Open Access

Pathogenicity of the MAGE family (Review)

  • Authors:
    • Sanyan Li
    • Xiang Shi
    • Jingping Li
    • Xianrong Zhou
  • View Affiliations

  • Published online on: October 21, 2021     https://doi.org/10.3892/ol.2021.13105
  • Article Number: 844
  • Copyright: © Li et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

The melanoma antigen gene (MAGE) protein family is a group of highly conserved proteins that share a common homology domain. Under normal circumstances, numerous MAGE proteins are only expressed in reproduction‑related tissues; however, abnormal expression levels are observed in a variety of tumor tissues. The MAGE family consists of type I and II proteins, several of which are cancer‑testis antigens that are highly expressed in cancer and serve a critical role in tumorigenesis. Therefore, this review will use the relationship between MAGEs and tumors as a starting point, focusing on the latest developments regarding the function of MAGEs as oncogenes, and preliminarily reveal their possible mechanisms.
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