Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Oncology Letters
      • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Biomedical Reports
      • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • Information for Authors
    • Information for Reviewers
    • Information for Librarians
    • Information for Advertisers
    • Conferences
  • Language Editing
Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • For Authors
    • For Reviewers
    • For Librarians
    • For Advertisers
    • Conferences
  • Language Editing
Login Register Submit
  • This site uses cookies
  • You can change your cookie settings at any time by following the instructions in our Cookie Policy. To find out more, you may read our Privacy Policy.

    I agree
Search articles by DOI, keyword, author or affiliation
Search
Advanced Search
presentation
Oncology Letters
Join Editorial Board Propose a Special Issue
Print ISSN: 1792-1074 Online ISSN: 1792-1082
Journal Cover
December-2021 Volume 22 Issue 6

Full Size Image

Sign up for eToc alerts
Recommend to Library

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
December-2021 Volume 22 Issue 6

Full Size Image

Sign up for eToc alerts
Recommend to Library

  • Article
  • Citations
    • Cite This Article
    • Download Citation
    • Create Citation Alert
    • Remove Citation Alert
    • Cited By
  • Similar Articles
    • Related Articles (in Spandidos Publications)
    • Similar Articles (Google Scholar)
    • Similar Articles (PubMed)
  • Download PDF
  • Download XML
  • View XML
Review Open Access

Pathogenicity of the MAGE family (Review)

  • Authors:
    • Sanyan Li
    • Xiang Shi
    • Jingping Li
    • Xianrong Zhou
  • View Affiliations / Copyright

    Affiliations: Department of Pathology, Qianjiang Central Hospital, Qianjiang, Hubei 433100, P.R. China, Department of Respiratory Medicine, Qianjiang Central Hospital, Qianjiang, Hubei 433100, P.R. China
    Copyright: © Li et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 844
    |
    Published online on: October 21, 2021
       https://doi.org/10.3892/ol.2021.13105
  • Expand metrics +
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
Cited By (CrossRef): 0 citations Loading Articles...

This article is mentioned in:



Abstract

The melanoma antigen gene (MAGE) protein family is a group of highly conserved proteins that share a common homology domain. Under normal circumstances, numerous MAGE proteins are only expressed in reproduction‑related tissues; however, abnormal expression levels are observed in a variety of tumor tissues. The MAGE family consists of type I and II proteins, several of which are cancer‑testis antigens that are highly expressed in cancer and serve a critical role in tumorigenesis. Therefore, this review will use the relationship between MAGEs and tumors as a starting point, focusing on the latest developments regarding the function of MAGEs as oncogenes, and preliminarily reveal their possible mechanisms.
View Figures
View References

1 

Tan S, Li D and Zhu X: Cancer immunotherapy: Pros, cons and beyond. Biomed Pharmacother. 124:1098212020. View Article : Google Scholar : PubMed/NCBI

2 

Yakirevich E, Sabo E, Lavie O, Mazareb S, Spagnoli GC and Resnick MB: Expression of the MAGE-A4 and NY-ESO-1 cancer-testis antigens in serous ovarian neoplasms. Clin Cancer Res. 9:6453–6460. 2003.PubMed/NCBI

3 

Scanlan MJ, Simpson AJ and Old LJ: The cancer/testis genes: Review, standardization, and commentary. Cancer Immun. 4:12004.PubMed/NCBI

4 

Liu Y, Wen L, Ma L, Kang Y, Liu KY, Huang XJ, Ruan GR and Lu J: MAGE genes: Prognostic indicators in AL amyloidosis patients. J Cell Mol Med. 23:5672–5678. 2019. View Article : Google Scholar : PubMed/NCBI

5 

Simpson AJ, Caballero OL, Jungbluth A, Chen YT and Old LJ: Cancer/testis antigens, gametogenesis and cancer. Nat Rev Cancer. 5:615–625. 2005. View Article : Google Scholar : PubMed/NCBI

