Open Access

NDRG4 sensitizes CRC cells to 5‑FU by upregulating DDIT3 expression

  • Authors:
    • Ruikai Li
    • Chenxiang He
    • Liangliang Shen
    • Shuai Wang
    • Yao Shen
    • Fan Feng
    • Jian Zhang
    • Jianyong Zheng
  • View Affiliations

  • Published online on: September 13, 2021     https://doi.org/10.3892/ol.2021.13043
  • Article Number: 782
  • Copyright: © Li et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

The incidence of colorectal cancer (CRC) has remained high in recent years, and 5‑fluorouracil (5‑FU) is a vital chemotherapeutic agent for its treatment. Our previous study reported that N‑myc downstream‑regulated gene 4 (NDRG4) plays a tumor‑suppressive role in CRC, but the mechanisms associated with NDRG4 and 5‑FU chemosensitivity remain unclear. The results of the present study demonstrate that NDRG4 sensitized CRC cells to 5‑FU by upregulating DNA damage inducible transcript 3 (DDIT3). NDRG4 inhibited the proliferation of CRC cells and the activation of PI3K/AKT and ERK signaling. Furthermore, NDRG4 promoted CRC cell apoptosis induced by 5‑FU. Mechanistic analyses revealed that NDRG4 upregulated DDIT3 expression, and that the proapoptotic effect of NDRG4 under 5‑FU treatment conditions was dependent on DDIT3. These findings support the biological value of the association between NDRG4, DDIT3 and 5‑FU chemosensitivity in CRC, and may advance the clinical treatment of CRC in the future.
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November-2021
Volume 22 Issue 5

Print ISSN: 1792-1074
Online ISSN:1792-1082

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Copy and paste a formatted citation
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Spandidos Publications style
Li R, He C, Shen L, Wang S, Shen Y, Feng F, Zhang J and Zheng J: NDRG4 sensitizes CRC cells to 5‑FU by upregulating DDIT3 expression. Oncol Lett 22: 782, 2021
APA
Li, R., He, C., Shen, L., Wang, S., Shen, Y., Feng, F. ... Zheng, J. (2021). NDRG4 sensitizes CRC cells to 5‑FU by upregulating DDIT3 expression. Oncology Letters, 22, 782. https://doi.org/10.3892/ol.2021.13043
MLA
Li, R., He, C., Shen, L., Wang, S., Shen, Y., Feng, F., Zhang, J., Zheng, J."NDRG4 sensitizes CRC cells to 5‑FU by upregulating DDIT3 expression". Oncology Letters 22.5 (2021): 782.
Chicago
Li, R., He, C., Shen, L., Wang, S., Shen, Y., Feng, F., Zhang, J., Zheng, J."NDRG4 sensitizes CRC cells to 5‑FU by upregulating DDIT3 expression". Oncology Letters 22, no. 5 (2021): 782. https://doi.org/10.3892/ol.2021.13043