Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Oncology Letters
      • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Biomedical Reports
      • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • Information for Authors
    • Information for Reviewers
    • Information for Librarians
    • Information for Advertisers
    • Conferences
  • Language Editing
Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • For Authors
    • For Reviewers
    • For Librarians
    • For Advertisers
    • Conferences
  • Language Editing
Login Register Submit
  • This site uses cookies
  • You can change your cookie settings at any time by following the instructions in our Cookie Policy. To find out more, you may read our Privacy Policy.

    I agree
Search articles by DOI, keyword, author or affiliation
Search
Advanced Search
presentation
Oncology Letters
Join Editorial Board Propose a Special Issue
Print ISSN: 1792-1074 Online ISSN: 1792-1082
Journal Cover
December-2021 Volume 22 Issue 6

Full Size Image

Sign up for eToc alerts
Recommend to Library

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
December-2021 Volume 22 Issue 6

Full Size Image

Sign up for eToc alerts
Recommend to Library

  • Article
  • Citations
    • Cite This Article
    • Download Citation
    • Create Citation Alert
    • Remove Citation Alert
    • Cited By
  • Similar Articles
    • Related Articles (in Spandidos Publications)
    • Similar Articles (Google Scholar)
    • Similar Articles (PubMed)
  • Download PDF
  • Download XML
  • View XML
Article Open Access

Aberrant expression of SFRP1, SFRP3, DVL2 and DVL3 Wnt signaling pathway components in diffuse gastric carcinoma

  • Authors:
    • Maja Sremac
    • Frane Paic
    • Katja Grubelic Ravic
    • Ljiljana Serman
    • Aja Pavicic Dujmovic
    • Iva Brcic
    • Zeljko Krznaric
    • Tamara Nikuseva Martic
  • View Affiliations / Copyright

    Affiliations: Division of Gastroenterology and Hepatology, University Hospital Center, 10000 Zagreb, Croatia, Laboratory for Epigenetics and Molecular Medicine, Department of Medical Biology, School of Medicine, University of Zagreb, 10000 Zagreb, Croatia, Department of Medical Biology, School of Medicine, University of Zagreb, 10000 Zagreb, Croatia, Department of Radiology, General Hospital ‘Dr. Ivo Pedisic’, 44000 Sisak, Croatia, Diagnostic and Research Institute of Pathology, Medical University of Graz, A‑8010 Graz, Austria
    Copyright: © Sremac et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 822
    |
    Published online on: October 8, 2021
       https://doi.org/10.3892/ol.2021.13083
  • Expand metrics +
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
Cited By (CrossRef): 0 citations Loading Articles...

This article is mentioned in:



Abstract

Diffuse gastric carcinoma (DGC) is characterized by poorly cohesive cells, highly invasive growth patterns, poor prognosis and resistance to the majority of available systemic therapeutic strategies. It has been previously reported that the Wnt/β‑catenin signaling pathway serves a prominent role in the tumorigenesis of gastric carcinoma. However, the mechanism underlying the dysregulation of this pathway in DGC has not been fully elucidated. Therefore, the present study aimed to investigate the expression profiles of Wnt antagonists, secreted frizzled‑related protein 1 (SFRP1) and secreted frizzled‑related protein 3 (SFRP3), and dishevelled protein family members, dishevelled segment polarity protein 2 (DVL2) and dishevelled segment polarity protein 3 (DVL3), in DGC tissues. The association between the expression levels of these factors and the clinicopathological parameters of the patients was determined. Protein and mRNA expression levels in 62 DGC tumor tissues and 62 normal gastric mucosal tissues obtained from patients with non‑malignant disease were measured using immunohistochemical and reverse transcription‑quantitative PCR (RT‑qPCR) analysis. Significantly lower protein expression levels of SFRP1 (P<0.001) and SFRP3 (P<0.001), but significantly higher protein expression levels of DVL2 (P<0.001) and DVL3 (P<0.001) were observed in DGC tissues compared with in control tissues by immunohistochemistry. In addition, significantly lower expression levels of SFRP1 (P<0.05) and higher expression levels of DVL3 (P<0.05) were found in in DGC tissues compared with those in normal gastric mucosal tissues using RT‑qPCR. According to correlation analysis between the SFRP1, SFRP3, DVL2 and DVL3 protein expression levels and the clinicopathological characteristics of patients with DGC, a statistically significant correlation was found between the SFRP3 volume density and T stage (r=0.304; P=0.017) and between the SFRP3 volume density and clinical stage (r=0.336; P=0.008). In conclusion, the findings of the present study suggested that the Wnt signaling pathway components SFRP1, SFRP3, DVL2 and DVL3 may be aberrantly expressed in DGC tissues, implicating their possible role in the development of this malignant disease. The present data also revealed a positive relationship between SFRP3 protein expression and the clinical and T stage of DGC.
View Figures
View References