6 

Sanderson JP, Crowley DJ, Wiedermann GE, Quinn LL, Crossland KL, Tunbridge HM, Cornforth TV, Barnes CS, Ahmed T, Howe K, et al: Preclinical evaluation of an affinity-enhanced MAGE-A4-specific T-cell receptor for adoptive T-cell therapy. Oncoimmunology. 9:16823812019. View Article : Google Scholar : PubMed/NCBI

7 

Lee AK and Potts PR: A comprehensive guide to the MAGE family of ubiquitin ligases. J Mol Biol. 429:1114–1142. 2017. View Article : Google Scholar : PubMed/NCBI

8 

Liu S, Zhao Y, Xu Y, Sang M, Zhao R, Gu L and Shan B: The clinical significance of methylation of MAGE-A1 and-A3 promoters and expression of DNA methyltransferase in patients with laryngeal squamous cell carcinoma. Am J Otolaryngol. 41:1023182020. View Article : Google Scholar : PubMed/NCBI

9 

De Donato M, Peters SO, Hussain T, Rodulfo H, Thomas BN, Babar ME and Imumorin IG: Molecular evolution of type II MAGE genes from ancestral MAGED2 gene and their phylogenetic resolution of basal mammalian clades. Mamm Genome. 28:443–454. 2017. View Article : Google Scholar : PubMed/NCBI

10 

Barker PA and Salehi A: The MAGE proteins: Emerging roles in cell cycle progression, apoptosis, and neurogenetic disease. J Neurosci Res. 67:705–712. 2002. View Article : Google Scholar : PubMed/NCBI

11 

Doyle JM, Gao J, Wang J, Yang M and Potts PR: MAGE-RING protein complexes comprise a family of E3 ubiquitin ligases. Mol Cell. 39:963–974. 2010. View Article : Google Scholar : PubMed/NCBI

12 

Feng Y, Gao J and Yang M: When MAGE meets RING: Insights into biological functions of MAGE proteins. Protein Cell. 2:7–12. 2011. View Article : Google Scholar : PubMed/NCBI

13 

Pineda CT, Ramanathan S, Fon Tacer K, Weon JL, Potts MB, Ou YH, White MA and Potts PR: Degradation of AMPK by a cancer-specific ubiquitin ligase. Cell. 160:715–728. 2015. View Article : Google Scholar : PubMed/NCBI

14 

Mao Y, Fan W, Hu H, Zhang L, Michel J, Wu Y, Wang J, Jia L, Tang X, Xu L, et al: MAGE-A1 in lung adenocarcinoma as a promising target of chimeric antigen receptor T cells. J Hematol Oncol. 12:1062019. View Article : Google Scholar : PubMed/NCBI

15 

Kerkar SP, Wang ZF, Lasota J, Park T, Patel K, Groh E, Rosenberg SA and Miettinen MM: MAGE-a is more highly expressed than NY-ESO-1 in a systematic immunohistochemical analysis of 3668 cases. J Immunother. 39:181–187. 2016. View Article : Google Scholar : PubMed/NCBI

16 

Hao YH, Doyle JM, Ramanathan S, Gomez TS, Jia D, Xu M, Chen ZJ, Billadeau DD, Rosen MK and Potts PR: Regulation of WASH-dependent actin polymerization and protein trafficking by ubiquitination. Cell. 152:1051–1064. 2013. View Article : Google Scholar : PubMed/NCBI

17 

Taniura H, Kobayashi M and Yoshikawa K: Functional domains of necdin for protein-protein interaction, nuclear matrix targeting, and cell growth suppression. J Cell Biochem. 94:804–815. 2005. View Article : Google Scholar : PubMed/NCBI

18 

Chen YC, Hsu WL, Chiu CY, Liao JW, Chang CC and Chang SC: Expression of MAGE-A restricted to testis and ovary or to various cancers in dogs. Vet Immunol Immunopathol. 153:26–34. 2013. View Article : Google Scholar : PubMed/NCBI

