Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Oncology Letters
      • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Biomedical Reports
      • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • Information for Authors
    • Information for Reviewers
    • Information for Librarians
    • Information for Advertisers
    • Conferences
  • Language Editing
Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • For Authors
    • For Reviewers
    • For Librarians
    • For Advertisers
    • Conferences
  • Language Editing
Login Register Submit
  • This site uses cookies
  • You can change your cookie settings at any time by following the instructions in our Cookie Policy. To find out more, you may read our Privacy Policy.

    I agree
Search articles by DOI, keyword, author or affiliation
Search
Advanced Search
presentation
Oncology Letters
Join Editorial Board Propose a Special Issue
Print ISSN: 1792-1074 Online ISSN: 1792-1082
Journal Cover
November-2021 Volume 22 Issue 5

Full Size Image

Sign up for eToc alerts
Recommend to Library

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
November-2021 Volume 22 Issue 5

Full Size Image

Sign up for eToc alerts
Recommend to Library

  • Article
  • Citations
    • Cite This Article
    • Download Citation
    • Create Citation Alert
    • Remove Citation Alert
    • Cited By
  • Similar Articles
    • Related Articles (in Spandidos Publications)
    • Similar Articles (Google Scholar)
    • Similar Articles (PubMed)
  • Download PDF
  • Download XML
  • View XML
Review Open Access

Towards an updated view on the clinical management of pancreatic adenocarcinoma: Current and future perspectives (Review)

  • Authors:
    • Leonel Pekarek
    • Oscar Fraile‑Μartinez
    • Cielo Garcia‑Montero
    • Miguel A. Alvarez‑Mon
    • Julio Acero
    • Lidia Ruiz‑Llorente
    • Natalio García‑Honduvilla
    • Agustin Albillos
    • Julia Buján
    • Melchor Alvarez‑Mon
    • Luis G. Guijarro
    • Miguel A. Ortega
  • View Affiliations / Copyright

    Affiliations: Department of Medicine and Medical Specialities, Faculty of Medicine and Health Sciences, University of Alcalá, Alcala de Henares, 28871 Madrid, Spain, Ramón y Cajal Institute of Sanitary Research, 28034 Madrid, Spain
    Copyright: © Pekarek et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 809
    |
    Published online on: September 27, 2021
       https://doi.org/10.3892/ol.2021.13070
  • Expand metrics +
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
Cited By (CrossRef): 0 citations Loading Articles...

This article is mentioned in:



Abstract

Pancreatic cancer has a dire prognosis and will represent the second leading cause of cancer death in the next 10 years. The multifactorial approach represents one of the main issues in controlling the extension of this neoplasm. In recent years, the characteristics of the tumor microenvironment, metastasis mechanisms and the relationship between immune system and neoplastic cells have been described, which has made it possible to understand the pathophysiology of pancreatic adenocarcinoma. Currently, there is a failure to provide an effective preventive method or early detection, so patients present with an advanced stage at the time of diagnosis. Despite numerous efforts, little progress has been made in clinical outcome and in improving survival in long term. Therefore, in the recent years, diverse diagnostic tests, treatments and possible approaches have been developed in the fields of radiotherapy, chemotherapy and surgery to find a combination of them that improves life expectancy in patients diagnosed with pancreatic cancer. At the moment, numerous clinical trials are being conducted to evaluate preventive diagnostic procedures such as serological markers or perfecting available imaging tests. On the other hand, implementation of immunotherapy is being studied in a neoplasm that has lagged in the application of this procedure since present possible treatments do not substantially improve quality of life. Therefore, the purpose of our study is to summarize the main progresses that have been made in the diagnosis, treatment and screening of this disease, explaining the limitations that have been observed and analyzing future prospects in the management of this illness.
View Figures
View References

1 

Ilic M and Ilic I: Epidemiology of pancreatic cancer. World J Gastroenterol. 28:9694–9705. 2016. View Article : Google Scholar : PubMed/NCBI

2 

Rahib L, Smith BD, Aizenberg R, Rosenzweig AB, Fleshman JM and Matrisian LM: Projecting cancer incidence and deaths to 2030: The unexpected burden of thyroid, liver, and pancreas cancers in the United States. Cancer Res. 74:2913–2921. 2014. View Article : Google Scholar : PubMed/NCBI

3 

Guren MG: The global challenge of colorectal cancer. Lancet Gastroenterol Hepatol. 4:894–895. 2019. View Article : Google Scholar : PubMed/NCBI

4 

Li D: Diabetes and pancreatic cancer. Mol Carcinog. 51:64–74. 2011. View Article : Google Scholar

5 

Yadav D and Lowenfels AB: The epidemiology of pancreatitis and pancreatic cancer. Gastroenterology. 144:1252–1261. 2013. View Article : Google Scholar : PubMed/NCBI

6 

Ansari D, Tingstedt B, Andersson B, Holmquist F, Sturesson C, Williamsson C, Sasor A, Borg D, Bauden M and Andersson R: Pancreatic cancer: Yesterday, today and tomorrow. Future Oncol. 12:1929–1246. 2016. View Article : Google Scholar : PubMed/NCBI

7 

Maisonneuve P: Epidemiology and burden of pancreatic cancer. Presse Med. 48:e113–e123. 2019. View Article : Google Scholar : PubMed/NCBI

8 

Mizrahi JD, Surana R, Valle JW and Shroff RT: Pancreatic cancer. Lancet. 395:2008–2020. 2020. View Article : Google Scholar : PubMed/NCBI

9 

McGuigan A, Kelly P, Turkington RC, Jones C, Coleman HG and McCain RS: Pancreatic cancer: A review of clinical diagnosis, epidemiology, treatment and outcomes. World J Gastroenterol. 24:4846–4861. 2018. View Article : Google Scholar : PubMed/NCBI

10 

Poruk KE, Firpo MA and Mulvihill SJ: Screening for pancreatic cancer. Ann Surg. 257:17–26. 2013. View Article : Google Scholar : PubMed/NCBI

