Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Oncology Letters
      • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Biomedical Reports
      • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • Information for Authors
    • Information for Reviewers
    • Information for Librarians
    • Information for Advertisers
    • Conferences
  • Language Editing
Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • For Authors
    • For Reviewers
    • For Librarians
    • For Advertisers
    • Conferences
  • Language Editing
Login Register Submit
  • This site uses cookies
  • You can change your cookie settings at any time by following the instructions in our Cookie Policy. To find out more, you may read our Privacy Policy.

    I agree
Search articles by DOI, keyword, author or affiliation
Search
Advanced Search
presentation
Oncology Letters
Join Editorial Board Propose a Special Issue
Print ISSN: 1792-1074 Online ISSN: 1792-1082
Journal Cover
December-2021 Volume 22 Issue 6

Full Size Image

Sign up for eToc alerts
Recommend to Library

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
December-2021 Volume 22 Issue 6

Full Size Image

Sign up for eToc alerts
Recommend to Library

  • Article
  • Citations
    • Cite This Article
    • Download Citation
    • Create Citation Alert
    • Remove Citation Alert
    • Cited By
  • Similar Articles
    • Related Articles (in Spandidos Publications)
    • Similar Articles (Google Scholar)
    • Similar Articles (PubMed)
  • Download PDF
  • Download XML
  • View XML
Article Open Access

Regulatory effect between HMGA2 and the Wnt/β‑catenin signaling pathway in the carcinogenesis of sporadic colorectal tubular adenoma

  • Authors:
    • Dan Li
    • Yanan Cao
    • Juan Wang
    • Haiyan Yang
    • Weina Liu
    • Jinfeng Cui
    • Wenxin Wu
  • View Affiliations / Copyright

    Affiliations: Department of Pathology, The Second Hospital of Hebei Medical University, Shijiazhuang, Hebei 050000, P.R. China
    Copyright: © Li et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 849
    |
    Published online on: October 25, 2021
       https://doi.org/10.3892/ol.2021.13110
  • Expand metrics +
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
Cited By (CrossRef): 0 citations Loading Articles...

This article is mentioned in:



Abstract

Due to the high incidence of colorectal cancer worldwide, the underlying molecular mechanisms have been extensively investigated. The Wnt/β‑catenin signaling pathway plays a key role in the carcinogenesis of colorectal adenoma. In addition, the high mobility group AT‑hook 2 (HMGA2) protein, which is involved in several biological processes, such as proliferation, differentiation, transformation and metastasis, is expressed at significantly high levels in colorectal cancer tissues compared with adjacent normal tissues. Currently, the role of HMGA2 in the carcinogenesis of sporadic colorectal tubular adenoma remains unclear. The downstream Wnt/β‑catenin signaling molecule, T‑cell factor/lymphoid enhancing factor (TCF/LEF), shares a similar domain with HMGA2, which enhances β‑catenin transcriptional activity and TCF/LEF binding. Thus, the present study investigated the association between HMGA2 and the Wnt/β‑catenin signaling pathway, and their role in the carcinogenesis of sporadic colorectal tubular adenoma via immunohistochemistry, siRNA, quantitative PCR and western blot analyses. The results demonstrated that the positive rate of HMGA2 expression gradually increased during tumor progression. Furthermore, HMGA2 expression was positively correlated with Wnt/β‑catenin signaling protein expression [Wnt, β‑catenin, cyclin‑dependent kinase 4 (CDK4) and cyclin D1], suggesting its involvement in the carcinogenesis of sporadic colorectal tubular adenoma and its potential to synergistically interact with the Wnt/β‑catenin signaling pathway. HMGA2 knockdown in the human colorectal cancer cell line, HCT 116 decreased β‑catenin expression and its downstream targets, CDK4 and cyclin D1. Furthermore, silencing of Wnt or β‑catenin decreased HMGA2 expression. Taken together, the results of the present study suggest the coordinated regulation of HMGA2 and the Wnt/β‑catenin signaling pathway in the carcinogenesis of sporadic colorectal tubular adenoma.
View Figures
View References

1 

Dilly CK and Kahi CJ: Does increased adenoma detection reduce the risk of colorectal cancer, and how good do we need to be? Curr Gastroenterol Rep. 21:92019. View Article : Google Scholar : PubMed/NCBI