19 

Fon Tacer K, Montoya MC, Oatley MJ, Lord T, Oatley JM, Klein J, Ravichandran R, Tillman H, Kim M, Connelly JP, et al: MAGE cancer-testis antigens protect the mammalian germline under environmental stress. Sci Adv. 5:eaav48322019. View Article : Google Scholar : PubMed/NCBI

20 

Mouri A, Sasaki A, Watanabe K, Sogawa C, Kitayama S, Mamiya T, Miyamoto Y, Yamada K, Noda Y and Nabeshima T: MAGE-D1 regulates expression of depression-like behavior through serotonin transporter ubiquitylation. J Neurosci. 32:4562–4580. 2012. View Article : Google Scholar : PubMed/NCBI

21 

Saenko V, Rogounovitch T, Shimizu-Yoshida Y, Abrosimov A, Lushnikov E, Roumiantsev P, Matsumoto N, Nakashima M, Meirmanov S, Ohtsuru A, et al: Novel tumorigenic rearrangement, delta rfp/ret, in a papillary thyroid carcinoma from externally irradiated patient. Mutat Res. 527:81–90. 2003. View Article : Google Scholar : PubMed/NCBI

22 

Cai X, Srivastava S, Sun Y, Li Z, Wu H, Zuvela-Jelaska L, Li J, Salamon RS, Backer JM and Skolnik EY: Tripartite motif containing protein 27 negatively regulates CD4 T cells by ubiquitinating and inhibiting the class II PI3K-C2β. Proc Natl Acad Sci USA. 108:20072–20077. 2011. View Article : Google Scholar : PubMed/NCBI

23 

van den Elsen GA, Tobben L, Ahmed AI, Verkes RJ, Kramers C, Marijnissen RM, Olde Rikkert MG and van der Marck MA: Effects of tetrahydrocannabinol on balance and gait in patients with dementia: A randomised controlled crossover trial. J Psychopharmacol. 31:184–191. 2017. View Article : Google Scholar : PubMed/NCBI

24 

Carias KV, Zoeteman M, Seewald A, Sanderson MR, Bischof JM and Wevrick R: A MAGEL2-deubiquitinase complex modulates the ubiquitination of circadian rhythm protein CRY1. PLoS One. 15:e02308742020. View Article : Google Scholar : PubMed/NCBI

25 

Faktor J, Pjechová M, Hernychová L and Vojtěšek B: Protein ubiquitination research in oncology. Klin Onkol. 32 (Suppl 3):S56–S64. 2019. View Article : Google Scholar : PubMed/NCBI

26 

Swatek KN and Komander D: Ubiquitin modifications. Cell Res. 26:399–422. 2016. View Article : Google Scholar : PubMed/NCBI

27 

Shaid S, Brandts CH, Serve H and Dikic I: Ubiquitination and selective autophagy. Cell Death Differ. 20:21–30. 2013. View Article : Google Scholar : PubMed/NCBI

28 

Mattiroli F and Penengo L: Histone ubiquitination: An integrative signaling platform in genome stability. Trends Genet. 37:566–581. 2021. View Article : Google Scholar : PubMed/NCBI

29 

Krützfeldt M, Ellis M, Weekes DB, Bull JJ, Eilers M, Vivanco MD, Sellers WR and Mittnacht S: Selective ablation of retinoblastoma protein function by the RET finger protein. Mol Cell. 18:213–224. 2005. View Article : Google Scholar : PubMed/NCBI

30 

Zoumpoulidou G, Broceño C, Li H, Bird D, Thomas G and Mittnacht S: Role of the tripartite motif protein 27 in cancer development. J Natl Cancer Inst. 104:941–952. 2012. View Article : Google Scholar : PubMed/NCBI

31 

Scott KL, Kabbarah O, Liang MC, Ivanova E, Anagnostou V, Wu J, Dhakal S, Wu M, Chen S, Feinberg T, et al: GOLPH3 modulates mTOR signalling and rapamycin sensitivity in cancer. Nature. 459:1085–1090. 2009. View Article : Google Scholar : PubMed/NCBI

