Open Access

Pathogenicity of the MAGE family (Review)

  • Authors:
    • Sanyan Li
    • Xiang Shi
    • Jingping Li
    • Xianrong Zhou
  • View Affiliations

  • Published online on: October 21, 2021
  • Article Number: 844
  • Copyright: © Li et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )


The melanoma antigen gene (MAGE) protein family is a group of highly conserved proteins that share a common homology domain. Under normal circumstances, numerous MAGE proteins are only expressed in reproduction‑related tissues; however, abnormal expression levels are observed in a variety of tumor tissues. The MAGE family consists of type I and II proteins, several of which are cancer‑testis antigens that are highly expressed in cancer and serve a critical role in tumorigenesis. Therefore, this review will use the relationship between MAGEs and tumors as a starting point, focusing on the latest developments regarding the function of MAGEs as oncogenes, and preliminarily reveal their possible mechanisms.
Something has gone wrong

HTTP Error 400

Well this is embarrassing. Something has gone wrong. Hopefully it is a transient error that will go away if you retry.

If the problem persists if you email our System Administrators letting them know what you were doing and telling them it was because:

Exception evaluating SpringEL expression: "dispArt?.images" (template: "article" - line 384, col 9)

and then they can get to work fixing it