11 

Capasso M, Franceschi M, Rodriguez-Castro KI, Crafa P, Cambiè G, Miraglia C, Barchi A, Nouvenne A, Leandro G, Meschi T, et al: Epidemiology and risk factors of pancreatic cancer. Acta Biomed. 89:141–146. 2018.PubMed/NCBI

12 

Vilaverde F, Reis A, Rodrigues P, Carvalho A and Scigliano H: Adult pancreatoblastoma-case report and review of literature. J Radiol Case Rep. 31:28–38. 2016.PubMed/NCBI

13 

Geurts JL: Inherited syndromes involving pancreatic neuroendocrine tumors. J Gastrointest Oncol. 11:559–566. 2020. View Article : Google Scholar : PubMed/NCBI

14 

Zhang Q, Chen S, Zeng L, Chen Y, Lian G, Qian C, Li J, Xie R and Huang KH: New developments in the early diagnosis of pancreatic cancer. Expert Rev Gastroenterol Hepatol. 11:149–156. 2017. View Article : Google Scholar : PubMed/NCBI

15 

Sung H, Ferlay J, Siegel RL, Laversanne M, Soerjomataram I, Jemal A and Bray F: Global cancer statistics 2020: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA Cancer J Clin. 71:209–249. 2021. View Article : Google Scholar : PubMed/NCBI

16 

Kolodecik T, Shugrue C, Ashat M and Thrower EC: Risk factors for pancreatic cancer: Underlying mechanisms and potential targets. Front Physiol. 16:4152014.

17 

Haeberle L and Esposito I: Pathology of pancreatic cancer. Transl Gastroenterol Hepatol. 27:502019. View Article : Google Scholar : PubMed/NCBI

18 

Pereira NP and Corrêa JR: Pancreatic cancer: Treatment approaches and trends. J Cancer Metastasis Treat. 4:302018. View Article : Google Scholar

19 

Berardi R, Mandolesi A, Pellei C, Maccaroni E, Onofri A, Lucarelli A, Biagetti S, Alfonsi S, Caramanti M, Savini A, et al: Prognostic factors in pancreatic cancer: The role of perineural, vascular and lymphatic invasion and of Ca19-9. J Gastroint Dig Syst. 3:1342013.

20 

Delpu Y, Hanoun N, Lulka H, Sicard F, Selves J, Buscail L, Torrisani J and Cordelier P: Genetic and epigenetic alterations in pancreatic carcinogenesis. Curr Genomics. 12:15–24. 2011. View Article : Google Scholar : PubMed/NCBI

21 

Andrén-Sandberg A: Non-pancreatic cancer tumors in the pancreatic region. N Am J Med Sci. 3:55–62. 2011. View Article : Google Scholar : PubMed/NCBI

22 

Kaur S, Baine MJ, Jain M, Sasson AR and Batra SK: Early diagnosis of pancreatic cancer: Challenges and new developments. Biomark Med. 6:597–612. 2012. View Article : Google Scholar : PubMed/NCBI

23 

Khan MA, Azim S, Zubair H, Bhardwaj A, Patel GK, Khushman M, Singh S and Singh AP: Molecular drivers of pancreatic cancer pathogenesis: Looking inward to move forward. Int J Mol Sci. 6:7792017. View Article : Google Scholar

24 

Hruban RH and Fukushima N: Pancreatic adenocarcinoma: Update on the surgical pathology of carcinomas of ductal origin and PanINs. Mod Pathol. 20 (Suppl 1):S61–S70. 2007. View Article : Google Scholar : PubMed/NCBI

25 

Fang Y, Yao Q, Chen Z, Xiang J, William FE, Gibbs RA and Chen C: Genetic and molecular alterations in pancreatic cancer: Implications for personalized medicine. Med Sci Monit. 31:916–926. 2013.PubMed/NCBI

26 

Visani M, Acquaviva G, Leo AD, Sanza V, Merlo L, Maloberti T, Brandes AA, Franceschi E, Battista MD, Masetti M, et al: Molecular alterations in pancreatic tumors. World J Gastroenterol. 7:2710–2726. 2021. View Article : Google Scholar : PubMed/NCBI

27 

Vernucci E, Abrego J, Gunda V, Shukla SK, Dasgupta A, Rai V, Chaika N, Buettner K, Illies A, Yu F, et al: Metabolic alterations in pancreatic cancer progression. Cancers (Basel). 18:22019. View Article : Google Scholar

28 

Gil YR, Sánchez PJ, Velasco RM, García AG and Lobo VJ: Molecular alterations in pancreatic cancer: Transfer to the clinic. Int J Mol Sci. 19:20772021.

29 

Pandol S, Edderkaoui M, Gukovsky I, Lugea A and Gukovskaya A: Desmoplasia of pancreatic ductal adenocarcinoma. Clin Gastroenterol Hepatol. 7 (Suppl 11):S44–S47. 2009. View Article : Google Scholar : PubMed/NCBI

30 

Merika EE, Syrigos KN and Saif MW: Desmoplasia in pancreatic cancer. Can we fight it? Gastroenterol Res Pract. 2012:7817652012.PubMed/NCBI

31 

Annese T, Tamma R, Ruggieri S and Ribatti D: Angiogenesis in pancreatic cancer: Pre-clinical and clinical studies. Cancers (Basel). 18:3812019. View Article : Google Scholar

32 

Li S, Xu HX, Wu CT, Wang WQ, Jin W, Gao HL, Li H, Zhang SR, Xu JZ, Qi ZH, et al: Angiogenesis in pancreatic cancer: Current research status and clinical implications. Angiogenesis. 22:15–36. 2019. View Article : Google Scholar : PubMed/NCBI

33 

Zeng S, Pöttler M, Lan B, Grützmann R, Pilarsky C and Yang H: Chemoresistance in pancreatic cancer. Int J Mol Sci. 11:45042019. View Article : Google Scholar

34 

Grasso C, Jansen G and Giovannetti E: Drug resistance in pancreatic cancer: Impact of altered energy metabolism. Crit Rev Oncol Hematol. 114:139–152. 2017. View Article : Google Scholar : PubMed/NCBI

35 

Wang S, Huang S and Sun YL: Epithelial-mesenchymal transition in pancreatic cancer: A review. Biomed Res Int. 2017:26461482017. View Article : Google Scholar : PubMed/NCBI

36 

Zheng X, Carstens JL, Kim J, Scheible M, Kaye J, Sugimoto H, Wu CC, LeBleu VS and Kalluri R: Epithelial-to-mesenchymal transition is dispensable for metastasis but induces chemoresistance in pancreatic cancer. Nature. 527:525–530. 2015. View Article : Google Scholar : PubMed/NCBI

37 

Safa AR: Epithelial-mesenchymal transition: A hallmark in pancreatic cancer stem cell migration, metastasis formation, and drug resistance. J Cancer Metastasis Treat. 6:362020.