32 

Kozakova L, Vondrova L, Stejskal K, Charalabous P, Kolesar P, Lehmann AR, Uldrijan S, Sanderson CM, Zdrahal Z and Palecek JJ: The melanoma-associated antigen 1 (MAGEA1) protein stimulates the E3 ubiquitin-ligase activity of TRIM31 within a TRIM31-MAGEA1-NSE4 complex. Cell Cycle. 14:920–930. 2015. View Article : Google Scholar : PubMed/NCBI

33 

Zech T, Calaminus SD, Caswell P, Spence HJ, Carnell M, Insall RH, Norman J and Machesky LM: The Arp2/3 activator WASH regulates α5β1-integrin-mediated invasive migration. J Cell Sci. 124:3753–3759. 2011. View Article : Google Scholar : PubMed/NCBI

34 

Small SA: Retromer sorting: A pathogenic pathway in late-onset Alzheimer disease. Arch Neurol. 65:323–328. 2008. View Article : Google Scholar : PubMed/NCBI

35 

Blalock EM, Geddes JW, Chen KC, Porter NM, Markesbery WR and Landfield PW: Incipient Alzheimer's disease: Microarray correlation analyses reveal major transcriptional and tumor suppressor responses. Proc Natl Acad Sci USA. 101:2173–2178. 2004. View Article : Google Scholar : PubMed/NCBI

36 

Osterlund C, Töhönen V, Forslund KO and Nordqvist K: Mage-b4, a novel melanoma antigen (MAGE) gene specifically expressed during germ cell differentiation. Cancer Res. 60:1054–1061. 2000.PubMed/NCBI

37 

Gjerstorff MF, Harkness L, Kassem M, Frandsen U, Nielsen O, Lutterodt M, Møllgård K and Ditzel HJ: Distinct GAGE and MAGE-A expression during early human development indicate specific roles in lineage differentiation. Hum Reprod. 23:2194–2201. 2008. View Article : Google Scholar : PubMed/NCBI

38 

Hao YH, Fountain MD Jr, Fon Tacer K, Xia F, Bi W, Kang SH, Patel A, Rosenfeld JA, Le Caignec C, Isidor B, et al: USP7 acts as a molecular rheostat to promote WASH-dependent endosomal protein recycling and is mutated in a human neurodevelopmental disorder. Mol Cell. 59:956–969. 2015. View Article : Google Scholar : PubMed/NCBI

39 

Wang J, Teng JL, Zhao D, Ge P, Li B, Woo PC and Liu CH: The ubiquitin ligase TRIM27 functions as a host restriction factor antagonized by mycobacterium tuberculosis PtpA during mycobacterial infection. Sci Rep. 6:348272016. View Article : Google Scholar : PubMed/NCBI

40 

Wang D, Wang J, Ding N, Li Y, Yang Y, Fang X and Zhao H: MAGE-A1 promotes melanoma proliferation and migration through C-JUN activation. Biochem Biophys Res Commun. 473:959–965. 2016. View Article : Google Scholar : PubMed/NCBI

41 

Sang M, Gu L, Yin D, Liu F, Lian Y, Zhang X, Liu S, Huang W, Wu Y and Shan B: MAGE-A family expression is correlated with poor survival of patients with lung adenocarcinoma: A retrospective clinical study based on tissue microarray. J Clin Pathol. 70:533–540. 2017. View Article : Google Scholar : PubMed/NCBI

42 

Sang M, Gu L, Liu F, Lian Y, Yin D, Fan X, Ding C, Huang W, Liu S and Shan B: Prognostic significance of MAGE-A11 in esophageal squamous cell carcinoma and identification of related genes based on DNA microarray. Arch Med Res. 47:151–161. 2016. View Article : Google Scholar : PubMed/NCBI

