Open Access

The mechanism of non‑coding RNAs in medulloblastoma (Review)

  • Authors:
    • Ying-Nan Zhao
    • Kun Li
    • Xing-Sheng Han
    • Ya-Wen Pan
  • View Affiliations

  • Published online on: September 2, 2021     https://doi.org/10.3892/ol.2021.13019
  • Article Number: 758
  • Copyright: © Zhao et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Medulloblastoma (MB) is one of the most common malignant tumors of the central nervous system in children. Although surgery, radiotherapy and chemotherapy have resulted in considerable progress in the treatment of this disease, the prognosis of patients with MB remains very poor. Therefore, highly specific molecular targeted treatment, which can improve the therapeutic efficacy and reduce the side effects of MB, has become a research hotspot. In recent years, non‑coding RNAs (ncRNAs), which were initially considered to be transcriptional noise, have been shown to possess regulatory functions. A series of ncRNAs have been identified, including microRNAs and circular RNAs, which affect the expression of specific genes in a variety of tumors. These genes lead to the formation of a specific complex of proteins or they directly participate in protein synthesis in order to regulate the occurrence and development of tumors. The aim of the present review article was to summarize the recent research studies that have explored the ability of ncRNAs to regulate the occurrence and development of MB.
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November-2021
Volume 22 Issue 5

Print ISSN: 1792-1074
Online ISSN:1792-1082

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Spandidos Publications style
Zhao Y, Li K, Han X and Pan Y: The mechanism of non‑coding RNAs in medulloblastoma (Review). Oncol Lett 22: 758, 2021
APA
Zhao, Y., Li, K., Han, X., & Pan, Y. (2021). The mechanism of non‑coding RNAs in medulloblastoma (Review). Oncology Letters, 22, 758. https://doi.org/10.3892/ol.2021.13019
MLA
Zhao, Y., Li, K., Han, X., Pan, Y."The mechanism of non‑coding RNAs in medulloblastoma (Review)". Oncology Letters 22.5 (2021): 758.
Chicago
Zhao, Y., Li, K., Han, X., Pan, Y."The mechanism of non‑coding RNAs in medulloblastoma (Review)". Oncology Letters 22, no. 5 (2021): 758. https://doi.org/10.3892/ol.2021.13019