Open Access

Circular RNA regulates the onset and progression of cancer through the mitogen‑activated protein kinase signaling pathway (Review)

  • Authors:
    • Qun Lai
    • Min Wang
    • Chunmei Hu
    • Yan Tang
    • Yarong Li
    • Shuhong Hao
  • View Affiliations

  • Published online on: October 5, 2021     https://doi.org/10.3892/ol.2021.13078
  • Article Number: 817
  • Copyright: © Lai et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

The rapid increase in cancer morbidity and mortality worldwide is a major challenge for public health providers. Therefore, there is an urgent need to explore the molecular mechanism of tumorigenesis and identify potential diagnostic biomarkers and therapeutic methods. Circular RNA (circRNA) is characterized by a stable structure and tissue‑specific expression; these features are useful in medical research and clinical applications. In recent years, with the development of high‑throughput sequencing technology, the potential use of circRNA in cancer prognosis and treatment has been extensively explored. Abnormal circRNA expression interferes with specific signaling pathways such as the MAPK pathway; this phenomenon may provide potential diagnostic biomarkers and new therapeutic targets. The present article discusses the research progress on the regulatory roles of MAPK/ERK pathway‑related circRNA molecules in the development and progression of different types of tumors. This review may provide insight into the development of circRNA‑based cancer management strategies.
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