43 

Tacer KF and Potts PR: Cellular and disease functions of the Prader-Willi syndrome gene MAGEL2. Biochem J. 474:2177–2190. 2017. View Article : Google Scholar : PubMed/NCBI

44 

Xiao TZ, Bhatia N, Urrutia R, Lomberk GA, Simpson A and Longley BJ: MAGE I transcription factors regulate KAP1 and KRAB domain zinc finger transcription factor mediated gene repression. PLoS One. 6:e237472011. View Article : Google Scholar : PubMed/NCBI

45 

Yang G, Fu Y, Lu X, Wang M, Dong H and Li Q: miR-34a regulates the chemosensitivity of retinoblastoma cells via modulation of MAGE-A/p53 signaling. Int J Oncol. 54:177–187. 2019.PubMed/NCBI

46 

Borden KL: RING domains: Master builders of molecular scaffolds? J Mol Biol. 295:1103–1112. 2000. View Article : Google Scholar : PubMed/NCBI

47 

Jackson PK, Eldridge AG, Freed E, Furstenthal L, Hsu JY, Kaiser BK and Reimann JD: The lore of the RINGs: Substrate recognition and catalysis by ubiquitin ligases. Trends Cell Biol. 10:429–439. 2000. View Article : Google Scholar : PubMed/NCBI

48 

Lupo A, Cesaro E, Montano G, Zurlo D, Izzo P and Costanzo P: KRAB-zinc finger proteins: A repressor family displaying multiple biological functions. Curr Genomics. 14:268–278. 2013. View Article : Google Scholar : PubMed/NCBI

49 

Santos J and Gil J: TRIM28/KAP1 regulates senescence. Immunol Lett. 162:281–289. 2014. View Article : Google Scholar : PubMed/NCBI

50 

Lian Y, Meng L, Ding P and Sang M: Epigenetic regulation of MAGE family in human cancer progression-DNA methylation, histone modification, and non-coding RNAs. Clin Epigenetics. 10:1152018. View Article : Google Scholar : PubMed/NCBI

51 

Ladelfa MF, Peche LY, Toledo MF, Laiseca JE, Schneider C and Monte M: Tumor-specific MAGE proteins as regulators of p53 function. Cancer Lett. 325:11–17. 2012. View Article : Google Scholar : PubMed/NCBI

52 

Gure AO, Chua R, Williamson B, Gonen M, Ferrera CA, Gnjatic S, Ritter G, Simpson AJ, Chen YT, Old LJ and Altorki NK: Cancer-testis genes are coordinately expressed and are markers of poor outcome in non-small cell lung cancer. Clin Cancer Res. 11:8055–8062. 2005. View Article : Google Scholar : PubMed/NCBI

53 

Zhang S, Zhai X, Wang G, Feng J, Zhu H, Xu L, Mao G and Huang J: High expression of MAGE-A9 in tumor and stromal cells of non-small cell lung cancer was correlated with patient poor survival. Int J Clin Exp Pathol. 8:541–550. 2015.PubMed/NCBI

54 

Carling D: AMPK signalling in health and disease. Curr Opin Cell Biol. 45:31–37. 2017. View Article : Google Scholar : PubMed/NCBI

55 

Yang F, Zhou X, Miao X, Zhang T, Hang X, Tie R, Liu N, Tian F, Wang F and Yuan J: MAGEC2, an epithelial-mesenchymal transition inducer, is associated with breast cancer metastasis. Breast Cancer Res Treat. 145:23–32. 2014. View Article : Google Scholar : PubMed/NCBI

56 

Daudi S, Eng KH, Mhawech-Fauceglia P, Morrison C, Miliotto A, Beck A, Matsuzaki J, Tsuji T, Groman A, Gnjatic S, et al: Expression and immune responses to MAGE antigens predict survival in epithelial ovarian cancer. PLoS One. 9:e1040992014. View Article : Google Scholar : PubMed/NCBI

