|
1
|
Chen YP, Chan ATC, Le QT, Blanchard P, Sun
Y and Ma J: Nasopharyngeal carcinoma. Lancet. 394:64–80. 2019.
View Article : Google Scholar : PubMed/NCBI
|
|
2
|
Long M, Fu Z, Li P and Nie Z: Cigarette
smoking and the risk of nasopharyngeal carcinoma: A meta-analysis
of epidemiological studies. BMJ Open. 7:e0165822017. View Article : Google Scholar : PubMed/NCBI
|
|
3
|
Liu YP, Lv X, Zou X, Hua YJ, You R, Yang
Q, Xia L, Guo SY, Hu W, Zhang MX, et al: Minimally invasive surgery
alone compared with intensity-modulated radiotherapy for primary
stage I nasopharyngeal carcinoma. Cancer Commun (Lond). 39:752019.
View Article : Google Scholar : PubMed/NCBI
|
|
4
|
Jaffray DA: Image-guided radiotherapy:
From current concept to future perspectives. Nat Rev Clin Oncol.
9:688–699. 2012. View Article : Google Scholar : PubMed/NCBI
|
|
5
|
Liu G, Zeng X, Wu B, Zhao J and Pan Y:
RNA-Seq analysis of peripheral blood mononuclear cells reveals
unique transcriptional signatures associated with radiotherapy
response of nasopharyngeal carcinoma and prognosis of head and neck
cancer. Cancer Biol Ther. 21:139–146. 2020. View Article : Google Scholar : PubMed/NCBI
|
|
6
|
Baidoo KE, Yong K and Brechbiel MW:
Molecular pathways: Targeted α-particle radiation therapy. Clin
Cancer Res. 19:530–537. 2013. View Article : Google Scholar : PubMed/NCBI
|
|
7
|
Srinivas US, Tan BWQ, Vellayappan BA and
Jeyasekharan AD: ROS and the DNA damage response in cancer. Redox
Biol. 25:1010842019. View Article : Google Scholar : PubMed/NCBI
|
|
8
|
Lee AWM, Ng WT, Chan JYW, Corry J, Mäkitie
A, Mendenhall WM, Rinaldo A, Rodrigo JP, Saba NF, Strojan P, et al:
Management of locally recurrent nasopharyngeal carcinoma. Cancer
Treat Rev. 79:1018902019. View Article : Google Scholar : PubMed/NCBI
|
|
9
|
Dixon SJ, Lemberg KM, Lamprecht MR, Skouta
R, Zaitsev EM, Gleason CE, Patel DN, Bauer AJ, Cantley AM, Yang WS,
et al: Ferroptosis: An iron-dependent form of nonapoptotic cell
death. Cell. 149:1060–1072. 2012. View Article : Google Scholar : PubMed/NCBI
|
|
10
|
Xu T, Ding W, Ji X, Ao X, Liu Y, Yu W and
Wang J: Molecular mechanisms of ferroptosis and its role in cancer
therapy. J Cell Mol Med. 23:4900–4912. 2019. View Article : Google Scholar : PubMed/NCBI
|
|
11
|
Friedmann Angeli JP, Schneider M, Proneth
B, Tyurina YY, Tyurin VA, Hammond VJ, Herbach N, Aichler M, Walch
A, Eggenhofer E, et al: Inactivation of the ferroptosis regulator
Gpx4 triggers acute renal failure in mice. Nat Cell Biol.
16:1180–1191. 2014. View
Article : Google Scholar : PubMed/NCBI
|
|
12
|
Raven EP, Lu PH, Tishler TA, Heydari P and
Bartzokis G: Increased iron levels and decreased tissue integrity
in hippocampus of Alzheimer's disease detected in vivo with
magnetic resonance imaging. J Alzheimers Dis. 37:127–136. 2013.
View Article : Google Scholar : PubMed/NCBI
|
|
13
|
Huang S, Cao B, Zhang J, Feng Y, Wang L,
Chen X, Su H, Liao S, Liu J, Yan J and Liang B: Induction of
ferroptosis in human nasopharyngeal cancer cells by cucurbitacin B:
molecular mechanism and therapeutic potential. Cell Death Dis.
12:2372021. View Article : Google Scholar : PubMed/NCBI
|
|
14
|
Li Z, Chen L, Chen C, Zhou Y, Hu D, Yang
J, Chen Y, Zhuo W, Mao M, Zhang X, et al: Targeting ferroptosis in
breast cancer. Biomark Res. 8:582020. View Article : Google Scholar : PubMed/NCBI
|
|
15
|
Xie Y, Hou W, Song X, Yu Y, Huang J, Sun
X, Kang R and Tang D: Ferroptosis: Process and function. Cell Death
Differ. 23:369–379. 2016. View Article : Google Scholar : PubMed/NCBI
|
|
16
|
Kazan HH, Urfali-Mamatoglu C and Gunduz U:
Iron metabolism and drug resistance in cancer. Biometals.
