Open Access

Towards an updated view on the clinical management of pancreatic adenocarcinoma: Current and future perspectives (Review)

  • Authors:
    • Leonel Pekarek
    • Oscar Fraile‑Μartinez
    • Cielo Garcia‑Montero
    • Miguel A. Alvarez‑Mon
    • Julio Acero
    • Lidia Ruiz‑Llorente
    • Natalio García‑Honduvilla
    • Agustin Albillos
    • Julia Buján
    • Melchor Alvarez‑Mon
    • Luis G. Guijarro
    • Miguel A. Ortega
  • View Affiliations

  • Published online on: September 27, 2021     https://doi.org/10.3892/ol.2021.13070
  • Article Number: 809
  • Copyright: © Pekarek et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Pancreatic cancer has a dire prognosis and will represent the second leading cause of cancer death in the next 10 years. The multifactorial approach represents one of the main issues in controlling the extension of this neoplasm. In recent years, the characteristics of the tumor microenvironment, metastasis mechanisms and the relationship between immune system and neoplastic cells have been described, which has made it possible to understand the pathophysiology of pancreatic adenocarcinoma. Currently, there is a failure to provide an effective preventive method or early detection, so patients present with an advanced stage at the time of diagnosis. Despite numerous efforts, little progress has been made in clinical outcome and in improving survival in long term. Therefore, in the recent years, diverse diagnostic tests, treatments and possible approaches have been developed in the fields of radiotherapy, chemotherapy and surgery to find a combination of them that improves life expectancy in patients diagnosed with pancreatic cancer. At the moment, numerous clinical trials are being conducted to evaluate preventive diagnostic procedures such as serological markers or perfecting available imaging tests. On the other hand, implementation of immunotherapy is being studied in a neoplasm that has lagged in the application of this procedure since present possible treatments do not substantially improve quality of life. Therefore, the purpose of our study is to summarize the main progresses that have been made in the diagnosis, treatment and screening of this disease, explaining the limitations that have been observed and analyzing future prospects in the management of this illness.
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November-2021
Volume 22 Issue 5

Print ISSN: 1792-1074
Online ISSN:1792-1082

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Spandidos Publications style
Pekarek L, Fraile‑Μartinez O, Garcia‑Montero C, Alvarez‑Mon MA, Acero J, Ruiz‑Llorente L, García‑Honduvilla N, Albillos A, Buján J, Alvarez‑Mon M, Alvarez‑Mon M, et al: Towards an updated view on the clinical management of pancreatic adenocarcinoma: Current and future perspectives (Review). Oncol Lett 22: 809, 2021
APA
Pekarek, L., Fraile‑Μartinez, O., Garcia‑Montero, C., Alvarez‑Mon, M.A., Acero, J., Ruiz‑Llorente, L. ... Ortega, M.A. (2021). Towards an updated view on the clinical management of pancreatic adenocarcinoma: Current and future perspectives (Review). Oncology Letters, 22, 809. https://doi.org/10.3892/ol.2021.13070
MLA
Pekarek, L., Fraile‑Μartinez, O., Garcia‑Montero, C., Alvarez‑Mon, M. A., Acero, J., Ruiz‑Llorente, L., García‑Honduvilla, N., Albillos, A., Buján, J., Alvarez‑Mon, M., Guijarro, L. G., Ortega, M. A."Towards an updated view on the clinical management of pancreatic adenocarcinoma: Current and future perspectives (Review)". Oncology Letters 22.5 (2021): 809.
Chicago
Pekarek, L., Fraile‑Μartinez, O., Garcia‑Montero, C., Alvarez‑Mon, M. A., Acero, J., Ruiz‑Llorente, L., García‑Honduvilla, N., Albillos, A., Buján, J., Alvarez‑Mon, M., Guijarro, L. G., Ortega, M. A."Towards an updated view on the clinical management of pancreatic adenocarcinoma: Current and future perspectives (Review)". Oncology Letters 22, no. 5 (2021): 809. https://doi.org/10.3892/ol.2021.13070