1 

Venerito M, Link A, Rokkas T and Malfertheiner P: Review: Gastric cancer-clinical aspects. Helicobacter. 24 (Suppl 1):e126432019. View Article : Google Scholar : PubMed/NCBI

2 

Machlowska J, Baj J, Sitarz M, Maciejewski R and Sitarz R: Gastric cancer: Epidemiology, risk factors, classification, genomic characteristics and treatment strategies. Int J Mol Sci. 21:40122020. View Article : Google Scholar : PubMed/NCBI

3 

Rawla P and Barsouk A: Epidemiology of gastric cancer: Global trends, risk factors and prevention. Prz Gastroenterol. 14:26–38. 2019.PubMed/NCBI

4 

Lauren P: The two histological main types of gastric carcinoma: Diffuse and so-called intestinal-type carcinoma. An attempt at a histoclinical classification. Acta Pathol Microbiol Scand. 64:31–49. 1965. View Article : Google Scholar : PubMed/NCBI

5 

Waldum HL and Fossmark R: Types of gastric carcinomas. Int J Mol Sci. 19:41092018. View Article : Google Scholar : PubMed/NCBI

6 

Yakirevich E and Resnick MB: Pathology of gastric cancer and its precursor lesions. Gastroenterol Clin North Am. 42:261–284. 2013. View Article : Google Scholar : PubMed/NCBI

7 

Yuasa Y: Control of gut differentiation and intestinal-type gastric carcinogenesis. Nat Rev Cancer. 3:592–600. 2003. View Article : Google Scholar : PubMed/NCBI

8 

Garcia-Pelaez J, Barbosa-Matos R, Gullo I, Carneiro F and Oliveira C: Histological and mutational profile of diffuse gastric cancer: Current knowledge and future challenges. Mol Oncol. Mar 16–2021.(Online ahead of print). View Article : Google Scholar

9 

Ansari S, Gantuya B, Tuan VP and Yamaoka Y: Diffuse gastric cancer: A summary of analogous contributing factors for its molecular pathogenicity. Int J Mol Sci. 19:24242018. View Article : Google Scholar : PubMed/NCBI

10 

Tsai JH, Jeng YM, Chen KH, Lee CH, Yuan CT and Liau JY: An integrative morphomolecular classification system of gastric carcinoma with distinct clinical outcomes. Am J Surg Pathol. 44:1017–1030. 2020. View Article : Google Scholar : PubMed/NCBI

11 

Lim B, Kim JH, Kim M and Kim SY: Genomic and epigenomic heterogeneity in molecular subtypes of gastric cancer. World J Gastroenterol. 22:1190–1201. 2016. View Article : Google Scholar : PubMed/NCBI

12 

Tan IB, Ivanova T, Lim KH, Ong CW, Deng N, Lee J, Tan SH, Wu J, Lee MH, Ooi CH, et al: Intrinsic subtypes of gastric cancer, based on gene expression pattern, predict survival and respond differently to chemotherapy. Gastroenterology. 141:476–485.e1-11. 2011. View Article : Google Scholar : PubMed/NCBI

13 

Petrovchich I and Ford JM: Genetic predisposition to gastric cancer. Semin Oncol. 43:554–559. 2016. View Article : Google Scholar : PubMed/NCBI

14 

Shenoy S: CDH1 (E-cadherin) mutation and gastric cancer: Genetics, molecular mechanisms and guidelines for management. Cancer Manag Res. 11:10477–10486. 2019. View Article : Google Scholar : PubMed/NCBI

15 

Machado JC, Oliveira C, Carvalho R, Soares P, Berx G, Caldas C, Seruca R, Carneiro F and Sobrinho-Simöes M: E-cadherin gene (CDH1) promoter methylation as the second hit in sporadic diffuse gastric carcinoma. Oncogene. 20:1525–1528. 2001. View Article : Google Scholar : PubMed/NCBI

16 

Tedaldi G, Molinari C, São José C, Barbosa-Matos R, André A, Danesi R, Arcangeli V, Ravegnani M, Saragoni L, Morgagni P, et al: Genetic and epigenetic alterations of CDH1 regulatory regions in hereditary and sporadic gastric cancer. Pharmaceuticals (Basel). 14:4572021. View Article : Google Scholar : PubMed/NCBI

17 

Gamble LA, Heller T and Davis JL: Hereditary diffuse gastric cancer syndrome and the role of CDH1: A review. JAMA Surg. 156:387–392. 2021. View Article : Google Scholar : PubMed/NCBI

18 

Cho SY, Park JW, Liu Y, Park YS, Kim JH, Yang H, Um H, Ko WR, Lee BI, Kwon SY, et al: Sporadic early-onset diffuse gastric cancers have high frequency of somatic CDH1 alterations, but low frequency of somatic RHOA mutations compared with late-onset cancers. Gastroenterology. 153:536–549.e26. 2017. View Article : Google Scholar : PubMed/NCBI