30:629–641. 2017. View Article : Google Scholar : PubMed/NCBI
|
|
17
|
He YJ, Liu XY, Xing L, Wan X, Chang X and
Jiang HL: Fenton reaction-independent ferroptosis therapy via
glutathione and iron redox couple sequentially triggered lipid
peroxide generator. Biomaterials. 241:1199112020. View Article : Google Scholar : PubMed/NCBI
|
|
18
|
Torti SV and Torti FM: Iron and cancer:
More ore to be mined. Nat Rev Cancer. 13:342–355. 2013. View Article : Google Scholar : PubMed/NCBI
|
|
19
|
Liang C, Zhang X, Yang M and Dong X:
Recent progress in ferroptosis inducers for cancer therapy. Adv
Mater. 31:e19041972019. View Article : Google Scholar : PubMed/NCBI
|
|
20
|
Lin LS, Song J, Song L, Ke K, Liu Y, Zhou
Z, Shen Z, Li J, Yang Z, Tang W and Niu G: Simultaneous fenton-like
ion delivery and glutathione depletion by MnO2-based
nanoagent to enhance chemodynamic therapy. Angew Chem Int Ed Engl.
57:4902–4906. 2018. View Article : Google Scholar : PubMed/NCBI
|
|
21
|
Wang H, Lin D, Yu Q, Li Z, Lenahan C, Dong
Y, Wei Q and Shao A: A promising future of ferroptosis in tumor
therapy. Front Cell Dev Biol. 9:6291502021. View Article : Google Scholar : PubMed/NCBI
|
|
22
|
Yang WS, SriRamaratnam R, Welsch ME,
Shimada K, Skouta R, Viswanathan VS, Cheah JH, Clemons PA, Shamji
AF, Clish CB, et al: Regulation of ferroptotic cancer cell death by
GPX4. Cell. 156:317–331. 2014. View Article : Google Scholar : PubMed/NCBI
|
|
23
|
Stockwell BR, Jiang X and Gu W: Emerging
mechanisms and disease relevance of ferroptosis. Trends Cell Biol.
30:478–490. 2020. View Article : Google Scholar : PubMed/NCBI
|
|
24
|
Sato H, Tamba M, Ishii T and Bannai S:
Cloning and expression of a plasma membrane cystine/glutamate
exchange transporter composed of two distinct proteins. J Biol
Chem. 274:11455–11458. 1999. View Article : Google Scholar : PubMed/NCBI
|
|
25
|
Lo M, Ling V, Wang YZ and Gout PW: The
xc-cystine/glutamate antiporter: A mediator of pancreatic cancer
growth with a role in drug resistance. Br J Cancer. 99:464–472.
2008. View Article : Google Scholar : PubMed/NCBI
|
|
26
|
Gao M, Yi J, Zhu J, Minikes AM, Monian P,
Thompson CB and Jiang X: Role of mitochondria in ferroptosis. Mol
Cell. 73:354–363.e3. 2019. View Article : Google Scholar : PubMed/NCBI
|
|
27
|
Tang D, Chen X, Kang R and Kroemer G:
Ferroptosis: Molecular mechanisms and health implications. Cell
Res. 31:107–125. 2021. View Article : Google Scholar : PubMed/NCBI
|
|
28
|
Yagoda N, von Rechenberg M, Zaganjor E,
Bauer AJ, Yang WS, Fridman DJ, Wolpaw AJ, Smukste I, Peltier JM,
Boniface J, et al: RAS-RAF-MEK-dependent oxidative cell death
involving voltage-dependent anion channels. Nature. 447:864–868.
2007. View Article : Google Scholar : PubMed/NCBI
|
|
29
|
Yang WH, Huang Z, Wu J, Ding CC, Murphy SK
and Chi JT: A TAZ-ANGPTL4-NOX2 axis regulates ferroptotic cell
death and chemoresistance in epithelial ovarian cancer. Mol Cancer
Res. 18:79–90. 2020. View Article : Google Scholar : PubMed/NCBI
|
|
30
|
Lang X, Green MD, Wang W, Yu J, Choi JE,
Jiang L, Liao P, Zhou J, Zhang Q, Dow A, et al: Radiotherapy and
immunotherapy promote tumoral lipid oxidation and ferroptosis via
synergistic repression of SLC7A11. Cancer Discov. 9:1673–1685.
2019. View Article : Google Scholar : PubMed/NCBI
|
|
31
|
Lei G, Mao C, Yan Y, Zhuang L and Gan B:
Ferroptosis, radiotherapy, and combination therapeutic strategies.
Protein Cell. Apr 23–2021.(Epub ahead of print). View Article : Google Scholar
|
|
32
|
Ye LF, Chaudhary KR, Zandkarimi F, Harken
AD, Kinslow CJ, Upadhyayula PS, Dovas A, Higgins DM, Tan H, Zhang
Y, et al: Radiation-induced lipid peroxidation triggers ferroptosis
and synergizes with ferroptosis inducers. ACS Chem Biol.