38 

Miura F, Takada T, Amano H, Yoshida M, Furui S and Takeshita K: Diagnosis of pancreatic cancer. HPB (Oxford). 8:337–342. 2006. View Article : Google Scholar : PubMed/NCBI

39 

Song SW, Cheng JF, Liu N and Zhao TH: Diagnosis and treatment of pancreatic metastases in 22 patients: A retrospective study. World J Surg Oncol. 25:2992014. View Article : Google Scholar : PubMed/NCBI

40 

Nalankilli K, Kannuthurai S and Moss A: A modern approach to ERCP: Maintaining efficacy while optimising safety. Dig Endosc. 28 (Suppl 1):S70–S76. 2016. View Article : Google Scholar : PubMed/NCBI

41 

Tryliskyy Y and Bryce GJ: Post-ERCP pancreatitis: Pathophysiology, early identification and risk stratification. Adv Clin Exp Med. 27:149–154. 2018. View Article : Google Scholar : PubMed/NCBI

42 

Dietrich CF and Christian J: Modern ultrasound imaging of pancreatic tumors. Ultrasonography. 39:105–113. 2020. View Article : Google Scholar : PubMed/NCBI

43 

Gañán IM, Ríos LF, de Toledo LS, Mombila ME and Mendoza LH: Estadificación mediante tomografía computarizada del carcinoma de páncreas. Radiologia. 60:10–23. 2018.(In English, Spanish). View Article : Google Scholar : PubMed/NCBI

44 

Azzaz HE, Abdullah MS and Habib RM: Role of multidetector computed tomography in evaluation of resectability of pancreatic cancer. Egyptian J Radiol Nuclear Med. 52:1402021. View Article : Google Scholar

45 

Deng L, Ke X, He Z, Yang D, Gong H, Zhang Y, Jing X, Yao J and Chen J: A MSLN-targeted multifunctional nanoimmunoliposome for MRI and targeting therapy in pancreatic cancer. Int J Nanomedicine. 7:5053–5065. 2012.PubMed/NCBI

46 

Le K, Wang J, Zhang T, Guo Y, Chang H, Wang S and Zhu B: Overexpression of mesothelin in pancreatic ductal adenocarcinoma (PDAC). Int J Med Sci. 17:422–427. 2020. View Article : Google Scholar : PubMed/NCBI

47 

Jha P and Bijan B: PET/CT for pancreatic malignancy: Potential and pitfalls. J Nucl Med Technol. 43:92–97. 2015. View Article : Google Scholar : PubMed/NCBI

48 

Bhutani MS, Koduru P, Joshi V, Saxena P, Suzuki R, Irisawa A and Yamao K: The role of endoscopic ultrasound in pancreatic cancer screening. Endosc Ultrasound. 5:8–16. 2016. View Article : Google Scholar : PubMed/NCBI

49 

Guijarro LG, Sanmartin-Salinas P, Pérez-Cuevas E, Toledo-Lobo MV, Monserrat J, Zoullas S, Sáez MA, Álvarez-Mon MA, Bujan J, Noguerales-Fraguas F, et al: Possible role of IRS-4 in the origin of multifocal hepatocellular carcinoma. Cancers (Basel). 23:25602021. View Article : Google Scholar

50 

Majumder S, Chari ST and Ahlquist DA: Molecular detection of pancreatic neoplasia: Current status and future promise. World J Gastroenterol. 28:11387–11395. 2015. View Article : Google Scholar : PubMed/NCBI

51 

Kato K, Kamada H, Fujimori T, Aritomo Y, Ono M and Masaki T: Molecular biologic approach to the diagnosis of pancreatic carcinoma using specimens obtained by EUS-guided fine needle aspiration. Gastroenterol Res Pract. 2012:2435242012. View Article : Google Scholar : PubMed/NCBI

52 

Hanada K, Minami T, Shimizu A, Fukuhara M, Yano S, Sasaki K, Koda M, Sugiyama K, Yonehara S and Yanagisawa A: Roles of ERCP in the early diagnosis of pancreatic cancer. Diagnostics (Basel). 7:302019. View Article : Google Scholar

53 

Bispo M, Marques S, Rio-Tinto R, Fidalgo P and Devière J: The role of endoscopic ultrasound in pancreatic cancer staging in the Era of neoadjuvant therapy and personalised medicine. GE Port J Gastroenterol. 28:111–120. 2021.PubMed/NCBI

54 

Sun B and Hu B: The role of intraductal ultrasonography in pancreatobiliary diseases. Endosc Ultrasound. 5:291–299. 2016. View Article : Google Scholar : PubMed/NCBI

55 

Puri R, Manrai M, Thandassery RB and Alfadda AA: Endoscopic ultrasound in the diagnosis and management of carcinoma pancreas. World J Gastrointest Endosc. 25:67–76. 2016. View Article : Google Scholar : PubMed/NCBI

56 

Yamashita Y, Kato J, Ueda K, Nakamura Y, Kawaji Y, Abe H, Nuta J, Tamura T, Itonaga M, Yoshida T, et al: Contrast-enhanced endoscopic ultrasonography for pancreatic tumors. Biomed Res Int. 2015:4917822015. View Article : Google Scholar : PubMed/NCBI

57 

Pentyala S, Whyard T, Pentyala S, Muller J, Pfail J, Parmar S, Helguero CG and Khan S: Prostate cancer markers: An update. Biomed Rep. 4:263–268. 2016. View Article : Google Scholar : PubMed/NCBI