57 

Wischnewski F, Friese O, Pantel K and Schwarzenbach H: Methyl-CpG binding domain proteins and their involvement in the regulation of the MAGE-A1, MAGE-A2, MAGE-A3, and MAGE-A12 gene promoters. Mol Cancer Res. 5:749–759. 2007. View Article : Google Scholar : PubMed/NCBI

58 

Xu Y, Wang C, Zhang Y, Jia L and Huang J: Overexpression of MAGE-A9 is predictive of poor prognosis in epithelial ovarian cancer. Sci Rep. 5:121042015. View Article : Google Scholar : PubMed/NCBI

59 

Jeon CH, Kim IH and Chae HD: Prognostic value of genetic detection using CEA and MAGE in peritoneal washes with gastric carcinoma after curative resection: Result of a 3-year follow-up. Medicine (Baltimore). 93:e832014. View Article : Google Scholar : PubMed/NCBI

60 

Gu X, Fu M, Ge Z, Zhan F, Ding Y, Ni H, Zhang W, Zhu Y, Tang X, Xiong L, et al: High expression of MAGE-A9 correlates with unfavorable survival in hepatocellular carcinoma. Sci Rep. 4:66252014. View Article : Google Scholar : PubMed/NCBI

61 

Hardie DG, Ross FA and Hawley SA: AMPK: A nutrient and energy sensor that maintains energy homeostasis. Nat Rev Mol Cell Biol. 13:251–262. 2012. View Article : Google Scholar : PubMed/NCBI

62 

White E: Deconvoluting the context-dependent role for autophagy in cancer. Nat Rev Cancer. 12:401–410. 2012. View Article : Google Scholar : PubMed/NCBI

63 

Karpf AR, Bai S, James SR, Mohler JL and Wilson EM: Increased expression of androgen receptor coregulator MAGE-11 in prostate cancer by DNA hypomethylation and cyclic AMP. Mol Cancer Res. 7:523–535. 2009. View Article : Google Scholar : PubMed/NCBI

64 

Kondo T, Zhu X, Asa SL and Ezzat S: The cancer/testis antigen melanoma-associated antigen-A3/A6 is a novel target of fibroblast growth factor receptor 2-IIIb through histone H3 modifications in thyroid cancer. Clin Cancer Res. 13:4713–4720. 2007. View Article : Google Scholar : PubMed/NCBI

65 

Yang B, Wu J, Maddodi N, Ma Y, Setaluri V and Longley BJ: Epigenetic control of MAGE gene expression by the KIT tyrosine kinase. J Invest Dermatol. 127:2123–2128. 2007. View Article : Google Scholar : PubMed/NCBI

66 

Kouhara H, Hadari YR, Spivak-Kroizman T, Schilling J, Bar-Sagi D, Lax I and Schlessinger J: A lipid-anchored Grb2-binding protein that links FGF-receptor activation to the Ras/MAPK signaling pathway. Cell. 89:693–702. 1997. View Article : Google Scholar : PubMed/NCBI

67 

Weber J, Salgaller M, Samid D, Johnson B, Herlyn M, Lassam N, Treisman J and Rosenberg SA: Expression of the MAGE-1 tumor antigen is up-regulated by the demethylating agent 5-aza-2′-deoxycytidine. Cancer Res. 54:1766–1771. 1994.PubMed/NCBI

68 

Vatolin S, Abdullaev Z, Pack SD, Flanagan PT, Custer M, Loukinov DI, Pugacheva E, Hong JA, Morse H III, Schrump DS, et al: Conditional expression of the CTCF-paralogous transcriptional factor BORIS in normal cells results in demethylation and derepression of MAGE-A1 and reactivation of other cancer-testis genes. Cancer Res. 65:7751–7762. 2005. View Article : Google Scholar : PubMed/NCBI

69 

Schwarzenbach H, Eichelser C, Steinbach B, Tadewaldt J, Pantel K, Lobanenkov V and Loukinov D: Differential regulation of MAGE-A1 promoter activity by BORIS and Sp1, both interacting with the TATA binding protein. BMC Cancer. 14:7962014. View Article : Google Scholar : PubMed/NCBI