15:469–484. 2020. View Article : Google Scholar : PubMed/NCBI
|
|
33
|
Lei G, Zhang Y, Koppula P, Liu X, Zhang J,
Lin SH, Ajani JA, Xiao Q, Liao Z, Wang H and Gan B: The role of
ferroptosis in ionizing radiation-induced cell death and tumor
suppression. Cell Res. 30:146–162. 2020. View Article : Google Scholar : PubMed/NCBI
|
|
34
|
Xie L, Song X, Yu J, Guo W, Wei L, Liu Y
and Wang X: Solute carrier protein family may involve in
radiation-induced radioresistance of non-small cell lung cancer. J
Cancer Res Clin Oncol. 137:1739–1747. 2011. View Article : Google Scholar : PubMed/NCBI
|
|
35
|
McDonald JT, Kim K, Norris AJ, Vlashi E,
Phillips TM, Lagadec C, Della Donna L, Ratikan J, Szelag H, Hlatky
L and McBride WH: Ionizing radiation activates the Nrf2 antioxidant
response. Cancer Res. 70:8886–8895. 2010. View Article : Google Scholar : PubMed/NCBI
|
|
36
|
Zong Y, Feng S, Cheng J, Yu C and Lu G:
Up-regulated ATF4 expression increases cell sensitivity to
apoptosis in response to radiation. Cell Physiol Biochem.
41:784–794. 2017. View Article : Google Scholar : PubMed/NCBI
|
|
37
|
Koppula P, Zhuang L and Gan B: Cystine
transporter SLC7A11/xCT in cancer: Ferroptosis, nutrient
dependency, and cancer therapy. Protein Cell. 12:599–620. 2021.
View Article : Google Scholar : PubMed/NCBI
|
|
38
|
Maier P, Hartmann L, Wenz F and Herskind
C: Cellular pathways in response to ionizing radiation and their
targetability for tumor radiosensitization. Int J Mol Sci.
17:1022016. View Article : Google Scholar : PubMed/NCBI
|
|
39
|
Stracker TH, Roig I, Knobel PA and
Marjanović M: The ATM signaling network in development and disease.
Front Genet. 4:372013. View Article : Google Scholar : PubMed/NCBI
|
|
40
|
Sanli T, Steinberg GR, Singh G and
Tsakiridis T: AMP-activated protein kinase (AMPK) beyond
metabolism: Anovel genomic stress sensor participating in the DNA
damage response pathway. Cancer Biol Ther. 15:156–169. 2014.
View Article : Google Scholar : PubMed/NCBI
|
|
41
|
Degterev A and Yuan J: Expansion and
evolution of cell death programmes. Nat Rev Mol Cell Biol.
9:378–390. 2008. View Article : Google Scholar : PubMed/NCBI
|
|
42
|
Gudkov AV and Komarova EA: The role of p53
in determining sensitivity to radiotherapy. Nat Rev Cancer.
3:117–129. 2003. View
Article : Google Scholar : PubMed/NCBI
|
|
43
|
Kirtonia A, Sethi G and Garg M: The
multifaceted role of reactive oxygen species in tumorigenesis. Cell
Mol Life Sci. 77:4459–4483. 2020. View Article : Google Scholar : PubMed/NCBI
|
|
44
|
Halliwell B and Cross CE: Oxygen-derived
species: Their relation to human disease and environmental stress.
Environ Health Perspect. 102 (Suppl 10):S5–S12. 1994. View Article : Google Scholar : PubMed/NCBI
|
|
45
|
Grivennikova VG and Vinogradov AD:
Generation of superoxide by the mitochondrial Complex I. Biochim
Biophys Acta. 1757:553–561. 2006. View Article : Google Scholar : PubMed/NCBI
|
|
46
|
Hentze MW, Muckenthaler MU, Galy B and
Camaschella C: Two to tango: Regulation of mammalian iron
metabolism. Cell. 142:24–38. 2010. View Article : Google Scholar : PubMed/NCBI
|
|
47
|
Gutteridge JM and Halliwell B: Iron
toxicity and oxygen radicals. Baillieres Clin Haematol. 2:195–256.
1989. View Article : Google Scholar : PubMed/NCBI
|
|
48
|
Doll S and Conrad M: Iron and ferroptosis:
A still ill-defined liaison. IUBMB Life. 69:423–434. 2017.
View Article : Google Scholar : PubMed/NCBI
|
|
49
|
Andrews NC: Disorders of iron metabolism.
N Engl J Med. 341:1986–1995. 1999. View Article : Google Scholar : PubMed/NCBI
|
|
50
|
Li B, Liao Z, Mo Y, Zhao W, Zhou X, Xiao
X, Cui W, Feng G, Zhong S, Liang Y, et al: Inactivation of
3-hydroxybutyrate dehydrogenase type 2 promotes proliferation and
metastasis of nasopharyngeal carcinoma by iron retention. Br J
Cancer. 122:102–110. 2020. View Article : Google Scholar : PubMed/NCBI
|
|
51
|
Xu Y, Wang Q, Li X, Chen Y and Xu G:
Itraconazole attenuates the stemness of nasopharyngeal carcinoma
cells via triggering ferroptosis. Environ Toxicol. 36:257–266.