19 

Kakiuchi M, Nishizawa T, Ueda H, Gotoh K, Tanaka A, Hayashi A, Yamamoto S, Tatsuno K, Katoh H, Watanabe Y, et al: Recurrent gain-of-function mutations of RHOA in diffuse-type gastric carcinoma. Nat Genet. 46:583–587. 2014. View Article : Google Scholar : PubMed/NCBI

20 

Zhou J, Hayakawa Y, Wang TC and Bass AJ: RhoA mutations identified in diffuse gastric cancer. Cancer Cell. 26:9–11. 2014. View Article : Google Scholar : PubMed/NCBI

21 

Nam S, Kim JH and Lee DH: RHOA in gastric cancer: Functional roles and therapeutic potential. Front Genet. 10:4382019. View Article : Google Scholar : PubMed/NCBI

22 

MacDonald BT, Tamai K and He X: Wnt/beta-catenin signaling: Components, mechanisms, and diseases. Dev Cell. 17:9–26. 2009. View Article : Google Scholar : PubMed/NCBI

23 

Tian X, Liu Z, Niu B, Zhang J, Tan TK, Lee SR, Zhao Y, Harris DC and Zheng G: E-cadherin/β-catenin complex and the epithelial barrier. J Biomed Biotechnol. 2011:5673052011. View Article : Google Scholar : PubMed/NCBI

24 

Liu X and Chu KM: E-cadherin and gastric cancer: Cause, consequence, and applications. Biomed Res Int. 2014:6373082014. View Article : Google Scholar : PubMed/NCBI

25 

Korourian A, Roudi R, Shariftabrizi A, Kalantari E, Sotoodeh K and Madjd Z: Differential role of Wnt signaling and base excision repair pathways in gastric adenocarcinoma aggressiveness. Clin Exp Med. 17:505–517. 2017. View Article : Google Scholar : PubMed/NCBI

26 

Reya T and Clevers H: Wnt signalling in stem cells and cancer. Nature. 434:843–850. 2005. View Article : Google Scholar : PubMed/NCBI

27 

Zhang Y and Wang X: Targeting the Wnt/β-catenin signaling pathway in cancer. J Hematol Oncol. 13:1652020. View Article : Google Scholar : PubMed/NCBI

28 

Krausova M and Korinek V: Wnt signaling in adult intestinal stem cells and cancer. Cell Signal. 26:570–579. 2014. View Article : Google Scholar : PubMed/NCBI

29 

Koushyar S, Powell AG, Vincan E and Phesse TJ: Targeting Wnt signaling for the treatment of gastric cancer. Int J Mol Sci. 21:39272020. View Article : Google Scholar : PubMed/NCBI

30 

Ooi CH, Ivanova T, Wu J, Lee M, Tan IB, Tao J, Ward L, Koo JH, Gopalakrishnan V, Zhu Y, et al: Oncogenic pathway combinations predict clinical prognosis in gastric cancer. PLoS Genet. 5:e10006762009. View Article : Google Scholar : PubMed/NCBI

31 

Yoda Y, Takeshima H, Niwa T, Kim JG, Ando T, Kushima R, Sugiyama T, Katai H, Noshiro H and Ushijima T: Integrated analysis of cancer-related pathways affected by genetic and epigenetic alterations in gastric cancer. Gastric Cancer. 18:65–76. 2015. View Article : Google Scholar : PubMed/NCBI

32 

Chiurillo MA: Role of the Wnt/β-catenin pathway in gastric cancer: An in-depth literature review. World J Exp Med. 5:84–102. 2015. View Article : Google Scholar : PubMed/NCBI

33 

Nojima M, Suzuki H, Toyota M, Watanabe Y, Maruyama R, Sasaki S, Sasaki Y, Mita H, Nishikawa N, Yamaguchi K, et al: Frequent epigenetic inactivation of SFRP genes and constitutive activation of Wnt signaling in gastric cancer. Oncogene. 26:4699–4713. 2007. View Article : Google Scholar : PubMed/NCBI

34 

Cheng YY, Yu J, Wong YP, Man EP, To KF, Jin VX, Li J, Tao Q, Sung JJ, Chan FK and Leung WK: Frequent epigenetic inactivation of secreted frizzled-related protein 2 (SFRP2) by promoter methylation in human gastric cancer. Br J Cancer. 97:895–901. 2007. View Article : Google Scholar : PubMed/NCBI

35 

Shin H, Kim JH, Lee YS and Lee YC: Change in gene expression profiles of secreted frizzled-related proteins (SFRPs) by sodium butyrate in gastric cancers: Induction of promoter demethylation and histone modification causing inhibition of Wnt signaling. Int J Oncol. 40:1533–1542. 2012.PubMed/NCBI

36 

Liu JB, Wu XM, Cai J, Zhang JY, Zhang JL, Zhou SH, Shi MX and Qiang FL: CpG island methylator phenotype and Helicobacter pylori infection associated with gastric cancer. World J Gastroenterol. 18:5129–5134. 2012. View Article : Google Scholar : PubMed/NCBI

