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Inhibition of Dishevelled‑2 suppresses the biological behavior of pancreatic cancer by downregulating Wnt/β‑catenin signaling

  • Authors:
    • Wei Hu
    • Mingxu Li
    • Junyi Wu
    • Hong Chen
    • Ting  Zhao
    • Chunjie Zhang
    • Zhong Wang
  • View Affiliations / Copyright

    Affiliations: Department of Hepatobiliary Surgery, The First Affiliated Hospital of Kangda College of Nanjing Medical University, Lianyungang, Jiangsu 222001, P.R. China, Department of Hepatobiliary Surgery, Affiliated Lianyungang Hospital of Xuzhou Medical University, Lianyungang, Jiangsu 222001, P.R. China, Department of Hepatobiliary and Pancreatic Surgery, Fujian Provincial Hospital, Fuzhou, Fujian 350001, P.R. China, Department of Pathology, The Second People's Hospital of Lianyungang, Lianyungang, Jiangsu 222001, P.R. China
    Copyright: © Hu et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 769
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    Published online on: September 8, 2021
       https://doi.org/10.3892/ol.2021.13030
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Abstract

Dishevelled‑2 (DVL2) has been proven to be involved in the tumorigenesis of several human cancers, such as colorectal cancer, lung cancer, prostate cancer, etc. However, its role in pancreatic ductal adenocarcinoma (PDAC) remains unclear. The present study investigated the effects of aberrantly expressed DVL2 on PDAC. A total of 97 pancreatic cancer (PC) samples and 85 adjacent normal samples were obtained from patients who were histopathologically diagnosed with primary PDAC. The present study demonstrated that DVL2 expression was upregulated in PDAC tissues and was positively associated with advanced clinical stage and lymph node metastasis in patients with PDAC. In addition, patients with high expression of DVL2 had a shorter overall survival rate compared with those with low expression. To elucidate the role of DVL2 in PDAC, lentivirus‑mediated short hairpin RNA was used to silence DVL2 and its physiological function was analyzed in CFPAC‑1 and PANC‑1 cells. The results indicated that DVL2 downregulation significantly impaired its oncogenic functions including cell proliferation, migration, invasion and epithelial‑mesenchymal transition. Furthermore, DVL2 knockdown inhibits the proliferation and invasion of PC cells in vivo. In addition, co‑immunoprecipitation assays revealed that DVL2 interacted with β‑catenin; knockdown of DVL2 reduced the expression level of β‑catenin and inhibited β‑catenin translocation into the nucleus. In conclusion the findings of the present study suggested that DVL2 may be a potential therapeutic target in the treatment of PDAC.
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Copy and paste a formatted citation
Spandidos Publications style
Hu W, Li M, Wu J, Chen H, Zhao T, Zhang C and Wang Z: Inhibition of Dishevelled‑2 suppresses the biological behavior of pancreatic cancer by downregulating Wnt/β‑catenin signaling. Oncol Lett 22: 769, 2021.
APA
Hu, W., Li, M., Wu, J., Chen, H., Zhao, T., Zhang, C., & Wang, Z. (2021). Inhibition of Dishevelled‑2 suppresses the biological behavior of pancreatic cancer by downregulating Wnt/β‑catenin signaling. Oncology Letters, 22, 769. https://doi.org/10.3892/ol.2021.13030
MLA
Hu, W., Li, M., Wu, J., Chen, H., Zhao, T., Zhang, C., Wang, Z."Inhibition of Dishevelled‑2 suppresses the biological behavior of pancreatic cancer by downregulating Wnt/β‑catenin signaling". Oncology Letters 22.5 (2021): 769.
Chicago
Hu, W., Li, M., Wu, J., Chen, H., Zhao, T., Zhang, C., Wang, Z."Inhibition of Dishevelled‑2 suppresses the biological behavior of pancreatic cancer by downregulating Wnt/β‑catenin signaling". Oncology Letters 22, no. 5 (2021): 769. https://doi.org/10.3892/ol.2021.13030
Copy and paste a formatted citation
x
Spandidos Publications style
Hu W, Li M, Wu J, Chen H, Zhao T, Zhang C and Wang Z: Inhibition of Dishevelled‑2 suppresses the biological behavior of pancreatic cancer by downregulating Wnt/β‑catenin signaling. Oncol Lett 22: 769, 2021.
APA
Hu, W., Li, M., Wu, J., Chen, H., Zhao, T., Zhang, C., & Wang, Z. (2021). Inhibition of Dishevelled‑2 suppresses the biological behavior of pancreatic cancer by downregulating Wnt/β‑catenin signaling. Oncology Letters, 22, 769. https://doi.org/10.3892/ol.2021.13030
MLA
Hu, W., Li, M., Wu, J., Chen, H., Zhao, T., Zhang, C., Wang, Z."Inhibition of Dishevelled‑2 suppresses the biological behavior of pancreatic cancer by downregulating Wnt/β‑catenin signaling". Oncology Letters 22.5 (2021): 769.
Chicago
Hu, W., Li, M., Wu, J., Chen, H., Zhao, T., Zhang, C., Wang, Z."Inhibition of Dishevelled‑2 suppresses the biological behavior of pancreatic cancer by downregulating Wnt/β‑catenin signaling". Oncology Letters 22, no. 5 (2021): 769. https://doi.org/10.3892/ol.2021.13030
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