2021. View Article : Google Scholar : PubMed/NCBI
|
|
52
|
Andrews NC: Forging a field: The golden
age of iron biology. Blood. 112:219–230. 2008. View Article : Google Scholar : PubMed/NCBI
|
|
53
|
Ivanov SD, Semenov AL, Kovan'ko EG and
Yamshanov VA: Effects of iron ions and iron chelation on the
efficiency of experimental radiotherapy of animals with gliomas.
Bull Exp Biol Med. 158:800–803. 2015. View Article : Google Scholar : PubMed/NCBI
|
|
54
|
Hou W, Xie Y, Song X, Sun X, Lotze MT, Zeh
HJ III, Kang R and Tang D: Autophagy promotes ferroptosis by
degradation of ferritin. Autophagy. 12:1425–1428. 2016. View Article : Google Scholar : PubMed/NCBI
|
|
55
|
Park E and Chung SW: ROS-mediated
autophagy increases intracellular iron levels and ferroptosis by
ferritin and transferrin receptor regulation. Cell Death Dis.
10:8222019. View Article : Google Scholar : PubMed/NCBI
|
|
56
|
Hong X, Roh W, Sullivan RJ, Wong KHK,
Wittner BS, Guo H, Dubash TD, Sade-Feldman M, Wesley B, Horwitz E,
et al: The lipogenic regulator SREBP2 induces transferrin in
circulating melanoma cells and suppresses ferroptosis. Cancer
Discov. 11:678–695. 2021. View Article : Google Scholar : PubMed/NCBI
|
|
57
|
Feng H, Schorpp K, Jin J, Yozwiak CE,
Hoffstrom BG, Decker AM, Rajbhandari P, Stokes ME, Bender HG, Csuka
JM, et al: Transferrin receptor is a specific ferroptosis marker.
Cell Rep. 30:3411–3423.e7. 2020. View Article : Google Scholar : PubMed/NCBI
|
|
58
|
Yang WS and Stockwell BR: Synthetic lethal
screening identifies compounds activating iron-dependent,
nonapoptotic cell death in oncogenic-RAS-harboring cancer cells.
Chem Biol. 15:234–245. 2008. View Article : Google Scholar : PubMed/NCBI
|
|
59
|
Guagnozzi D, Severi C, Ialongo P, Viscido
A, Patrizi F, Testino G, Vannella L, Labriola R, Strom R and
Caprilli R: Ferritin as a simple indicator of iron deficiency in
anemic IBD patients. Inflamm Bowel Dis. 12:150–151. 2006.
View Article : Google Scholar : PubMed/NCBI
|
|
60
|
Ma BB, Leungm SF, Hui EP, Mo F, Kwan WH,
Zee B, Yuen J and Chan AT: Prospective validation of serum CYFRA
21-1, beta-2-microglobulin, and ferritin levels as prognostic
markers in patients with nonmetastatic nasopharyngeal carcinoma
undergoing radiotherapy. Cancer. 101:776–781. 2004. View Article : Google Scholar : PubMed/NCBI
|
|
61
|
Chen X, Long X, Liang Z, Lei H, Li L, Qu S
and Zhu X: Higher N stage and serum ferritin, but lower serum
albumin levels are associated with distant metastasis and poor
survival in patients with nasopharyngeal carcinoma following
intensity-modulated radiotherapy. Oncotarget. 8:73177–73186. 2017.
View Article : Google Scholar : PubMed/NCBI
|
|
62
|
Zhang W, Fan S, Zou G, Shi L, Zeng Z, Ma
J, Zhou Y, Li X, Zhang X, Li X, et al: Lactotransferrin could be a
novel independent molecular prognosticator of nasopharyngeal
carcinoma. Tumour Biol. 36:675–683. 2015. View Article : Google Scholar : PubMed/NCBI
|
|
63
|
Zhou Y, Zeng Z, Zhang W, Xiong W, Wu M,
Tan Y, Yi W, Xiao L, Li X, Huang C, et al: Lactotransferrin: A
candidate tumor suppressor-deficient expression in human
nasopharyngeal carcinoma and inhibition of NPC cell proliferation
by modulating the mitogen-activated protein kinase pathway. Int J
Cancer. 123:2065–2072. 2008. View Article : Google Scholar : PubMed/NCBI
|
|
64
|
Zhang H, Feng X, Liu W, Jiang X, Shan W,
Huang C, Yi H, Zhu B, Zhou W, Wang L, et al: Underlying mechanisms
for LTF inactivation and its functional analysis in nasopharyngeal
carcinoma cell lines. J Cell Biochem. 112:1832–1843. 2011.