37 

To KF, Chan MW, Leung WK, Yu J, Tong JH, Lee TL, Chan FK and Sung JJ: Alterations of frizzled (FzE3) and secreted frizzled related protein (hsFRP) expression in gastric cancer. Life Sci. 70:483–489. 2001. View Article : Google Scholar : PubMed/NCBI

38 

Guo Y, Guo W, Chen Z, Kuang G, Yang Z and Dong Z: Hypermethylation and aberrant expression of Wnt-antagonist family genes in gastric cardia adenocarcinoma. Neoplasma. 58:110–117. 2011. View Article : Google Scholar : PubMed/NCBI

39 

Wang Z, Ye Y, Liu D, Yang X and Wang F: Hypermethylation of multiple Wnt antagonist genes in gastric neoplasia: Is H pylori infection blasting fuse? Medicine (Baltimore). 97:e137342018. View Article : Google Scholar : PubMed/NCBI

40 

Nagasaka T, Tanaka N, Cullings HM, Sun DS, Sasamoto H, Uchida T, Koi M, Nishida N, Naomoto Y, Boland CR, et al: Analysis of fecal DNA methylation to detect gastrointestinal neoplasia. J Natl Cancer Ins. 101:1244–1258. 2009. View Article : Google Scholar : PubMed/NCBI

41 

Zhao C, Bu X, Zhang N and Wang W: Downregulation of SFRP5 expression and its inverse correlation with those of MMP-7 and MT1-MMP in gastric cancer. BMC Cancer. 9:2242009. View Article : Google Scholar : PubMed/NCBI

42 

Liu C, Li N, Lu H, Wang Z, Chen C, Wu L, Liu J, Lu Y and Wang F: Circulating SFRP1 promoter methylation status in gastric adenocarcinoma and esophageal square cell carcinoma. Biomed Rep. 3:123–127. 2015. View Article : Google Scholar : PubMed/NCBI

43 

Yu J, Xie Y, Li M, Zhou F, Zhong Z, Liu Y, Wang F and Qi J: Association between SFRP promoter hypermethylation and different types of cancer: A systematic review and meta-analysis. Oncol Lett. 18:3481–3492. 2019.PubMed/NCBI

44 

Kim SK, Kim HJ, Park JL, Heo H, Kim SY, Lee SI, Song KS, Kim WH and Kim YS: Identification of a molecular signature of prognostic subtypes in diffuse-type gastric cancer. Gastric Cancer. 23:473–482. 2020. View Article : Google Scholar : PubMed/NCBI

45 

Liu D, Sun C, Kim N, Bhan C, Tuason JPW, Chen Y, Ma S, Huang Y, Cheng C, Zhou Q, et al: Comprehensive analysis of SFRP family members prognostic value and immune infiltration in gastric cancer. Life (Basel). 11:5222021.PubMed/NCBI

46 

Baharudin R, Tieng FYF, Lee LH and Ab Mutalib NS: Epigenetics of SFRP1: The dual roles in human cancers. Cancers (Basel). 12:4452020. View Article : Google Scholar : PubMed/NCBI

47 

Gao C and Chen YG: Dishevelled: The hub of Wnt signaling. Cell Signal. 22:717–727. 2010. View Article : Google Scholar : PubMed/NCBI

48 

Katoh M: WNT/PCP signaling pathway and human cancer (review). Oncol Rep. 14:1583–1588. 2005.PubMed/NCBI

49 

Liu Y, Zhang J, Yu W, Zhang X, Wang G and Zhao Z: Dapper homolog 1 alpha suppresses metastasis ability of gastric cancer through inhibiting planar cell polarity pathway. Oncotarget. 7:81423–81434. 2016. View Article : Google Scholar : PubMed/NCBI

50 

Gnad T, Feoktistova M, Leverkus M, Lendeckel U and Naumann M: Helicobacter pylori-induced activation of beta-catenin involves low density lipoprotein receptor-related protein 6 and Dishevelled. Mol Cancer. 9:312010. View Article : Google Scholar : PubMed/NCBI

51 

Bosman FT: WHO classification of tumours of the digestive system. World Health Organization classification of tumours. Bosman FT, Carneiro F, Hruban R H and Theise N: 4th edition. IARC Press; Lyon: 2010

52 

Sadeghipour A and Babaheidarian P: Making formalin-fixed, paraffin embedded blocks. Methods Mol Biol. 1897:253–268. 2019. View Article : Google Scholar : PubMed/NCBI

53 

Nikuševa-Martić T, Serman L, Zeljko M, Vidas Z, Gašparov S, Zeljko HM, Kosović M and Pećina-Šlaus N: Expression of secreted frizzled-related protein 1 and 3, T-cell factor 1 and lymphoid enhancer factor 1 in clear cell renal cell carcinoma. Pathol Oncol Res. 19:545–551. 2013. View Article : Google Scholar : PubMed/NCBI

