Open Access

Cross‑link between ferroptosis and nasopharyngeal carcinoma: New approach to radiotherapy sensitization (Review)

  • Authors:
    • Hai-Long Li
    • Nian-Hua Deng
    • Jia-Xin Xiao
    • Xiu-Sheng He
  • View Affiliations

  • Published online on: September 9, 2021     https://doi.org/10.3892/ol.2021.13031
  • Article Number: 770
  • Copyright: © Li et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Ferroptosis is a recently discovered special type of regulated cell death that is strongly associated with both homeostasis maintenance and cancer development. Previous studies have indicated that a number of small‑molecular agents inducing ferroptosis have great potential in the treatment of different types of cancer, including breast, pancreatic, prostate and head and neck cancer. However, the role of ferroptosis in nasopharyngeal carcinoma (NPC) has remained to be fully determined. To the best of our knowledge, no review of the currently available studies on this subject has been published to date. The metabolism and expression of specific genes that regulate ferroptosis may represent a promising radiosensitization target in cancer treatment. The aim of the present review was to describe the cross‑link between ferroptosis and NPC and to discuss the potential value of regulators and the possible mechanism underlying the role of ferroptosis in the radiosensitization of NPC, in the hope that linking the mechanism of ferroptosis with the development of NPC will accelerate the development of novel ferroptosis‑based targets and radiotherapy strategies in NPC.
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November-2021
Volume 22 Issue 5

Print ISSN: 1792-1074
Online ISSN:1792-1082

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Copy and paste a formatted citation
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Spandidos Publications style
Li H, Deng N, Xiao J and He X: Cross‑link between ferroptosis and nasopharyngeal carcinoma: New approach to radiotherapy sensitization (Review). Oncol Lett 22: 770, 2021
APA
Li, H., Deng, N., Xiao, J., & He, X. (2021). Cross‑link between ferroptosis and nasopharyngeal carcinoma: New approach to radiotherapy sensitization (Review). Oncology Letters, 22, 770. https://doi.org/10.3892/ol.2021.13031
MLA
Li, H., Deng, N., Xiao, J., He, X."Cross‑link between ferroptosis and nasopharyngeal carcinoma: New approach to radiotherapy sensitization (Review)". Oncology Letters 22.5 (2021): 770.
Chicago
Li, H., Deng, N., Xiao, J., He, X."Cross‑link between ferroptosis and nasopharyngeal carcinoma: New approach to radiotherapy sensitization (Review)". Oncology Letters 22, no. 5 (2021): 770. https://doi.org/10.3892/ol.2021.13031