2 

Fabišíková K, Behulová RL and Repiska V: Molecular biomarkers in the diagnostic of patients with colorectal cancer. Neuro Endocrinol Lett. 40:215–221. 2019.PubMed/NCBI

3 

Roberts BS, Hardigan AA, Moore DE, Ramaker RC, Jones AL, Fitz-Gerald MB, Cooper GM, Wilcox CM, Kimberly RP and Myers RM: Discovery and validation of circulating biomarkers of colorectal adenoma by high-depth small RNA sequencing. Clin Cancer Res. 24:2092–2099. 2018. View Article : Google Scholar : PubMed/NCBI

4 

Versace VL, Forsyth AD, Vaughan R, Morrice MG and Morphett BJ: Evidence of elevated colorectal cancer and adenoma rates for regional National bowel cancer screening program participants. Aust J Rural Health. 26:63–64. 2018. View Article : Google Scholar : PubMed/NCBI

5 

Zhou H, Shen Z, Zhao J, Zhou Z and Xu Y: Distribution characteristics and risk factors of colorectal adenomas. Zhonghua Wei Chang Wai Ke Za Zhi. 21:678–684. 2018.(In Chinese). PubMed/NCBI

6 

Yang B, Mao L, Li Y, Li Q, Li X, Zhang Y and Zhai Z: β-catenin, leucine-rich repeat-containing G protein-coupled receptor 5 and GATA-binding factor 6 are associated with the normal mucosa-adenoma-adenocarcinoma sequence of colorectal tumorigenesis. Oncol Lett. 15:2287–2295. 2018.PubMed/NCBI

7 

Lee JK, Jensen CD, Levin TR, Doubeni CA, Zauber AG, Chubak J, Kamineni AS, Schottinger JE, Ghai NR, Udaltsova N, et al: Long-term risk of colorectal cancer and related death after adenoma removal in a large, community-based population. Gastroenterology. 158:884–894.e5. 2020. View Article : Google Scholar : PubMed/NCBI

8 

Lochhead P, Chan AT, Giovannucci E, Fuchs CS, Wu K, Nishihara R, O'Brien M and Ogino S: Progress and opportunities in molecular pathological epidemiology of colorectal premalignant lesions. Am J Gastroenterol. 109:1205–1214. 2014. View Article : Google Scholar : PubMed/NCBI

9 

Dinarvand P, Davaro EP, Doan JV, Ising ME, Evans NR, Phillips NJ, Lai J and Guzman MA: Familial adenomatous polyposis syndrome: An update and review of extraintestinal manifestations. Arch Pathol Lab Med. 143:1382–1398. 2019. View Article : Google Scholar : PubMed/NCBI

10 

Taherian M, Lotfollahzadeh S, Daneshpajouhnejad P and Arora K: Tubular Adenoma. StatPearls. StatPearls Publishing LLC; Treasure Island, FL: 2020

11 

Tischoff I and Tannapfel A: Precancerous colorectal tumors. Internist (Berl). 54:691–698. 2013.(In German). View Article : Google Scholar : PubMed/NCBI

12 

Nguyen LH, Goel A and Chung DC: Pathways of colorectal carcinogenesis. Gastroenterology. 158:291–302. 2020. View Article : Google Scholar : PubMed/NCBI

13 

Guo Y, Bao Y and Yang W: Regulatory miRNAs in colorectal carcinogenesis and metastasis. Int J Mol Sci. 18:8902017. View Article : Google Scholar : PubMed/NCBI

14 

Schatoff EM, Leach BI and Dow LE: Wnt signaling and colorectal cancer. Curr Colorectal Cancer Rep. 13:101–110. 2017. View Article : Google Scholar : PubMed/NCBI

15 

Wang L, Li D, Liu Y, Wang Y, Cui J, Cui A and Wu W: Expression of RUNX3 and β-catenin in the carcinogenesis of sporadic colorectal tubular adenoma. Tumour Biol. 35:6039–6046. 2014. View Article : Google Scholar : PubMed/NCBI

16 

Kirchner T and Brabletz T: Patterning and nuclear beta-catenin expression in the colonic adenoma-carcinoma sequence. Analogies with embryonic gastrulation. Am J Pathol. 157:1113–1121. 2000. View Article : Google Scholar : PubMed/NCBI