58 

Gonssaud B, Goussot V, Berriolo-Riedinger A, Saïtta-Aribau E, Coutant C, Cochet A, Fumoleau P and Riedinger JM: Clinical value of CA 15-3 for detection of distant metastases in newly diagnosed breast cancer. Ann Biol Clin (Paris). 1:421–429. 2017.PubMed/NCBI

59 

Bottoni P and Scatena R: The role of CA 125 as tumor marker: Biochemical and clinical aspects. Adv Exp Med Biol. 867:229–244. 2015. View Article : Google Scholar : PubMed/NCBI

60 

Coelho R, Silva M, Rodrigues-Pinto E, Cardoso H, Lopes S, Pereira P, Vilas-Boas F, Santos-Antunes J, Costa-Maia J and Macedo G: CA 19-9 as a marker of survival and a predictor of metastization in cholangiocarcinoma. GE Port J Gastroenterol. 24:114–121. 2017. View Article : Google Scholar : PubMed/NCBI

61 

Poruk KE, Gay DZ, Brown K, Mulvihill JD, Boucher KM, Scaife CL, Firpo MA and Mulvihill SJ: The clinical utility of CA 19-9 in pancreatic adenocarcinoma: Diagnostic and prognostic updates. Curr Mol Med. 13:340–351. 2013. View Article : Google Scholar : PubMed/NCBI

62 

Liu C, Deng S, Jin K, Gong Y, Cheng H, Fan Z, Qian Y, Huang Q, Ni Q, Luo G and Yu X: Lewis antigen-negative pancreatic cancer: An aggressive subgroup. Int J Oncol. 56:900–908. 2020.PubMed/NCBI

63 

Salleh S, Thyagarajan A and Sahu RP: Exploiting the relevance of CA 19-9 in pancreatic cancer. J Cancer Metastasis Treat. 6:312020.

64 

Amburn TL, Ginn M, Patel R, Pandalai PK, Kim J and Cavnar MJ: Clinical utility of symptoms and serum carbohydrate antigen (CA) 19-9 for detection of recurrence after curative intent resection of periampullary arcinoma. JACS. 231:E122–E1123. 2020.

65 

Pereira SP, Oldfield L, Ney A, Hart PA, Keane MG, Pandol SJ, Li D, Greenhalf W, Jeon CY, Koay EJ, et al: Early detection of pancreatic cancer. Lancet Gastroenterol Hepatol. 5:698–710. 2020. View Article : Google Scholar : PubMed/NCBI

66 

Agrawal S: Potential prognostic biomarkers in pancreatic juice of resectable pancreatic ductal adenocarcinoma. World J Clin Oncol. 10:255–260. 2017. View Article : Google Scholar : PubMed/NCBI

67 

Yip-Schneider MT, Soufi M, Carr RA, Flick KF, Wu H, Colgate CL and Schmidt CM: Performance of candidate urinary biomarkers for pancreatic cancer-correlation with pancreatic cyst malignant progression? Am J Surg. 219:492–495. 2020. View Article : Google Scholar : PubMed/NCBI

68 

Lim JH, Park JS and Yoon DS: Preoperative fecal elastase-1 is a useful prognostic marker following curative resection of pancreatic cancer. HPB (Oxford). 19:388–395. 2017. View Article : Google Scholar : PubMed/NCBI

69 

Xu R, Xu Q, Huang G, Yin X, Zhu J, Peng Y and Song J: Combined analysis of the aberrant epigenetic alteration of pancreatic ductal adenocarcinoma. Biomed Res Int. 28:93798642019.PubMed/NCBI

70 

Rückert F, Pilarsky C and Grützmann R: Serum tumor markers in pancreatic cancer-recent discoveries. Cancers (Basel). 2:1107–1124. 2010. View Article : Google Scholar : PubMed/NCBI

71 

Zhang J, Wang Y, Zhao T, Li Y, Tian L, Zhao J and Zhang J: Evaluation of serum MUC5AC in combination with CA19-9 for the diagnosis of pancreatic cancer. World J Surg Oncol. 7:312020. View Article : Google Scholar

72 

Kim H, Kang KN, Shin YS, Byun Y, Han Y, Kwon W, Kim CW and Jang JY: Biomarker panel for the diagnosis of pancreatic ductal adenocarcinoma. Cancers (Basel). 1:14432020. View Article : Google Scholar

73 

Loosen SH, Neumann UP, Trautwein C, Roderburg C and Luedde T: Current and future biomarkers for pancreatic adenocarcinoma. Tumor Biol. 39:1010428317692232017. View Article : Google Scholar : PubMed/NCBI

74 

Lee HS, Jang CY, Kim SA, Park SB, Jung DE, Kim BO, Kim HY, Chung MJ, Park JY, Bang S, et al: Combined use of CEMIP and CA 19-9 enhances diagnostic accuracy for pancreatic cancer. Sci Rep. 21:33832018. View Article : Google Scholar : PubMed/NCBI

75 

Kim J, Bamlet WR, Oberg AL, Chaffee KG, Donahue G, Cao XJ, Chari S, Garcia BA, Petersen GM and Zaret KS: Detection of early pancreatic ductal adenocarcinoma with thrombospondin-2 and CA19-9 blood markers. Sci Transl Med. 12:eaah55832017. View Article : Google Scholar

76 

Jenkinson C, Elliott VL, Evans A, Oldfield L, Jenkins RE, O'Brien DP, Apostolidou S, Gentry-Maharaj A, Fourkala EO, Jacobs IJ, et al: Decreased serum thrombospondin-1 levels in pancreatic cancer patients up to 24 months prior to clinical diagnosis: Association with diabetes mellitus. Clin Cancer Res. 22:1734–1743. 2016. View Article : Google Scholar : PubMed/NCBI

77 

Radon TP, Massat NJ, Jones R, Alrawashdeh W, Dumartin L, Ennis D, Duffy SW, Kocher HM, Pereira SP, posthumous LG, et al: Identification of a three-biomarker panel in urine for early detection of pancreatic adenocarcinoma. Clin Cancer Res. 1:3512–3521. 2015. View Article : Google Scholar : PubMed/NCBI

