Open Access

Downregulation of amine oxidase copper containing 1 inhibits tumor progression by suppressing IL‑6/JAK/STAT3 pathway activation in hepatocellular carcinoma

  • Authors:
    • Qian Ding
    • Dongdong Lin
    • Yajing Zhou
    • Feng Li
    • Jianming  Lai
    • Jianping Duan
    • Jing Chen
    • Caihua Jiang
  • View Affiliations

  • Published online on: October 30, 2021     https://doi.org/10.3892/ol.2021.13118
  • Article Number: 857
  • Copyright: © Ding et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Amine oxidase copper containing 1 (AOC1) is a copper‑containing amine oxidase that catalyzes the deamination of polyamines. AOC1 functions as an oncogene in human gastric cancer. There is little information available regarding the function of AOC1 in hepatocellular carcinoma (HCC). In the present study, reverse transcription‑quantitative PCR was used to detect the expression levels of AOC1 in HCC tissues, and the role of AOC1 in HCC progression was determined using western blot, Cell Counting Kit 8, clone formation, wound‑healing and Transwell assays. An AOC1 survival curve was generated with data downloaded from The Cancer Genome Atlas, and Gene Set Enrichment Analysis was performed to investigate the potential biological mechanisms of AOC1 in HCC. AOC1 was found to be upregulated in HCC tissues, which was associated with a poor prognosis. Furthermore, AOC1‑knockdown inhibited HCC cell proliferation, migration and invasiveness, suppressed IL‑6 expression, as well as decreasing JAK2 and STAT3 phosphorylation. Ultimately, the results of the present study illustrate that AOC1 promoted the proliferation, migration and invasiveness of HCC cells by regulating the IL‑6/JAK/STAT3 pathway.
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