17 

Kirsanov K, Fetisov T, Lesovaya EA, Maksimova V, Trukhanova L, Antoshina E, Gor'kova T, Morozova O, Safina A, Fleyshman D, et al: Prevention of colorectal carcinogenesis by DNA-binding small-molecule curaxin CBL0137 involves suppression of Wnt signaling. Cancer Prev Res (Phila). 13:53–64. 2020. View Article : Google Scholar : PubMed/NCBI

18 

Lo YH, Noah TK, Chen MS, Zou W, Borras E, Vilar E and Shroyer NF: SPDEF induces quiescence of colorectal cancer cells by changing the transcriptional targets of β-catenin. Gastroenterology. 153:205–218.e8. 2017. View Article : Google Scholar : PubMed/NCBI

19 

Dong J, Wang R, Ren G, Li X, Wang J, Sun Y, Liang J, Nie Y, Wu K, Feng B, et al: HMGA2-FOXL2 axis regulates metastases and epithelial-to-mesenchymal transition of chemoresistant gastric cancer. Clin Cancer Res. 23:3461–3473. 2017. View Article : Google Scholar : PubMed/NCBI

20 

El Ayachi I, Fatima I, Wend P, Alva-Ornelas JA, Runke S, Kuenzinger WL, Silva J, Silva W, Gray JK, Lehr S, et al: The WNT10B network is associated with survival and metastases in chemoresistant triple-negative breast cancer. Cancer Res. 79:982–993. 2019. View Article : Google Scholar : PubMed/NCBI

21 

Gao X, Dai M, Li Q, Wang Z, Lu Y and Song Z: HMGA2 regulates lung cancer proliferation and metastasis. Thorac Cancer. 8:501–510. 2017. View Article : Google Scholar : PubMed/NCBI

22 

Li XX, Di X, Cong S, Wang Y and Wang K: The role of let-7 and HMGA2 in the occurrence and development of lung cancer: A systematic review and meta-analysis. Eur Rev Med Pharmacol Sci. 22:8353–8366. 2018.PubMed/NCBI

23 

Xu L, Du B, Lu QJ, Fan XW, Tang K, Yang L and Liao WL: MiR-541 suppresses proliferation and invasion of squamous cell lung carcinoma cell lines via directly targeting high-mobility group AT-hook 2. Cancer Med. 7:2581–2591. 2018. View Article : Google Scholar : PubMed/NCBI

24 

Mansoori B, Duijf PHG, Mohammadi A, Najafi S, Roshani E, Shanehbandi D, Hajiasgharzadeh K, Shirjang S, Ditzel HJ, Kazemi T, et al: Overexpression of HMGA2 in breast cancer promotes cell proliferation, migration, invasion and stemness. Expert Opin Ther Targets. 1–11. 2020.(Epub ahead of print). PubMed/NCBI

25 

Sgarra R, Pegoraro S, Ros G, Penzo C, Chiefari E, Foti D, Brunetti A and Manfioletti G: High mobility group A (HMGA) proteins: Molecular instigators of breast cancer onset and progression. Biochim Biophys Acta Rev Cancer. 1869:216–229. 2018. View Article : Google Scholar : PubMed/NCBI

26 

Cai X, Nie J, Chen L and Yu F: Circ_0000267 promotes gastric cancer progression via sponging MiR-503-5p and regulating HMGA2 expression. Mol Genet Genomic Med. 8:e10932020. View Article : Google Scholar : PubMed/NCBI

27 

Li W, Li J, Mu H, Guo M and Deng H: MiR-503 suppresses cell proliferation and invasion of gastric cancer by targeting HMGA2 and inactivating WNT signaling pathway. Cancer Cell Int. 19:1642019. View Article : Google Scholar : PubMed/NCBI

28 

Wang X, Wang J and Wu J: Emerging roles for HMGA2 in colorectal cancer. Transl Oncol. 14:1008942021. View Article : Google Scholar : PubMed/NCBI

29 

Jiang H, Li Y, Li J, Zhang X, Niu G, Chen S and Yao S: Long noncoding RNA LSINCT5 promotes endometrial carcinoma cell proliferation, cycle, and invasion by promoting the Wnt/β-catenin signaling pathway via HMGA2. Ther Adv Med Oncol. Sep 29–2019.(Epub ahead of print). doi: 10.1177/1758835919874649. View Article : Google Scholar