78 

Benassai G, Quarto G, Perrotta S, Furino E, Benassai GL, Amato B, Bianco T, Palma GD and Forestieri P: Long-term survival after curative resection for pancreatic ductal adenocarcinoma-surgical treatment. Int J Surg. 21 (Suppl 1):S1–S3. 2015. View Article : Google Scholar : PubMed/NCBI

79 

Jeekel H: Prognostic factors following curative resection for pancreatic adenocarcinoma. Ann Surg. 240:3842004. View Article : Google Scholar : PubMed/NCBI

80 

Brunner M, Wu Z, Krautz C, Pilarsky C, Grützmann R and Weber GF: Current clinical strategies of pancreatic cancer treatment and open molecular questions. Int J Mol Sci. 13:45432019. View Article : Google Scholar

81 

Ho CK, Kleeff J, Friess H and Büchler MW: Complications of pancreatic surgery. HPB (Oxford). 7:99–108. 2005. View Article : Google Scholar : PubMed/NCBI

82 

Andren-Sandberg A: Complications of pancreatic surgery. N Am J Med Sci. 3:531–535. 2011. View Article : Google Scholar : PubMed/NCBI

83 

Liu M, Ji S, Xu W, Liu W, Qin Y, Hu Q, Sun Q, Zhang Z, Yu X and Xu X: Laparoscopic pancreaticoduodenectomy: Are the best times coming? World J Surg Oncol. 10:812019. View Article : Google Scholar : PubMed/NCBI

84 

Zhu R, Cao Z, Qiu J and Zhang T: Minimally invasive pancreatic surgery: An upward spiral. Laparoscopic, Endoscopic and Robotic Surgery. 3:29–33. 2020. View Article : Google Scholar : PubMed/NCBI

85 

Magge D, Zureikat A, Hogg M and Zeh HJ III: Minimally invasive approaches to pancreatic surgery. Surg Oncol Clin N Am. 25:273–286. 2016. View Article : Google Scholar : PubMed/NCBI

86 

Liu R, Wakabayashi G, Palanivelu C, Tsung A, Yang K, Goh BK, Chong CC, Kang CM, Peng C, Kakiashvili E, et al: International consensus statement on robotic pancreatic surgery. Hepatobiliary Surg Nutr. 8:345–360. 2019. View Article : Google Scholar : PubMed/NCBI

87 

Rashid OM, Mullinax JE, Pimiento JM, Meredith KL and Malafa MP: Robotic whipple procedure for pancreatic cancer: The moffitt cancer center pathway. Cancer Control. 22:340–351. 2015. View Article : Google Scholar : PubMed/NCBI

88 

Rehders A, Stoecklein NH, Güray A, Riediger R, Alexander A and Knoefel WT: Vascular invasion in pancreatic cancer: Tumor biology or tumor topography? Surgery. 152 (Suppl 1):S143–S151. 2012. View Article : Google Scholar : PubMed/NCBI

89 

Zaky AM, Wolfgang CL, Weiss MJ, Javed AA, Fishman EK and Zaheer A: Tumor-vessel relationships in pancreatic ductal adenocarcinoma at multidetector CT: Different classification systems and their influence on treatment planning. Radiographics. 37:93–112. 2017. View Article : Google Scholar : PubMed/NCBI

90 

Dua MM, Tran TB, Klausner J, Hwa KJ, Poultsides GA, Norton JA and Visser BC: Pancreatectomy with vein reconstruction: Technique matters. HPB (Oxford). 17:824–831. 2015. View Article : Google Scholar : PubMed/NCBI

91 

Delpero JR and Sauvanet A: Vascular resection for pancreatic cancer: 2019 French recommendations based on a literature review from 2008 to 6-2019. Front Oncol. 4:402020. View Article : Google Scholar : PubMed/NCBI

92 

Sgroi MD, Narayan RR, Lane JS, Demirjian A, Kabutey NK, Fujitani RM and Imagawa DK: Vascular reconstruction plays an important role in the treatment of pancreatic adenocarcinoma. J Vasc Surg. 61:475–480. 2015. View Article : Google Scholar : PubMed/NCBI

93 

Rebelo A, Michalski C, Ukkat J and Kleeff J: Pancreatic cancer surgery with vascular resection: Current concepts and perspectives. J Pancreatol. 2:1–5. 2019. View Article : Google Scholar

94 

Perinel J and Adham M: Palliative therapy in pancreatic cancer-palliative surgery. Transl Gastroenterol Hepatol. 7:282019. View Article : Google Scholar : PubMed/NCBI

95 

Pencovich N, Orbach L, Lessing Y, Elazar A, Barnes S, Berman P, Blachar A, Nachmany I and Sagie B: Palliative bypass surgery for patients with advanced pancreatic adenocarcinoma: Experience from a tertiary center. World J Surg Oncol. 1:632020. View Article : Google Scholar : PubMed/NCBI

96 

Assfalg V, Hüser N, Michalski C, Gillen S, Kleeff J and Friess H: Palliative interventional and surgical therapy for unresectable pancreatic cancer. Cancers (Basel). 14:652–661. 2011. View Article : Google Scholar : PubMed/NCBI

97 

Pezzilli R: Neuropathic pain in pancreatic cancer: An update of the last five years. Gastroenterol Insights. 12:302–309. 2021. View Article : Google Scholar

98 

Zhong W, Yu Z, Zeng JX, Lin Y, Yu T, Min XH, Yuan YH and Chen QK: Celiac plexus block for treatment of pain associated with pancreatic cancer: A meta-analysis. Pain Pract. 14:43–51. 2014. View Article : Google Scholar : PubMed/NCBI

99 

Springfeld C, Jäger D, Büchler MW, Strobel O, Hackert T, Palmer DH and Neoptolemos JP: Chemotherapy for pancreatic cancer. Presse Med. 48:e159–e174. 2019. View Article : Google Scholar : PubMed/NCBI

100 

Hajatdoost L, Sedaghat K, Walker EJ, Thomas J and Kosari S: Chemotherapy in pancreatic cancer: A systematic review. Medicina (Kaunas). 11:482018. View Article : Google Scholar

