:2652020. View Article : Google Scholar : PubMed/NCBI

36 

Pal R and Greene S: microRNA-10b is overexpressed and critical for cell survival and proliferation in medulloblastoma. PLoS One. 10:e01378452015. View Article : Google Scholar : PubMed/NCBI

37 

Grunder E, D'ambrosio R, Fiaschetti G, Abela L, Arcaro A, Zuzak T, Ohgaki H, Lv SQ, Shalaby T and Grotzer M: MicroRNA-21 suppression impedes medulloblastoma cell migration. Eur J Cancer. 47:2479–2490. 2011. View Article : Google Scholar : PubMed/NCBI

38 

Yang SY, Choi SA, Lee JY, Park AK, Wang KC, Phi JH, Koh EJ, Park WY, Park SH, Hwang DW, et al: miR-192 suppresses leptomeningeal dissemination of medulloblastoma by modulating cell proliferation and anchoring through the regulation of DHFR, integrins, and CD47. Oncotarget. 6:43712–43730. 2015. View Article : Google Scholar : PubMed/NCBI

39 

Zhang J, Li N, Fu J and Zhou W: Long noncoding RNA HOTAIR promotes medulloblastoma growth, migration and invasion by sponging miR-1/miR-206 and targeting YY1. Biomed Pharmacother. 124:1098872020. View Article : Google Scholar : PubMed/NCBI

40 

Senfter D, Samadaei M, Mader R, Gojo J, Peyrl A, Krupitza G, Kool M, Sill M, Haberler C, Ricken G, et al: High impact of miRNA-4521 on FOXM1 expression in medulloblastoma. Cell death & disease. 10:6962019. View Article : Google Scholar : PubMed/NCBI

41 

Kumar V, Kumar V, Chaudhary AK, Coulter DW, McGuire T and Mahato RI: Impact of miRNA-mRNA profiling and their correlation on medulloblastoma tumorigenesis. Mol Ther Nucleic Acids. 12:490–503. 2018. View Article : Google Scholar : PubMed/NCBI

42 

Li Y, Jiang T, Shao L, Liu Y, Zheng C, Zhong Y, Zhang J and Chang Q: Mir-449a, a potential diagnostic biomarker for WNT group of medulloblastoma. J Neurooncol. 129:423–431. 2016. View Article : Google Scholar : PubMed/NCBI

43 

Pezuk JA, Brassesco MS, De Oliveira RS, Machado HR, Neder L, Scrideli CA and Tone LG: PLK1-associated microRNAs are correlated with pediatric medulloblastoma prognosis. Childs Nerv Syst. 33:609–615. 2017. View Article : Google Scholar : PubMed/NCBI

44 

de Antonellis P, Medaglia C, Cusanelli E, Andolfo I, Liguori L, De Vita G, Carotenuto M, Bello A, Formiggini F, Galeone A, et al: MiR-34a targeting of Notch ligand delta-like 1 impairs CD15+/CD133+ tumor-propagating cells and supports neural differentiation in medulloblastoma. PLoS One. 6:e245842011. View Article : Google Scholar : PubMed/NCBI

45 

Silber J, Hashizume R, Felix T, Hariono S, Yu M, Berger MS, Huse JT, VandenBerg SR, James CD, Hodgson JG and Gupta N: Expression of miR-124 inhibits growth of medulloblastoma cells. Neuro Oncol. 15:83–90. 2013. View Article : Google Scholar : PubMed/NCBI

46 

Nigro JM, Cho KR, Fearon ER, Kern SE, Ruppert JM, Oliner JD, Kinzler KW and Vogelstein B: Scrambled exons. Cell. 64:607–613. 1991. View Article : Google Scholar : PubMed/NCBI

47 

Salzman J, Gawad C, Wang PL, Lacayo N and Brown PO: Circular RNAs Are the predominant transcript isoform from hundreds of human genes in diverse cell types. PLoS One. 7:e307332012. View Article : Google Scholar : PubMed/NCBI