30 

Wend P, Runke S, Wend K, Anchondo B, Yesayan M, Jardon M, Hardie N, Loddenkemper C, Ulasov I, Lesniak MS, et al: WNT10B/β-catenin signalling induces HMGA2 and proliferation in metastatic triple-negative breast cancer. EMBO Mol Med. 5:264–279. 2013. View Article : Google Scholar : PubMed/NCBI

31 

Shia J, Klimstra DS, Bagci P, Basturk O and Adsay NV: TNM staging of colorectal carcinoma: Issues and caveats. Semin Diagn Pathol. 29:142–153. 2012. View Article : Google Scholar : PubMed/NCBI

32 

Barca I, Mignogna C, Donato G and Cristofaro MG: Expression of PLAG1, HMGA1 and HMGA2 in minor salivary glands tumours. Gland Surg. 10:1609–1617. 2021. View Article : Google Scholar : PubMed/NCBI

33 

Zhou Y, Huang Y, Cao X, Xu J, Zhang L, Wang J, Huang L, Huang S, Yuan L, Jia W, et al: WNT2 promotes cervical carcinoma metastasis and induction of epithelial-mesenchymal transition. PLoS One. 11:e01604142016. View Article : Google Scholar : PubMed/NCBI

34 

Zou Y, Zhang Y, Church J and Liu X: Comparison of β-Catenin and LEF1 immunohistochemical stains in desmoid-type fibromatosis and its selected mimickers, with unexpected finding of LEF1 positivity in scars. Appl Immunohistochem Mol Morphol. 26:648–653. 2018. View Article : Google Scholar : PubMed/NCBI

35 

Chen H, Gao J, Du Z, Zhang X, Yang F and Gao W: Expression of factors and key components associated with the PI3K signaling pathway in colon cancer. Oncol Lett. 15:5465–5472. 2018.PubMed/NCBI

36 

Zhao H, Cao Y, Wang G and Luo Z: Expression of FOXC2, PinX1, Ki-67 and Cyclin D1 in cutaneous cell carcinoma. Oncol Lett. 14:635–638. 2017. View Article : Google Scholar : PubMed/NCBI

37 

Livak KJ and Schmittgen TD: Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) method. Methods. 25:402–408. 2001. View Article : Google Scholar : PubMed/NCBI

38 

Valenta T, Hausmann G and Basler K: The many faces and functions of β-catenin. EMBO J. 31:2714–2736. 2012. View Article : Google Scholar : PubMed/NCBI

39 

Zhu J, Wang H, Xu S and Hao Y: Clinicopathological and prognostic significance of HMGA2 overexpression in gastric cancer: A meta-analysis. Oncotarget. 8:100478–100489. 2017. View Article : Google Scholar : PubMed/NCBI

40 

Ma Y, Zheng W, Chen H, Shao X, Lin P, Liu X, Li X and Ye H: Glucosamine promotes chondrocyte proliferation via the Wnt/β-catenin signaling pathway. Int J Mol Med. 42:61–70. 2018.PubMed/NCBI

41 

Doumpas N, Lampart F, Robinson MD, Lentini A, Nestor CE, Cantù C and Basler K: TCF/LEF dependent and independent transcriptional regulation of Wnt/β-catenin target genes. EMBO J. 38:e988732019. View Article : Google Scholar : PubMed/NCBI

42 

Testa U, Pelosi E and Castelli G: Colorectal cancer: Genetic abnormalities, tumor progression, tumor heterogeneity, clonal evolution and tumor-initiating cells. Med Sci (Basel). 6:312018.PubMed/NCBI

43 

Wei R, Shang Z, Leng J and Cui L: Increased expression of high-mobility group A2: A novel independent indicator of poor prognosis in patients with esophageal squamous cell carcinoma. J Cancer Res Ther. 12:1291–1297. 2016. View Article : Google Scholar : PubMed/NCBI

44 

Binabaj MM, Soleimani A, Rahmani F, Avan A, Khazaei M, Fiuji H, Soleimanpour S, Ryzhikov M, Ferns GA, Bahrami A and Hassanian SM: Prognostic value of high mobility group protein A2 (HMGA2) over-expression in cancer progression. Gene. 706:131–139. 2019. View Article : Google Scholar : PubMed/NCBI