101 

Marco MD, Cicilia RD, Macchini M, Nobili E, Vecchiarelli S, Brandi G and Biasco G: Metastatic pancreatic cancer: Is gemcitabine still the best standard treatment? (Review). Oncol Rep. 23:1183–1192. 2010. View Article : Google Scholar : PubMed/NCBI

102 

Martín AM, Hidalgo M, Alvarez R, Arrazubi V, Martínez-Galán J, Salgado M, Macarulla T and Carrato A: From first line to sequential treatment in the management of metastatic pancreatic cancer. J Cancer. 30:1978–1988. 2018. View Article : Google Scholar

103 

Conroy T, Hammel P, Hebbar M, Abdelghani MB, Wei AC, Raoul JL, Choné L, Francois E, Artru P, Biagi JJ, et al: FOLFIRINOX or gemcitabine as adjuvant therapy for pancreatic cancer. N Engl J Med. 20:2395–2406. 2018. View Article : Google Scholar : PubMed/NCBI

104 

Azam F, Latif MF, Farooq A, Tirmazy SH, AlShahrani S, Bashir S and Bukhari N: Performance status assessment by using ECOG (Eastern Cooperative Oncology Group) score for cancer patients by oncology healthcare professionals. Case Rep Oncol. 25:728–736. 2019. View Article : Google Scholar : PubMed/NCBI

105 

Lee J, Lee JC, Gromski MA, Kim HW, Kim J, Kim J and Hwang JH: Clinical outcomes of FOLFIRINOX in locally advanced pancreatic cancer: A single center experience. Medicine (Baltimore). 97:e135922018. View Article : Google Scholar : PubMed/NCBI

106 

Yoo C, Kang J, Kim KP, Lee JL, Ryoo BY, Chang HM, Lee SS, Park DH, Song TJ, Seo DW, et al: Efficacy and safety of neoadjuvant FOLFIRINOX for borderline resectable pancreatic adenocarcinoma: Improved efficacy compared with gemcitabine-based regimen. Oncotarget. 11:46337–46347. 2017. View Article : Google Scholar : PubMed/NCBI

107 

Tahara J, Shimizu K, Otsuka N, Akao J, Takayama Y and Tokushige K: Gemcitabine plus nab-paclitaxel vs. FOLFIRINOX for patients with advanced pancreatic cancer. Cancer Chemother Pharmacol. 82:245–250. 2018. View Article : Google Scholar : PubMed/NCBI

108 

Ma P and Mumper RJ: Paclitaxel nano-delivery systems: A comprehensive review. J Nanomed Nanotechnol. 18:10001642013.PubMed/NCBI

109 

Chatterjee M, Ben-Josef E, Robb R, Vedaie M, Seum S, Thirumoorthy K, Palanichamy K, Harbrecht M, Chakravarti A and Williams TM: Caveolae-mediated endocytosis is critical for albumin cellular uptake and response to albumin-bound chemotherapy. Cancer Res. 1:5925–5937. 2017. View Article : Google Scholar : PubMed/NCBI

110 

Yardley DA: Nab-paclitaxel mechanisms of action and delivery. J Control Release. 28:365–372. 2013. View Article : Google Scholar : PubMed/NCBI

111 

Kang J, Hwang I, Yoo C, Kim KP, Jeong JH, Chang HM, Lee SS, Park DH, Song TJ, Seo DW, et al: Nab-paclitaxel plus gemcitabine versus FOLFIRINOX as the first-line chemotherapy for patients with metastatic pancreatic cancer: Retrospective analysis. Invest New Drugs. 36:732–741. 2018. View Article : Google Scholar : PubMed/NCBI

112 

Kim G: Nab-paclitaxel for the treatment of pancreatic cancer. Cancer Manag Res. 16:85–96. 2017. View Article : Google Scholar : PubMed/NCBI

113 

Wolfe AR, Prabhakar D, Yildiz VO, Cloyd JM, Dillhoff M, Abushahin L, Diaz DA, Miller ED, Chen W, Frankel WL, et al: Neoadjuvant-modified FOLFIRINOX vs. nab-paclitaxel plus gemcitabine for borderline resectable or locally advanced pancreatic cancer patients who achieved surgical resection. Cancer Med. 9:4711–4723. 2020. View Article : Google Scholar : PubMed/NCBI

114 

Sarabi M, Mais L, Oussaid N, Desseigne F, Guibert P and Fouchardiere CD: Use of gemcitabine as a second-line treatment following chemotherapy with folfirinox for metastatic pancreatic adenocarcinoma. Oncol Lett. 13:4917–4924. 2017. View Article : Google Scholar : PubMed/NCBI

115 

Kordes M, Yu J, Malgerud O, Liljefors MG and Löhr JM: Survival benefits of chemotherapy for patients with advanced pancreatic cancer in a clinical real-world cohort. Cancers (Basel). 7:13262019. View Article : Google Scholar

116 

Oba A, Ho F, Bao QR, Al-Musawi MH, Schulick RD and Chiaro MD: Neoadjuvant treatment in pancreatic cancer. Front Oncol. 28:2452020. View Article : Google Scholar : PubMed/NCBI

117 

Versteijne E, Vogel JA, Besselink MG, Busch OR, Wilmink JW, Daams JG, van Eijck CHJ, Koerkamp BG, Rasch CR, van Tienhoven G, et al: Meta-analysis comparing upfront surgery with neoadjuvant treatment in patients with resectable or borderline resectable pancreatic cancer. Br J Surg. 105:946–958. 2018. View Article : Google Scholar : PubMed/NCBI

118 

Seufferlein T and Ettrich TJ: Treatment of pancreatic cancer-neoadjuvant treatment in resectable pancreatic cancer (PDAC). Transl Gastroenterol Hepatol. 27:212019. View Article : Google Scholar : PubMed/NCBI

119 

Müller PC, Frey MC, Ruzza CM, Nickel F, Jost C, Gwerder C, Hackert T, Z'graggen K and Kessler U: Neoadjuvant chemotherapy in pancreatic cancer: An appraisal of the current high-level evidence. Pharmacology. 106:143–153. 2021.PubMed/NCBI