54 

Partl JZ, Fabijanovic D, Skrtic A, Vranic S, Martic TN and Serman L: Immunohistochemical expression of SFRP1 and SFRP3 proteins in normal and malignant reproductive tissues of rats and humans. Appl Immunohistochem Mol Morphol. 22:681–687. 2014. View Article : Google Scholar : PubMed/NCBI

55 

Weibel ER: Stereological methods. 1. practical methods for biological morphometry. Academic press; London: pp. 1–415. 1979

56 

Wicksell SD: The corpuscle problem A mathematical study of a biometric problem. Biometrika. 17:84–99. 1925. View Article : Google Scholar

57 

Wicksell SD: The corpuscle problem Second memoir case of ellipsoidal corpuscles. Biometrika. 18:151–172. 1926. View Article : Google Scholar

58 

Livak KJ and Schmittgen TD: Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) method. Methods. 25:402–408. 2001. View Article : Google Scholar : PubMed/NCBI

59 

Goldman MJ, Craft B, Hastie M, Repečka K, McDade F, Kamath A, Banerjee A, Luo Y, Rogers D, Brooks AN, et al: Visualizing and interpreting cancer genomics data via the Xena platform. Nat Biotechnol. 38:675–678. 2020. View Article : Google Scholar : PubMed/NCBI

60 

Chandrashekar DS, Bashel B, Balasubramanya SAH, Creighton CJ, Ponce-Rodriguez I, Chakravarthi BVSK and Varambally S: UALCAN: A portal for facilitating tumor subgroup gene expression and survival analyses. Neoplasia. 19:649–658. 2017. View Article : Google Scholar : PubMed/NCBI

61 

Aran D, Camarda R, Odegaard J, Paik H, Oskotsky B, Krings G, Goga A, Sirota M and Butte AJ: Comprehensive analysis of normal adjacent to tumor transcriptomes. Nat Commun. 8:10772017. View Article : Google Scholar : PubMed/NCBI

62 

Zeng WZD, Glicksberg BS, Li Y and Chen B: Selecting precise reference normal tissue samples for cancer research using a deep learning approach. BMC Med Genomics. 12 (Suppl 1):S212019. View Article : Google Scholar

63 

GTEx Consortium: The genotype-tissue expression (GTEx) project. Nat Genet. 45:580–585. 2013. View Article : Google Scholar : PubMed/NCBI

64 

Ming SC: Gastric carcinoma. A pathobiological classification. Cancer. 39:2475–2485. 1977. View Article : Google Scholar : PubMed/NCBI

65 

Nakamura K, Sugano H and Takagi K: Carcinoma of the stomach in incipient phase: Its histogenesis and histological appearances. Gan. 59:251–258. 1968.PubMed/NCBI

66 

Patel MI, Rhoads KF, Ma Y, Ford JM, Visser BC, Kunz PL, Fisher GA, Chang DT, Koong A, Norton JA and Poultsides GA: Seventh edition (2010) of the AJCC/UICC staging system for gastric adenocarcinoma: Is there room for improvement? Ann Surg Oncol. 20:1631–1638. 2013. View Article : Google Scholar : PubMed/NCBI

67 

Zhao CH, Bu XM and Zhang N: Hypermethylation and aberrant expression of Wnt antagonist secreted frizzled-related protein 1 in gastric cancer. World J Gastroenterol. 13:2214–2217. 2007. View Article : Google Scholar : PubMed/NCBI

68 

Zhang T, Wu Y, Fang Z, Yan Q, Zhang S, Sun R, Khaliq J and Li Y: Low expression of RBMS3 and SFRP1 are associated with poor prognosis in patients with gastric cancer. Am J Cancer Res. 6:2679–2689. 2016.PubMed/NCBI

69 

Kinoshita T, Nomoto S, Kodera Y, Koike M, Fujiwara M and Nakao A: Decreased expression and aberrant hypermethylation of the SFRP genes in human gastric cancer. Hepatogastroenterology. 58:1051–1056. 2011.PubMed/NCBIPubMed/NCBI

70 

Katoh Y and Katoh M: WNT antagonist, SFRP1, is Hedgehog signaling target. Int J Mol Med. 17:171–175. 2006.PubMed/NCBI

71 

Katoh M and Katoh M: Integrative genomic analyses of ZEB2: Transcriptional regulation of ZEB2 based on SMADs, ETS1, HIF1alpha, POU/OCT, and NF-kappaB. Int J Oncol. 34:1737–1742. 2009. View Article : Google Scholar : PubMed/NCBI

72 

Kim JH, Shin HS, Lee SH, Lee I, Lee YS, Park JC, Kim YJ, Chung JB and Lee YC: Contrasting activity of Hedgehog and Wnt pathways according to gastric cancer cell differentiation: Relevance of crosstalk mechanisms. Cancer Sci. 101:328–335. 2010. View Article : Google Scholar : PubMed/NCBI