45 

Yang S, Gu Y, Wang G, Hu Q, Chen S, Wang Y and Zhao M: HMGA2 regulates acute myeloid leukemia progression and sensitivity to daunorubicin via Wnt/β-catenin signaling. Int J Mol Med. 44:427–436. 2019.PubMed/NCBI

46 

Sebio A, Kahn M and Lenz HJ: The potential of targeting Wnt/β-catenin in colon cancer. Expert Opin Ther Targets. 18:611–615. 2014. View Article : Google Scholar : PubMed/NCBI

47 

Prossomariti A, Piazzi G, Alquati C and Ricciardiello L: Are Wnt/β-Catenin and PI3K/AKT/mTORC1 distinct pathways in colorectal cancer? Cell Mol Gastroenterol Hepatol. 10:491–506. 2020. View Article : Google Scholar : PubMed/NCBI

48 

Mansoori B, Mohammadi A, Ditzel HJ, Duijf PHG, Khaze V, Gjerstorff MF and Baradaran B: HMGA2 as a critical regulator in cancer development. Genes (Basel). 12:2692021. View Article : Google Scholar : PubMed/NCBI

49 

Zhang S, Mo Q and Wang X: Oncological role of HMGA2 (Review). Int J Oncol. 55:775–788. 2019.PubMed/NCBI

Related Articles

  • Abstract
  • View
  • Download
  • Twitter
Copy and paste a formatted citation
Spandidos Publications style
Li D, Cao Y, Wang J, Yang H, Liu W, Cui J and Wu W: Regulatory effect between HMGA2 and the Wnt/β‑catenin signaling pathway in the carcinogenesis of sporadic colorectal tubular adenoma. Oncol Lett 22: 849, 2021.
APA
Li, D., Cao, Y., Wang, J., Yang, H., Liu, W., Cui, J., & Wu, W. (2021). Regulatory effect between HMGA2 and the Wnt/β‑catenin signaling pathway in the carcinogenesis of sporadic colorectal tubular adenoma. Oncology Letters, 22, 849. https://doi.org/10.3892/ol.2021.13110
MLA
Li, D., Cao, Y., Wang, J., Yang, H., Liu, W., Cui, J., Wu, W."Regulatory effect between HMGA2 and the Wnt/β‑catenin signaling pathway in the carcinogenesis of sporadic colorectal tubular adenoma". Oncology Letters 22.6 (2021): 849.
Chicago
Li, D., Cao, Y., Wang, J., Yang, H., Liu, W., Cui, J., Wu, W."Regulatory effect between HMGA2 and the Wnt/β‑catenin signaling pathway in the carcinogenesis of sporadic colorectal tubular adenoma". Oncology Letters 22, no. 6 (2021): 849. https://doi.org/10.3892/ol.2021.13110
Copy and paste a formatted citation
x
Spandidos Publications style
Li D, Cao Y, Wang J, Yang H, Liu W, Cui J and Wu W: Regulatory effect between HMGA2 and the Wnt/β‑catenin signaling pathway in the carcinogenesis of sporadic colorectal tubular adenoma. Oncol Lett 22: 849, 2021.
APA
Li, D., Cao, Y., Wang, J., Yang, H., Liu, W., Cui, J., & Wu, W. (2021). Regulatory effect between HMGA2 and the Wnt/β‑catenin signaling pathway in the carcinogenesis of sporadic colorectal tubular adenoma. Oncology Letters, 22, 849. https://doi.org/10.3892/ol.2021.13110
MLA
Li, D., Cao, Y., Wang, J., Yang, H., Liu, W., Cui, J., Wu, W."Regulatory effect between HMGA2 and the Wnt/β‑catenin signaling pathway in the carcinogenesis of sporadic colorectal tubular adenoma". Oncology Letters 22.6 (2021): 849.
Chicago
Li, D., Cao, Y., Wang, J., Yang, H., Liu, W., Cui, J., Wu, W."Regulatory effect between HMGA2 and the Wnt/β‑catenin signaling pathway in the carcinogenesis of sporadic colorectal tubular adenoma". Oncology Letters 22, no. 6 (2021): 849. https://doi.org/10.3892/ol.2021.13110
Follow us
  • Twitter
  • LinkedIn
  • Facebook
About
  • Spandidos Publications
  • Careers
  • Cookie Policy
  • Privacy Policy
How can we help?
  • Help
  • Live Chat
  • Contact
  • Email to our Support Team