48 

Li X, Yang L and Chen LL: The biogenesis, functions, and challenges of circular RNAs. Mol Cell. 71:428–442. 2018. View Article : Google Scholar : PubMed/NCBI

49 

Chen LL: The expanding regulatory mechanisms and cellular functions of circular RNAs. Nat Rev Mol Cell Biol. 21:475–490. 2020. View Article : Google Scholar : PubMed/NCBI

50 

Nilsen TW and Graveley BR: Expansion of the eukaryotic proteome by alternative splicing. Nature. 463:457–463. 2010. View Article : Google Scholar : PubMed/NCBI

51 

Moore MJ and Proudfoot NJ: Pre-mRNA processing reaches back to transcription and ahead to translation. Cell. 136:688–700. 2009. View Article : Google Scholar : PubMed/NCBI

52 

Salzman J, Chen RE, Olsen MN, Wang PL and Brown PO: Cell-type specific features of circular RNA expression. PLoS Genet. 9:e10037772018. View Article : Google Scholar : PubMed/NCBI

53 

Hansen TB, Jensen TI, Clausen BH, Bramsen JB, Finsen B, Damgaard CK and Kjems J: Natural RNA circles function as efficient microRNA sponges. Nature. 495:384–388. 2013. View Article : Google Scholar : PubMed/NCBI

54 

Belter A, Popenda M, Sajek M, Woźniak T, Naskręt-Barciszewska MZ, Szachniuk M, Jurga S and Barciszewski J: A new molecular mechanism of RNA circularization and the microRNA sponge formation. J Biomol Struct Dyn. Nov 17–2020.(Epub ahead of print). View Article : Google Scholar : PubMed/NCBI

55 

Guo JU, Agarwal V, Guo H and Bartel DP: Expanded identification and characterization of mammalian circular RNAs. Genome Biol. 15:4092014. View Article : Google Scholar : PubMed/NCBI

56 

Xie H, Ren X, Xin S, Lan X, Lu G, Lin Y, Yang S, Zeng Z, Liao W, Ding YQ and Liang L: Emerging roles of circRNA_001569 targeting miR-145 in the proliferation and invasion of colorectal cancer. Oncotarget. 7:26680–26691. 2016. View Article : Google Scholar : PubMed/NCBI

57 

Wei Y, Chen X, Liang C, Ling Y, Yang X, Ye X, Zhang H, Yang P, Cui X, Ren Y, et al: A noncoding regulatory RNAs Network Driven by Circ-CDYL acts specifically in the early stages hepatocellular carcinoma. Hepatology. 71:130–147. 2020. View Article : Google Scholar : PubMed/NCBI

58 

Han J, Zhao G, Ma X, Dong Q, Zhang H, Wang Y and Cui J: CircRNA circ-BANP-mediated miR-503/LARP1 signaling contributes to lung cancer progression. Biochem Biophys Res Commun. 503:2429–2435. 2018. View Article : Google Scholar : PubMed/NCBI

59 

Gong J, Jiang H, Shu C, Hu MQ, Huang Y, Liu Q, Li RF and Wei YZ: Integrated analysis of circular RNA-associated ceRNA network in cervical cancer: Observational Study. Medicine (Baltimore). 98:e169222019. View Article : Google Scholar : PubMed/NCBI

60 

Huang M, He YR, Liang LC, Huang Q and Zhu ZQ: Circular RNA hsa_circ_0000745 may serve as a diagnostic marker for gastric cancer. World J Gastroenterol. 23:6330–6338. 2017. View Article : Google Scholar : PubMed/NCBI

61 

Li G, Huang M, Cai Y, Yang Y, Sun X and Ke Y: Circ-U2AF1 promotes human glioma via derepressing neuro-oncological ventral antigen 2 by sponging hsa-miR-7-5p. J Cell Physiol. 234:9144–9155. 2019. View Article : Google Scholar : PubMed/NCBI