73 

Peng JX, Liang SY and Li L: sFRP1 exerts effects on gastric cancer cells through GSK3β/Rac1-mediated restraint of TGFβ/Smad3 signaling. Oncol Rep. 41:224–234. 2019.PubMed/NCBI

74 

Yang HJ, Kim SG, Lim JH, Choi JM, Kim WH and Jung HC: Helicobacter pylori-induced modulation of the promoter methylation of Wnt antagonist genes in gastric carcinogenesis. Gastric Cancer. 21:237–248. 2018. View Article : Google Scholar : PubMed/NCBI

75 

Wu F, Li J, Guo N, Wang XH and Liao YQ: MiRNA-27a promotes the proliferation and invasion of human gastric cancer MGC803 cells by targeting SFRP1 via Wnt/β-catenin signaling pathway. Am J Cancer Res. 7:405–416. 2017.PubMed/NCBI

76 

Feng C, She J, Chen X, Zhang Q, Zhang X, Wang Y, Ye J, Shi J, Tao J, Feng M, et al: Exosomal miR-196a-1 promotes gastric cancer cell invasion and metastasis by targeting SFRP1. Nanomedicine (Lond). 14:2579–2593. 2019. View Article : Google Scholar : PubMed/NCBI

77 

Ouyang J, Xie Z, Lei X, Tang G, Gan R and Yang X: Clinical crosstalk between microRNAs and gastric cancer (Review). Int J Oncol. 58:72021. View Article : Google Scholar : PubMed/NCBI

78 

Xu C, Cheng H, Li N, Zhou N and Tang X: Relationship between microRNA-27a and efficacy of neoadjuvant chemotherapy in gastric cancer and its mechanism in gastric cancer cell growth and metastasis. Biosci Rep. 39:BSR201811752019. View Article : Google Scholar : PubMed/NCBI

79 

Ren J, Huang HJ, Gong Y, Yue S, Tang LM and Cheng SY: MicroRNA-206 suppresses gastric cancer cell growth and metastasis. Cell Biosci. 4:262014. View Article : Google Scholar : PubMed/NCBI

80 

Alessandrini L, Manchi M, De Re V, Dolcetti R and Canzonieri V: Proposed molecular and miRNA classification of gastric cancer. Int J Mol Sc. 19:16832018. View Article : Google Scholar

81 

Qu Y, Ray PS, Li J, Cai Q, Bagaria SP, Moran C, Sim MS, Zhang J, Turner RR, Zhu Z, et al: High levels of secreted frizzled-related protein 1 correlate with poor prognosis and promote tumourigenesis in gastric cancer. Eur J Cancer. 49:3718–3728. 2013. View Article : Google Scholar : PubMed/NCBI

82 

Cui HB, Ge HE, Wang YS and Bai XY: miR-208a enhances cell proliferation and invasion of gastric cancer by targeting SFRP1 and negatively regulating MEG3. Int J Biochem Cell Biol. 102:31–39. 2018. View Article : Google Scholar : PubMed/NCBI

83 

Peng JX, Liang SY and Li L: sFRP1 exerts effects on gastric cancer cells through GSK3β/Rac1-mediated restraint of TGFβ/Smad3 signaling. Oncol Rep. 41:224–234. 2019.PubMed/NCBI

84 

Surana R, Sikka S, Cai W, Shin EM, Warrier SR, Tan HJ, Arfuso F, Fox SA, Dharmarajan AM and Kumar AP: Secreted frizzled related proteins: Implications in cancers. Biochim Biophys Acta. 1845:53–65. 2014.PubMed/NCBI

85 

Lin K, Wang S, Julius MA, Kitajewski J, Moos M Jr and Luyten FP: The cysteine-rich frizzled domain of Frzb-1 is required and sufficient for modulation of Wnt signaling. Proc Natl Acad Sci USA. 94:11196–11200. 1997. View Article : Google Scholar : PubMed/NCBI

86 

Qu Y, Li JF, Cai Q, Wang YW, Gu QL, Zhu ZG and Liu BY: Over-expression of FRZB in gastric cancer cell suppresses proliferation and induces differentiation. J Cancer Res Clin Oncol. 134:353–364. 2008. View Article : Google Scholar : PubMed/NCBI

87 

Byun T, Karimi M, Marsh JL, Milovanovic T, Lin F and Holcombe RF: Expression of secreted Wnt antagonists in gastrointestinal tissues: Potential role in stem cell homeostasis. J Clin Pathol. 58:515–519. 2005. View Article : Google Scholar : PubMed/NCBI

88 

Qin S, Zhang Z, Li J and Zang L: FRZB knockdown upregulates β-catenin activity and enhances cell aggressiveness in gastric cancer. Oncol Rep. 31:2351–2357. 2014. View Article : Google Scholar : PubMed/NCBI

89 

Uematsu K, He B, You L, Xu Z, McCormick F and Jablons DM: Activation of the Wnt pathway in non small cell lung cancer: Evidence of dishevelled overexpression. Oncogene. 22:7218–7221. 2003. View Article : Google Scholar : PubMed/NCBI