View Article : Google Scholar : PubMed/NCBI
|
|
65
|
Deng M, Zhang W, Tang H, Ye Q, Liao Q,
Zhou Y, Wu M, Xiong W, Zheng Y, Guo X, et al: Lactotransferrin acts
as a tumor suppressor in nasopharyngeal carcinoma by repressing AKT
through multiple mechanisms. Oncogene. 32:4273–4283. 2013.
View Article : Google Scholar : PubMed/NCBI
|
|
66
|
Song M, Bode AM, Dong Z and Lee MH: AKT as
a therapeutic target for cancer. Cancer Res. 79:1019–1031. 2019.
View Article : Google Scholar : PubMed/NCBI
|
|
67
|
Dodson M, Castro-Portuguez R and Zhang DD:
NRF2 plays a critical role in mitigating lipid peroxidation and
ferroptosis. Redox Biol. 23:1011072019. View Article : Google Scholar : PubMed/NCBI
|
|
68
|
Qiang Z, Dong H, Xia Y, Chai D, Hu R and
Jiang H: Nrf2 and STAT3 alleviates ferroptosis-mediated IIR-ALI by
regulating SLC7A11. Oxid Med Cell Longev. 2020:51469822020.
View Article : Google Scholar : PubMed/NCBI
|
|
69
|
Sun X, Ou Z, Chen R, Niu X, Chen D, Kang R
and Tang D: Activation of the p62-Keap1-NRF2 pathway protects
against ferroptosis in hepatocellular carcinoma cells. Hepatology.
63:173–184. 2016. View Article : Google Scholar : PubMed/NCBI
|
|
70
|
Cloer EW, Goldfarb D, Schrank TP, Weissman
BE and Major MB: NRF2 activation in cancer: From DNA to protein.
Cancer Res. 79:889–898. 2019. View Article : Google Scholar : PubMed/NCBI
|
|
71
|
Huang W, Shi G, Yong Z, Li J, Qiu J, Cao
Y, Zhao Y and Yuan L: Downregulation of RKIP promotes
radioresistance of nasopharyngeal carcinoma by activating NRF2/NQO1
axis via downregulating miR-450b-5p. Cell Death Dis. 11:5042020.
View Article : Google Scholar : PubMed/NCBI
|
|
72
|
Zhou J, Ding J, Ma X, Zhang M, Huo Z, Yao
Y, Li D and Wang Z: The NRF2/KEAP1 pathway modulates nasopharyngeal
carcinoma cell radiosensitivity via ROS elimination. Onco Targets
Ther. 13:9113–9122. 2020. View Article : Google Scholar : PubMed/NCBI
|
|
73
|
Zhang G, Wang W, Yao C, Ren J, Zhang S and
Han M: Salinomycin overcomes radioresistance in nasopharyngeal
carcinoma cells by inhibiting Nrf2 level and promoting ROS
generation. Biomed Pharmacother. 91:147–154. 2017. View Article : Google Scholar : PubMed/NCBI
|
|
74
|
Yun SM, Kim YS and Hur DY: LMP1 and 2A
induce the expression of Nrf2 through Akt signaling pathway in
Epstein-Barr virus-transformed B cells. Transl Oncol. 12:775–783.
2019. View Article : Google Scholar : PubMed/NCBI
|
|
75
|
Hsu JL, Chou JW, Chen TF, Hsu JT, Su FY,
Lan JL, Wu PC, Hu CM, Lee EY and Lee WH: Glutathione peroxidase 8
negatively regulates caspase-4/11 to protect against colitis. EMBO
Mol Med. 12:e93862020. View Article : Google Scholar : PubMed/NCBI
|
|
76
|
Koeberle SC, Gollowitzer A, Laoukili J,
Kranenburg O, Werz O, Koeberle A and Kipp AP: Distinct and
overlapping functions of glutathione peroxidases 1 and 2 in
limiting NF-κB-driven inflammation through redox-active mechanisms.
Redox Biol. 28:1013882020. View Article : Google Scholar : PubMed/NCBI
|
|
77
|
Maiorino M, Conrad M and Ursini F: GPx4,
lipid peroxidation, and cell death: Discoveries, rediscoveries, and
open issues. Antioxid Redox Signal. 29:61–74. 2018. View Article : Google Scholar : PubMed/NCBI
|
|
78
|
Nunes SC and Serpa J: Glutathione in
ovarian cancer: A Double-edged sword. Int J Mol Sci. 19:18822018.
View Article : Google Scholar : PubMed/NCBI
|
|
79
|
Meng DF, Guo LL, Peng LX, Zheng LS, Xie P,
Mei Y, Li CZ, Peng XS, Lang YH, Liu ZJ, et al: Antioxidants
suppress radiation-induced apoptosis via inhibiting MAPK pathway in
nasopharyngeal carcinoma cells. Biochem Biophys Res Commun.