70 

Colemon A, Harris TM and Ramanathan S: DNA hypomethylation drives changes in MAGE-A gene expression resulting in alteration of proliferative status of cells. Genes Environ. 42:242020. View Article : Google Scholar : PubMed/NCBI

71 

Gu L, Sang M, Li J, Liu F, Wu Y, Liu S, Wang P and Shan B: Expression and prognostic significance of MAGE-A11 and transcription factors (SP1,TFCP2 and ZEB1) in ESCC tissues. Pathol Res Pract. 215:1524462019. View Article : Google Scholar : PubMed/NCBI

72 

Chen A, Santana AL, Doudican N, Roudiani N, Laursen K, Therrien JP, Lee J, Felsen D and Carucci JA: MAGE-A3 is a prognostic biomarker for poor clinical outcome in cutaneous squamous cell carcinoma with perineural invasion via modulation of cell proliferation. PLoS One. 15:e02415512020. View Article : Google Scholar : PubMed/NCBI

73 

Bai S, He B and Wilson EM: Melanoma antigen gene protein MAGE-11 regulates androgen receptor function by modulating the interdomain interaction. Mol Cell Biol. 25:1238–1257. 2005. View Article : Google Scholar : PubMed/NCBI

74 

Li XF, Ren P, Shen WZ, Jin X and Zhang J: The expression, modulation and use of cancer-testis antigens as potential biomarkers for cancer immunotherapy. Am J Transl Res. 12:7002–7019. 2020.PubMed/NCBI

75 

Bai S and Wilson EM: Epidermal-growth-factor-dependent phosphorylation and ubiquitinylation of MAGE-11 regulates its interaction with the androgen receptor. Mol Cell Biol. 28:1947–1963. 2008. View Article : Google Scholar : PubMed/NCBI

76 

Aprelikova O, Pandolfi S, Tackett S, Ferreira M, Salnikow K, Ward Y, Risinger JI, Barrett JC and Niederhuber J: Melanoma antigen-11 inhibits the hypoxia-inducible factor prolyl hydroxylase 2 and activates hypoxic response. Cancer Res. 69:616–624. 2009. View Article : Google Scholar : PubMed/NCBI

77 

James SR, Cedeno CD, Sharma A, Zhang W, Mohler JL, Odunsi K, Wilson EM and Karpf AR: DNA methylation and nucleosome occupancy regulate the cancer germline antigen gene MAGEA11. Epigenetics. 8:849–863. 2013. View Article : Google Scholar : PubMed/NCBI

78 

Krüger S, Ola V, Feller AC, Fischer D and Friedrich M: Expression of cancer-testis antigen CT7 (MAGE-C1) in breast cancer: An immunohistochemical study with emphasis on prognostic utility. Pathol Oncol Res. 13:91–96. 2007. View Article : Google Scholar : PubMed/NCBI

79 

Bai S, Grossman G, Yuan L, Lessey BA, French FS, Young SL and Wilson EM: Hormone control and expression of androgen receptor coregulator MAGE-11 in human endometrium during the window of receptivity to embryo implantation. Mol Hum Reprod. 14:107–116. 2008. View Article : Google Scholar : PubMed/NCBI

80 

Wilson EM: Androgen receptor molecular biology and potential targets in prostate cancer. Ther Adv Urol. 2:105–117. 2010. View Article : Google Scholar : PubMed/NCBI

81 

Askew EB, Bai S, Hnat AT, Minges JT and Wilson EM: Melanoma antigen gene protein-A11 (MAGE-11) F-box links the androgen receptor NH2-terminal transactivation domain to p160 coactivators. J Biol Chem. 284:34793–34808. 2009. View Article : Google Scholar : PubMed/NCBI