90 

Sareddy GR, Panigrahi M, Challa S, Mahadevan A and Babu PP: Activation of Wnt/β-catenin/Tcf signaling pathway in human astrocytomas. Neurochem Int. 55:307–317. 2009. View Article : Google Scholar : PubMed/NCBI

91 

You XJ, Bryant PJ, Jurnak F and Holcombe RF: Expression of Wnt pathway components frizzled and disheveled in colon cancer arising in patients with inflammatory bowel disease. Oncol Rep. 18:691–694. 2007.PubMed/NCBI

92 

Hegazy SA, Alshareef A, Gelebart P, Anand M, Armanious H, Ingham RJ, Ingham RJ and Lai R: Disheveled proteins promote cell growth and tumorigenicity in ALK-positive anaplastic large cell lymphoma. Cell Signal. 25:295–307. 2013. View Article : Google Scholar : PubMed/NCBI

93 

Kafka A, Karin-Kujundžić V, Šerman L, Bukovac A, Njirić N, Jakovčević A and Pećina-Šlaus N: Hypermethylation of secreted frizzled related protein 1 gene promoter in different astrocytoma grades. Croat Med J. 59:213–223. 2018. View Article : Google Scholar : PubMed/NCBI

94 

Astudillo P: Wnt5a signaling in gastric cancer. Front Cell Dev Biol. 8:1102020. View Article : Google Scholar : PubMed/NCBI

95 

Ara H, Takagishi M, Enomoto A, Asai M, Ushida K, Asai N, Shimoyama Y, Kaibuchi K, Kodera Y and Takahashi M: Role for Daple in non-canonical Wnt signaling during gastric cancer invasion and metastasis. Cancer Sci. 107:133–139. 2016. View Article : Google Scholar : PubMed/NCBI

96 

Peng Q, Chen L, Wu W, Wang J, Zheng X, Chen Z, Jiang Q, Han J, Wei L, Wang L, et al: EPH receptor A2 governs a feedback loop that activates Wnt/β-catenin signaling in gastric cancer. Cell Death Dis. 9:11462018. View Article : Google Scholar : PubMed/NCBI

97 

Gao J, Zhao C, Liu Q, Hou X, Li S, Xing X, Yang C and Luo Y: Cyclin G2 suppresses Wnt/β-catenin signaling and inhibits gastric cancer cell growth and migration through Dapper1. J Exp Clin Cancer Res. 37:3172018. View Article : Google Scholar : PubMed/NCBI

98 

Peng Y and Wang HH: Cir-ITCH inhibits gastric cancer migration, invasion and proliferation by regulating the Wnt/β-catenin pathway. Sci Rep. 101:174432020. View Article : Google Scholar : PubMed/NCBI

99 

Deng YZ, Yao F, Li JJ, Mao ZF, Hu PT, Long LY, Li G, Ji XD, Shi S, Guan DX, et al: RACK1 suppresses gastric tumorigenesis by stabilizing the β-catenin destruction complex. Gastroenterology. 142:812–823.e15. 2012. View Article : Google Scholar : PubMed/NCBI

100 

Demirci U, Örenay Boyacıoğlu S, Kasap E, Bilgiç F, Gerçeker E, Yıldırım H, Baykan A, Ellidokuz E, Yüceyar M and Korkmaz M: P-014 are RHOA, CSNK1A1, DVL2, FZD8 and LRP5 genes novel biomarkers in the conversion from intestinal metaplasia to gastric Cancer? Ann Oncol. 27 (Suppl 2):ii42016. View Article : Google Scholar

101 

Chong Y, Mia-Jan K, Ryu H, Abdul-Ghafar J, Munkhdelger J, Lkhagvadorj S, Jung SY, Lee M, Ji SY, Choi E and Cho MY: DNA methylation status of a distinctively different subset of genes is associated with each histologic Lauren classification subtype in early gastric carcinogenesis. Oncol Rep. 31:2535–2544. 2014. View Article : Google Scholar : PubMed/NCBI

102 

Cancer Genome Atlas Research Network, . Comprehensive molecular characterization of gastric adenocarcinoma. Nature. 513:202–209. 2014. View Article : Google Scholar : PubMed/NCBI

103 

Cristescu R, Lee J, Nebozhyn M, Kim KM, Ting JC, Wong SS, Liu J, Yue YG, Wang J, Yu K, et al: Molecular analysis of gastric cancer identifies subtypes associated with distinct clinical outcomes. Nat Med. 2:449–456. 2015. View Article : Google Scholar : PubMed/NCBI

104 

Katona BW and Rustgi AK: Gastric cancer genomics: Advances and future directions. Cell Mol Gastroenterol Hepatol. 3:211–217. 2017. View Article : Google Scholar : PubMed/NCBI

105 

Oh SC, Sohn BH, Cheong JH, Kim SB, Lee JE, Park KC, Lee SH, Park JL, Park YY, Lee HS, et al: Clinical and genomic landscape of gastric cancer with a mesenchymal phenotype. Nat Commun. 9:17772018. View Article : Google Scholar : PubMed/NCBI