527:770–777. 2020. View Article : Google Scholar : PubMed/NCBI
|
|
80
|
Song X, Xie Y, Kang R, Hou W, Sun X,
Epperly MW, Greenberger JS and Tang D: FANCD2 protects against bone
marrow injury from ferroptosis. Biochem Biophys Res Commun.
480:443–449. 2016. View Article : Google Scholar : PubMed/NCBI
|
|
81
|
Bao Y, Feng H, Zhao F, Zhang L, Xu S,
Zhang C, Zhao C and Qin G: FANCD2 knockdown with shRNA interference
enhances the ionizing radiation sensitivity of nasopharyngeal
carcinoma CNE-2 cells. Neoplasma. 68:40–52. 2021. View Article : Google Scholar : PubMed/NCBI
|
|
82
|
Xu S, Zhao F, Liang Z, Feng H, Bao Y, Xu
W, Zhao C and Qin G: Expression of FANCD2 is associated with
prognosis in patients with nasopharyngeal carcinoma. Int J Clin Exp
Pathol. 12:3465–3473. 2019.PubMed/NCBI
|
|
83
|
Suttner DM and Dennery PA: Reversal of
HO-1 related cytoprotection with increased expression is due to
reactive iron. FASEB J. 13:1800–1809. 1999. View Article : Google Scholar : PubMed/NCBI
|
|
84
|
Adedoyin O, Boddu R, Traylor A, Lever JM,
Bolisetty S, George JF and Agarwal A: Heme oxygenase-1 mitigates
ferroptosis in renal proximal tubule cells. Am J Physiol Renal
Physiol. 314:F702–F714. 2018. View Article : Google Scholar : PubMed/NCBI
|
|
85
|
Shi L and Fang J: Implication of heme
oxygenase-1 in the sensitivity of nasopharyngeal carcinomas to
radiotherapy. J Exp Clin Cancer Res. 27:132008. View Article : Google Scholar : PubMed/NCBI
|
|
86
|
Jiang L, Kon N, Li T, Wang SJ, Su T,
Hibshoosh H, Baer R and Gu W: Ferroptosis as a p53-mediated
activity during tumour suppression. Nature. 520:57–62. 2015.
View Article : Google Scholar : PubMed/NCBI
|
|
87
|
Wang SJ, Li D, Ou Y, Jiang L, Chen Y, Zhao
Y and Gu W: Acetylation is crucial for p53-mediated ferroptosis and
tumor suppression. Cell Rep. 17:366–373. 2016. View Article : Google Scholar : PubMed/NCBI
|
|
88
|
Xie Y, Zhu S, Song X, Sun X, Fan Y, Liu J,
Zhong M, Yuan H, Zhang L, Billiar TR, et al: The tumor suppressor
p53 limits Ferroptosis by blocking DPP4 activity. Cell Rep.
20:1692–1704. 2017. View Article : Google Scholar : PubMed/NCBI
|
|
89
|
Wang Z, Mao JW, Liu GY, Wang FG, Ju ZS,
Zhou D and Wang RY: MicroRNA-372 enhances radiosensitivity while
inhibiting cell invasion and metastasis in nasopharyngeal carcinoma
through activating the PBK-dependent p53 signaling pathway. Cancer
Med. 8:712–728. 2019. View Article : Google Scholar : PubMed/NCBI
|
|
90
|
Ma WS, Ma JG and Xing LN: Efficacy and
safety of recombinant human adenovirus p53 combined with
chemoradiotherapy in the treatment of recurrent nasopharyngeal
carcinoma. Anticancer Drugs. 28:230–236. 2017. View Article : Google Scholar : PubMed/NCBI
|
|
91
|
Song X, Zhu S, Chen P, Hou W, Wen Q, Liu
J, Xie Y, Liu J, Klionsky DJ, Kroemer G, et al: AMPK-mediated BECN1
phosphorylation promotes ferroptosis by directly blocking System
Xc− activity. Curr Biol. 28:2388–2399.e5. 2018.
View Article : Google Scholar : PubMed/NCBI
|
|
92
|
Kang R, Zhu S, Zeh HJ, Klionsky DJ and
Tang D: BECN1 is a new driver of ferroptosis. Autophagy.
14:2173–2175. 2018. View Article : Google Scholar : PubMed/NCBI
|
|
93
|
Wan XB, Fan XJ, Chen MY, Xiang J, Huang
PY, Guo L, Wu XY, Xu J, Long ZJ, Zhao Y, et al: Elevated Beclin 1
expression is correlated with HIF-1alpha in predicting poor
prognosis of nasopharyngeal carcinoma. Autophagy. 6:395–404. 2010.