62 

Lv T, Miao Y, Jin K, Han S, Xu TQ, Qiu ZL and Zhang XH: Dysregulated circular RNAs in medulloblastoma regulate proliferation and growth of tumor cells via host genes. Cancer Med. 7:6147–6157. 2018. View Article : Google Scholar : PubMed/NCBI

63 

Wang X, Xu D, Pei X, Zhang Y, Zhang Y, Gu Y and Li Y: CircSKA3 modulates FOXM1 to facilitate cell proliferation, migration, and invasion while confine apoptosis in medulloblastoma via miR-383-5p. Cancer Manag Res. 12:13415–13426. 2020. View Article : Google Scholar : PubMed/NCBI

64 

Shibayama Y, Fanucchi S, Magagula L and Mhlanga MM: lncRNA and gene looping: What's the connection? Transcription. 5:e286582014. View Article : Google Scholar : PubMed/NCBI

65 

Lin CY, Erkek S, Tong Y, Yin L, Federation AJ, Zapatka M, Haldipur P, Kawauchi D, Risch T, Warnatz HJ, et al: Active medulloblastoma enhancers reveal subgroup-specific cellular origins. Nature. 530:57–62. 2016. View Article : Google Scholar : PubMed/NCBI

66 

Shi PF, Ji HL, Luo YK, Mao TM, Chen X and Zhou KY: Effect of long noncoding RNA SPRY4-IT1 on proliferation and metastasis of medulloblastoma. Zhongguo Ying Yong Sheng Li Xue Za Zhi. 33:78–82. 2017.(In Chinese). PubMed/NCBI

Related Articles

  • Abstract
  • View
  • Download
  • Twitter
Copy and paste a formatted citation
Spandidos Publications style
Zhao Y, Li K, Han X and Pan Y: The mechanism of non‑coding RNAs in medulloblastoma (Review). Oncol Lett 22: 758, 2021.
APA
Zhao, Y., Li, K., Han, X., & Pan, Y. (2021). The mechanism of non‑coding RNAs in medulloblastoma (Review). Oncology Letters, 22, 758. https://doi.org/10.3892/ol.2021.13019
MLA
Zhao, Y., Li, K., Han, X., Pan, Y."The mechanism of non‑coding RNAs in medulloblastoma (Review)". Oncology Letters 22.5 (2021): 758.
Chicago
Zhao, Y., Li, K., Han, X., Pan, Y."The mechanism of non‑coding RNAs in medulloblastoma (Review)". Oncology Letters 22, no. 5 (2021): 758. https://doi.org/10.3892/ol.2021.13019
Copy and paste a formatted citation
x
Spandidos Publications style
Zhao Y, Li K, Han X and Pan Y: The mechanism of non‑coding RNAs in medulloblastoma (Review). Oncol Lett 22: 758, 2021.
APA
Zhao, Y., Li, K., Han, X., & Pan, Y. (2021). The mechanism of non‑coding RNAs in medulloblastoma (Review). Oncology Letters, 22, 758. https://doi.org/10.3892/ol.2021.13019
MLA
Zhao, Y., Li, K., Han, X., Pan, Y."The mechanism of non‑coding RNAs in medulloblastoma (Review)". Oncology Letters 22.5 (2021): 758.
Chicago
Zhao, Y., Li, K., Han, X., Pan, Y."The mechanism of non‑coding RNAs in medulloblastoma (Review)". Oncology Letters 22, no. 5 (2021): 758. https://doi.org/10.3892/ol.2021.13019
Follow us
  • Twitter
  • LinkedIn
  • Facebook
About
  • Spandidos Publications
  • Careers
  • Cookie Policy
  • Privacy Policy
How can we help?
  • Help
  • Live Chat
  • Contact
  • Email to our Support Team