106 

Carino A, Graziosi L, Marchianò S, Biagioli M, Marino E, Sepe V, Zampella E, Distrutti E, Donini A and Fiorucci S: Analysis of gastric cancer transcriptome allows the identification of histotype specific molecular signatures with prognostic potential. Front Oncol. 11:6637712021. View Article : Google Scholar : PubMed/NCBI

107 

Sexton RE, Hallak MNA, Uddin MH, Diab M and Azmi AS: Gastric cancer heterogeneity and clinical outcomes. Technol Cancer Res Treat. 19:15330338209354772020. View Article : Google Scholar : PubMed/NCBI

108 

Li L and Wang X: Identification of gastric cancer subtypes based on pathway clustering. NPJ Precis Oncol. 5:462021. View Article : Google Scholar : PubMed/NCBI

109 

Wong SS, Kim KM, Ting JC, Yu K, Fu J, Liu S, Cristescu R, Nebozhyn M, Gong L, Yue YG, et al: Genomic landscape and genetic heterogeneity in gastric adenocarcinoma revealed by whole-genome sequencing. Nat Commun. 5:54772014. View Article : Google Scholar : PubMed/NCBI

Related Articles

  • Abstract
  • View
  • Download
  • Twitter
Copy and paste a formatted citation
Spandidos Publications style
Sremac M, Paic F, Grubelic Ravic K, Serman L, Pavicic Dujmovic A, Brcic I, Krznaric Z and Nikuseva Martic T: Aberrant expression of SFRP1, SFRP3, DVL2 and DVL3 Wnt signaling pathway components in diffuse gastric carcinoma. Oncol Lett 22: 822, 2021.
APA
Sremac, M., Paic, F., Grubelic Ravic, K., Serman, L., Pavicic Dujmovic, A., Brcic, I. ... Nikuseva Martic, T. (2021). Aberrant expression of SFRP1, SFRP3, DVL2 and DVL3 Wnt signaling pathway components in diffuse gastric carcinoma. Oncology Letters, 22, 822. https://doi.org/10.3892/ol.2021.13083
MLA
Sremac, M., Paic, F., Grubelic Ravic, K., Serman, L., Pavicic Dujmovic, A., Brcic, I., Krznaric, Z., Nikuseva Martic, T."Aberrant expression of SFRP1, SFRP3, DVL2 and DVL3 Wnt signaling pathway components in diffuse gastric carcinoma". Oncology Letters 22.6 (2021): 822.
Chicago
Sremac, M., Paic, F., Grubelic Ravic, K., Serman, L., Pavicic Dujmovic, A., Brcic, I., Krznaric, Z., Nikuseva Martic, T."Aberrant expression of SFRP1, SFRP3, DVL2 and DVL3 Wnt signaling pathway components in diffuse gastric carcinoma". Oncology Letters 22, no. 6 (2021): 822. https://doi.org/10.3892/ol.2021.13083
Copy and paste a formatted citation
x
Spandidos Publications style
Sremac M, Paic F, Grubelic Ravic K, Serman L, Pavicic Dujmovic A, Brcic I, Krznaric Z and Nikuseva Martic T: Aberrant expression of SFRP1, SFRP3, DVL2 and DVL3 Wnt signaling pathway components in diffuse gastric carcinoma. Oncol Lett 22: 822, 2021.
APA
Sremac, M., Paic, F., Grubelic Ravic, K., Serman, L., Pavicic Dujmovic, A., Brcic, I. ... Nikuseva Martic, T. (2021). Aberrant expression of SFRP1, SFRP3, DVL2 and DVL3 Wnt signaling pathway components in diffuse gastric carcinoma. Oncology Letters, 22, 822. https://doi.org/10.3892/ol.2021.13083
MLA
Sremac, M., Paic, F., Grubelic Ravic, K., Serman, L., Pavicic Dujmovic, A., Brcic, I., Krznaric, Z., Nikuseva Martic, T."Aberrant expression of SFRP1, SFRP3, DVL2 and DVL3 Wnt signaling pathway components in diffuse gastric carcinoma". Oncology Letters 22.6 (2021): 822.
Chicago
Sremac, M., Paic, F., Grubelic Ravic, K., Serman, L., Pavicic Dujmovic, A., Brcic, I., Krznaric, Z., Nikuseva Martic, T."Aberrant expression of SFRP1, SFRP3, DVL2 and DVL3 Wnt signaling pathway components in diffuse gastric carcinoma". Oncology Letters 22, no. 6 (2021): 822. https://doi.org/10.3892/ol.2021.13083
Follow us
  • Twitter
  • LinkedIn
  • Facebook
About
  • Spandidos Publications
  • Careers
  • Cookie Policy
  • Privacy Policy
How can we help?
  • Help
  • Live Chat
  • Contact
  • Email to our Support Team