View Article : Google Scholar : PubMed/NCBI
|
|
94
|
Wang Y, Chen W, Lian J, Zhang H, Yu B,
Zhang M, Wei F, Wu J, Jiang J, Jia Y, et al: The lncRNA PVT1
regulates nasopharyngeal carcinoma cell proliferation via
activating the KAT2A acetyltransferase and stabilizing HIF-1α. Cell
Death Differ. 27:695–710. 2020. View Article : Google Scholar : PubMed/NCBI
|
|
95
|
Majidinia M, Karimian A, Alemi F, Yousefi
B and Safa A: Targeting miRNAs by polyphenols: Novel therapeutic
strategy for aging. Biochem Pharmacol. 173:1136882020. View Article : Google Scholar : PubMed/NCBI
|
|
96
|
Ding C, Ding X, Zheng J, Wang B, Li Y,
Xiang H, Dou M, Qiao Y, Tian P and Xue W: miR-182-5p and
miR-378a-3p regulate ferroptosis in I/R-induced renal injury. Cell
Death Dis. 11:9292020. View Article : Google Scholar : PubMed/NCBI
|
|
97
|
Deng SH, Wu DM, Li L, Liu T, Zhang T, Li
J, Yu Y, He M, Zhao YY, Han R and Xu Y: miR-324-3p reverses
cisplatin resistance by inducing GPX4-mediated ferroptosis in lung
adenocarcinoma cell line A549. Biochem Biophys Res Commun.
549:54–60. 2021. View Article : Google Scholar : PubMed/NCBI
|
|
98
|
Xiao FJ, Zhang D, Wu Y, Jia QH, Zhang L,
Li YX, Yang YF, Wang H, Wu CT and Wang LS: miRNA-17-92 protects
endothelial cells from erastin-induced ferroptosis through
targeting the A20-ACSL4 axis. Biochem Biophys Res Commun.
515:448–454. 2019. View Article : Google Scholar : PubMed/NCBI
|
|
99
|
Ma LL, Liang L, Zhou D and Wang SW: Tumor
suppressor miR-424-5p abrogates ferroptosis in ovarian cancer
through targeting ACSL4. Neoplasma. 68:165–173. 2021. View Article : Google Scholar : PubMed/NCBI
|
|
100
|
Tomita K, Fukumoto M, Itoh K, Kuwahara Y,
Igarashi K, Nagasawa T, Suzuki M, Kurimasa A and Sato T: MiR-7-5p
is a key factor that controls radioresistance via intracellular
Fe2+ content in clinically relevant radioresistant
cells. Biochem Biophys Res Commun. 518:712–718. 2019. View Article : Google Scholar : PubMed/NCBI
|
|
101
|
Zhang K, Wu L, Zhang P, Luo M, Du J, Gao
T, O'Connell D, Wang G, Wang H and Yang Y: miR-9 regulates
ferroptosis by targeting glutamic-oxaloacetic transaminase GOT1 in
melanoma. Mol Carcinog. 57:1566–1576. 2018. View Article : Google Scholar : PubMed/NCBI
|
|
102
|
Luo M, Wu L, Zhang K, Wang H, Zhang T,
Gutierrez L, O'Connell D, Zhang P, Li Y, Gao T, et al: miR-137
regulates ferroptosis by targeting glutamine transporter SLC1A5 in
melanoma. Cell Death Differ. 25:1457–1472. 2018. View Article : Google Scholar : PubMed/NCBI
|
|
103
|
Qi YF, Yang Y, Zhang Y, Liu S, Luo B and
Liu W: Down regulation of lactotransferrin enhanced
radio-sensitivity of nasopharyngeal carcinoma. Comput Biol Chem.
90:1074262021. View Article : Google Scholar : PubMed/NCBI
|
|
104
|
He W, Jin H, Liu Q and Sun Q: miR-182-5p
contributes to radioresistance in nasopharyngeal carcinoma by
regulating BNIP3 expression. Mol Med Rep. 23:1302021. View Article : Google Scholar : PubMed/NCBI
|
|
105
|
Zhang Y, Zheng L, Lin S, Liu Y, Wang Y and
Gao F: MiR-124 enhances cell radiosensitivity by targeting PDCD6 in
nasopharyngeal carcinoma. Int J Clin Exp Pathol. 10:11461–11470.
2017.PubMed/NCBI
|
|
106
|
Tian Y, Tian Y, Tu Y, Zhang G, Zeng X, Lin
J, Ai M, Mao Z, Zheng R and Yuan Y: microRNA-124 inhibits stem-like
properties and enhances radiosensitivity in nasopharyngeal
carcinoma cells via direct repression of expression of JAMA. J Cell
Mol Med. 24:9533–9544. 2020. View Article : Google Scholar : PubMed/NCBI
|
|
107
|
Chen L, Zhou H and Guan Z: CircRNA_000543
knockdown sensitizes nasopharyngeal carcinoma to irradiation by
targeting miR-9/platelet-derived growth factor receptor B axis.
Biochem Biophys Res Commun. 512:786–792. 2019. View Article : Google Scholar : PubMed/NCBI
|
|
108
|
Hu JL, He GY, Lan XL, Zeng ZC, Guan J,
Ding Y, Qian XL, Liao WT, Ding YQ and Liang L: Inhibition of
ATG12-mediated autophagy by miR-214 enhances radiosensitivity in
colorectal cancer. Oncogenesis. 7:162018. View Article : Google Scholar : PubMed/NCBI
|
|
109
|
Han JB, Huang ML, Li F, Yang R, Chen SM
and Tao ZZ: MiR-214 mediates cell proliferation and apoptosis of
nasopharyngeal carcinoma through targeting both WWOX and PTEN.