82 

Su S, Minges JT, Grossman G, Blackwelder AJ, Mohler JL and Wilson EM: Proto-oncogene activity of melanoma antigen-A11 (MAGE-A11) regulates retinoblastoma-related p107 and E2F1 proteins. J Biol Chem. 288:24809–24824. 2013. View Article : Google Scholar : PubMed/NCBI

83 

Yin B, Zeng Y, Liu G, Wang X, Wang P and Song Y: MAGE-A3 is highly expressed in a cancer stem cell-like side population of bladder cancer cells. Int J Clin Exp Pathol. 7:2934–2941. 2014.PubMed/NCBI

84 

Wienand K and Shires K: The use of MAGE C1 and flow cytometry to determine the malignant cell type in multiple myeloma. PLoS One. 10:e01207342015. View Article : Google Scholar : PubMed/NCBI

85 

Atanackovic D, Luetkens T, Hildebrandt Y, Arfsten J, Bartels K, Horn C, Stahl T, Cao Y, Zander AR, Bokemeyer C and Kröger N: Longitudinal analysis and prognostic effect of cancer-testis antigen expression in multiple myeloma. Clin Cancer Res. 15:1343–1352. 2009. View Article : Google Scholar : PubMed/NCBI

86 

Chen X, Wang L, Liu J, Huang L, Yang L, Gao Q, Shi X, Li J, Li F, Zhang Z, et al: Expression and prognostic relevance of MAGE-A3 and MAGE-C2 in non-small cell lung cancer. Oncol Lett. 13:1609–1618. 2017. View Article : Google Scholar : PubMed/NCBI

87 

Yang B, O'Herrin SM, Wu J, Reagan-Shaw S, Ma Y, Bhat KM, Gravekamp C, Setaluri V, Peters N, Hoffmann FM, et al: MAGE-A, mMage-b, and MAGE-C proteins form complexes with KAP1 and suppress p53-dependent apoptosis in MAGE-positive cell lines. Cancer Res. 67:9954–9962. 2007. View Article : Google Scholar : PubMed/NCBI

Related Articles

  • Abstract
  • View
  • Download
  • Twitter
Copy and paste a formatted citation
Spandidos Publications style
Li S, Shi X, Li J and Zhou X: Pathogenicity of the MAGE family (Review). Oncol Lett 22: 844, 2021.
APA
Li, S., Shi, X., Li, J., & Zhou, X. (2021). Pathogenicity of the MAGE family (Review). Oncology Letters, 22, 844. https://doi.org/10.3892/ol.2021.13105
MLA
Li, S., Shi, X., Li, J., Zhou, X."Pathogenicity of the MAGE family (Review)". Oncology Letters 22.6 (2021): 844.
Chicago
Li, S., Shi, X., Li, J., Zhou, X."Pathogenicity of the MAGE family (Review)". Oncology Letters 22, no. 6 (2021): 844. https://doi.org/10.3892/ol.2021.13105
Copy and paste a formatted citation
x
Spandidos Publications style
Li S, Shi X, Li J and Zhou X: Pathogenicity of the MAGE family (Review). Oncol Lett 22: 844, 2021.
APA
Li, S., Shi, X., Li, J., & Zhou, X. (2021). Pathogenicity of the MAGE family (Review). Oncology Letters, 22, 844. https://doi.org/10.3892/ol.2021.13105
MLA
Li, S., Shi, X., Li, J., Zhou, X."Pathogenicity of the MAGE family (Review)". Oncology Letters 22.6 (2021): 844.
Chicago
Li, S., Shi, X., Li, J., Zhou, X."Pathogenicity of the MAGE family (Review)". Oncology Letters 22, no. 6 (2021): 844. https://doi.org/10.3892/ol.2021.13105
Follow us
  • Twitter
  • LinkedIn
  • Facebook
About
  • Spandidos Publications
  • Careers
  • Cookie Policy
  • Privacy Policy
How can we help?
  • Help
  • Live Chat
  • Contact
  • Email to our Support Team