120 

Hall WA and Karyn A: Goodman: Radiation therapy for pancreatic adenocarcinoma, a treatment option that must be considered in the management of a devastating malignancy. Radiat Oncol. 26:1142019. View Article : Google Scholar : PubMed/NCBI

121 

Tchelebi LT, Zaorsky NG, Rosenberg JC, Sharma NK, Tuanquin LC, Mackley HB and Ellis RJ: Reducing the toxicity of radiotherapy for pancreatic cancer with magnetic resonance-guided radiotherapy. Toxicol Sci. 1:19–23. 2020. View Article : Google Scholar : PubMed/NCBI

122 

Buwenge M, Macchia G, Arcelli A, Frakulli R, Fuccio L, Guerri S, Grassi E, Cammelli S, Cellini F and Morganti AG: Stereotactic radiotherapy of pancreatic cancer: A systematic review on pain relief. J Pain Res. 4:2169–2178. 2018. View Article : Google Scholar : PubMed/NCBI

123 

Palta M, Godfrey D, Goodman KA, Hoffe S, Dawson LA, Dessert D, Hall WA, Herman JM, Khorana AA, Merchant N, et al: Radiation therapy for pancreatic cancer: Executive summary of an ASTRO clinical practice guideline. Pract Radiat Oncol. 9:322–332. 2019. View Article : Google Scholar : PubMed/NCBI

124 

Shah AP, Strauss JB and Abrams RA: Review and commentary on the role of radiation therapy in the adjuvant management of pancreatic cancer. Am J Clin Oncol. 33:101–106. 2010. View Article : Google Scholar : PubMed/NCBI

125 

Jiang W, Haque W, Verma V, Butler EB and Teh BS: Neoadjuvant stereotactic body radiation therapy for nonmetastatic pancreatic adenocarcinoma. Acta Oncol. 58:1259–1266. 2019. View Article : Google Scholar : PubMed/NCBI

126 

Glicksman RM, Chung H, Myrehaug S, Erler D, Korol R, Karotki A, Taggar A and Ung YC: Stereotactic radiotherapy for pancreatic cancer: A single-institution experience. Cureus. 23:e106182020.PubMed/NCBI

127 

Gou Q, Dong C, Xu H, Khan B, Jin J, Liu Q, Shi J and Hou Y: PD-L1 degradation pathway and immunotherapy for cancer. Cell Death Dis. 6:9552020. View Article : Google Scholar : PubMed/NCBI

128 

Jiang T, Shi T, Zhang H, Hu J, Song Y, Wei J, Ren S and Zhou C: Tumor neoantigens: From basic research to clinical applications. J Hematol Oncol. 6:932019. View Article : Google Scholar

129 

Das M, Zhou X, Liu Y, Das A, Vincent BG, Li J, Liu R and Huang L: Tumor neoantigen heterogeneity impacts bystander immune inhibition of pancreatic cancer growth. Transl Oncol. 13:1008562020. View Article : Google Scholar : PubMed/NCBI

130 

Chi J, Patel R, Rehman H, Goyal S and Saif MW: Recent advances in immunotherapy for pancreatic cancer. J Cancer Metastasis Treat. 6:432020.

131 

Chen H, Yang G, Xiao J, Zheng L, You L and Zhang T: Neoantigen-based immunotherapy in pancreatic ductal adenocarcinoma (PDAC). Cancer Lett. 10:12–19. 2020. View Article : Google Scholar

132 

Looi CK, Chung FFL, Leong CO, Wong SF, Rosli R and Mai CW: Therapeutic challenges and current immunomodulatory strategies in targeting the immunosuppressive pancreatic tumor microenvironment. J Exp Clin Cancer Res. 15:1622019. View Article : Google Scholar : PubMed/NCBI

133 

Royal RE, Levy C, Turner K, Mathur A, Hughes M, Kammula US, Sherry RM, Topalian SL, Yang JC, Lowy I and Rosenberg SA: Phase 2 trial of single agent ipilimumab (Anti-CTLA-4) for locally advanced or metastatic pancreatic adenocarcinoma. J Immunother. 33:828–833. 2010. View Article : Google Scholar : PubMed/NCBI

134 

Taube JM, Klein A, Brahmer JR, Xu H, Pan X, Kim JH, Chen L, Pardoll DM, Topalian SL and Anders RA: Association of PD-1, PD-1 ligands, and other features of the tumor immune microenvironment with response to anti-PD-1 therapy. Clin Cancer Res. 1:5064–5074. 2014. View Article : Google Scholar : PubMed/NCBI

135 

Amin S, Baine M, Meza J, Alam M and Lin C: The impact of immunotherapy on the survival of pancreatic adenocarcinoma patients who do not receive definitive surgery of the tumor. Clin Transl Radiat Oncol. 7:34–40. 2020. View Article : Google Scholar : PubMed/NCBI

136 

Brouwer TP, Vahrmeijer AL and de Miranda NF: Immunotherapy for pancreatic cancer: Chasing the light at the end of the tunnel. Cell Oncol (Dordr). 44:261–278. 2021. View Article : Google Scholar : PubMed/NCBI

137 

Krishnamoorthy M, Lenehan JG, Burton JP and Vareki SM: Immunomodulation in pancreatic cancer. Cancers (Basel). 12:33402020. View Article : Google Scholar : PubMed/NCBI

138 

Sideras K, Braat H, Kwekkeboom J, van Eijck CH, Peppelenbosch MP, Sleijfer S and Bruno M: Role of the immune system in pancreatic cancer progression and immune modulating treatment strategies. Cancer Treat Rev. 40:513–522. 2014. View Article : Google Scholar : PubMed/NCBI

139 

Amedei A, Niccolai E and Prisco D: Pancreatic cancer: Role of the immune system in cancer progression and vaccine-based immunotherapy. Hum Vaccin Immunother. 10:3354–3368. 2014. View Article : Google Scholar : PubMed/NCBI