Cancer Biother Radiopharm. 35:615–625. 2020. View Article : Google Scholar : PubMed/NCBI
|
|
110
|
Zhang ZC, Li YY, Wang HY, Fu S, Wang XP,
Zeng MS, Zeng YX and Shao JY: Knockdown of miR-214 promotes
apoptosis and inhibits cell proliferation in nasopharyngeal
carcinoma. PLoS One. 9:e861492014. View Article : Google Scholar : PubMed/NCBI
|
|
111
|
He J, Tang Y and Tian Y: MicroRNA-214
promotes proliferation and inhibits apoptosis via targeting Bax in
nasopharyngeal carcinoma cells. Mol Med Rep. 12:6286–6292. 2015.
View Article : Google Scholar : PubMed/NCBI
|
|
112
|
Deng M, Ye Q, Qin Z, Zheng Y, He W, Tang
H, Zhou Y, Xiong W, Zhou M, Li X, et al: miR-214 promotes
tumorigenesis by targeting lactotransferrin in nasopharyngeal
carcinoma. Tumour Biol. 34:1793–1800. 2013. View Article : Google Scholar : PubMed/NCBI
|
|
113
|
Deng X, Ma L, Wu M, Zhang G, Jin C, Guo Y
and Liu R: miR-124 radiosensitizes human glioma cells by targeting
CDK4. J Neurooncol. 114:263–274. 2013. View Article : Google Scholar : PubMed/NCBI
|
|
114
|
Luo Y, Wang J, Wang F, Liu X, Lu J, Yu X,
Ma X, Peng X and Li X: Foxq1 promotes metastasis of nasopharyngeal
carcinoma by inducing vasculogenic mimicry via the EGFR signaling
pathway. Cell Death Dis. 12:4112021. View Article : Google Scholar : PubMed/NCBI
|
|
115
|
Lu J, Xu F and Lu H: LncRNA PVT1 regulates
ferroptosis through miR-214-mediated TFR1 and p53. Life Sci.
260:1183052020. View Article : Google Scholar : PubMed/NCBI
|
|
116
|
Bao WD, Zhou XT, Zhou LT, Wang F, Yin X,
Lu Y, Zhu LQ and Liu D: Targeting miR-124/Ferroportin signaling
ameliorated neuronal cell death through inhibiting apoptosis and
ferroptosis in aged intracerebral hemorrhage murine model. Aging
Cell. 19:e132352020. View Article : Google Scholar : PubMed/NCBI
|
|
117
|
Li Y, Chen F, Chen J, Chan S, He Y, Liu W
and Zhang G: Disulfiram/Copper induces antitumor activity against
both nasopharyngeal cancer cells and cancer-associated fibroblasts
through ROS/MAPK and Ferroptosis pathways. Cancers (Basel).
12:1382020. View Article : Google Scholar : PubMed/NCBI
|
|
118
|
He X, Yao Q, Fan D, Duan L, You Y, Liang
W, Zhou Z, Teng S, Liang Z, Hall DD, et al: Cephalosporin
antibiotics specifically and selectively target nasopharyngeal
carcinoma through HMOX1-induced ferroptosis. Life Sci.
277:1194572021. View Article : Google Scholar : PubMed/NCBI
|
|
119
|
Shibata Y, Yasui H, Higashikawa K,
Miyamoto N and Kuge Y: Erastin, a ferroptosis-inducing agent,
sensitized cancer cells to X-ray irradiation via glutathione
starvation in vitro and in vivo. PLoS One. 14:e02259312019.
View Article : Google Scholar : PubMed/NCBI
|
|
120
|
Li M, Wang X, Lu S, He C, Wang C, Wang L,
Wang X, Ge P and Song D: Erastin triggers autophagic death of
breast cancer cells by increasing intracellular iron levels. Oncol
Lett. 20:572020.PubMed/NCBI
|
|
121
|
Tam SY, Wu VW and Law HK: Influence of
autophagy on the efficacy of radiotherapy. Radiat Oncol. 12:572017.
View Article : Google Scholar : PubMed/NCBI
|
|
122
|
Mou Y, Wang J, Wu J, He D, Zhang C, Duan C
and Li B: Ferroptosis, a new form of cell death: opportunities and
challenges in cancer. J Hematol Oncol. 12:342019. View Article : Google Scholar : PubMed/NCBI
|
|
123
|
Friedmann Angeli JP, Krysko DV and Conrad
M: Ferroptosis at the crossroads of cancer-acquired drug resistance
and immune evasion. Nat Rev Cancer. 19:405–414. 2019. View Article : Google Scholar : PubMed/NCBI
|