140 

Luo W, Yang G, Luo W, Cao Z, Liu Y, Qiu J, Chen G, You L, Zhao F, Zheng L and Zhang T: Novel therapeutic strategies and perspectives for metastatic pancreatic cancer: Vaccine therapy is more than just a theory. Cancer Cell Int. 4:662020. View Article : Google Scholar : PubMed/NCBI

141 

Akce M, Zaidi MY, Waller EK, El-Rayes BF and Lesinski GB: The potential of CAR T cell therapy in pancreatic cancer. Front Immunol. 25:21662018. View Article : Google Scholar : PubMed/NCBI

142 

Penack O and Koenecke C: Complications after CD19+ CAR T-cell therapy. Cancers (Basel). 19:34452020. View Article : Google Scholar

143 

Golan T, Hammel P, Reni M, Cutsem EV, Macarulla T, Hall MJ, Park JO, Hochhauser D, Arnold D, Oh DY, et al: Maintenance olaparib for germline brca-mutated metastatic pancreatic cancer. N Engl J Med. 25:317–327. 2019. View Article : Google Scholar : PubMed/NCBI

144 

Picozzi V, Alseidi A, Winter J, Pishvaian M, Mody K, Glaspy J, Larson T, Matrana M, Carney M, Porter S, et al: Gemcitabine/nab-paclitaxel with pamrevlumab: A novel drug combination and trial design for the treatment of locally advanced pancreatic cancer. ESMO Open. 5:e0006682020. View Article : Google Scholar : PubMed/NCBI

145 

Alistar A, Morris BB, Desnoyer R, Klepin HD, Hosseinzadeh K, Clark C, Cameron A, Leyendecker J, D'Agostino R Jr, Topaloglu U, et al: Safety and tolerability of the first-in-class agent CPI-613 in combination with modified FOLFIRINOX in patients with metastatic pancreatic cancer: A single-centre, open-label, dose-escalation, phase 1 trial. Lancet Oncol. 18:770–778. 2017. View Article : Google Scholar : PubMed/NCBI

Related Articles

  • Abstract
  • View
  • Download
  • Twitter
Copy and paste a formatted citation
Spandidos Publications style
Pekarek L, Fraile‑Μartinez O, Garcia‑Montero C, Alvarez‑Mon MA, Acero J, Ruiz‑Llorente L, García‑Honduvilla N, Albillos A, Buján J, Alvarez‑Mon M, Alvarez‑Mon M, et al: Towards an updated view on the clinical management of pancreatic adenocarcinoma: Current and future perspectives (Review). Oncol Lett 22: 809, 2021.
APA
Pekarek, L., Fraile‑Μartinez, O., Garcia‑Montero, C., Alvarez‑Mon, M.A., Acero, J., Ruiz‑Llorente, L. ... Ortega, M.A. (2021). Towards an updated view on the clinical management of pancreatic adenocarcinoma: Current and future perspectives (Review). Oncology Letters, 22, 809. https://doi.org/10.3892/ol.2021.13070
MLA
Pekarek, L., Fraile‑Μartinez, O., Garcia‑Montero, C., Alvarez‑Mon, M. A., Acero, J., Ruiz‑Llorente, L., García‑Honduvilla, N., Albillos, A., Buján, J., Alvarez‑Mon, M., Guijarro, L. G., Ortega, M. A."Towards an updated view on the clinical management of pancreatic adenocarcinoma: Current and future perspectives (Review)". Oncology Letters 22.5 (2021): 809.
Chicago
Pekarek, L., Fraile‑Μartinez, O., Garcia‑Montero, C., Alvarez‑Mon, M. A., Acero, J., Ruiz‑Llorente, L., García‑Honduvilla, N., Albillos, A., Buján, J., Alvarez‑Mon, M., Guijarro, L. G., Ortega, M. A."Towards an updated view on the clinical management of pancreatic adenocarcinoma: Current and future perspectives (Review)". Oncology Letters 22, no. 5 (2021): 809. https://doi.org/10.3892/ol.2021.13070
Copy and paste a formatted citation
x
Spandidos Publications style
Pekarek L, Fraile‑Μartinez O, Garcia‑Montero C, Alvarez‑Mon MA, Acero J, Ruiz‑Llorente L, García‑Honduvilla N, Albillos A, Buján J, Alvarez‑Mon M, Alvarez‑Mon M, et al: Towards an updated view on the clinical management of pancreatic adenocarcinoma: Current and future perspectives (Review). Oncol Lett 22: 809, 2021.
APA
Pekarek, L., Fraile‑Μartinez, O., Garcia‑Montero, C., Alvarez‑Mon, M.A., Acero, J., Ruiz‑Llorente, L. ... Ortega, M.A. (2021). Towards an updated view on the clinical management of pancreatic adenocarcinoma: Current and future perspectives (Review). Oncology Letters, 22, 809. https://doi.org/10.3892/ol.2021.13070
MLA
Pekarek, L., Fraile‑Μartinez, O., Garcia‑Montero, C., Alvarez‑Mon, M. A., Acero, J., Ruiz‑Llorente, L., García‑Honduvilla, N., Albillos, A., Buján, J., Alvarez‑Mon, M., Guijarro, L. G., Ortega, M. A."Towards an updated view on the clinical management of pancreatic adenocarcinoma: Current and future perspectives (Review)". Oncology Letters 22.5 (2021): 809.
Chicago
Pekarek, L., Fraile‑Μartinez, O., Garcia‑Montero, C., Alvarez‑Mon, M. A., Acero, J., Ruiz‑Llorente, L., García‑Honduvilla, N., Albillos, A., Buján, J., Alvarez‑Mon, M., Guijarro, L. G., Ortega, M. A."Towards an updated view on the clinical management of pancreatic adenocarcinoma: Current and future perspectives (Review)". Oncology Letters 22, no. 5 (2021): 809. https://doi.org/10.3892/ol.2021.13070
Follow us
  • Twitter
  • LinkedIn
  • Facebook
About
  • Spandidos Publications
  • Careers
  • Cookie Policy
  • Privacy Policy
How can we help?
  • Help
  • Live Chat
  • Contact
  • Email to our Support Team